Pedro Serrano, PhD.

serrano@scripps.edu
phone: +1 858 784 8366  
fax     : +1 858 784 8014 

Research Interests

I am interested on the structure determination of proteins as potential therapeutic targets, and the study of their interaction with small organic molecules by NMR spectroscopy, as a basis for drug design.  

Curriculum Vitae

1999 University degree (Chemistry), Universitat de Barcelona, Spain.

2002 Diploma Master (Organic Chemistry), Universitat de Barcelona, Spain.

2004 Ph.D (Organic Chemistry), Research Unit of BioActive Molecules (RUBAM), IIQAB, Barcelona, Spain.

Since January 2005 Research Associate, The Scripps Research Institute, La Jolla, CA, USA.

Publications

1. P. Serrano, M. A. Johnson, A. Chatterjee, Neuman, B., J. S. Joseph, M. J. Buchmeier, P. Kuhn, K. Wüthrich. NMR Structure of the Nucleic Acid-Binding Domain of the SARS Coronavirus Nonstructural Protein 3. J Virol. 2009. In press.

2. Chatterjee, A., M. A. Johnson, P. Serrano, B. Pedrini, J. S. Joseph, B. W. Neuman, K. Saikatendu, M. J. Buchmeier, P. Kuhn, and K. Wuthrich. Nuclear magnetic resonance structure shows that the severe acute respiratory syndrome coronavirus-unique domain contains a macrodomain fold. J Virol. 2009, 83 (4), 1823–36.

3. Neuman, B. W., J. S. Joseph, K. S. Saikatendu, P. Serrano, A. Chatterjee, M. A. Johnson, L. Liao, J. P. Klaus, J. R. Yates, 3rd, K. Wuthrich, R. C. Stevens, M. J. Buchmeier, and P. Kuhn. Proteomics analysis unravels the functional repertoire of coronavirus nonstructural protein 3. J Virol. 2008, 82 (11), 5279–94.

4. P. Serrano, M. A. Johnson, A. Chatterjee, B. Pedrini, and K. Wuthrich. NMR assignment of the nonstructural protein nsp3(1066–1181) from SARS-CoV. Biomol NMR Assign. 2008, 2, 135–138.

5. A. Chatterjee, M. A. Johnson, P. Serrano, B. Pedrini, and K. Wuthrich. NMR assignment of the domain 513–651 from the SARS-CoV nonstructural protein nsp3. Biomol NMR Assign. 2007, 1, 191–194.

6. P. Serrano, M. Ejido-Gabas, A. Llebaria, A. Delgado . An unexpected access to 5-epi-cyclophellitol, a new cyclitol member. Tetrahedrom. Asymethy .2007, 18, 1971–1974.

7. P. Serrano , M. A. Johnson, M. S. Almeida, R. Horst, T. Herrmann, J. S. Joseph, B. W. Neuman, V. Subramanian, K. S. Saikatendu, M. J. Buchmeier, R. C. Stevens, P. Kuhn, K. Wüthrich NMR Structure of the N-terminal Domain of the Nonstructural Protein 3 from the SARS Coronavirus. J. Virol. 2007, 81 (21), 2049–12060.

8. P. Serrano, J. Casas, A. Llebaria, M. Zucco, G. Emeric, A. Delgado. Parallel Synthesis and yeast growth inhibition screening of succinamic acid libraries. J. Comb. Chem. 2007, 9, 635–643.

9. P. Serrano, J. Casas , A. Llebaria, M. Zucco, G. Emeric, A. Delgado. Combinatorial approach to N-Substituted Aminocyclitol Libraries by Solution-Phase Parallel synthesis and Preliminary Evaluation as Glucocerebroside inhibitors. J. Comb. Chem. 2007, 9, 43–52.

10. P. Serrano, M.S. Almeida, M. A. Johnson, K. Wuthrich, NMR assignment of the protein nsp3a from SARS coronavirus. J. Biomol. NMR. 2006, 36, 45.

11. P. Serrano, A. Llebaria, J. Vazquez, J.M. Anglada, A. Delgado. On the regio- and stereoselective synthesis of aminocyclitols from cyclitol epoxides. The effect of Li as a Chelating agent. Chem. Eur. J. 2005, 11, 4465–4472.

12. P. Serrano, A. Llebaria, A. Delgado. Regio- and stereoselective synthesis of aminoinositols and 1,2-diaminoinositols from conduritol B epoxide. J. Org. Chem. 2005 , 70, 7829–7840.

13. M. Ejido-Gabas, P. Serrano, Casas, J. Llebaria, A., Delgado, A. New aminocyclitols as modulators of glucosylceramide metabolism. Org. Biomol. Chem. 2005, 7, 1195–1201.

14. P. Serrano, A. Llebaria, A. Delgado. An unexpected chelation controlled by Yb(OTf)3 catalyzed aminolysis and azidolysis of cyclitol epoxides. J. Org. Chem. 2002, 67, 7165–7167.