Wilson Laboratory Publications

(Last updated Sun Aug 3 22:11:04 PDT 2008 )

-- 2008 (18) --

Recent Avian H5N1 Viruses Exhibit Increased Propensity for Acquiring Human Receptor Specificity. J Stevens, O Blixt, LM Chen, RO Donis, JC Paulson, IA Wilson (2008) J Mol Biol

Structure determination of the 1918 H1N1 neuraminidase from a crystal with lattice-translocation defects. X Zhu, X Xu, IA Wilson (2008) Acta Crystallogr D Biol Crystallogr 64: 843-50.

Structure determination of an anti-HIV-1 Fab 447-52D-peptide complex from an epitaxially twinned data set. AK Dhillon, RL Stanfield, MK Gorny, C Williams, S Zolla-Pazner, IA Wilson (2008) Acta Crystallogr D Biol Crystallogr 64: 792-802.

pH-dependent interdomain tethers of CD1b regulate its antigen capture. M Relloso, TY Cheng, JS Im, E Parisini, C Roura-Mir, C DeBono, DM Zajonc, LF Murga, MJ Ondrechen, IA Wilson, SA Porcelli, DB Moody (2008) Immunity 28: 774-86.

A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120. RD Astronomo, HK Lee, CN Scanlan, R Pantophlet, CY Huang, IA Wilson, O Blixt, RA Dwek, CH Wong, DR Burton (2008) J Virol 82: 6359-68.

Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus. CJ Wei, L Xu, WP Kong, W Shi, K Canis, J Stevens, ZY Yang, A Dell, SM Haslam, IA Wilson, GJ Nabel (2008) J Virol 82: 6200-8.

Conformational isomerism can limit antibody catalysis. EW Debler, R Müller, D Hilvert, IA Wilson (2008) J Biol Chem 283: 16554-60.

Crystal structures of MW1337R and lin2004: representatives of a novel protein family that adopt a four-helical bundle fold. P Kozbial, Q Xu, HJ Chiu, D McMullan, SS Krishna, MD Miller, P Abdubek, C Acosta, T Astakhova, HL Axelrod, D Carlton, T Clayton, M Deller, L Duan, Y Elias, MA Elsliger, J Feuerhelm, SK Grzechnik, J Hale, GW Han, L Jaroszewski, KK Jin, HE Klock, MW Knuth, E Koesema, A Kumar, D Marciano, AT Morse, KD Murphy, E Nigoghossian, L Okach, S Oommachen, R Reyes, CL Rife, G Spraggon, CV Trout, H van den Bedem, D Weekes, A White, G Wolf, C Zubieta, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2008) Proteins 71: 1589-96.

Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex. EW Debler, GF Kaufmann, MM Meijler, A Heine, JM Mee, G Pljevaljcic, AJ Di Bilio, PG Schultz, DP Millar, KD Janda, IA Wilson, HB Gray, RA Lerner (2008) Science 319: 1232-5.

Crystal structures of mouse CD1d-iGb3 complex and its cognate Valpha14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids. DM Zajonc, PB Savage, A Bendelac, IA Wilson, L Teyton (2008) J Mol Biol 377: 1104-16.

Crystal structure of an ADP-ribosylated protein with a cytidine deaminase-like fold, but unknown function (TM1506), from Thermotoga maritima at 2.70 A resolution. Q Xu, P Kozbial, D McMullan, SS Krishna, SM Brittain, SB Ficarro, M DiDonato, MD Miller, P Abdubek, HL Axelrod, HJ Chiu, T Clayton, L Duan, MA Elsliger, J Feuerhelm, SK Grzechnik, J Hale, GW Han, L Jaroszewski, HE Klock, AT Morse, E Nigoghossian, J Paulsen, R Reyes, CL Rife, H van den Bedem, A White, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2008) Proteins 71: 1546-52.

Crystal structure of AICAR transformylase IMP cyclohydrolase (TM1249) from Thermotoga maritima at 1.88 A resolution. HL Axelrod, D McMullan, SS Krishna, MD Miller, MA Elsliger, P Abdubek, E Ambing, T Astakhova, D Carlton, HJ Chiu, T Clayton, L Duan, J Feuerhelm, SK Grzechnik, J Hale, GW Han, J Haugen, L Jaroszewski, KK Jin, HE Klock, MW Knuth, E Koesema, AT Morse, E Nigoghossian, L Okach, S Oommachen, J Paulsen, K Quijano, R Reyes, CL Rife, H van den Bedem, D Weekes, A White, G Wolf, Q Xu, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2008) Proteins 71: 1042-9.

Protein production and purification. , , , S Gräslund, P Nordlund, J Weigelt, BM Hallberg, J Bray, O Gileadi, S Knapp, U Oppermann, C Arrowsmith, R Hui, J Ming, S dhe-Paganon, HW Park, A Savchenko, A Yee, A Edwards, R Vincentelli, C Cambillau, R Kim, SH Kim, Z Rao, Y Shi, TC Terwilliger, CY Kim, LW Hung, GS Waldo, Y Peleg, S Albeck, T Unger, O Dym, J Prilusky, JL Sussman, RC Stevens, SA Lesley, IA Wilson, A Joachimiak, F Collart, I Dementieva, MI Donnelly, WH Eschenfeldt, Y Kim, L Stols, R Wu, M Zhou, SK Burley, JS Emtage, JM Sauder, D Thompson, K Bain, J Luz, T Gheyi, F Zhang, S Atwell, SC Almo, JB Bonanno, A Fiser, S Swaminathan, FW Studier, MR Chance, A Sali, TB Acton, R Xiao, L Zhao, LC Ma, JF Hunt, L Tong, K Cunningham, M Inouye, S Anderson, H Janjua, R Shastry, CK Ho, D Wang, H Wang, M Jiang, GT Montelione, DI Stuart, RJ Owens, S Daenke, A Schütz, U Heinemann, S Yokoyama, K Büssow, KC Gunsalus (2008) Nat Methods 5: 135-46.

A peptide inhibitor of HIV-1 neutralizing antibody 2G12 is not a structural mimic of the natural carbohydrate epitope on gp120. A Menendez, DA Calarese, RL Stanfield, KC Chow, CN Scanlan, R Kunert, H Katinger, DR Burton, IA Wilson, JK Scott (2008) FASEB J 22: 1380-92.

Contributions to the NIH-NIGMS Protein Structure Initiative from the PSI Production Centers. SK Burley, A Joachimiak, GT Montelione, IA Wilson (2008) Structure 16: 5-11.

Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. SM Johnson, S Connelly, IA Wilson, JW Kelly (2008) J Med Chem 51: 260-70.

Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization. CH Bell, R Pantophlet, A Schiefner, LA Cavacini, RL Stanfield, DR Burton, IA Wilson (2008) J Mol Biol 375: 969-78.

Crystal structure of 2-keto-3-deoxygluconate kinase (TM0067) from Thermotoga maritima at 2.05 A resolution. II Mathews, D McMullan, MD Miller, JM Canaves, MA Elsliger, R Floyd, SK Grzechnik, L Jaroszewski, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, TM McPhillips, AT Morse, K Quijano, CL Rife, R Schwarzenbacher, G Spraggon, RC Stevens, H van den Bedem, D Weekes, G Wolf, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2008) Proteins 70: 603-8.

-- 2007 (23) --

The challenge of protein structure determination--lessons from structural genomics. L Slabinski, L Jaroszewski, AP Rodrigues, L Rychlewski, IA Wilson, SA Lesley, A Godzik (2007) Protein Sci 16: 2472-82.

XtalPred: a web server for prediction of protein crystallizability. L Slabinski, L Jaroszewski, L Rychlewski, IA Wilson, SA Lesley, A Godzik (2007) Bioinformatics 23: 3403-5.

Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. CC Huang, SN Lam, P Acharya, M Tang, SH Xiang, SS Hussan, RL Stanfield, J Robinson, J Sodroski, IA Wilson, R Wyatt, CA Bewley, PD Kwong (2007) Science 317: 1930-4.

Immunology. Square-dancing antibodies. DR Burton, IA Wilson (2007) Science 317: 1507-8.

Structure of the Wilms tumor suppressor protein zinc finger domain bound to DNA. R Stoll, BM Lee, EW Debler, JH Laity, IA Wilson, HJ Dyson, PE Wright (2007) J Mol Biol 372: 1227-45.

Reactivation of methionine synthase from Thermotoga maritima (TM0268) requires the downstream gene product TM0269. S Huang, G Romanchuk, K Pattridge, SA Lesley, IA Wilson, RG Matthews, M Ludwig (2007) Protein Sci 16: 1588-95.

Crystal structure of MtnX phosphatase from Bacillus subtilis at 2.0 A resolution provides a structural basis for bipartite phosphomonoester hydrolysis of 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate. Q Xu, KS Saikatendu, SS Krishna, D McMullan, P Abdubek, S Agarwalla, E Ambing, T Astakhova, HL Axelrod, D Carlton, HJ Chiu, T Clayton, M DiDonato, L Duan, MA Elsliger, J Feuerhelm, SK Grzechnik, J Hale, E Hampton, GW Han, J Haugen, L Jaroszewski, KK Jin, HE Klock, MW Knuth, E Koesema, MD Miller, AT Morse, E Nigoghossian, L Okach, S Oommachen, J Paulsen, R Reyes, CL Rife, R Schwarzenbacher, H van den Bedem, A White, G Wolf, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2007) Proteins 69: 433-9.

Identification and structural characterization of heme binding in a novel dye-decolorizing peroxidase, TyrA. C Zubieta, R Joseph, SS Krishna, D McMullan, M Kapoor, HL Axelrod, MD Miller, P Abdubek, C Acosta, T Astakhova, D Carlton, HJ Chiu, T Clayton, MC Deller, L Duan, Y Elias, MA Elsliger, J Feuerhelm, SK Grzechnik, J Hale, GW Han, L Jaroszewski, KK Jin, HE Klock, MW Knuth, P Kozbial, A Kumar, D Marciano, AT Morse, KD Murphy, E Nigoghossian, L Okach, S Oommachen, R Reyes, CL Rife, P Schimmel, CV Trout, H van den Bedem, D Weekes, A White, Q Xu, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2007) Proteins 69: 234-43.

Crystal structures of two novel dye-decolorizing peroxidases reveal a beta-barrel fold with a conserved heme-binding motif. C Zubieta, SS Krishna, M Kapoor, P Kozbial, D McMullan, HL Axelrod, MD Miller, P Abdubek, E Ambing, T Astakhova, D Carlton, HJ Chiu, T Clayton, MC Deller, L Duan, MA Elsliger, J Feuerhelm, SK Grzechnik, J Hale, E Hampton, GW Han, L Jaroszewski, KK Jin, HE Klock, MW Knuth, A Kumar, D Marciano, AT Morse, E Nigoghossian, L Okach, S Oommachen, R Reyes, CL Rife, P Schimmel, H van den Bedem, D Weekes, A White, Q Xu, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2007) Proteins 69: 223-33.

Crystal structure of NMA1982 from Neisseria meningitidis at 1.5 A resolution provides a structural scaffold for nonclassical, eukaryotic-like phosphatases. SS Krishna, L Tautz, Q Xu, D McMullan, MD Miller, P Abdubek, E Ambing, T Astakhova, HL Axelrod, D Carlton, HJ Chiu, T Clayton, M DiDonato, L Duan, MA Elsliger, SK Grzechnik, J Hale, E Hampton, GW Han, J Haugen, L Jaroszewski, KK Jin, HE Klock, MW Knuth, E Koesema, AT Morse, T Mustelin, E Nigoghossian, S Oommachen, R Reyes, CL Rife, H van den Bedem, D Weekes, A White, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2007) Proteins 69: 415-21.

Architecture of CD1 proteins. DM Zajonc, IA Wilson (2007) Curr Top Microbiol Immunol 314: 27-50.

Crystal structure of homoserine O-succinyltransferase from Bacillus cereus at 2.4 A resolution. C Zubieta, SS Krishna, D McMullan, MD Miller, P Abdubek, S Agarwalla, E Ambing, T Astakhova, HL Axelrod, D Carlton, HJ Chiu, T Clayton, M Deller, M DiDonato, L Duan, MA Elsliger, SK Grzechnik, J Hale, E Hampton, GW Han, J Haugen, L Jaroszewski, KK Jin, HE Klock, MW Knuth, E Koesema, A Kumar, D Marciano, AT Morse, E Nigoghossian, S Oommachen, R Reyes, CL Rife, H van den Bedem, D Weekes, A White, Q Xu, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2007) Proteins 68: 999-1005.

Specific recognition of a DNA immunogen by its elicited antibody. S Sanguineti, JM Centeno Crowley, MF Lodeiro Merlo, ML Cerutti, IA Wilson, FA Goldbaum, RL Stanfield, G de Prat-Gay (2007) J Mol Biol 370: 183-95.

Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies. EO Saphire, M Montero, A Menendez, NE van Houten, MB Irving, R Pantophlet, MB Zwick, PW Parren, DR Burton, JK Scott, IA Wilson (2007) J Mol Biol 369: 696-709.

Crystal structure of TM1030 from Thermotoga maritima at 2.3 A resolution reveals molecular details of its transcription repressor function. L Premkumar, CL Rife, S Sri Krishna, D McMullan, MD Miller, P Abdubek, E Ambing, T Astakhova, HL Axelrod, JM Canaves, D Carlton, HJ Chiu, T Clayton, M DiDonato, L Duan, MA Elsliger, J Feuerhelm, R Floyd, SK Grzechnik, J Hale, E Hampton, GW Han, J Haugen, L Jaroszewski, KK Jin, HE Klock, MW Knuth, E Koesema, JS Kovarik, A Kreusch, I Levin, TM McPhillips, AT Morse, E Nigoghossian, L Okach, S Oommachen, J Paulsen, K Quijano, R Reyes, F Rezezadeh, D Rodionov, R Schwarzenbacher, G Spraggon, H van den Bedem, A White, G Wolf, Q Xu, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2007) Proteins 68: 418-24.

Crystal structures of a quorum-quenching antibody. EW Debler, GF Kaufmann, RN Kirchdoerfer, JM Mee, KD Janda, IA Wilson (2007) J Mol Biol 368: 1392-402.

Structure-based design, synthesis, evaluation, and crystal structures of transition state analogue inhibitors of inosine monophosphate cyclohydrolase. L Xu, Y Chong, I Hwang, A D'Onofrio, K Amore, GP Beardsley, C Li, AJ Olson, DL Boger, IA Wilson (2007) J Biol Chem 282: 13033-46.

An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10. JD Nelson, FM Brunel, R Jensen, ET Crooks, RM Cardoso, M Wang, A Hessell, IA Wilson, JM Binley, PE Dawson, DR Burton, MB Zwick (2007) J Virol 81: 4033-43.

Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy. M Law, RM Cardoso, IA Wilson, DR Burton (2007) J Virol 81: 4272-85.

Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding. RL Stanfield, H Dooley, P Verdino, MF Flajnik, IA Wilson (2007) J Mol Biol 367: 358-72.

Crystal structure of a transcription regulator (TM1602) from Thermotoga maritima at 2.3 A resolution. D Weekes, MD Miller, SS Krishna, D McMullan, TM McPhillips, C Acosta, JM Canaves, MA Elsliger, R Floyd, SK Grzechnik, L Jaroszewski, HE Klock, E Koesema, JS Kovarik, A Kreusch, AT Morse, K Quijano, G Spraggon, H van den Bedem, G Wolf, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2007) Proteins 67: 247-52.

Bifunctional catalysis of proton transfer at an antibody active site. R Müller, EW Debler, M Steinmann, FP Seebeck, IA Wilson, D Hilvert (2007) J Am Chem Soc 129: 460-1.

Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10. RM Cardoso, FM Brunel, S Ferguson, M Zwick, DR Burton, PE Dawson, IA Wilson (2007) J Mol Biol 365: 1533-44.

-- 2006 (33) --

The effects of antibodies on stilbene excited-state energetics. F Tian, EW Debler, DP Millar, AA Deniz, IA Wilson, PG Schultz (2006) Angew Chem Int Ed Engl 45: 7763-5.

Enhanced major histocompatibility complex class I binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide. E Lazoura, J Lodding, W Farrugia, PA Ramsland, J Stevens, IA Wilson, GA Pietersz, V Apostolopoulos (2006) Immunology 119: 306-16.

Glycan microarray technologies: tools to survey host specificity of influenza viruses. J Stevens, O Blixt, JC Paulson, IA Wilson (2006) Nat Rev Microbiol 4: 857-64.

Comparative structural analysis of a novel glutathioneS-transferase (ATU5508) from Agrobacterium tumefaciens at 2.0 A resolution. M Kosloff, GW Han, SS Krishna, R Schwarzenbacher, M Fasnacht, MA Elsliger, P Abdubek, S Agarwalla, E Ambing, T Astakhova, HL Axelrod, JM Canaves, D Carlton, HJ Chiu, T Clayton, M DiDonato, L Duan, J Feuerhelm, C Grittini, SK Grzechnik, J Hale, E Hampton, J Haugen, L Jaroszewski, KK Jin, H Johnson, HE Klock, MW Knuth, E Koesema, A Kreusch, P Kuhn, I Levin, D McMullan, MD Miller, AT Morse, K Moy, E Nigoghossian, L Okach, S Oommachen, R Page, J Paulsen, K Quijano, R Reyes, CL Rife, E Sims, G Spraggon, V Sridhar, RC Stevens, H van den Bedem, J Velasquez, A White, G Wolf, Q Xu, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2006) Proteins 65: 527-37.

Structural characterization of mycobacterial phosphatidylinositol mannoside binding to mouse CD1d. DM Zajonc, GD Ainge, GF Painter, WB Severn, IA Wilson (2006) J Immunol 177: 4577-83.

Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. ZD Cooper, D Narasimhan, RK Sunahara, P Mierzejewski, EM Jutkiewicz, NA Larsen, IA Wilson, DW Landry, JH Woods (2006) Mol Pharmacol 70: 1885-91.

Crystal structure of an ORFan protein (TM1622) from Thermotoga maritima at 1.75 A resolution reveals a fold similar to the Ran-binding protein Mog1p. Q Xu, SS Krishna, D McMullan, R Schwarzenbacher, MD Miller, P Abdubek, S Agarwalla, E Ambing, T Astakhova, HL Axelrod, JM Canaves, D Carlton, HJ Chiu, T Clayton, M DiDonato, L Duan, MA Elsliger, J Feuerhelm, SK Grzechnik, J Hale, E Hampton, GW Han, J Haugen, L Jaroszewski, KK Jin, HE Klock, MW Knuth, E Koesema, A Kreusch, P Kuhn, AT Morse, E Nigoghossian, L Okach, S Oommachen, J Paulsen, K Quijano, R Reyes, CL Rife, G Spraggon, RC Stevens, H van den Bedem, A White, G Wolf, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2006) Proteins 65: 777-82.

Crystal structure of 2-phosphosulfolactate phosphatase (ComB) from Clostridium acetobutylicum at 2.6 A resolution reveals a new fold with a novel active site. M DiDonato, SS Krishna, R Schwarzenbacher, D McMullan, S Agarwalla, SM Brittain, MD Miller, P Abdubek, E Ambing, HL Axelrod, JM Canaves, HJ Chiu, AM Deacon, L Duan, MA Elsliger, A Godzik, SK Grzechnik, J Hale, E Hampton, J Haugen, L Jaroszewski, KK Jin, HE Klock, MW Knuth, E Koesema, A Kreusch, P Kuhn, SA Lesley, I Levin, AT Morse, E Nigoghossian, L Okach, S Oommachen, J Paulsen, K Quijano, R Reyes, CL Rife, G Spraggon, RC Stevens, H van den Bedem, A White, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2006) Proteins 65: 771-6.

Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Y Kinjo, E Tupin, D Wu, M Fujio, R Garcia-Navarro, MR Benhnia, DM Zajonc, G Ben-Menachem, GD Ainge, GF Painter, A Khurana, K Hoebe, SM Behar, B Beutler, IA Wilson, M Tsuji, TJ Sellati, CH Wong, M Kronenberg (2006) Nat Immunol 7: 978-86.

Crystal structure of phosphoribosylformyl-glycinamidine synthase II, PurS subunit (TM1244) from Thermotoga maritima at 1.90 A resolution. II Mathews, SS Krishna, R Schwarzenbacher, D McMullan, L Jaroszewski, MD Miller, P Abdubek, S Agarwalla, E Ambing, HL Axelrod, JM Canaves, D Carlton, HJ Chiu, T Clayton, M DiDonato, L Duan, MA Elsliger, SK Grzechnik, J Hale, E Hampton, J Haugen, KK Jin, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, I Levin, AT Morse, E Nigoghossian, L Okach, S Oommachen, J Paulsen, K Quijano, R Reyes, CL Rife, G Spraggon, RC Stevens, H van den Bedem, A White, G Wolf, Q Xu, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2006) Proteins 65: 249-54.

Crystal structure of a glycerate kinase (TM1585) from Thermotoga maritima at 2.70 A resolution reveals a new fold. R Schwarzenbacher, D McMullan, SS Krishna, Q Xu, MD Miller, JM Canaves, MA Elsliger, R Floyd, SK Grzechnik, L Jaroszewski, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, TM McPhillips, AT Morse, K Quijano, G Spraggon, RC Stevens, H van den Bedem, G Wolf, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2006) Proteins 65: 243-8.

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Z Jiang, P Georgel, C Li, J Choe, K Crozat, S Rutschmann, X Du, T Bigby, S Mudd, S Sovath, IA Wilson, A Olson, B Beutler (2006) Proc Natl Acad Sci U S A 103: 10961-6.

Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120. JM Binley, S Ngo-Abdalla, P Moore, M Bobardt, U Chatterji, P Gallay, DR Burton, IA Wilson, JH Elder, A de Parseval (2006) Retrovirology 3: 39.

Role of lipid trimming and CD1 groove size in cellular antigen presentation. TY Cheng, M Relloso, I Van Rhijn, DC Young, GS Besra, V Briken, DM Zajonc, IA Wilson, S Porcelli, DB Moody (2006) EMBO J 25: 2989-99.

Crystal structure of acireductone dioxygenase (ARD) from Mus musculus at 2.06 angstrom resolution. Q Xu, R Schwarzenbacher, SS Krishna, D McMullan, S Agarwalla, K Quijano, P Abdubek, E Ambing, H Axelrod, T Biorac, JM Canaves, HJ Chiu, MA Elsliger, C Grittini, SK Grzechnik, M DiDonato, J Hale, E Hampton, GW Han, J Haugen, M Hornsby, L Jaroszewski, HE Klock, MW Knuth, E Koesema, A Kreusch, P Kuhn, MD Miller, K Moy, E Nigoghossian, J Paulsen, R Reyes, C Rife, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, A White, G Wolf, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2006) Proteins 64: 808-13.

Crystal structure of the ApbE protein (TM1553) from Thermotoga maritima at 1.58 A resolution. GW Han, S Sri Krishna, R Schwarzenbacher, D McMullan, K Ginalski, MA Elsliger, SM Brittain, P Abdubek, S Agarwalla, E Ambing, T Astakhova, H Axelrod, JM Canaves, HJ Chiu, M DiDonato, SK Grzechnik, J Hale, E Hampton, J Haugen, L Jaroszewski, KK Jin, HE Klock, MW Knuth, E Koesema, A Kreusch, P Kuhn, MD Miller, AT Morse, K Moy, E Nigoghossian, S Oommachen, J Ouyang, J Paulsen, K Quijano, R Reyes, C Rife, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, X Wang, B West, A White, G Wolf, Q Xu, KO Hodgson, J Wooley, AM Deacon, A Godzik, SA Lesley, IA Wilson (2006) Proteins 64: 1083-90.

Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity. RL Stanfield, MK Gorny, S Zolla-Pazner, IA Wilson (2006) J Virol 80: 6093-105.

Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. JK DeMartino, I Hwang, L Xu, IA Wilson, DL Boger (2006) J Med Chem 49: 2998-3002.

Solution structure of Asl1650, an acyl carrier protein from Anabaena sp. PCC 7120 with a variant phosphopantetheinylation-site sequence. MA Johnson, W Peti, T Herrmann, IA Wilson, K Wüthrich (2006) Protein Sci 15: 1030-41.

How TCRs bind MHCs, peptides, and coreceptors. MG Rudolph, RL Stanfield, IA Wilson (2006) Annu Rev Immunol 24: 419-66.

Crystal structure of phosphoribosylformylglycinamidine synthase II (smPurL) from Thermotoga maritima at 2.15 A resolution. II Mathews, SS Krishna, R Schwarzenbacher, D McMullan, P Abdubek, E Ambing, JM Canaves, HJ Chiu, AM Deacon, M DiDonato, MA Elsliger, A Godzik, C Grittini, SK Grzechnik, J Hale, E Hampton, GW Han, J Haugen, L Jaroszewski, HE Klock, E Koesema, A Kreusch, P Kuhn, SA Lesley, I Levin, MD Miller, K Moy, E Nigoghossian, J Paulsen, K Quijano, R Reyes, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, A White, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2006) Proteins 63: 1106-11.

Crystal structure of TM1367 from Thermotoga maritima at 1.90 A resolution reveals an atypical member of the cyclophilin (peptidylprolyl isomerase) fold. KK Jin, SS Krishna, R Schwarzenbacher, D McMullan, P Abdubek, S Agarwalla, E Ambing, H Axelrod, JM Canaves, HJ Chiu, AM Deacon, M DiDonato, MA Elsliger, J Feuerhelm, A Godzik, C Grittini, SK Grzechnik, J Hale, E Hampton, J Haugen, M Hornsby, L Jaroszewski, HE Klock, MW Knuth, E Koesema, A Kreusch, P Kuhn, SA Lesley, MD Miller, K Moy, E Nigoghossian, L Okach, S Oommachen, J Paulsen, K Quijano, R Reyes, C Rife, RC Stevens, G Spraggon, H van den Bedem, J Velasquez, A White, G Wolf, GW Han, Q Xu, KO Hodgson, J Wooley, IA Wilson (2006) Proteins 63: 1112-8.

Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. J Stevens, O Blixt, TM Tumpey, JK Taubenberger, JC Paulson, IA Wilson (2006) Science 312: 404-10.

Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d. D Wu, DM Zajonc, M Fujio, BA Sullivan, Y Kinjo, M Kronenberg, IA Wilson, CH Wong (2006) Proc Natl Acad Sci U S A 103: 3972-7.

Cofactor-containing antibodies: crystal structure of the original yellow antibody. X Zhu, P Wentworth, RA Kyle, RA Lerner, IA Wilson (2006) Proc Natl Acad Sci U S A 103: 3581-5.

Crystal structure of the TCR co-receptor CD8alphaalpha in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 A resolution. DA Shore, L Teyton, RA Dwek, PM Rudd, IA Wilson (2006) J Mol Biol 358: 347-54.

Antibody elbow angles are influenced by their light chain class. RL Stanfield, A Zemla, IA Wilson, B Rupp (2006) J Mol Biol 357: 1566-74.

Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. DJ Stauber, EW Debler, PA Horton, KA Smith, IA Wilson (2006) Proc Natl Acad Sci U S A 103: 2788-93.

Complete reaction cycle of a cocaine catalytic antibody at atomic resolution. X Zhu, TJ Dickerson, CJ Rogers, GF Kaufmann, JM Mee, KM McKenzie, KD Janda, IA Wilson (2006) Structure 14: 205-16.

Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody. FM Brunel, MB Zwick, RM Cardoso, JD Nelson, IA Wilson, DR Burton, PE Dawson (2006) J Virol 80: 1680-7.

Crystal structure of a single-stranded DNA-binding protein (TM0604) from Thermotoga maritima at 2.60 A resolution. M DiDonato, SS Krishna, R Schwarzenbacher, D McMullan, L Jaroszewski, MD Miller, P Abdubek, S Agarwalla, E Ambing, H Axelrod, T Biorac, HJ Chiu, AM Deacon, MA Elsliger, J Feuerhelm, A Godzik, C Grittini, SK Grzechnik, J Hale, E Hampton, J Haugen, M Hornsby, HE Klock, MW Knuth, E Koesema, A Kreusch, P Kuhn, SA Lesley, K Moy, E Nigoghossian, L Okach, J Paulsen, K Quijano, R Reyes, C Rife, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, A White, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2006) Proteins 63: 256-60.

Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities. J Stevens, O Blixt, L Glaser, JK Taubenberger, P Palese, JC Paulson, IA Wilson (2006) J Mol Biol 355: 1143-55.

Crystal structure of virulence factor CJ0248 from Campylobacter jejuni at 2.25 A resolution reveals a new fold. Q Xu, R Schwarzenbacher, D McMullan, P Abdubek, S Agarwalla, E Ambing, H Axelrod, T Biorac, JM Canaves, HJ Chiu, AM Deacon, M DiDonato, MA Elsliger, A Godzik, C Grittini, SK Grzechnik, J Hale, E Hampton, GW Han, J Haugen, M Hornsby, L Jaroszewski, HE Klock, E Koesema, A Kreusch, P Kuhn, SA Lesley, MD Miller, K Moy, E Nigoghossian, J Paulsen, K Quijano, R Reyes, C Rife, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, A White, G Wolf, KO Hodgson, J Wooley, IA Wilson (2006) Proteins 62: 292-6.

-- 2005 (38) --

Structural studies of human HIV-1 V3 antibodies. RL Stanfield, IA Wilson (2005) Hum Antibodies 14: 73-80.

Glycosylation and the function of the T cell co-receptor CD8. DA Shore, IA Wilson, RA Dwek, PM Rudd (2005) Adv Exp Med Biol 564: 71-84.

Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. DM Zajonc, I Maricic, D Wu, R Halder, K Roy, CH Wong, V Kumar, IA Wilson (2005) J Exp Med 202: 1517-26.

Structure of a V3-containing HIV-1 gp120 core. CC Huang, M Tang, MY Zhang, S Majeed, E Montabana, RL Stanfield, DS Dimitrov, B Korber, J Sodroski, IA Wilson, R Wyatt, PD Kwong (2005) Science 310: 1025-8.

Towards miniaturization of a structural genomics pipeline using micro-expression and microcoil NMR. W Peti, R Page, K Moy, M O'Neil-Johnson, IA Wilson, RC Stevens, K Wüthrich (2005) J Struct Funct Genomics 6: 259-67.

Crystal structure of a conserved hypothetical protein (gi: 13879369) from Mouse at 1.90 A resolution reveals a new fold. HE Klock, R Schwarzenbacher, Q Xu, D McMullan, P Abdubek, E Ambing, H Axelrod, T Biorac, JM Canaves, HJ Chiu, AM Deacon, M DiDonato, MA Elsliger, A Godzik, C Grittini, SK Grzechnik, J Hale, E Hampton, GW Han, J Haugen, M Hornsby, L Jaroszewski, E Koesema, A Kreusch, P Kuhn, MD Miller, K Moy, E Nigoghossian, J Paulsen, K Quijano, R Reyes, C Rife, E Sims, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, A White, G Wolf, KO Hodgson, J Wooley, SA Lesley, IA Wilson (2005) Proteins 61: 1132-6.

Antibody vs. HIV in a clash of evolutionary titans. DR Burton, RL Stanfield, IA Wilson (2005) Proc Natl Acad Sci U S A 102: 14943-8.

Protein production and crystallization at the joint center for structural genomics. SA Lesley, IA Wilson (2005) J Struct Funct Genomics 6: 71-9.

NMR structure of the conserved hypothetical protein TM0487 from Thermotoga maritima: implications for 216 homologous DUF59 proteins. MS Almeida, T Herrmann, W Peti, IA Wilson, K Wüthrich (2005) Protein Sci 14: 2880-6.

Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12. DA Calarese, HK Lee, CY Huang, MD Best, RD Astronomo, RL Stanfield, H Katinger, DR Burton, CH Wong, IA Wilson (2005) Proc Natl Acad Sci U S A 102: 13372-7.

Crystal structure of Hsp33 chaperone (TM1394) from Thermotoga maritima at 2.20 A resolution. L Jaroszewski, R Schwarzenbacher, D McMullan, P Abdubek, S Agarwalla, E Ambing, H Axelrod, T Biorac, JM Canaves, HJ Chiu, AM Deacon, M DiDonato, MA Elsliger, A Godzik, C Grittini, SK Grzechnik, J Hale, E Hampton, GW Han, J Haugen, M Hornsby, HE Klock, E Koesema, A Kreusch, P Kuhn, SA Lesley, MD Miller, K Moy, E Nigoghossian, J Paulsen, K Quijano, R Reyes, C Rife, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, A White, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2005) Proteins 61: 669-73.

Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7A. JG Luz, M Yu, Y Su, Z Wu, Z Zhou, R Sun, IA Wilson (2005) J Mol Biol 352: 1019-28.

Crystal structure of a putative modulator of DNA gyrase (pmbA) from Thermotoga maritima at 1.95 A resolution reveals a new fold. C Rife, R Schwarzenbacher, D McMullan, P Abdubek, E Ambing, H Axelrod, T Biorac, JM Canaves, HJ Chiu, AM Deacon, M DiDonato, MA Elsliger, A Godzik, C Grittini, SK Grzechnik, J Hale, E Hampton, GW Han, J Haugen, M Hornsby, L Jaroszewski, HE Klock, E Koesema, A Kreusch, P Kuhn, SA Lesley, MD Miller, K Moy, E Nigoghossian, J Paulsen, K Quijano, R Reyes, E Sims, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, A White, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2005) Proteins 61: 444-8.

Crystal structure of the global regulatory protein CsrA from Pseudomonas putida at 2.05 A resolution reveals a new fold. C Rife, R Schwarzenbacher, D McMullan, P Abdubek, E Ambing, H Axelrod, T Biorac, JM Canaves, HJ Chiu, AM Deacon, M DiDonato, MA Elsliger, A Godzik, C Grittini, SK Grzechnik, J Hale, E Hampton, GW Han, J Haugen, M Hornsby, L Jaroszewski, HE Klock, E Koesema, A Kreusch, P Kuhn, SA Lesley, MD Miller, K Moy, E Nigoghossian, J Paulsen, K Quijano, R Reyes, E Sims, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, A White, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2005) Proteins 61: 449-53.

A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity. L Glaser, J Stevens, D Zamarin, IA Wilson, A García-Sastre, TM Tumpey, CF Basler, JK Taubenberger, P Palese (2005) J Virol 79: 11533-6.

Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. DM Zajonc, C Cantu, J Mattner, D Zhou, PB Savage, A Bendelac, IA Wilson, L Teyton (2005) Nat Immunol 6: 810-8.

Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation. B Giabbai, S Sidobre, MD Crispin, Y Sanchez-Ruìz, A Bachi, M Kronenberg, IA Wilson, M Degano (2005) J Immunol 175: 977-84.

Crystal structure of an Apo mRNA decapping enzyme (DcpS) from Mouse at 1.83 A resolution. GW Han, R Schwarzenbacher, D McMullan, P Abdubek, E Ambing, H Axelrod, T Biorac, JM Canaves, HJ Chiu, X Dai, AM Deacon, M DiDonato, MA Elsliger, A Godzik, C Grittini, SK Grzechnik, J Hale, E Hampton, J Haugen, M Hornsby, L Jaroszewski, HE Klock, E Koesema, A Kreusch, P Kuhn, SA Lesley, TM McPhillips, MD Miller, K Moy, E Nigoghossian, J Paulsen, K Quijano, R Reyes, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, A White, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2005) Proteins 60: 797-802.

Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. J Choe, MS Kelker, IA Wilson (2005) Science 309: 581-5.

T-cell activation by lipopeptide antigens. I Van Rhijn, DM Zajonc, IA Wilson, DB Moody (2005) Curr Opin Immunol 17: 222-9.

Anatomy of CD1-lipid antigen complexes. DB Moody, DM Zajonc, IA Wilson (2005) Nat Rev Immunol 5: 387-99.

Synthesis and biological evaluation of N-[4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroacetyl)pentyl]benzoyl]-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway. H Cheng, I Hwang, Y Chong, A Tavassoli, ME Webb, Y Zhang, IA Wilson, SJ Benkovic, DL Boger (2005) Bioorg Med Chem 13: 3593-9.

Synthesis and biological evaluation of alpha- and gamma-carboxamide derivatives of 10-CF3CO-DDACTHF. Y Chong, I Hwang, A Tavassoli, Y Zhang, IA Wilson, SJ Benkovic, DL Boger (2005) Bioorg Med Chem 13: 3587-92.

Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. H Cheng, Y Chong, I Hwang, A Tavassoli, Y Zhang, IA Wilson, SJ Benkovic, DL Boger (2005) Bioorg Med Chem 13: 3577-85.

MHC restriction: slip-sliding away. IA Wilson, RL Stanfield (2005) Nat Immunol 6: 434-5.

Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine. Y Zhang, L Wang, PG Schultz, IA Wilson (2005) Protein Sci 14: 1340-9.

Kinetic stabilization of an oligomeric protein by a single ligand binding event. RL Wiseman, SM Johnson, MS Kelker, T Foss, IA Wilson, JW Kelly (2005) J Am Chem Soc 127: 5540-51.

Crystal structure of S-adenosylmethionine:tRNA ribosyltransferase-isomerase (QueA) from Thermotoga maritima at 2.0 A resolution reveals a new fold. I Mathews, R Schwarzenbacher, D McMullan, P Abdubek, E Ambing, H Axelrod, T Biorac, JM Canaves, HJ Chiu, AM Deacon, M DiDonato, MA Elsliger, A Godzik, C Grittini, SK Grzechnik, J Hale, E Hampton, GW Han, J Haugen, M Hornsby, L Jaroszewski, HE Klock, E Koesema, A Kreusch, P Kuhn, SA Lesley, I Levin, MD Miller, K Moy, E Nigoghossian, J Ouyang, J Paulsen, K Quijano, R Reyes, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, A White, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2005) Proteins 59: 869-74.

Crystal structure of an indigoidine synthase A (IndA)-like protein (TM1464) from Thermotoga maritima at 1.90 A resolution reveals a new fold. I Levin, MD Miller, R Schwarzenbacher, D McMullan, P Abdubek, E Ambing, T Biorac, J Cambell, JM Canaves, HJ Chiu, AM Deacon, M DiDonato, MA Elsliger, A Godzik, C Grittini, SK Grzechnik, J Hale, E Hampton, GW Han, J Haugen, M Hornsby, L Jaroszewski, C Karlak, HE Klock, E Koesema, A Kreusch, P Kuhn, SA Lesley, A Morse, K Moy, E Nigoghossian, J Ouyang, R Page, K Quijano, R Reyes, A Robb, E Sims, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, Q Xu, O Zagnitko, KO Hodgson, J Wooley, IA Wilson (2005) Proteins 59: 864-8.

Structural origins of efficient proton abstraction from carbon by a catalytic antibody. EW Debler, S Ito, FP Seebeck, A Heine, D Hilvert, IA Wilson (2005) Proc Natl Acad Sci U S A 102: 4984-9.

Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis. TR Foss, MS Kelker, RL Wiseman, IA Wilson, JW Kelly (2005) J Mol Biol 347: 841-54.

Molecular mechanism of lipopeptide presentation by CD1a. DM Zajonc, MD Crispin, TA Bowden, DC Young, TY Cheng, J Hu, CE Costello, PM Rudd, RA Dwek, MJ Miller, MB Brenner, DB Moody, IA Wilson (2005) Immunity 22: 209-19.

Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41. RM Cardoso, MB Zwick, RL Stanfield, R Kunert, JM Binley, H Katinger, DR Burton, IA Wilson (2005) Immunity 22: 163-73.

NMR screening and crystal quality of bacterially expressed prokaryotic and eukaryotic proteins in a structural genomics pipeline. R Page, W Peti, IA Wilson, RC Stevens, K Wüthrich (2005) Proc Natl Acad Sci U S A 102: 1901-5.

Crystal structure of an alanine-glyoxylate aminotransferase from Anabaena sp. at 1.70 A resolution reveals a noncovalently linked PLP cofactor. GW Han, R Schwarzenbacher, R Page, L Jaroszewski, P Abdubek, E Ambing, T Biorac, JM Canaves, HJ Chiu, X Dai, AM Deacon, M DiDonato, MA Elsliger, A Godzik, C Grittini, SK Grzechnik, J Hale, E Hampton, J Haugen, M Hornsby, HE Klock, E Koesema, A Kreusch, P Kuhn, SA Lesley, I Levin, D McMullan, TM McPhillips, MD Miller, A Morse, K Moy, E Nigoghossian, J Ouyang, J Paulsen, K Quijano, R Reyes, E Sims, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, F von Delft, X Wang, B West, A White, G Wolf, Q Xu, O Zagnitko, KO Hodgson, J Wooley, IA Wilson (2005) Proteins 58: 971-5.

CD1 assembly and the formation of CD1-antigen complexes. DL Hava, M Brigl, P van den Elzen, DM Zajonc, IA Wilson, MB Brenner (2005) Curr Opin Immunol 17: 88-94.

Crystal structure of a formiminotetrahydrofolate cyclodeaminase (TM1560) from Thermotoga maritima at 2.80 A resolution reveals a new fold. Q Xu, R Schwarzenbacher, D McMullan, P Abdubek, E Ambing, T Biorac, JM Canaves, HJ Chiu, X Dai, AM Deacon, M DiDonato, MA Elsliger, A Godzik, C Grittini, SK Grzechnik, E Hampton, M Hornsby, L Jaroszewski, HE Klock, E Koesema, A Kreusch, P Kuhn, SA Lesley, I Levin, MD Miller, A Morse, K Moy, J Ouyang, R Page, K Quijano, R Reyes, A Robb, E Sims, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, F von Delft, X Wang, B West, A White, G Wolf, O Zagnitko, KO Hodgson, J Wooley, IA Wilson (2005) Proteins 58: 976-81.

Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 A resolution. JW Arndt, R Schwarzenbacher, R Page, P Abdubek, E Ambing, T Biorac, JM Canaves, HJ Chiu, X Dai, AM Deacon, M DiDonato, MA Elsliger, A Godzik, C Grittini, SK Grzechnik, J Hale, E Hampton, GW Han, J Haugen, M Hornsby, HE Klock, E Koesema, A Kreusch, P Kuhn, L Jaroszewski, SA Lesley, I Levin, D McMullan, TM McPhillips, MD Miller, A Morse, K Moy, E Nigoghossian, J Ouyang, WS Peti, K Quijano, R Reyes, E Sims, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, F von Delft, X Wang, B West, A White, G Wolf, Q Xu, O Zagnitko, KO Hodgson, J Wooley, IA Wilson (2005) Proteins 58: 755-8.

-- 2004 (52) --

Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors. C Li, L Xu, DW Wolan, IA Wilson, AJ Olson (2004) J Med Chem 47: 6681-90.

Printed covalent glycan array for ligand profiling of diverse glycan binding proteins. O Blixt, S Head, T Mondala, C Scanlan, ME Huflejt, R Alvarez, MC Bryan, F Fazio, D Calarese, J Stevens, N Razi, DJ Stevens, JJ Skehel, I van Die, DR Burton, IA Wilson, R Cummings, N Bovin, CH Wong, JC Paulson (2004) Proc Natl Acad Sci U S A 101: 17033-8.

Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 A. MS Kelker, EW Debler, IA Wilson (2004) J Mol Biol 344: 1175-81.

On the use of DXMS to produce more crystallizable proteins: structures of the T. maritima proteins TM0160 and TM1171. G Spraggon, D Pantazatos, HE Klock, IA Wilson, VL Woods, SA Lesley (2004) Protein Sci 13: 3187-99.

Protein biophysical properties that correlate with crystallization success in Thermotoga maritima: maximum clustering strategy for structural genomics. JM Canaves, R Page, IA Wilson, RC Stevens (2004) J Mol Biol 344: 977-91.

Improved design of an antigen with enhanced specificity for the broadly HIV-neutralizing antibody b12. R Pantophlet, IA Wilson, DR Burton (2004) Protein Eng Des Sel 17: 749-58.

The origin of enantioselectivity in aldolase antibodies: crystal structure, site-directed mutagenesis, and computational analysis. X Zhu, F Tanaka, Y Hu, A Heine, R Fuller, G Zhong, AJ Olson, RA Lerner, CF Barbas, IA Wilson (2004) J Mol Biol 343: 1269-80.

COPII-dependent export of cystic fibrosis transmembrane conductance regulator from the ER uses a di-acidic exit code. X Wang, J Matteson, Y An, B Moyer, JS Yoo, S Bannykh, IA Wilson, JR Riordan, WE Balch (2004) J Cell Biol 167: 65-74.

Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99A resolution. A Heine, JG Luz, CH Wong, IA Wilson (2004) J Mol Biol 343: 1019-34.

Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. L Xu, C Li, AJ Olson, IA Wilson (2004) J Biol Chem 279: 50555-65.

Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 A. MS Kelker, TR Foss, W Peti, L Teyton, JW Kelly, K Wüthrich, IA Wilson (2004) J Mol Biol 342: 1237-48.

Crystal structure of a tandem cystathionine-beta-synthase (CBS) domain protein (TM0935) from Thermotoga maritima at 1.87 A resolution. MD Miller, R Schwarzenbacher, F von Delft, P Abdubek, E Ambing, T Biorac, LS Brinen, JM Canaves, J Cambell, HJ Chiu, X Dai, AM Deacon, M DiDonato, MA Elsliger, S Eshagi, R Floyd, A Godzik, C Grittini, SK Grzechnik, E Hampton, L Jaroszewski, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, I Levin, D McMullan, TM McPhillips, A Morse, K Moy, J Ouyang, R Page, K Quijano, A Robb, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 57: 213-7.

Crystal structure of a shark single-domain antibody V region in complex with lysozyme. RL Stanfield, H Dooley, MF Flajnik, IA Wilson (2004) Science 305: 1770-3.

Covalent display of oligosaccharide arrays in microtiter plates. MC Bryan, F Fazio, HK Lee, CY Huang, A Chang, MD Best, DA Calarese, O Blixt, JC Paulson, D Burton, IA Wilson, CH Wong (2004) J Am Chem Soc 126: 8640-1.

Crystal structure of a putative NADPH-dependent oxidoreductase (GI: 18204011) from mouse at 2.10 A resolution. I Levin, R Schwarzenbacher, D McMullan, P Abdubek, E Ambing, T Biorac, J Cambell, JM Canaves, HJ Chiu, X Dai, AM Deacon, M DiDonato, MA Elsliger, A Godzik, C Grittini, SK Grzechnik, E Hampton, L Jaroszewski, C Karlak, HE Klock, E Koesema, A Kreusch, P Kuhn, SA Lesley, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, R Page, K Quijano, R Reyes, A Robb, E Sims, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, F von Delft, X Wang, B West, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 56: 629-33.

Crystal structure of an allantoicase (YIR029W) from Saccharomyces cerevisiae at 2.4 A resolution. Q Xu, R Schwarzenbacher, R Page, E Sims, P Abdubek, E Ambing, T Biorac, LS Brinen, J Cambell, JM Canaves, HJ Chiu, X Dai, AM Deacon, M DiDonato, MA Elsliger, R Floyd, A Godzik, C Grittini, SK Grzechnik, E Hampton, L Jaroszewski, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, I Levin, D McMullan, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, K Quijano, R Reyes, F Rezezadeh, A Robb, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, F von Delft, X Wang, B West, G Wolf, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 56: 619-24.

Crystal structure of a novel Thermotoga maritima enzyme (TM1112) from the cupin family at 1.83 A resolution. D McMullan, R Schwarzenbacher, L Jaroszewski, F von Delft, HE Klock, J Vincent, K Quijano, P Abdubek, E Ambing, T Biorac, LS Brinen, JM Canaves, X Dai, AM Deacon, M DiDonato, MA Elsliger, S Eshaghi, R Floyd, A Godzik, C Grittini, SK Grzechnik, E Hampton, C Karlak, E Koesema, A Kreusch, P Kuhn, I Levin, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, R Page, R Reyes, F Rezezadeh, A Robb, E Sims, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, X Wang, B West, G Wolf, Q Xu, KO Hodgson, J Wooley, SA Lesley, IA Wilson (2004) Proteins 56: 615-8.

Crystal structure of a novel manganese-containing cupin (TM1459) from Thermotoga maritima at 1.65 A resolution. L Jaroszewski, R Schwarzenbacher, F von Delft, D McMullan, LS Brinen, JM Canaves, X Dai, AM Deacon, M DiDonato, MA Elsliger, S Eshagi, R Floyd, A Godzik, C Grittini, SK Grzechnik, E Hampton, I Levin, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, R Page, K Quijano, R Reyes, F Rezezadeh, A Robb, E Sims, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 56: 611-4.

Crystal structure of an orphan protein (TM0875) from Thermotoga maritima at 2.00-A resolution reveals a new fold. C Bakolitsa, R Schwarzenbacher, D McMullan, LS Brinen, JM Canaves, X Dai, AM Deacon, MA Elsliger, S Eshagi, R Floyd, A Godzik, C Grittini, SK Grzechnik, L Jaroszewski, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, R Page, K Quijano, A Robb, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, F von Delft, X Wang, B West, G Wolf, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 56: 607-10.

Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 A resolution. JB Reiser, L Teyton, IA Wilson (2004) J Mol Biol 340: 909-17.

Crystal structure of a PIN (PilT N-terminus) domain (AF0591) from Archaeoglobus fulgidus at 1.90 A resolution. I Levin, R Schwarzenbacher, R Page, P Abdubek, E Ambing, T Biorac, LS Brinen, J Campbell, JM Canaves, HJ Chiu, X Dai, AM Deacon, M DiDonato, MA Elsliger, R Floyd, A Godzik, C Grittini, SK Grzechnik, E Hampton, L Jaroszewski, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, D McMullan, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, K Quijano, R Reyes, F Rezezadeh, A Robb, E Sims, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, F von Delft, X Wang, B West, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 56: 404-8.

Crystal structure of a methionine aminopeptidase (TM1478) from Thermotoga maritima at 1.9 A resolution. G Spraggon, R Schwarzenbacher, A Kreusch, D McMullan, LS Brinen, JM Canaves, X Dai, AM Deacon, MA Elsliger, S Eshagi, R Floyd, A Godzik, C Grittini, SK Grzechnik, L Jaroszewski, C Karlak, HE Klock, E Koesema, JS Kovarik, P Kuhn, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, R Page, K Quijano, F Rezezadeh, A Robb, E Sims, RC Stevens, H van den Bedem, J Velasquez, J Vincent, F von Delft, X Wang, B West, G Wolf, Q Xu, KO Hodgson, J Wooley, SA Lesley, IA Wilson (2004) Proteins 56: 396-400.

Crystal structure of a putative oxalate decarboxylase (TM1287) from Thermotoga maritima at 1.95 A resolution. R Schwarzenbacher, F von Delft, L Jaroszewski, P Abdubek, E Ambing, T Biorac, LS Brinen, JM Canaves, J Cambell, HJ Chiu, X Dai, AM Deacon, M DiDonato, MA Elsliger, S Eshagi, R Floyd, A Godzik, C Grittini, SK Grzechnik, E Hampton, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, I Levin, D McMullan, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, R Page, K Quijano, A Robb, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 56: 392-5.

Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution. A Heine, JM Canaves, F von Delft, LS Brinen, X Dai, AM Deacon, MA Elsliger, S Eshaghi, R Floyd, A Godzik, C Grittini, SK Grzechnik, C Guda, L Jaroszewski, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, D McMullan, TM McPhillips, MA Miller, MD Miller, A Morse, K Moy, J Ouyang, R Page, A Robb, K Rodrigues, R Schwarzenbacher, TL Selby, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 56: 387-91.

Crystallographic and biochemical analysis of cocaine-degrading antibody 15A10. NA Larsen, P de Prada, SX Deng, A Mittal, M Braskett, X Zhu, IA Wilson, DW Landry (2004) Biochemistry 43: 8067-76.

Crystal structure of a ribose-5-phosphate isomerase RpiB (TM1080) from Thermotoga maritima at 1.90 A resolution. Q Xu, R Schwarzenbacher, D McMullan, F von Delft, LS Brinen, JM Canaves, X Dai, AM Deacon, MA Elsliger, S Eshagi, R Floyd, A Godzik, C Grittini, SK Grzechnik, L Jaroszewski, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, I Levin, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, R Page, K Quijano, A Robb, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 56: 171-5.

Crystal structure of a glycerophosphodiester phosphodiesterase (GDPD) from Thermotoga maritima (TM1621) at 1.60 A resolution. E Santelli, R Schwarzenbacher, D McMullan, T Biorac, LS Brinen, JM Canaves, J Cambell, X Dai, AM Deacon, MA Elsliger, S Eshagi, R Floyd, A Godzik, C Grittini, SK Grzechnik, L Jaroszewski, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, R Page, K Quijano, F Rezezadeh, A Robb, E Sims, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, F von Delft, X Wang, B West, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 56: 167-70.

Monoglucosylated glycans in the secreted human complement component C3: implications for protein biosynthesis and structure. MD Crispin, GE Ritchie, AJ Critchley, BP Morgan, IA Wilson, RA Dwek, RB Sim, PM Rudd (2004) FEBS Lett 566: 270-4.

Crystal structure of an Udp-n-acetylmuramate-alanine ligase MurC (TM0231) from Thermotoga maritima at 2.3 A resolution. G Spraggon, R Schwarzenbacher, A Kreusch, CC Lee, P Abdubek, E Ambing, T Biorac, LS Brinen, JM Canaves, J Cambell, HJ Chiu, X Dai, AM Deacon, M DiDonato, MA Elsliger, S Eshagi, R Floyd, A Godzik, C Grittini, SK Grzechnik, E Hampton, L Jaroszewski, C Karlak, HE Klock, E Koesema, JS Kovarik, P Kuhn, I Levin, D McMullan, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, R Page, K Quijano, A Robb, RC Stevens, H van den Bedem, J Velasquez, J Vincent, F von Delft, X Wang, B West, G Wolf, Q Xu, KO Hodgson, J Wooley, SA Lesley, IA Wilson (2004) Proteins 55: 1078-81.

Crystal structure of a type II quinolic acid phosphoribosyltransferase (TM1645) from Thermotoga maritima at 2.50 A resolution. R Schwarzenbacher, L Jaroszewski, F von Delft, P Abdubek, E Ambing, T Biorac, LS Brinen, JM Canaves, J Cambell, HJ Chiu, X Dai, AM Deacon, M DiDonato, MA Elsliger, S Eshagi, R Floyd, A Godzik, C Grittini, SK Grzechnik, E Hampton, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, I Levin, D McMullan, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, R Page, K Quijano, A Robb, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 55: 768-71.

Crystal structure of an aspartate aminotransferase (TM1255) from Thermotoga maritima at 1.90 A resolution. R Schwarzenbacher, L Jaroszewski, F von Delft, P Abdubek, E Ambing, T Biorac, LS Brinen, JM Canaves, J Cambell, HJ Chiu, X Dai, AM Deacon, M DiDonato, MA Elsliger, S Eshagi, R Floyd, A Godzik, C Grittini, SK Grzechnik, E Hampton, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, I Levin, D McMullan, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, R Page, K Quijano, A Robb, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 55: 759-63.

Cognitive aging and the hippocampus: how old rats represent new environments. IA Wilson, S Ikonen, I Gureviciene, RW McMahan, M Gallagher, H Eichenbaum, H Tanila (2004) J Neurosci 24: 3870-8.

Supine orientation of a murine MHC class I molecule on the membrane bilayer. AK Mitra, H Célia, G Ren, JG Luz, IA Wilson, L Teyton (2004) Curr Biol 14: 718-24.

Crystal structure of a phosphoribosylaminoimidazole mutase PurE (TM0446) from Thermotoga maritima at 1.77-A resolution. R Schwarzenbacher, L Jaroszewski, F von Delft, P Abdubek, E Ambing, T Biorac, LS Brinen, JM Canaves, J Cambell, HJ Chiu, X Dai, AM Deacon, M DiDonato, MA Elsliger, S Eshagi, R Floyd, A Godzik, C Grittini, SK Grzechnik, E Hampton, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, I Levin, D McMullan, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, R Page, K Quijano, A Robb, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 55: 474-8.

Combined pseudo-merohedral twinning, non-crystallographic symmetry and pseudo-translation in a monoclinic crystal form of the gammadelta T-cell ligand T10. MG Rudolph, C Wingren, MP Crowley, YH Chien, IA Wilson (2004) Acta Crystallogr D Biol Crystallogr 60: 656-64.

Crystal structure of a putative PII-like signaling protein (TM0021) from Thermotoga maritima at 2.5 A resolution. R Schwarzenbacher, F von Delft, P Abdubek, E Ambing, T Biorac, LS Brinen, JM Canaves, J Cambell, HJ Chiu, X Dai, AM Deacon, M DiDonato, MA Elsliger, S Eshagi, R Floyd, A Godzik, C Grittini, SK Grzechnik, E Hampton, L Jaroszewski, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, I Levin, D McMullan, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, R Page, K Quijano, A Robb, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, Q Xu, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 54: 810-3.

Crystal structure of an HEPN domain protein (TM0613) from Thermotoga maritima at 1.75 A resolution. H Erlandsen, JM Canaves, MA Elsliger, F von Delft, LS Brinen, X Dai, AM Deacon, R Floyd, A Godzik, C Grittini, SK Grzechnik, L Jaroszewski, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, D McMullan, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, R Page, A Robb, K Quijano, R Schwarzenbacher, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 54: 806-9.

Crystal structure of a putative glutamine amido transferase (TM1158) from Thermotoga maritima at 1.7 A resolution. R Schwarzenbacher, AM Deacon, L Jaroszewski, LS Brinen, JM Canaves, X Dai, MA Elsliger, R Floyd, A Godzik, C Grittini, SK Grzechnik, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, D McMullan, TM McPhillips, MD Miller, A Morse, K Moy, MS Nelson, J Ouyang, R Page, A Robb, K Quijano, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, F von Delft, X Wang, B West, G Wolf, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 54: 801-5.

The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5. MB Zwick, HK Komori, RL Stanfield, S Church, M Wang, PW Parren, R Kunert, H Katinger, IA Wilson, DR Burton (2004) J Virol 78: 3155-61.

Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor. SE Kuhmann, P Pugach, KJ Kunstman, J Taylor, RL Stanfield, A Snyder, JM Strizki, J Riley, BM Baroudy, IA Wilson, BT Korber, SM Wolinsky, JP Moore (2004) J Virol 78: 2790-807.

HIV vaccine design and the neutralizing antibody problem. DR Burton, RC Desrosiers, RW Doms, WC Koff, PD Kwong, JP Moore, GJ Nabel, J Sodroski, IA Wilson, RT Wyatt (2004) Nat Immunol 5: 233-6.

Probing the antibody-catalyzed water-oxidation pathway at atomic resolution. X Zhu, P Wentworth, AD Wentworth, A Eschenmoser, RA Lerner, IA Wilson (2004) Proc Natl Acad Sci U S A 101: 2247-52.

A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects. MG Rudolph, LQ Shen, SA Lamontagne, JG Luz, JR Delaney, Q Ge, BK Cho, D Palliser, CA McKinley, J Chen, IA Wilson, HN Eisen (2004) J Immunol 172: 2994-3002.

Reactivity-based one-pot synthesis of oligomannoses: defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody. HK Lee, CN Scanlan, CY Huang, AY Chang, DA Calarese, RA Dwek, PM Rudd, DR Burton, IA Wilson, CH Wong (2004) Angew Chem Int Ed Engl 43: 1000-3.

Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. CG Cheong, DW Wolan, SE Greasley, PA Horton, GP Beardsley, IA Wilson (2004) J Biol Chem 279: 18034-45.

Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D. RL Stanfield, MK Gorny, C Williams, S Zolla-Pazner, IA Wilson (2004) Structure 12: 193-204.

Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus. J Stevens, AL Corper, CF Basler, JK Taubenberger, P Palese, IA Wilson (2004) Science 303: 1866-70.

Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor. DW Wolan, CG Cheong, SE Greasley, IA Wilson (2004) Biochemistry 43: 1171-83.

T cell activation by lipopeptide antigens. DB Moody, DC Young, TY Cheng, JP Rosat, C Roura-Mir, PB O'Connor, DM Zajonc, A Walz, MJ Miller, SB Levery, IA Wilson, CE Costello, MB Brenner (2004) Science 303: 527-31.

Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS. D Pantazatos, JS Kim, HE Klock, RC Stevens, IA Wilson, SA Lesley, VL Woods (2004) Proc Natl Acad Sci U S A 101: 751-6.

Crystal structure of an iron-containing 1,3-propanediol dehydrogenase (TM0920) from Thermotoga maritima at 1.3 A resolution. R Schwarzenbacher, F von Delft, JM Canaves, LS Brinen, X Dai, AM Deacon, MA Elsliger, S Eshaghi, R Floyd, A Godzik, C Grittini, SK Grzechnik, C Guda, L Jaroszewski, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, D McMullan, TM McPhillips, MA Miller, MD Miller, A Morse, K Moy, J Ouyang, R Page, A Robb, K Rodrigues, TL Selby, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 54: 174-7.

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 A resolution. R Page, MS Nelson, F von Delft, MA Elsliger, JM Canaves, LS Brinen, X Dai, AM Deacon, R Floyd, A Godzik, C Grittini, SK Grzechnik, L Jaroszewski, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, D McMullan, TM McPhillips, MD Miller, A Morse, K Moy, J Ouyang, A Robb, K Rodrigues, R Schwarzenbacher, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, KO Hodgson, J Wooley, IA Wilson (2004) Proteins 54: 157-61.

-- 2003 (26) --

The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12. CN Scanlan, R Pantophlet, MR Wormald, EO Saphire, D Calarese, R Stanfield, IA Wilson, H Katinger, RA Dwek, DR Burton, PM Rudd (2003) Adv Exp Med Biol 535: 205-18.

Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design. EO Saphire, RL Stanfield, MD Crispin, G Morris, MB Zwick, RA Pantophlet, PW Parren, PM Rudd, RA Dwek, DR Burton, IA Wilson (2003) Adv Exp Med Biol 535: 55-66.

Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop. RL Stanfield, JB Ghiara, E Ollmann Saphire, AT Profy, IA Wilson (2003) Virology 315: 159-73.

Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. J Desharnais, I Hwang, Y Zhang, A Tavassoli, J Baboval, SJ Benkovic, IA Wilson, DL Boger (2003) Bioorg Med Chem 11: 4511-21.

10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase. TH Marsilje, MP Hedrick, J Desharnais, K Capps, A Tavassoli, Y Zhang, IA Wilson, SJ Benkovic, DL Boger (2003) Bioorg Med Chem 11: 4503-9.

Design, synthesis, and biological evaluation of simplified alpha-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase. TH Marsilje, MP Hedrick, J Desharnais, A Tavassoli, Y Zhang, IA Wilson, SJ Benkovic, DL Boger (2003) Bioorg Med Chem 11: 4487-501.

Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor beta-DADF identifies the folate binding site. DW Wolan, SE Greasley, MJ Wall, SJ Benkovic, IA Wilson (2003) Biochemistry 42: 10904-14.

A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy. C Rader, JM Turner, A Heine, D Shabat, SC Sinha, IA Wilson, RA Lerner, CF Barbas (2003) J Mol Biol 332: 889-99.

Crystal structure of uronate isomerase (TM0064) from Thermotoga maritima at 2.85 A resolution. R Schwarzenbacher, JM Canaves, LS Brinen, X Dai, AM Deacon, MA Elsliger, S Eshaghi, R Floyd, A Godzik, C Grittini, SK Grzechnik, C Guda, L Jaroszewski, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, D McMullan, TM McPhillips, MA Miller, MD Miller, A Morse, K Moy, J Ouyang, A Robb, K Rodrigues, TL Selby, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, KO Hodgson, J Wooley, IA Wilson (2003) Proteins 53: 142-5.

Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 A. DM Zajonc, MA Elsliger, L Teyton, IA Wilson (2003) Nat Immunol 4: 808-15.

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. DA Calarese, CN Scanlan, MB Zwick, S Deechongkit, Y Mimura, R Kunert, P Zhu, MR Wormald, RL Stanfield, KH Roux, JW Kelly, PM Rudd, RA Dwek, H Katinger, DR Burton, IA Wilson (2003) Science 300: 2065-71.

Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Y Zhang, J Desharnais, TH Marsilje, C Li, MP Hedrick, LT Gooljarsingh, A Tavassoli, SJ Benkovic, AJ Olson, DL Boger, IA Wilson (2003) Biochemistry 42: 6043-56.

Structural basis for antibody catalysis of a cationic cyclization reaction. X Zhu, A Heine, F Monnat, KN Houk, KD Janda, IA Wilson (2003) J Mol Biol 329: 69-83.

Hyperglycosylated mutants of human immunodeficiency virus (HIV) type 1 monomeric gp120 as novel antigens for HIV vaccine design. R Pantophlet, IA Wilson, DR Burton (2003) J Virol 77: 5889-901.

Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120. MB Zwick, PW Parren, EO Saphire, S Church, M Wang, JK Scott, PE Dawson, IA Wilson, DR Burton (2003) J Virol 77: 5863-76.

XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. JG Luz, CA Hassig, C Pickle, A Godzik, BJ Meyer, IA Wilson (2003) Genes Dev 17: 977-90.

Expression and characterization of a humanized cocaine-binding antibody. el-RM Redwan, NA Larsen, B Zhou, P Wirsching, KD Janda, IA Wilson (2003) Biotechnol Bioeng 82: 612-8.

Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems. L Royle, A Roos, DJ Harvey, MR Wormald, D van Gijlswijk-Janssen, el-RM Redwan, IA Wilson, MR Daha, RA Dwek, PM Rudd (2003) J Biol Chem 278: 20140-53.

Geranylgeranyl switching regulates GDI-Rab GTPase recycling. Y An, Y Shao, C Alory, J Matteson, T Sakisaka, W Chen, RA Gibbs, IA Wilson, WE Balch (2003) Structure 11: 347-57.

Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif. Y Zhu, AY Rudensky, AL Corper, L Teyton, IA Wilson (2003) J Mol Biol 326: 1157-74.

Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens. P Wentworth, AD Wentworth, X Zhu, IA Wilson, KD Janda, A Eschenmoser, RA Lerner (2003) Proc Natl Acad Sci U S A 100: 1490-3.

Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1beta. MG Rudolph, MS Kelker, TR Schneider, TO Yeates, V Oseroff, DK Heidary, PA Jennings, IA Wilson (2003) Acta Crystallogr D Biol Crystallogr 59: 290-8.

Crystal structure of a zinc-containing glycerol dehydrogenase (TM0423) from Thermotoga maritima at 1.5 A resolution. LS Brinen, JM Canaves, X Dai, AM Deacon, MA Elsliger, S Eshaghi, R Floyd, A Godzik, C Grittini, SK Grzechnik, C Guda, L Jaroszewski, C Karlak, HE Klock, E Koesema, JS Kovarik, A Kreusch, P Kuhn, SA Lesley, D McMullan, TM McPhillips, MA Miller, MD Miller, A Morse, K Moy, J Ouyang, A Robb, K Rodrigues, TL Selby, G Spraggon, RC Stevens, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, SS Taylor, KO Hodgson, J Wooley, IA Wilson (2003) Proteins 50: 371-4.

Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120. R Pantophlet, E Ollmann Saphire, P Poignard, PW Parren, IA Wilson, DR Burton (2003) J Virol 77: 642-58.

Structure-based mutagenesis approaches toward expanding the substrate specificity of D-2-deoxyribose-5-phosphate aldolase. G DeSantis, J Liu, DP Clark, A Heine, IA Wilson, CH Wong (2003) Bioorg Med Chem 11: 43-52.

Observation of an arsenic adduct in an acetyl esterase crystal structure. X Zhu, NA Larsen, A Basran, NC Bruce, IA Wilson (2003) J Biol Chem 278: 2008-14.

-- 2002 (20) --

Structural insights into the avian AICAR transformylase mechanism. DW Wolan, SE Greasley, GP Beardsley, IA Wilson (2002) Biochemistry 41: 15505-13.

Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-B. MG Rudolph, J Stevens, JA Speir, J Trowsdale, GW Butcher, E Joly, IA Wilson (2002) J Mol Biol 324: 975-90.

Structure determination of a cocaine hydrolytic antibody from a pseudomerohedrally twinned crystal. NA Larsen, A Heine, P de Prada, el-R Redwan, TO Yeates, DW Landry, IA Wilson (2002) Acta Crystallogr D Biol Crystallogr 58: 2055-9.

Crystal structures of human GAR Tfase at low and high pH and with substrate beta-GAR. Y Zhang, J Desharnais, SE Greasley, GP Beardsley, DL Boger, IA Wilson (2002) Biochemistry 41: 14206-15.

Biochemical characterization and structural analysis of a highly proficient cocaine esterase. JM Turner, NA Larsen, A Basran, CF Barbas, NC Bruce, IA Wilson, RA Lerner (2002) Biochemistry 41: 12297-307.

Crystal structure of thy1, a thymidylate synthase complementing protein from Thermotoga maritima at 2.25 A resolution. P Kuhn, SA Lesley, II Mathews, JM Canaves, LS Brinen, X Dai, AM Deacon, MA Elsliger, S Eshaghi, R Floyd, A Godzik, C Grittini, SK Grzechnik, C Guda, KO Hodgson, L Jaroszewski, C Karlak, HE Klock, E Koesema, JM Kovarik, AT Kreusch, D McMullan, TM McPhillips, MA Miller, M Miller, A Morse, K Moy, J Ouyang, A Robb, K Rodrigues, TL Selby, G Spraggon, RC Stevens, SS Taylor, H van den Bedem, J Velasquez, J Vincent, X Wang, B West, G Wolf, J Wooley, IA Wilson (2002) Proteins 49: 142-5.

Structural genomics of the Thermotoga maritima proteome implemented in a high-throughput structure determination pipeline. SA Lesley, P Kuhn, A Godzik, AM Deacon, I Mathews, A Kreusch, G Spraggon, HE Klock, D McMullan, T Shin, J Vincent, A Robb, LS Brinen, MD Miller, TM McPhillips, MA Miller, D Scheibe, JM Canaves, C Guda, L Jaroszewski, TL Selby, MA Elsliger, J Wooley, SS Taylor, KO Hodgson, IA Wilson, PG Schultz, RC Stevens (2002) Proc Natl Acad Sci U S A 99: 11664-9.

Crystal structure of a non-canonical high affinity peptide complexed with MHC class I: a novel use of alternative anchors. V Apostolopoulos, M Yu, AL Corper, W Li, IF McKenzie, L Teyton, IA Wilson, M Plebanski (2002) J Mol Biol 318: 1307-16.

Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design. V Apostolopoulos, M Yu, AL Corper, L Teyton, GA Pietersz, IF McKenzie, IA Wilson, M Plebanski (2002) J Mol Biol 318: 1293-305.

The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of alpha1-->2 mannose residues on the outer face of gp120. CN Scanlan, R Pantophlet, MR Wormald, E Ollmann Saphire, R Stanfield, IA Wilson, H Katinger, RA Dwek, PM Rudd, DR Burton (2002) J Virol 76: 7306-21.

10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway. TH Marsilje, MA Labroli, MP Hedrick, Q Jin, J Desharnais, SJ Baker, LT Gooljarsingh, J Ramcharan, A Tavassoli, Y Zhang, IA Wilson, GP Beardsley, SJ Benkovic, DL Boger (2002) Bioorg Med Chem 10: 2739-49.

Contrasting IgG structures reveal extreme asymmetry and flexibility. EO Saphire, RL Stanfield, MD Crispin, PW Parren, PM Rudd, RA Dwek, DR Burton, IA Wilson (2002) J Mol Biol 319: 9-18.

Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions. JG Luz, M Huang, KC Garcia, MG Rudolph, V Apostolopoulos, L Teyton, IA Wilson (2002) J Exp Med 195: 1175-86.

Structural and thermodynamic correlates of T cell signaling. MG Rudolph, JG Luz, IA Wilson (2002) Annu Rev Biophys Biomol Struct 31: 121-49.

Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex. EP Grant, EM Beckman, SM Behar, M Degano, D Frederique, GS Besra, IA Wilson, SA Porcelli, ST Furlong, MB Brenner (2002) J Immunol 168: 3933-40.

Protein engineering for crystallization of the GTPase Sar1 that regulates ER vesicle budding. M Huang, JT Weissman, C Wang, WE Balch, IA Wilson (2002) Acta Crystallogr D Biol Crystallogr 58: 700-3.

Don C. Wiley. IA Wilson (2002) Nat Struct Biol 9: 164-6.

The specificity of TCR/pMHC interaction. MG Rudolph, IA Wilson (2002) Curr Opin Immunol 14: 52-65.

Probing ligand recognition in the decarboxylase antibody 21D8: implications for the catalytic mechanism. K Hotta, IA Wilson, D Hilvert (2002) Biochemistry 41: 772-9.

Crystal structure of a bacterial cocaine esterase. NA Larsen, JM Turner, J Stevens, SJ Rosser, A Basran, RA Lerner, NC Bruce, IA Wilson (2002) Nat Struct Biol 9: 17-21.

-- 2001 (20) --

Crystal structure of Sar1-GDP at 1.7 A resolution and the role of the NH2 terminus in ER export. M Huang, JT Weissman, S Beraud-Dufour, P Luan, C Wang, W Chen, M Aridor, IA Wilson, WE Balch (2001) J Cell Biol 155: 937-48.

Structural basis for a disfavored elimination reaction in catalytic antibody 1D4. NA Larsen, A Heine, L Crane, BF Cravatt, RA Lerner, IA Wilson (2001) J Mol Biol 314: 93-102.

Crystal structure of an isolated V(alpha) domain of the 2C T-cell receptor. MG Rudolph, M Huang, L Teyton, IA Wilson (2001) J Mol Biol 314: 1-8.

Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase. SE Greasley, TH Marsilje, H Cai, S Baker, SJ Benkovic, DL Boger, IA Wilson (2001) Biochemistry 40: 13538-47.

Observation of covalent intermediates in an enzyme mechanism at atomic resolution. A Heine, G DeSantis, JG Luz, M Mitchell, CH Wong, IA Wilson (2001) Science 294: 369-74.

Global efforts in structural genomics. RC Stevens, S Yokoyama, IA Wilson (2001) Science 294: 89-92.

Getting into the groove: unusual features of peptide binding to MHC class I molecules and implications in vaccine design. V Apostolopoulos, IF McKenzie, IA Wilson (2001) Front Biosci 6: D1311-20.

Antibody catalysis of the oxidation of water. P Wentworth , LH Jones, AD Wentworth, X Zhu, NA Larsen, IA Wilson, X Xu, WA Goddard , KD Janda, A Eschenmoser, RA Lerner (2001) Science 293: 1806-11.

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. EO Saphire, PW Parren, R Pantophlet, MB Zwick, GM Morris, PM Rudd, RA Dwek, RL Stanfield, DR Burton, IA Wilson (2001) Science 293: 1155-9.

Crystal structure of a cocaine-binding antibody. NA Larsen, B Zhou, A Heine, P Wirsching, KD Janda, IA Wilson (2001) J Mol Biol 311: 9-15.

Tech.Sight. Industrializing structural biology. RC Stevens, IA Wilson (2001) Science 293: 519-20.

Unraveling the mysteries of gammadelta T cell recognition. IA Wilson, RL Stanfield (2001) Nat Immunol 2: 579-81.

The hHFE gene of browsing and grazing rhinoceroses: a possible site of adaptation to a low-iron diet. E Beutler, C West, JA Speir, IA Wilson, M Worley (2001) Blood Cells Mol Dis 27: 342-50.

Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis. SE Greasley, P Horton, J Ramcharan, GP Beardsley, SJ Benkovic, IA Wilson (2001) Nat Struct Biol 8: 402-6.

The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity. MG Rudolph, JA Speir, A Brunmark, N Mattsson, MR Jackson, PA Peterson, L Teyton, IA Wilson (2001) Immunity 14: 231-42.

Glycosylation and the immune system. PM Rudd, T Elliott, P Cresswell, IA Wilson, RA Dwek (2001) Science 291: 2370-6.

Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 A. DW Wolan, L Teyton, MG Rudolph, B Villmow, S Bauer, DH Busch, IA Wilson (2001) Nat Immunol 2: 248-54.

Preliminary X-ray diffraction studies of the transcriptional inhibitory antibody Fab41.4. J Mazlo , RL Stanfield , IA Wilson , SH Hinrichs , JJ Stezowski (2001) Acta Crystallogr D Biol Crystallogr 57: 462-4.

Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-Aa. JA Speir, J Stevens, E Joly, GW Butcher, IA Wilson (2001) Immunity 14: 81-92.

Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: an antibody that broadly neutralizes primary isolates of HIV-1. EO Saphire, PW Parren, CF Barbas, DR Burton, IA Wilson (2001) Acta Crystallogr D Biol Crystallogr 57: 168-71.

-- 2000 (10) --

Structural implications for the design of molecular vaccines. V Apostolopoulos, M Yu, IF McKenzie, IA Wilson (2000) Curr Opin Mol Ther 2: 29-36.

Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8. K Hotta, H Lange, DJ Tantillo, KN Houk, D Hilvert, IA Wilson (2000) J Mol Biol 302: 1213-25.

A new functional domain of guanine nucleotide dissociation inhibitor (alpha-GDI) involved in Rab recycling. P Luan, A Heine, K Zeng, B Moyer, SE Greasely, P Kuhn, WE Balch, IA Wilson (2000) Traffic 1: 270-81.

A functional hot spot for antigen recognition in a superagonist TCR/MHC complex. M Degano, KC Garcia, V Apostolopoulos, MG Rudolph, L Teyton, IA Wilson (2000) Immunity 12: 251-61.

The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder. T Stratmann, V Apostolopoulos, V Mallet-Designe, AL Corper, CA Scott, IA Wilson, AS Kang, L Teyton (2000) J Immunol 165: 3214-25.

Structural requirements for antigen presentation by mouse CD1. N Burdin, L Brossay, M Degano, H Iijima, M Gui, IA Wilson, M Kronenberg (2000) Proc Natl Acad Sci U S A 97: 10156-61.

Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in Escherichia coli. VM Reyes, SE Greasley, EA Stura, GP Beardsley, IA Wilson (2000) Acta Crystallogr D Biol Crystallogr 56: 1051-4.

A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes. AL Corper, T Stratmann, V Apostolopoulos, CA Scott, KC Garcia, AS Kang, IA Wilson, L Teyton (2000) Science 288: 505-11.

Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task. A Karlstrom, G Zhong, C Rader, NA Larsen, A Heine, R Fuller, B List, F Tanaka, IA Wilson, CF Barbas, RA Lerner (2000) Proc Natl Acad Sci U S A 97: 3878-83.

Crystal structure of a gammadelta T cell receptor ligand T22: a truncated MHC-like fold. C Wingren, MP Crowley, M Degano, Y Chien, IA Wilson (2000) Science 287: 310-4.

-- 1999 (15) --

Emerging principles for T cell receptor recognition of antigen in cellular immunity. KC Garcia, M Degano, JA Speir, IA Wilson (1999) Rev Immunogenet 1: 75-90.

The molecular basis of CD1-mediated presentation of lipid antigens. DB Moody, GS Besra, IA Wilson, SA Porcelli (1999) Immunol Rev 172: 285-96.

Perspectives: protein structure. Class-conscious TCR? IA Wilson (1999) Science 286: 1867-8.

The structure, organization, activation and plasticity of the erythropoietin receptor. IA Wilson, LK Jolliffe (1999) Curr Opin Struct Biol 9: 696-704.

New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid. SE Greasley, MM Yamashita, H Cai, SJ Benkovic, DL Boger, IA Wilson (1999) Biochemistry 38: 16783-93.

Evolution of shape complementarity and catalytic efficiency from a primordial antibody template. J Xu, Q Deng, J Chen, KN Houk, J Bartek, D Hilvert, IA Wilson (1999) Science 286: 2345-8.

Roles for glycosylation of cell surface receptors involved in cellular immune recognition. PM Rudd, MR Wormald, RL Stanfield, M Huang, N Mattsson, JA Speir, JA DiGennaro, JS Fetrow, RA Dwek, IA Wilson (1999) J Mol Biol 293: 351-66.

Structural basis of T cell recognition. KC Garcia, L Teyton, IA Wilson (1999) Annu Rev Immunol 17: 369-97.

Structural basis for antibody catalysis of a disfavored ring closure reaction. K Gruber, B Zhou, KN Houk, RA Lerner, CG Shevlin, IA Wilson (1999) Biochemistry 38: 7062-74.

Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide. SA Middleton, FP Barbone, DL Johnson, RL Thurmond, Y You, FJ McMahon, R Jin, O Livnah, J Tullai, FX Farrell, MA Goldsmith, IA Wilson, LK Jolliffe (1999) J Biol Chem 274: 14163-9.

Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL. JA Speir, UM Abdel-Motal, M Jondal, IA Wilson (1999) Immunity 10: 51-61.

Erythropoietin receptor activation by a ligand-induced conformation change. I Remy, IA Wilson, SW Michnick (1999) Science 283: 990-3.

Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. O Livnah, EA Stura, SA Middleton, DL Johnson, LK Jolliffe, IA Wilson (1999) Science 283: 987-90.

Molecular recognition of lipid antigens by T cell receptors. EP Grant, M Degano, JP Rosat, S Stenger, RL Modlin, IA Wilson, SA Porcelli, MB Brenner (1999) J Exp Med 189: 195-205.

-- 1998 (12) --

An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation. O Livnah, DL Johnson, EA Stura, FX Farrell, FP Barbone, Y You, KD Liu, MA Goldsmith, W He, CD Krause, S Pestka, LK Jolliffe, IA Wilson (1998) Nat Struct Biol 5: 993-1004.

The CD1 family of lipid antigen-presenting molecules. SA Porcelli, BW Segelke, M Sugita, IA Wilson, MB Brenner (1998) Immunol Today 19: 362-8.

A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A. Y Su, MM Yamashita, SE Greasley, CA Mullen, JH Shim, PA Jennings, SJ Benkovic, IA Wilson (1998) J Mol Biol 281: 485-99.

Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes. JA Speir, KC Garcia, A Brunmark, M Degano, PA Peterson, L Teyton, IA Wilson (1998) Immunity 8: 553-62.

Alanine scanning mutagenesis of an alphabeta T cell receptor: mapping the energy of antigen recognition. TC Manning, CJ Schlueter, TC Brodnicki, EA Parke, JA Speir, KC Garcia, L Teyton, IA Wilson, DM Kranz (1998) Immunity 8: 413-25.

An antibody exo Diels-Alderase inhibitor complex at 1.95 angstrom resolution. A Heine, EA Stura, JT Yli-Kauhaluoma, C Gao, Q Deng, BR Beno, KN Houk, KD Janda, IA Wilson (1998) Science 279: 1934-40.

Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues. CA Scott, PA Peterson, L Teyton, IA Wilson (1998) Immunity 8: 319-29.

Unusual MHC-like molecules: CD1, Fc receptor, the hemochromatosis gene product, and viral homologs. IA Wilson, PJ Bjorkman (1998) Curr Opin Immunol 10: 67-73.

Identification of a 13 amino acid peptide mimetic of erythropoietin and description of amino acids critical for the mimetic activity of EMP1. DL Johnson, FX Farrell, FP Barbone, FJ McMahon, J Tullai, K Hoey, O Livnah, NC Wrighton, SA Middleton, DA Loughney, EA Stura, WJ Dower, LS Mulcahy, IA Wilson, LK Jolliffe (1998) Biochemistry 37: 3699-710.

Engineering protein for X-ray crystallography: the murine Major Histocompatibility Complex class II molecule I-Ad. CA Scott, KC Garcia, EA Stura, PA Peterson, IA Wilson, L Teyton (1998) Protein Sci 7: 413-8.

The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex. M Huang, R Syed, EA Stura, MJ Stone, RS Stefanko, W Ruf, TS Edgington, IA Wilson (1998) J Mol Biol 275: 873-94.

Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. KC Garcia, M Degano, LR Pease, M Huang, PA Peterson, L Teyton, IA Wilson (1998) Science 279: 1166-72.

-- 1997 (7) --

Immune versus natural selection: antibody aldolases with enzymic rates but broader scope. CF Barbas, A Heine, G Zhong, T Hoffmann, S Gramatikova, R Björnestedt, B List, J Anderson, EA Stura, IA Wilson, RA Lerner (1997) Science 278: 2085-92.

Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization. KC Garcia, MD Tallquist, LR Pease, A Brunmark, CA Scott, M Degano, EA Stura, PA Peterson, IA Wilson, L Teyton (1997) Proc Natl Acad Sci U S A 94: 13838-43.

T-cell receptor structure and TCR complexes. IA Wilson, KC Garcia (1997) Curr Opin Struct Biol 7: 839-48.

Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove. Z Zeng, AR Castaño, BW Segelke, EA Stura, PA Peterson, IA Wilson (1997) Science 277: 339-45.

Sequence, specificity and crystallization of an oestrone-3-glucuronide antibody (3910). M He, M Gani, O Livnah, EA Stura, D Beale, J Coley, IA Wilson, MJ Taussig (1997) Immunology 90: 632-9.

Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site. JB Ghiara, DC Ferguson, AC Satterthwait, HJ Dyson, IA Wilson (1997) J Mol Biol 266: 31-9.

Computation of the binding of fully flexible peptides to proteins with flexible side chains. J Desmet, IA Wilson, M Joniau, M De Maeyer, I Lasters (1997) FASEB J 11: 164-72.

-- 1996 (7) --

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. KC Garcia, CA Scott, A Brunmark, FR Carbone, PA Peterson, IA Wilson, L Teyton (1996) Nature 384: 577-81.

Structural insights into the function of the Rab GDI superfamily. SK Wu, K Zeng, IA Wilson, WE Balch (1996) Trends Biochem Sci 21: 472-6.

An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex. KC Garcia, M Degano, RL Stanfield, A Brunmark, MR Jackson, PA Peterson, L Teyton, IA Wilson (1996) Science 274: 209-19.

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 A. O Livnah, EA Stura, DL Johnson, SA Middleton, LS Mulcahy, NC Wrighton, WJ Dower, LK Jolliffe, IA Wilson (1996) Science 273: 464-71.

Another twist to MHC-peptide recognition. IA Wilson (1996) Science 272: 973-4.

Structure and mutational analysis of Rab GDP-dissociation inhibitor. I Schalk, K Zeng, SK Wu, EA Stura, J Matteson, M Huang, A Tandon, IA Wilson, WE Balch (1996) Nature 381: 42-8.

Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules. CA Scott, KC Garcia, FR Carbone, IA Wilson, L Teyton (1996) J Exp Med 183: 2087-95.

-- 1995 (9) --

CTL escape viral variants. I. Generation and molecular characterization. H Lewicki, A Tishon, P Borrow, CF Evans, JE Gairin, KM Hahn, DA Jewell, IA Wilson, MB Oldstone (1995) Virology 210: 29-40.

Differential localization of the mRNA of the M and B isoforms of creatine kinase in myoblasts. IA Wilson, KM Brindle, AM Fulton (1995) Biochem J 308 ( Pt 2): 599-605.

Antigen processing and presentation. IA Wilson (1995) Clin Transplant 9: 260-1.

A Trojan horse with a sweet tooth. IA Wilson, RL Stanfield (1995) Nat Struct Biol 2: 433-6.

Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution. C Klein, P Chen, JH Arevalo, EA Stura, A Marolewski, MS Warren, SJ Benkovic, IA Wilson (1995) J Mol Biol 249: 153-75.

Crystallization and preliminary crystallographic data for class I deoxyribose-5-phosphate aldolase from Escherichia coli: an application of reverse screening. EA Stura, S Ghosh, E Garcia-Junceda, L Chen, CH Wong, IA Wilson (1995) Proteins 22: 67-72.

Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove. DH Fremont, EA Stura, M Matsumura, PA Peterson, IA Wilson (1995) Proc Natl Acad Sci U S A 92: 2479-83.

Protein-peptide interactions. RL Stanfield, IA Wilson (1995) Curr Opin Struct Biol 5: 103-13.

Immune recognition of viral antigens. IA Wilson, RL Stanfield, DA Jewell, JB Ghiara, DH Fremont, EA Stura (1995) Infect Agents Dis 3: 155-62.

-- 1994 (12) --

Crystallization and preliminary crystallographic data for Rab guanine nucleotide dissociation inhibitor (RabGDI) from bovine brain. IJ Schalk, EA Stura, J Matteson, IA Wilson, WE Balch (1994) J Mol Biol 244: 469-73.

Antibody-antigen interactions: new structures and new conformational changes. IA Wilson, RL Stanfield (1994) Curr Opin Struct Biol 4: 857-67.

Structural analysis of antibody specificity. Detailed comparison of five Fab'-steroid complexes. JH Arevalo, CA Hassig, EA Stura, MJ Sims, MJ Taussig, IA Wilson (1994) J Mol Biol 241: 663-90.

Crystal structure of a peptide complex of anti-influenza peptide antibody Fab 26/9. Comparison of two different antibodies bound to the same peptide antigen. ME Churchill, EA Stura, C Pinilla, JR Appel, RA Houghten, DH Kono, RS Balderas, GG Fieser, U Schulze-Gahmen, IA Wilson (1994) J Mol Biol 241: 534-56.

Reverse screening. EA Stura, AC Satterthwait, JC Calvo, DC Kaslow, IA Wilson (1994) Acta Crystallogr D Biol Crystallogr 50: 448-55.

Antigen-induced conformational changes in antibodies: a problem for structural prediction and design. RL Stanfield, IA Wilson (1994) Trends Biotechnol 12: 275-9.

Covalently linked ligand stabilizes expression of heterodimeric receptor. IA Wilson (1994) Structure 2: 561-2.

Crystal structure of the principal neutralization site of HIV-1. JB Ghiara, EA Stura, RL Stanfield, AT Profy, IA Wilson (1994) Science 264: 82-5.

Routes to catalysis: structure of a catalytic antibody and comparison with its natural counterpart. MR Haynes, EA Stura, D Hilvert, IA Wilson (1994) Science 263: 646-52.

Crystallization and preliminary structural studies of a chorismate mutase catalytic antibody complexed with a transition state analog. MR Haynes, EA Stura, D Hilvert, IA Wilson (1994) Proteins 18: 198-200.

Monoclonal antibodies against progesterone: effect of steroid-carrier coupling position on antibody specificity. M Gani, J Coley, J Piron, AS Humphreys, J Arevalo, IA Wilson, MJ Taussig (1994) J Steroid Biochem Mol Biol 48: 277-82.

Structure of anti-peptide antibody complexes. IA Wilson, JB Ghiara, RL Stanfield (1994) Res Immunol 145: 73-8.

-- 1993 (7) --

Detailed analysis of the free and bound conformations of an antibody. X-ray structures of Fab 17/9 and three different Fab-peptide complexes. U Schulze-Gahmen, JM Rini, IA Wilson (1993) J Mol Biol 234: 1098-118.

Molecular basis of crossreactivity and the limits of antibody-antigen complementarity. JH Arevalo, MJ Taussig, IA Wilson (1993) Nature 365: 859-63.

Major antigen-induced domain rearrangements in an antibody. RL Stanfield, M Takimoto-Kamimura, JM Rini, AT Profy, IA Wilson (1993) Structure 1: 83-93.

Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen. JM Rini, RL Stanfield, EA Stura, PA Salinas, AT Profy, IA Wilson (1993) Proc Natl Acad Sci U S A 90: 6325-9.

Three-dimensional structure of an anti-steroid Fab' and progesterone-Fab' complex. JH Arevalo, EA Stura, MJ Taussig, IA Wilson (1993) J Mol Biol 231: 103-18.

Structural analysis of MHC class I molecules with bound peptide antigens. IA Wilson, DH Fremont (1993) Semin Immunol 5: 75-80.

Crystal structure of phospholipase A2 from Indian cobra reveals a trimeric association. DH Fremont, DH Anderson, IA Wilson, EA Dennis, NH Xuong (1993) Proc Natl Acad Sci U S A 90: 342-6.

-- 1992 (9) --

Crystallization of murine major histocompatibility complex class I H-2Kb with single peptides. EA Stura, M Matsumura, DH Fremont, Y Saito, PA Peterson, IA Wilson (1992) J Mol Biol 228: 975-82.

Crystallization, sequence, and preliminary crystallographic data for an antipeptide Fab 50.1 and peptide complexes with the principal neutralizing determinant of HIV-1 gp120. EA Stura, RL Stanfield, GG Fieser, S Silver, M Roguska, LM Hincapie, HK Simmerman, AT Profy, IA Wilson (1992) Proteins 14: 499-508.

Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy. P Chen, U Schulze-Gahmen, EA Stura, J Inglese, DL Johnson, A Marolewski, SJ Benkovic, IA Wilson (1992) J Mol Biol 227: 283-92.

Emerging principles for the recognition of peptide antigens by MHC class I molecules. M Matsumura, DH Fremont, PA Peterson, IA Wilson (1992) Science 257: 927-34.

Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb. DH Fremont, M Matsumura, EA Stura, PA Peterson, IA Wilson (1992) Science 257: 919-27.

Intermonomer disulfide bonds impair the fusion activity of influenza virus hemagglutinin. GW Kemble, DL Bodian, J Rosé, IA Wilson, JM White (1992) J Virol 66: 4940-50.

Structural evidence for induced fit as a mechanism for antibody-antigen recognition. JM Rini, U Schulze-Gahmen, IA Wilson (1992) Science 255: 959-65.

Crystallization studies of glycosylated and unglycosylated human recombinant interleukin-2. EA Stura, P Chen, CM Wilmot, JH Arevalo, IA Wilson (1992) Proteins 12: 24-30.

Monoclonal antibodies against an identical short peptide sequence shared by two unrelated proteins. U Schulze-Gahmen, IA Wilson (1992) Pept Res 2: 322-31.

-- 1991 (2) --

Structural aspects of antibodies and antibody-antigen complexes. IA Wilson, RL Stanfield, JM Rini, JH Arevalo, U Schulze-Gahmen, DH Fremont, EA Stura (1991) Ciba Found Symp 159: 13-28; discussion 28-39.

X-ray crystallographic analysis of free and antigen-complexed Fab fragments to investigate structural basis of immune recognition. IA Wilson, JM Rini, DH Fremont, GG Fieser, EA Stura (1991) Methods Enzymol 203: 153-76.

-- 1990 (2) --

Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A. RL Stanfield, TM Fieser, RA Lerner, IA Wilson (1990) Science 248: 712-9.

Structural basis of immune recognition of influenza virus hemagglutinin. IA Wilson, NJ Cox (1990) Annu Rev Immunol 8: 737-71.

-- 1989 (3) --

Preliminary crystallographic data and primary sequence for anti-peptide Fab' B13I2 and its complex with the C-helix peptide from myohemerythrin. EA Stura, RL Stanfield, TM Fieser, RS Balderas, LR Smith, RA Lerner, IA Wilson (1989) J Biol Chem 264: 15721-5.

Crystallization and preliminary X-ray diffraction studies of a complex between interleukin-2 and a soluble form of the p55 component of the high affinity interleukin-2 receptor. G Lambert, EA Stura, IA Wilson (1989) J Biol Chem 264: 12730-6.

Preliminary crystallographic investigations of glycinamide ribonucleotide transformylase. EA Stura, DL Johnson, J Inglese, JM Smith, SJ Benkovic, IA Wilson (1989) J Biol Chem 264: 9703-6.

-- 1988 (2) --

Preliminary crystallographic data, primary sequence, and binding data for an anti-peptide Fab and its complex with a synthetic peptide from influenza virus hemagglutinin. U Schulze-Gahmen, JM Rini, J Arevalo, EA Stura, JH Kenten, IA Wilson (1988) J Biol Chem 263: 17100-5.

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. J Field, J Nikawa, D Broek, B MacDonald, L Rodgers, IA Wilson, RA Lerner, M Wigler (1988) Mol Cell Biol 8: 2159-65.

-- 1987 (4) --

Analysis of an anti-progesterone antibody: variable crystal morphology of the Fab' and steroid-Fab' complexes. EA Stura, JH Arevalo, A Feinstein, RB Heap, MJ Taussig, IA Wilson (1987) Immunology 62: 511-21.

Anti-peptide antibodies detect steps in a protein conformational change: low-pH activation of the influenza virus hemagglutinin. JM White, IA Wilson (1987) J Cell Biol 105: 2887-96.

Crystallographic analysis of the three-dimensional structure of baboon alpha-lactalbumin at low resolution. Homology with lysozyme. SG Smith, M Lewis, R Aschaffenburg, RE Fenna, IA Wilson, M Sundaralingam, DI Stuart, DC Phillips (1987) Biochem J 242: 353-60.

Crystallization and preliminary crystallographic data for an antiprogesterone monoclonal antibody Fab' and steroid-Fab' complexes. EA Stura, A Feinstein, IA Wilson (1987) J Mol Biol 193: 229-31.

-- 1986 (2) --

Selection by site-directed antibodies of small regions of peptides which are ordered in water. HJ Dyson, KJ Cross, J Ostresh, RA Houghten, IA Wilson, PE Wright, RA Lerner (1986) Ciba Found Symp 119: 58-75.

The immunodominant site of a synthetic immunogen has a conformational preference in water for a type-II reverse turn. HJ Dyson, KJ Cross, RA Houghten, IA Wilson, PE Wright, RA Lerner (1986) Nature 318: 480-3.

-- 1985 (2) --

Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition. IA Wilson, DH Haft, ED Getzoff, JA Tainer, RA Lerner, S Brenner (1985) Proc Natl Acad Sci U S A 82: 5255-9.

Studies with monoclonal antibodies prepared against X-31 influenza virus haemagglutinin. JJ Skehel, E Brown, RS Daniels, AR Douglas, M Knossow, IA Wilson, NG Wrigley, DC Wiley (1985) Biochem Soc Trans 13: 12-4.