WELCOME TO THE McHEYZER-WILLIAMS LAB
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Michael McHeyzer-Williams, PhD |
Professor
Department of Immunology & Microbial Science
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Phone: (858) 784-8259
Fax: (858) 784-8350
Email: mcheyzer@scripps.edu
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BRIEF BIOGRAPHY
Michael McHeyzer-Williams received a PhD in Immunology in 1991 from the Walter and Eliza Hall Institute of Medical Research, University of Melbourne, Australia. As a Lucille P. Markey Fellow, Michael undertook post-doctoral work in the Immunology Department at Stanford University Medical Center in 1992. In 1995, he was appointed Assistant Professor in Immunology at Duke University Medical Center in Durham, NC. Since 2001, Michael has continued his work at The Scripps Research Institute in La Jolla, California, as a Professor in the Department of Immunology & Microbial Science.
RESEARCH FOCUS
Memory B Cell Mechanisms in Host Defense. Helper T cells are the central regulators of adaptive immunity that control the development of antigen-specific B cell immunity. Our research seeks to define the cellular and molecular details of the major developmental checkpoints that regulate these cell fate decisions in vivo. We have recently extended our studies into the earliest innate immune events that initiate and shape this adaptive immune response to infectious challenge. If we can understand the rules that control adaptive immunity, it will be possible to design safe and effective protein sub-unit vaccines that prevent infectious diseases.
RECENT PUBLICATIONS
Wang N.S., McHeyzer-Williams L.J., Okitsu S.L., Burris T.P., Reiner S.L., McHeyzer-Williams M.G. (2012) Divergent transcriptional programming of class-specific B cell memory by T-bet and RORalpha. Nature Immunology 6: 604-11.PubMed Abstract
Pelletier, N., McHeyzer-Williams, L.J., Wong, K.A., Urich, E., Fazilleau, N.R., and McHeyzer-Williams, M.G. (2010) Plasma cells negatively regulate the follicular helper T cell program. Nature Immunology 11:1110-1118 PubMed Abstract
Fazilleau, N.R., McHeyzer-Williams L.J., Rosen, H., and McHeyzer-Williams, M.G., (2009) The function of follicular helper T cells is regulated by the strength of T cell antigen receptor binding. Nature Immunology 10:375-384 PubMed Abstract
Malherbe, L.P., Mark, L., Fazilleau, N.R., McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. (2008) Vaccine adjuvants alter TCR-based selection thresholds. Immunity 28(5):698-709 PubMed Abstract
Fazilleau, N.R., Eisenbraun, M.D., Malherbe, L.P., Ebright, J.N., McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. (2007) Lymphoid reservoirs of antigen-specific memory T helper cells. Nature Immunology 8:753-761 PubMed Abstract
REVIEWS
McHeyzer-Williams, M.G., Okitsu, S.L., Wang, N.S., McHeyzer-Williams, L.J. (2011) Molecular programming of B cell memory. Nat Rev Immunol. 12(1): 24-34. Review. PubMed Abstract
Fazilleau, N., Mark, L., McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. (2009) Follicular helper T cells: lineage and location. Immunity. 30 (3):324-35 PubMed Abstract
McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. (2005) Antigen-Specific Memory B Cell Development. Annual Reviews Immunol. Vol. 23:487-513. PubMed Abstract
TSRI STORIES
