Wilson Laboratory Publications

(Last updated Mon Jul 11 2011; click here for JCSG Publications )

-- 2011 --

A highly conserved neutralizing epitope on group 2 influenza A viruses. DC Ekiert, RH Friesen, G Bhabha, T Kwaks, M Jongeneelen, W Yu, C Ophorst, F Cox, HJ Korse, B Brandenburg, R Vogels, JP Brakenhoff, R Kompier, MH Koldijk, LA Cornelissen, LL Poon, M Peiris, W Koudstaal, IA Wilson, and J Goudsmit. (2011) Science in press.

Trimeric HIV-1 gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures. A Harris, D Shi, A Bartesaghi, MJ Borgnia, H He, R Pejchal, K Kang, R Depetris, A Marozsan, RW Sanders, PJ Klasse, JLS Milne, IA Wilson, WC Olson, JP Moore, and S Subramanium. (2011) Proc Natl Acad Sci U S A in press.

Structural characterization of an early fusion intermediate of influenza virus hemagglutinin. R Xu and IA Wilson. (2011) J Virol 85:5172-5182.

cDNA sequence and Fab crystal structure of HL4E10, a hamster IgG ? light chain antibody stimulatory for ?? T cells. P Verdino, DA Witherden, K Podshivalova, SE Rieder, WL Havran, and IA Wilson. (2011) PLoS One 6:e19828.

Molecular insights into ?? T cell costimulation by an anti-JAML antibody. P Verdino, DA Witherden, MS Ferguson, AL Corper, A Schiefner, WL Havran, and IA Wilson. (2011) Structure 19:80-89.

JAML and CAR: Two more players in T-cell activation. P Verdino and IA Wilson. (2011) Cell Cycle 10:1341-1342.

A structural analysis of M protein in coronavirus assembly and morphology. BW Neuman, G Kiss, AH Kunding, D Bhella, MF Baksh, S Connelly, B Droese, JP Klaus, S Makino, SG Sawicki, SG Siddell, DG Stamou, IA Wilson, P Kuhn, and MJ Buchmeier. (2011) J Struct Biol 174:11-22.

An insertion mutation that distorts antibody binding site architecture enhances function of a human antibody. JC Krause, DC Ekiert, TM Tumpey, PB Smith, IA Wilson, and JE Crowe, Jr. (2011) MBio 2:e00345-00310.

Structural Basis for Ligand Recognition and Discrimination of a Quorum-quenching Antibody. RN Kirchdoerfer, AL Garner, CE Flack, JM Mee, AR Horswill, KD Janda, GF Kaufmann, and IA Wilson. (2011) J Biol Chem 286:17351-17358.

Crystal structure of the human N-Myc downstream-regulated gene 2 protein provides insight into its role as a tumor suppressor. J Hwang, Y Kim, HB Kang, L Jaroszewski, AM Deacon, H Lee, WC Choi, KJ Kim, CH Kim, BS Kang, JO Lee, TK Oh, JW Kim, IA Wilson, and MH Kim. (2011) J Biol Chem 286:12450-12460.

Structural basis of steroid hormone receptor perception by a membrane receptor kinases. M Hothorn, Y Belkhadir, M Dreux, D Tsegaye, JP Noel, IA Wilson, and J Chory. (2011) Nature 474:467-471.

Crystal structure of a metal-dependent phosphoesterase (YP_910028.1) from Bifidobacterium adolescentis: Computational prediction and experimental validation of phosphoesterase activity. GW Han, J Ko, CL Farr, MC Deller, Q Xu, HJ Chiu, MD Miller, J Sefcikova, S Somarowthu, PJ Beuning, MA Elsliger, AM Deacon, A Godzik, SA Lesley, IA Wilson, and MJ Ondrechen. (2011) Proteins 79:2146-2160.

Computational design of proteins targeting the conserved stem region of influenza hemagglutinin. SJ Fleishman, TA Whitehead, DC Ekiert, C Dreyfus, JE Corn, EM Strauch, IA Wilson, and D Baker. (2011) Science 332:816-821.

Structure and function of the first full-length murein Peptide ligase (mpl) cell wall recycling protein. D Das, M Herve, J Feuerhelm, CL Farr, HJ Chiu, MA Elsliger, MW Knuth, HE Klock, MD Miller, A Godzik, SA Lesley, AM Deacon, D Mengin-Lecreulx, and IA Wilson. (2011) PLoS One 6:e17624.

A dynamic knockout reveals that conformational fluctuations influence the chemical step of enzyme catalysis. G Bhabha, J Lee, DC Ekiert, J Gam, IA Wilson, HJ Dyson, SJ Benkovic, and PE Wright. (2011) Science 332:234-238.

-- 2010 --

The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity. K Yoshida, AL Corper, R Herro, B Jabri, IA Wilson, and L Teyton. (2010) J Clin Invest 120:1578-1590.

Vaccination with a synthetic peptide from the influenza virus hemagglutinin provides protection against distinct viral subtypes. TT Wang, GS Tan, R Hai, N Pica, L Ngai, DC Ekiert, IA Wilson, A Garcia-Sastre, TM Moran, and P Palese. (2010) Proc Natl Acad Sci U S A 107:18979-18984.

The junctional adhesion molecule JAML is a costimulatory receptor for epithelial ?? T cell activation. DA Witherden, P Verdino, SE Rieder, O Garijo, RE Mills, L Teyton, WH Fischer, IA Wilson, and WL Havran. (2010) Science 329:1205-1210.

Structure-based vaccine design in HIV: Blind men and the elephant. R Pejchal and IA Wilson. (2010) Curr Pharm Des 16:3744-3755.

The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. P Verdino, DA Witherden, WL Havran, and IA Wilson. (2010) Science 329:1210-1214.

An ?? T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex. Science. 1996. 274: 209-219. KC Garcia, M Degano, RL Stanfield, A Brunmark, MR Jackson, PA Peterson, L Teyton, and IA Wilson. (2010) J Immunol 185:6402-6412.

A nonself sugar mimic of the HIV glycan shield shows enhanced antigenicity. KJ Doores, Z Fulton, V Hong, MK Patel, CN Scanlan, MR Wormald, MG Finn, DR Burton, IA Wilson, and BG Davis. (2010) Proc Natl Acad Sci U S A 107:17107-17112.

Very few substitutions in a germline antibody are required to initiate significant domain exchange. M Huber, KM Le, KJ Doores, Z Fulton, RL Stanfield, IA Wilson, and DR Burton. (2010) J Virol.

Antibody 2G12 recognizes di-mannose wquivalently in domain- and non-domain-exchanged forms, but only binds the HIV-1 glycan shield if domain-exchanged. KJ Doores, Z Fulton, M Huber, IA Wilson, and DR Burton. (2010) J Virol.

Structure and function of broadly reactive antibody PG16 reveal an H3 subdomain that mediates potent neutralization of HIV-1. R Pejchal, LM Walker, RL Stanfield, SK Phogat, WC Koff, P Poignard, DR Burton, and IA Wilson. (2010) Proc Natl Acad Sci U S A 107:11483-11488.

Crystal structure of soluble MD-1 and its interaction with lipid IVa. SI Yoon, M Hong, GW Han, and IA Wilson. (2010) Proc Natl Acad Sci U S A 107:10990-10995.

The diabetogenic mouse MHC class II molecule I-Ag7 is endowed with a switch that modulates TCR affinity. K Yoshida, AL Corper, R Herro, B Jabri, IA Wilson, and L Teyton. (2010) J Clin Invest 120:1578-1590.

Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus. R Xu, DC Ekiert, JC Krause, R Hai, JE Crowe, Jr., and IA Wilson. (2010) Science. download reprint here

Structure, receptor binding, and antigenicity of influenza virus hemagglutinins from the 1957 H2N2 pandemic. R Xu, R McBride, JC Paulson, CF Basler, and IA Wilson. (2010) J Virol 84:1715-1721.

Chemoselective small molecules that covalently modify one lysine in a non-enzyme protein in plasma. S Choi, S Connelly, N Reixach, IA Wilson, and JW Kelly. (2010) Nat Chem Biol 6:133-139.

A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. S Choi, N Reixach, S Connelly, SM Johnson, IA Wilson, and JW Kelly. (2010) J Am Chem Soc 132:1359-1370.

Structure-based design of kinetic stabilizers that ameliorate the transthyretin amyloidoses. S Connelly, S Choi, SM Johnson, JW Kelly, and IA Wilson. (2010) Curr Opin Struct Biol 20:54-62

-- 2009 (13) --

HIV-1 and influenza antibodies: seeing antigens in new ways. PD Kwong and IA Wilson. (2009) Nat Immunol 10:573-578.

Antibody recognition of a highly conserved influenza virus epitope. DC Ekiert, G Bhabha, MA Elsliger, RH Friesen, M Jongeneelen, M Throsby, J Goudsmit, and IA Wilson. (2009) Science 324:246-251.

The phosphatidylinositol 3-kinase/akt cassette regulates purine nucleotide synthesis. W Wang, A Fridman, W Blackledge, S Connelly, IA Wilson, RB Pilz, and GR Boss. (2009) J Biol Chem 284:3521-3528.

Toward optimization of the second aryl substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. SM Johnson, S Connelly, IA Wilson, and JW Kelly. (2009) J Med Chem 52:1115-1125.

Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering. Y An, CY Chen, B Moyer, P Rotkiewicz, MA Elsliger, A Godzik, IA Wilson, and WE Balch. (2009) J Mol Biol 391:26-41.

A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies. R Pejchal, JS Gach, FM Brunel, RM Cardoso, RL Stanfield, PE Dawson, DR Burton, MB Zwick, and IA Wilson. (2009) J Virol 83:8451-8462.

An aspartate and a water molecule mediate efficient acid-base catalysis in a tailored antibody pocket. EW Debler, R Muller, D Hilvert, and IA Wilson. (2009) Proc Natl Acad Sci U S A 106:18539-18544.

Presentation of lipid antigens by CD1 glycoproteins. A Schiefner and IA Wilson. (2009) Curr Pharm Des 15:3311-3317.

Structural evaluation of potent NKT cell agonists: implications for design of novel stimulatory ligands. A Schiefner, M Fujio, D Wu, CH Wong, and IA Wilson. (2009) J Mol Biol 394:71-82.

Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2. MJ Jimenez-Dalmaroni, N Xiao, AL Corper, P Verdino, GD Ainge, DS Larsen, GF Painter, PM Rudd, RA Dwek, K Hoebe, B Beutler, and IA Wilson. (2009) PLoS One 4:e7411.

New design of MHC class II tetramers to accommodate fundamental principles of antigen presentation. E Landais, PA Romagnoli, AL Corper, J Shires, JD Altman, IA Wilson, KC Garcia, and L Teyton. (2009) J Immunol 183:7949-7957.

Direct observation of an enamine intermediate in amine catalysis. X Zhu, F Tanaka, RA Lerner, CF Barbas, 3rd, and IA Wilson. (2009) J Am Chem Soc 131:18206-18207.

A substructure combination strategy to create potent and selective transthyretin kinetic stabilizers that prevent amyloidogenesis and cytotoxicity. S Choi, N Reixach, S Connelly, SM Johnson, IA Wilson, and JW Kelly. (2009) J Am Chem Soc 131:18206-18207.

-- 2008 (20) --

Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. SM Johnson, S Connelly, IA Wilson, and JW Kelly. (2008) J Med Chem 51:260-270.

Deeply inverted electron-hole recombination in a luminescent antibody-stilbene complex. EW Debler, GF Kaufmann, MM Meijler, A Heine, JM Mee, G Pljevaljcic, AJ Di Bilio, PG Schultz, DP Millar, KD Janda, IA Wilson, HB Gray, and RA Lerner. (2008) Science 319:1232-1235.

Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization. CH Bell, R Pantophlet, A Schiefner, LA Cavacini, RL Stanfield, DR Burton, and IA Wilson. (2008) J Mol Biol 375:969-978.

Crystal structures of mouse CD1d-iGb3 complex and its cognate Va14 T cell receptor suggest a model for dual recognition of foreign and self glycolipids. DM Zajonc, PB Savage, A Bendelac, IA Wilson, and L Teyton. (2008) J Mol Biol 377:1104-1116.

A peptide inhibitor of HIV-1 neutralizing antibody 2G12 is not a structural mimic of the natural carbohydrate epitope on gp120. A Menendez, DA Calarese, RL Stanfield, KC Chow, CN Scanlan, R Kunert, H Katinger, DR Burton, IA Wilson, and JK Scott. (2008) Faseb J 22:1380-1392.

Comparative efficacy of neutralizing antibodies elicited by recombinant hemagglutinin proteins from avian H5N1 influenza virus. CJ Wei, L Xu, WP Kong, W Shi, K Canis, J Stevens, ZY Yang, A Dell, SM Haslam, IA Wilson, and GJ Nabel. (2008) J Virol 82:6200-6208.

Conformational isomerism can limit antibody catalysis. EW Debler, R Muller, D Hilvert, and IA Wilson. (2008) J Biol Chem 283:16554-16560.

Recent avian H5N1 viruses exhibit increased propensity for acquiring human receptor specificity. J Stevens, O Blixt, LM Chen, RO Donis, JC Paulson, and IA Wilson. (2008) J Mol Biol 381:1382-1394.

Structure determination of the 1918 H1N1 neuraminidase from a crystal with lattice-translocation defects. X Zhu, X Xu, and IA Wilson. (2008) Acta Cryst D 64:843-850.

Structure determination of an anti-HIV-1 Fab 447-52D-peptide complex from an epitaxially twinned data set. AK Dhillon, RL Stanfield, MK Gorny, C Williams, S Zolla-Pazner, and IA Wilson. (2008) Acta Cryst D 64:792-802.

pH-dependent interdomain tethers of CD1b regulate its antigen capture. M Relloso, TY Cheng, JS Im, E Parisini, C Roura-Mir, C DeBono, DM Zajonc, LF Murga, MJ Ondrechen, IA Wilson, SA Porcelli, and DB Moody. (2008) Immunity 28:774-786.

Antigen recognition by variable lymphocyte receptors. BW Han, BR Herrin, MD Cooper, and IA Wilson. (2008) Science 321:1834-1837.

Closely related antibody receptors exploit fundamentally different strategies for steroid recognition. P Verdino, C Aldag, D Hilvert, and IA Wilson. (2008) Proc Natl Acad Sci U S A 105:11725-11730.

Asymmetric synthesis of inhibitors of glycinamide ribonucleotide transformylase. JK DeMartino, I Hwang, S Connelly, IA Wilson, and DL Boger. (2008) J Med Chem 51:5441-5448.

Neutralizing antibodies derived from the B cells of 1918 influenza pandemic survivors. X Yu, T Tsibane, PA McGraw, FS House, CJ Keefer, MD Hicar, TM Tumpey, C Pappas, LA Perrone, O Martinez, J Stevens, IA Wilson, PV Aguilar, EL Altschuler, CF Basler, and JE Crowe, Jr. (2008) Nature 455:532-536.

Structural characterization of the 1918 influenza virus H1N1 neuraminidase. X Xu, X Zhu, RA Dwek, J Stevens, and IA Wilson. (2008) J Virol 82:10493-10501.

Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. SM Johnson, S Connelly, IA Wilson, and JW Kelly. (2008) J Med Chem 51:6348-6358.

A glycoconjugate antigen based on the recognition motif of a broadly neutralizing human immunodeficiency virus antibody, 2G12, is immunogenic but elicits antibodies unable to bind to the self glycans of gp120. RD Astronomo, HK Lee, CN Scanlan, R Pantophlet, CY Huang, IA Wilson, O Blixt, RA Dwek, CH Wong, and DR Burton. (2008) J Virol 82:6359-6368.

The crystal structure of avian CD1 reveals a smaller, more primordial antigen-binding pocket compared to mammalian CD1. DM Zajonc, H Striegl, CC Dascher, and IA Wilson. (2008) Proc Natl Acad Sci U S A 105:17925-17930.

The crystal structure of CD8 in complex with YTS156.7.7 Fab and interaction with other CD8 antibodies define the binding mode of CD8 a&be; to MHC class I. DA Shore, H Issafras, E Landais, L Teyton, and IA Wilson. (2008) J Mol Biol 384:1190-1202.

-- 2007 (12) --

Bifunctional catalysis of proton transfer at an antibody active site. R Muller, EW Debler, M Steinmann, FP Seebeck, IA Wilson, and D Hilvert. (2007) J Am Chem Soc 129:460-461.

Maturation of shark single-domain (IgNAR) antibodies: evidence for induced-fit binding. RL Stanfield, H Dooley, P Verdino, MF Flajnik, and IA Wilson. (2007) J Mol Biol 367:358-372.

Structural basis of enhanced binding of extended and helically constrained peptide epitopes of the broadly neutralizing HIV-1 antibody 4E10. RM Cardoso, FM Brunel, S Ferguson, M Zwick, DR Burton, PE Dawson, and IA Wilson. (2007) J Mol Biol 365:1533-1544.

Architecture of CD1 proteins. DM Zajonc and IA Wilson. (2007) Curr Top Microbiol Immunol 314:27-50.

Structure of a high-affinity "mimotope" peptide bound to HIV-1-neutralizing antibody b12 explains its inability to elicit gp120 cross-reactive antibodies. EO Saphire, M Montero, A Menendez, NE van Houten, MB Irving, R Pantophlet, MB Zwick, PW Parren, DR Burton, JK Scott, and IA Wilson. (2007) J Mol Biol 369:696-709.

Specific recognition of a DNA immunogen by its elicited antibody. S Sanguineti, JM Centeno Crowley, MF Lodeiro Merlo, ML Cerutti, IA Wilson, FA Goldbaum, RL Stanfield, and G de Prat-Gay. (2007) J Mol Biol 370:183-195.

Antigenic and immunogenic study of membrane-proximal external region-grafted gp120 antigens by a DNA prime-protein boost immunization strategy. M Law, RM Cardoso, IA Wilson, and DR Burton. (2007) J Virol 81:4272-4285.

Crystal structures of a quorum-quenching antibody. EW Debler, GF Kaufmann, RN Kirchdoerfer, JM Mee, KD Janda, and IA Wilson. (2007) J Mol Biol 368:1392-1402.

An affinity-enhanced neutralizing antibody against the membrane-proximal external region of human immunodeficiency virus type 1 gp41 recognizes an epitope between those of 2F5 and 4E10. JD Nelson, FM Brunel, R Jensen, ET Crooks, RM Cardoso, M Wang, A Hessell, IA Wilson, JM Binley, PE Dawson, DR Burton, and MB Zwick. (2007) J Virol 81:4033-4043.

Immunology. Square-dancing antibodies. DR Burton and IA Wilson. (2007) Science 317:1507-1508.

Structures of the CCR5 N terminus and of a tyrosine-sulfated antibody with HIV-1 gp120 and CD4. CC Huang, SN Lam, P Acharya, M Tang, SH Xiang, SS Hussan, RL Stanfield, J Robinson, J Sodroski, IA Wilson, R Wyatt, CA Bewley, and PD Kwong. (2007) Science 317:1930-1934.

Structure of the Wilms tumor suppressor protein zinc finger domain bound to DNA. R Stoll, BM Lee, EW Debler, JH Laity, IA Wilson, HJ Dyson, and PE Wright. (2007) J Mol Biol 372:1227-1245.

-- 2006 (21) --

Glycan microarray analysis of the hemagglutinins from modern and pandemic influenza viruses reveals different receptor specificities. J Stevens, O Blixt, L Glaser, JK Taubenberger, P Palese, JC Paulson, and IA Wilson. (2006) J Mol Biol 355:1143-1155.

Structure-function analysis of the epitope for 4E10, a broadly neutralizing human immunodeficiency virus type 1 antibody. FM Brunel, MB Zwick, RM Cardoso, JD Nelson, IA Wilson, DR Burton, and PE Dawson. (2006) J Virol 80:1680-1687.

Design of natural killer T cell activators: structure and function of a microbial glycosphingolipid bound to mouse CD1d. D Wu, DM Zajonc, M Fujio, BA Sullivan, Y Kinjo, M Kronenberg, IA Wilson, and CH Wong. (2006) Proc Natl Acad Sci U S A 103:3972-3977.

Antibody elbow angles are influenced by their light chain class. RL Stanfield, A Zemla, IA Wilson, and B Rupp. (2006) J Mol Biol 357:1566-1574.

How TCRs bind MHCs, peptides, and coreceptors. MG Rudolph, RL Stanfield, and IA Wilson. (2006) Annu Rev Immunol 24:419-466.

Structure and receptor specificity of the hemagglutinin from an H5N1 influenza virus. J Stevens, O Blixt, TM Tumpey, JK Taubenberger, JC Paulson, and IA Wilson. (2006) Science 312:404-410.

Complete reaction cycle of a cocaine catalytic antibody at atomic resolution. X Zhu, TJ Dickerson, CJ Rogers, GF Kaufmann, JM Mee, KM McKenzie, KD Janda, and IA Wilson. (2006) Structure 14:205-216.

Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. DJ Stauber, EW Debler, PA Horton, KA Smith, and IA Wilson. (2006) Proc Natl Acad Sci U S A 103:2788-2793.

Crystal structure of the TCR co-receptor CD8aa in complex with monoclonal antibody YTS 105.18 Fab fragment at 2.88 Å resolution. DA Shore, L Teyton, RA Dwek, PM Rudd, and IA Wilson. (2006) J Mol Biol 358:347-354.

Discovery of a potent, nonpolyglutamatable inhibitor of glycinamide ribonucleotide transformylase. JK DeMartino, I Hwang, L Xu, IA Wilson, and DL Boger. (2006) J Med Chem 49:2998-3002.

Crystal structures of human immunodeficiency virus type 1 (HIV-1) neutralizing antibody 2219 in complex with three different V3 peptides reveal a new binding mode for HIV-1 cross-reactivity. RL Stanfield, MK Gorny, S Zolla-Pazner, and IA Wilson. (2006) J Virol 80:6093-6105.

Cofactor-containing antibodies: crystal structure of the original yellow antibody. X Zhu, P Wentworth, Jr., RA Kyle, RA Lerner, and IA Wilson. (2006) Proc Natl Acad Sci U S A 103:3581-3585.

Details of Toll-like receptor:adapter interaction revealed by germ-line mutagenesis. Z Jiang, P Georgel, C Li, J Choe, K Crozat, S Rutschmann, X Du, T Bigby, S Mudd, S Sovath, IA Wilson, A Olson, and B Beutler. (2006) Proc Natl Acad Sci U S A 103:10961-10966.

Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Y Kinjo, E Tupin, D Wu, M Fujio, R Garcia-Navarro, MR Benhnia, DM Zajonc, G Ben-Menachem, GD Ainge, GF Painter, A Khurana, K Hoebe, SM Behar, B Beutler, IA Wilson, M Tsuji, TJ Sellati, CH Wong, and M Kronenberg. (2006) Nat Immunol 7:978-986.

Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120. JM Binley, S Ngo-Abdalla, P Moore, M Bobardt, U Chatterji, P Gallay, DR Burton, IA Wilson, JH Elder, and A de Parseval. (2006) Retrovirology 3:39.

Role of lipid trimming and CD1 groove size in cellular antigen presentation. TY Cheng, M Relloso, I Van Rhijn, DC Young, GS Besra, V Briken, DM Zajonc, IA Wilson, S Porcelli, and DB Moody. (2006) Embo J 25:2989-2999.

Structural characterization of mycobacterial phosphatidylinositol mannoside binding to mouse CD1d. DM Zajonc, GD Ainge, GF Painter, WB Severn, and IA Wilson. (2006) J Immunol 177:4577-4583.

Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase. ZD Cooper, D Narasimhan, RK Sunahara, P Mierzejewski, EM Jutkiewicz, NA Larsen, IA Wilson, DW Landry, and JH Woods. (2006) Mol Pharmacol 70:1885-1891.

Glycan microarray technologies: tools to survey host specificity of influenza viruses. J Stevens, O Blixt, JC Paulson, and IA Wilson. (2006) Nat Rev Microbiol 4:857-864.

Enhanced major histocompatibility complex class I binding and immune responses through anchor modification of the non-canonical tumour-associated mucin 1-8 peptide. E Lazoura, J Lodding, W Farrugia, PA Ramsland, J Stevens, IA Wilson, GA Pietersz, and V Apostolopoulos. (2006) Immunology 119:306-316.

The effects of antibodies on stilbene excited-state energetics. F Tian, EW Debler, DP Millar, AA Deniz, IA Wilson, and PG Schultz. (2006) Angew Chem Int Ed 45:7763-7765.

-- 2005 (24) --

CD1 assembly and the formation of CD1-antigen complexes. DL Hava, M Brigl, P van den Elzen, DM Zajonc, IA Wilson, and MB Brenner. (2005) Curr Opin Immunol 17:88-94.

Broadly neutralizing anti-HIV antibody 4E10 recognizes a helical conformation of a highly conserved fusion-associated motif in gp41. RM Cardoso, MB Zwick, RL Stanfield, R Kunert, JM Binley, H Katinger, DR Burton, and IA Wilson. (2005) Immunity 22:163-173.

Kinetic stabilization of the native state by protein engineering: implications for inhibition of transthyretin amyloidogenesis. TR Foss, MS Kelker, RL Wiseman, IA Wilson, and JW Kelly. (2005) J Mol Biol 347:841-854.

Molecular mechanism of lipopeptide presentation by CD1a. DM Zajonc, MD Crispin, TA Bowden, DC Young, TY Cheng, J Hu, CE Costello, PM Rudd, RA Dwek, MJ Miller, MB Brenner, DB Moody, and IA Wilson. (2005) Immunity 22:209-219.

Kinetic stabilization of an oligomeric protein by a single ligand binding event. RL Wiseman, SM Johnson, MS Kelker, T Foss, IA Wilson, and JW Kelly. (2005) J Am Chem Soc 127:5540-5551.

Structural origins of efficient proton abstraction from carbon by a catalytic antibody. EW Debler, S Ito, FP Seebeck, A Heine, D Hilvert, and IA Wilson. (2005) Proc Natl Acad Sci U S A 102:4984-4989.

Crystal structures of apo wild-type M. jannaschii tyrosyl-tRNA synthetase (TyrRS) and an engineered TyrRS specific for O-methyl-L-tyrosine. Y Zhang, L Wang, PG Schultz, and IA Wilson. (2005) Protein Sci 14:1340-1349.

MHC restriction: slip-sliding away. IA Wilson and RL Stanfield. (2005) Nat Immunol 6:434-435.

T-cell activation by lipopeptide antigens. I Van Rhijn, DM Zajonc, IA Wilson, and DB Moody. (2005) Curr Opin Immunol 17:222-229.

Anatomy of CD1-lipid antigen complexes. DB Moody, DM Zajonc, and IA Wilson. (2005) Nat Rev Immunol 5:387-399.

Synthesis and biological evaluation of N-{4-[5-(2,4-diamino-6-oxo-1,6-dihydropyrimidin-5-yl)-2-(2,2,2-trifluoroac etyl)pentyl]benzoyl}-L-glutamic acid as a potential inhibitor of GAR Tfase and the de novo purine biosynthetic pathway. H Cheng, I Hwang, Y Chong, A Tavassoli, ME Webb, Y Zhang, IA Wilson, SJ Benkovic, and DL Boger. (2005) Bioorg Med Chem 13:3593-3599.

Structure and function of a potent agonist for the semi-invariant natural killer T cell receptor. DM Zajonc, C Cantu, 3rd, J Mattner, D Zhou, PB Savage, A Bendelac, IA Wilson, and L Teyton. (2005) Nat Immunol 6:810-818.

Crystal structure of human toll-like receptor 3 (TLR3) ectodomain. J Choe, MS Kelker, and IA Wilson. (2005) Science 309:581-585.

A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity. L Glaser, J Stevens, D Zamarin, IA Wilson, A Garcia-Sastre, TM Tumpey, CF Basler, JK Taubenberger, and P Palese. (2005) J Virol 79:11533-11536.

Crystal structure of mouse CD1d bound to the self ligand phosphatidylcholine: a molecular basis for NKT cell activation. B Giabbai, S Sidobre, MD Crispin, Y Sanchez-Ruiz, A Bachi, M Kronenberg, IA Wilson, and M Degano. (2005) J Immunol 175:977-984.

Design, synthesis, and biological evaluation of 10-methanesulfonyl-DDACTHF, 10-methanesulfonyl-5-DACTHF, and 10-methylthio-DDACTHF as potent inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. H Cheng, Y Chong, I Hwang, A Tavassoli, Y Zhang, IA Wilson, SJ Benkovic, and DL Boger. (2005) Bioorg Med Chem 13:3577-3585.

Synthesis and biological evaluation of a- and γ-carboxamide derivatives of 10-CF3CO-DDACTHF. Y Chong, I Hwang, A Tavassoli, Y Zhang, IA Wilson, SJ Benkovic, and DL Boger. (2005) Bioorg Med Chem 13:3587-3592.

Crystal structure of viral macrophage inflammatory protein I encoded by Kaposi's sarcoma-associated herpesvirus at 1.7 Å. JG Luz, M Yu, Y Su, Z Wu, Z Zhou, R Sun, and IA Wilson. (2005) J Mol Biol 352:1019-1028.

Structure of a V3-containing HIV-1 gp120 core. CC Huang, M Tang, MY Zhang, S Majeed, E Montabana, RL Stanfield, DS Dimitrov, B Korber, J Sodroski, IA Wilson, R Wyatt, and PD Kwong. (2005) Science 310:1025-1028.

Structural basis for CD1d presentation of a sulfatide derived from myelin and its implications for autoimmunity. DM Zajonc, I Maricic, D Wu, R Halder, K Roy, CH Wong, V Kumar, and IA Wilson. (2005) J Exp Med 202:1517-1526.

Antibody vs. HIV in a clash of evolutionary titans. DR Burton, RL Stanfield, and IA Wilson. (2005) Proc Natl Acad Sci U S A 102:14943-14948.

Structural studies of human HIV-1 V3 antibodies. RL Stanfield and IA Wilson. (2005) Hum Antibodies 14:73-80.

Glycosylation and the function of the T cell co-receptor CD8. DA Shore, IA Wilson, RA Dwek, and PM Rudd. (2005) Adv Exp Med Biol 564:71-84.

Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12. DA Calarese, HK Lee, CY Huang, MD Best, RD Astronomo, RL Stanfield, H Katinger, DR Burton, CH Wong, and IA Wilson. (2005) Proc Natl Acad Sci U S A 102:13372-13377.

-- 2004 (29) --

T cell activation by lipopeptide antigens. DB Moody, DC Young, TY Cheng, JP Rosat, C Roura-Mir, PB O'Connor, DM Zajonc, A Walz, MJ Miller, SB Levery, IA Wilson, CE Costello, and MB Brenner. (2004) Science 303:527-531.

Structural insights into the human and avian IMP cyclohydrolase mechanism via crystal structures with the bound XMP inhibitor. DW Wolan, CG Cheong, SE Greasley, and IA Wilson. (2004) Biochemistry 43:1171-1183.

Reactivity-based one-pot synthesis of oligomannoses: defining antigens recognized by 2G12, a broadly neutralizing anti-HIV-1 antibody. HK Lee, CN Scanlan, CY Huang, AY Chang, DA Calarese, RA Dwek, PM Rudd, DR Burton, IA Wilson, and CH Wong. (2004) Angew Chem Int Ed 43:1000-1003.

Genetic and phenotypic analyses of HIV-1 escape from a small-molecule CCR5 inhibitor. SE Kuhmann, P Pugach, KJ Kunstman, J Taylor, RL Stanfield, A Snyder, JM Strizki, J Riley, BM Baroudy, IA Wilson, B Korber, SM Wolinsky, and JP Moore. (2004) J Virol 78:2790-2807.

HIV vaccine design and the neutralizing antibody problem. DR Burton, RC Desrosiers, RW Doms, WC Koff, PD Kwong, JP Moore, GJ Nabel, J Sodroski, IA Wilson, and RT Wyatt. (2004) Nat Immunol 5:233-236.

Probing the antibody-catalyzed water-oxidation pathway at atomic resolution. X Zhu, P Wentworth, Jr., AD Wentworth, A Eschenmoser, RA Lerner, and IA Wilson. (2004) Proc Natl Acad Sci U S A 101:2247-2252.

A peptide that antagonizes TCR-mediated reactions with both syngeneic and allogeneic agonists: functional and structural aspects. MG Rudolph, LQ Shen, SA Lamontagne, JG Luz, JR Delaney, Q Ge, BK Cho, D Palliser, CA McKinley, J Chen, IA Wilson, and HN Eisen. (2004) J Immunol 172:2994-3002.

Structural rationale for the broad neutralization of HIV-1 by human monoclonal antibody 447-52D. RL Stanfield, MK Gorny, C Williams, S Zolla-Pazner, and IA Wilson. (2004) Structure 12:193-204.

Rapid refinement of crystallographic protein construct definition employing enhanced hydrogen/deuterium exchange MS. D Pantazatos, JS Kim, HE Klock, RC Stevens, IA Wilson, SA Lesley, and VL Woods, Jr. (2004) Proc Natl Acad Sci U S A 101:751-756.

Genetic and phenotypic analyses of human immunodeficiency virus type 1 escape from a small-molecule CCR5 inhibitor. SE Kuhmann, P Pugach, KJ Kunstman, J Taylor, RL Stanfield, A Snyder, JM Strizki, J Riley, BM Baroudy, IA Wilson, BT Korber, SM Wolinsky, and JP Moore. (2004) J Virol 78:2790-2807.

The long third complementarity-determining region of the heavy chain is important in the activity of the broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2F5. MB Zwick, HK Komori, RL Stanfield, S Church, M Wang, PW Parren, R Kunert, H Katinger, IA Wilson, and DR Burton. (2004) J Virol 78:3155-3161.

Supine orientation of a murine MHC class I molecule on the membrane bilayer. AK Mitra, H Celia, G Ren, JG Luz, IA Wilson, and L Teyton. (2004) Curr Biol 14:718-724.

Combined pseudo-merohedral twinning, non-crystallographic symmetry and pseudo-translation in a monoclinic crystal form of the γδ T-cell ligand T10. MG Rudolph, C Wingren, MP Crowley, YH Chien, and IA Wilson. (2004) Acta Cryst D 60:656-664.

Monoglucosylated glycans in the secreted human complement component C3: implications for protein biosynthesis and structure. MD Crispin, GE Ritchie, AJ Critchley, BP Morgan, IA Wilson, RA Dwek, RB Sim, and PM Rudd. (2004) FEBS Lett 566:270-274.

Structure of the uncleaved human H1 hemagglutinin from the extinct 1918 influenza virus. J Stevens, AL Corper, CF Basler, JK Taubenberger, P Palese, and IA Wilson. (2004) Science 303:1866-1870.

Crystal structures of human bifunctional enzyme aminoimidazole-4-carboxamide ribonucleotide transformylase/IMP cyclohydrolase in complex with potent sulfonyl-containing antifolates. CG Cheong, DW Wolan, SE Greasley, PA Horton, GP Beardsley, and IA Wilson. (2004) J Biol Chem 279:18034-18045.

Crystallographic and biochemical analysis of cocaine-degrading antibody 15A10. NA Larsen, P de Prada, SX Deng, A Mittal, M Braskett, X Zhu, IA Wilson, and DW Landry. (2004) Biochemistry 43:8067-8076.

Covalent display of oligosaccharide arrays in microtiter plates. MC Bryan, F Fazio, HK Lee, CY Huang, A Chang, MD Best, DA Calarese, O Blixt, JC Paulson, D Burton, IA Wilson, and CH Wong. (2004) J Am Chem Soc 126:8640-8641.

Crystal structure of the Drosophila peptidoglycan recognition protein (PGRP)-SA at 1.56 Å resolution. JB Reiser, L Teyton, and IA Wilson. (2004) J Mol Biol 340:909-917.

The origin of enantioselectivity in aldolase antibodies: crystal structure, site-directed mutagenesis, and computational analysis. X Zhu, F Tanaka, Y Hu, A Heine, R Fuller, G Zhong, AJ Olson, RA Lerner, CF Barbas, 3rd, and IA Wilson. (2004) J Mol Biol 343:1269-1280.

Analysis of the class I aldolase binding site architecture based on the crystal structure of 2-deoxyribose-5-phosphate aldolase at 0.99 Å resolution. A Heine, JG Luz, CH Wong, and IA Wilson. (2004) J Mol Biol 343:1019-1034.

Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 Å. MS Kelker, TR Foss, W Peti, L Teyton, JW Kelly, K Wüthrich, and IA Wilson. (2004) J Mol Biol 342:1237-1248.

Crystal structure of a shark single-domain antibody V region in complex with lysozyme. RL Stanfield, H Dooley, MF Flajnik, and IA Wilson. (2004) Science 305:1770-1773.

COPII-dependent export of cystic fibrosis transmembrane conductance regulator from the ER uses a di-acidic exit code. X Wang, J Matteson, Y An, B Moyer, JS Yoo, S Bannykh, IA Wilson, JR Riordan, and WE Balch. (2004) J Cell Biol 167:65-74.

Printed covalent glycan array for ligand profiling of diverse glycan binding proteins. O Blixt, S Head, T Mondala, C Scanlan, ME Huflejt, R Alvarez, MC Bryan, F Fazio, D Calarese, J Stevens, N Razi, DJ Stevens, JJ Skehel, I van Die, DR Burton, IA Wilson, R Cummings, N Bovin, CH Wong, and JC Paulson. (2004) Proc Natl Acad Sci U S A 101:17033-17038.

Crystal structure of avian aminoimidazole-4-carboxamide ribonucleotide transformylase in complex with a novel non-folate inhibitor identified by virtual ligand screening. L Xu, C Li, AJ Olson, and IA Wilson. (2004) J Biol Chem 279:50555-50565.

Virtual screening of human 5-aminoimidazole-4-carboxamide ribonucleotide transformylase against the NCI diversity set by use of AutoDock to identify novel nonfolate inhibitors. C Li, L Xu, DW Wolan, IA Wilson, and AJ Olson. (2004) J Med Chem 47:6681-6690.

Improved design of an antigen with enhanced specificity for the broadly HIV-neutralizing antibody b12. R Pantophlet, IA Wilson, and DR Burton. (2004) Protein Eng Des Sel 17:749-758.

Crystal structure of mouse triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.76 Å. MS Kelker, EW Debler, and IA Wilson. (2004) J Mol Biol 344:1175-1181.

-- 2003 (25) --

Use of multiple anomalous dispersion to phase highly merohedrally twinned crystals of interleukin-1β. MG Rudolph, MS Kelker, TR Schneider, TO Yeates, V Oseroff, DK Heidary, PA Jennings, and IA Wilson. (2003) Acta Cryst D 59:290-298.

Observation of an arsenic adduct in an acetyl esterase crystal structure. X Zhu, NA Larsen, A Basran, NC Bruce, and IA Wilson. (2003) J Biol Chem 278:2008-2014.

Fine mapping of the interaction of neutralizing and nonneutralizing monoclonal antibodies with the CD4 binding site of human immunodeficiency virus type 1 gp120. R Pantophlet, E Ollmann Saphire, P Poignard, PW Parren, IA Wilson, and DR Burton. (2003) J Virol 77:642-658.

Structure-based mutagenesis approaches toward expanding the substrate specificity of D-2-deoxyribose-5-phosphate aldolase. G DeSantis, J Liu, DP Clark, A Heine, IA Wilson, and CH Wong. (2003) Bioorg Med Chem 11:43-52.

Directed evolution of N-acetylneuraminic acid aldolase to catalyze enantiomeric aldol reactions M Wada, C-C Hsu, D Franke, M Mitchell, A Heine, IA Wilson, and CH Wong. (2003) Bioorg Med Chem 11:2091-2098.

Hyperglycosylated mutants of human immunodeficiency virus (HIV) type 1 monomeric gp120 as novel antigens for HIV vaccine design. R Pantophlet, IA Wilson, and DR Burton. (2003) J Virol 77:5889-5901.

Crystal structure of MHC class II I-Ab in complex with a human CLIP peptide: prediction of an I-Ab peptide-binding motif. Y Zhu, AY Rudensky, AL Corper, L Teyton, and IA Wilson. (2003) J Mol Biol 326:1157-1174.

Evidence for the production of trioxygen species during antibody-catalyzed chemical modification of antigens. P Wentworth, Jr., AD Wentworth, X Zhu, IA Wilson, KD Janda, A Eschenmoser, and RA Lerner. (2003) Proc Natl Acad Sci U S A 100:1490-1493.

Expression and characterization of a humanized cocaine-binding antibody. RM Redwan el, NA Larsen, B Zhou, P Wirsching, KD Janda, and IA Wilson. (2003) Biotechnol Bioeng 82:612-618.

XOL-1, primary determinant of sexual fate in C. elegans, is a GHMP kinase family member and a structural prototype for a class of developmental regulators. JG Luz, CA Hassig, C Pickle, A Godzik, BJ Meyer, and IA Wilson. (2003) Genes Dev 17:977-990.

Molecular features of the broadly neutralizing immunoglobulin G1 b12 required for recognition of human immunodeficiency virus type 1 gp120. MB Zwick, PW Parren, EO Saphire, S Church, M Wang, JK Scott, PE Dawson, IA Wilson, and DR Burton. (2003) J Virol 77:5863-5876.

Geranylgeranyl switching regulates GDI-Rab GTPase recycling. Y An, Y Shao, C Alory, J Matteson, T Sakisaka, W Chen, RA Gibbs, IA Wilson, and WE Balch. (2003) Structure 11:347-357.

Structural basis for antibody catalysis of a cationic cyclization reaction. X Zhu, A Heine, F Monnat, KN Houk, KD Janda, and IA Wilson. (2003) J Mol Biol 329:69-83.

Rational design, synthesis, evaluation, and crystal structure of a potent inhibitor of human GAR Tfase: 10-(trifluoroacetyl)-5,10-dideazaacyclic-5,6,7,8-tetrahydrofolic acid. Y Zhang, J Desharnais, TH Marsilje, C Li, MP Hedrick, LT Gooljarsingh, A Tavassoli, SJ Benkovic, AJ Olson, DL Boger, and IA Wilson. (2003) Biochemistry 42:6043-6056.

Secretory IgA N- and O-glycans provide a link between the innate and adaptive immune systems. L Royle, A Roos, DJ Harvey, MR Wormald, D van Gijlswijk-Janssen, RM Redwan el, IA Wilson, MR Daha, RA Dwek, and PM Rudd. (2003) J Biol Chem 278:20140-20153.

Antibody domain exchange is an immunological solution to carbohydrate cluster recognition. DA Calarese, CN Scanlan, MB Zwick, S Deechongkit, Y Mimura, R Kunert, P Zhu, MR Wormald, RL Stanfield, KH Roux, JW Kelly, PM Rudd, RA Dwek, H Katinger, DR Burton, and IA Wilson. (2003) Science 300:2065-2071.

Crystal structure of CD1a in complex with a sulfatide self antigen at a resolution of 2.15 Å. DM Zajonc, MA Elsliger, L Teyton, and IA Wilson. (2003) Nat Immunol 4:808-815.

Design, synthesis and biological evaluation of 10-CF3CO-DDACTHF analogues and derivatives as inhibitors of GAR Tfase and the de novo purine biosynthetic pathway. J Desharnais, I Hwang, Y Zhang, A Tavassoli, J Baboval, SJ Benkovic, IA Wilson, and DL Boger. (2003) Bioorg Med Chem 11:4511-4521.

10-(2-benzoxazolcarbonyl)-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid: a potential inhibitor of GAR transformylase and AICAR transformylase. TH Marsilje, MP Hedrick, J Desharnais, K Capps, A Tavassoli, Y Zhang, IA Wilson, SJ Benkovic, and DL Boger. (2003) Bioorg Med Chem 11:4503-4509.

Design, synthesis, and biological evaluation of simplified a-keto heterocycle, trifluoromethyl ketone, and formyl substituted folate analogues as potential inhibitors of GAR transformylase and AICAR transformylase. TH Marsilje, MP Hedrick, J Desharnais, A Tavassoli, Y Zhang, IA Wilson, SJ Benkovic, and DL Boger. (2003) Bioorg Med Chem 11:4487-4501.

Structure of avian AICAR transformylase with a multisubstrate adduct inhibitor β-DADF identifies the folate binding site. DW Wolan, SE Greasley, MJ Wall, SJ Benkovic, and IA Wilson. (2003) Biochemistry 42:10904-10914.

A humanized aldolase antibody for selective chemotherapy and adaptor immunotherapy. C Rader, JM Turner, A Heine, D Shabat, SC Sinha, IA Wilson, RA Lerner, and CF Barbas. (2003) J Mol Biol 332:889-899.

Recurring conformation of the human immunodeficiency virus type 1 gp120 V3 loop. RL Stanfield, JB Ghiara, E Ollmann Saphire, AT Profy, and IA Wilson. (2003) Virology 315:159-173.

The carbohydrate epitope of the neutralizing anti-HIV-1 antibody 2G12. CN Scanlan, R Pantophlet, MR Wormald, EO Saphire, D Calarese, R Stanfield, IA Wilson, H Katinger, RA Dwek, DR Burton, and PM Rudd. (2003) Adv Exp Med Biol 535:205-218.

Crystal structure of an intact human IgG: antibody asymmetry, flexibility, and a guide for HIV-1 vaccine design. EO Saphire, RL Stanfield, MD Crispin, G Morris, MB Zwick, RA Pantophlet, PW Parren, PM Rudd, RA Dwek, DR Burton, and IA Wilson. (2003) Adv Exp Med Biol 535:55-66.

-- 2002 (18) --

Probing ligand recognition in the decarboxylase antibody 21D8: implications for the catalytic mechanism. K Hotta, IA Wilson, and D Hilvert. (2002) Biochemistry 41:772-779.

The specificity of TCR/pMHC interaction. MG Rudolph and IA Wilson. (2002) Curr Opin Immunol 14:52-65.

Crystal structure of a bacterial cocaine esterase. NA Larsen, JM Turner, J Stevens, SJ Rosser, A Basran, RA Lerner, NC Bruce, and IA Wilson. (2002) Nat Struct Biol 9:17-21.

Structural and thermodynamic correlates of T cell signaling. MG Rudolph, JG Luz, and IA Wilson. (2002) Annu Rev Biophys Biomol Struct 31:121-149.

Protein engineering for crystallization of the GTPase Sar1 that regulates ER vesicle budding. M Huang, JT Weissman, C Wang, WE Balch, and IA Wilson. (2002) Acta Cryst D 58:700-703.

Fine specificity of TCR complementarity-determining region residues and lipid antigen hydrophilic moieties in the recognition of a CD1-lipid complex. EP Grant, EM Beckman, SM Behar, M Degano, D Frederique, GS Besra, IA Wilson, SA Porcelli, ST Furlong, and MB Brenner. (2002) J Immunol 168:3933-3940.

Contrasting IgG structures reveal extreme asymmetry and flexibility. EO Saphire, RL Stanfield, MD Crispin, PW Parren, PM Rudd, RA Dwek, DR Burton, and IA Wilson. (2002) J Mol Biol 319:9-18.

Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing Vβ Interactions. JG Luz, M Huang, KC Garcia, MG Rudolph, V Apostolopoulos, L Teyton, and IA Wilson. (2002) J Exp Med 195:1175-1186.

The broadly neutralizing anti-human immunodeficiency virus type 1 antibody 2G12 recognizes a cluster of α1⇒2 mannose residues on the outer face of gp120. CN Scanlan, R Pantophlet, MR Wormald, E Ollmann Saphire, R Stanfield, IA Wilson, H Katinger, RA Dwek, PM Rudd, and DR Burton. (2002) J Virol 76:7306-7321.

Crystal structure of a non-canonical low-affinity peptide complexed with MHC class I: a new approach for vaccine design. V Apostolopoulos, M Yu, AL Corper, L Teyton, GA Pietersz, IF McKenzie, IA Wilson, and M Plebanski. (2002) J Mol Biol 318:1293-1305.

Crystal structure of a non-canonical high affinity peptide complexed with MHC class I: a novel use of alternative anchors. V Apostolopoulos, M Yu, AL Corper, W Li, IF McKenzie, L Teyton, IA Wilson, and M Plebanski. (2002) J Mol Biol 318:1307-1316.

Biochemical characterization and structural analysis of a highly proficient cocaine esterase. JM Turner, NA Larsen, A Basran, CF Barbas, 3rd, NC Bruce, IA Wilson, and RA Lerner. (2002) Biochemistry 41:12297-12307.

10-Formyl-5,10-dideaza-acyclic-5,6,7,8-tetrahydrofolic acid (10-formyl-DDACTHF): a potent cytotoxic agent acting by selective inhibition of human GAR Tfase and the de novo purine biosynthetic pathway. TH Marsilje, MA Labroli, MP Hedrick, Q Jin, J Desharnais, SJ Baker, LT Gooljarsingh, J Ramcharan, A Tavassoli, Y Zhang, IA Wilson, GP Beardsley, SJ Benkovic, and DL Boger. (2002) Bioorg Med Chem 10:2739-2749.

Don C. Wiley. IA Wilson. (2002) Nat Struct Biol 9:164-166.

Structure determination of a cocaine hydrolytic antibody from a pseudomerohedrally twinned crystal. NA Larsen, A Heine, P de Prada, R Redwan el, TO Yeates, DW Landry, and IA Wilson. (2002) Acta Cryst D 58:2055-2059.

Crystal structures of human GAR Tfase at low and high pH and with substrate β-GAR. Y Zhang, J Desharnais, SE Greasley, GP Beardsley, DL Boger, and IA Wilson. (2002) Biochemistry 41:14206-14215.

Crystal structures of two rat MHC class Ia (RT1-A) molecules that are associated differentially with peptide transporter alleles TAP-A and TAP-B. MG Rudolph, J Stevens, JA Speir, J Trowsdale, GW Butcher, E Joly, and IA Wilson. (2002) J Mol Biol 324:975-990.

Structural insights into the avian AICAR transformylase mechanism. DW Wolan, SE Greasley, GP Beardsley, and IA Wilson. (2002) Biochemistry 41:15505-15513.

-- 2001 (20) --

Crystal structure of Sar1-GDP at 1.7 Å resolution and the role of the NH2 terminus in ER export. M Huang, JT Weissman, S Beraud-Dufour, P Luan, C Wang, W Chen, M Aridor, IA Wilson, WE Balch (2001) J Cell Biol 155: 937-48.

Structural basis for a disfavored elimination reaction in catalytic antibody 1D4. NA Larsen, A Heine, L Crane, BF Cravatt, RA Lerner, IA Wilson (2001) J Mol Biol 314: 93-102.

Crystal structure of an isolated Vα domain of the 2C T-cell receptor. MG Rudolph, M Huang, L Teyton, IA Wilson (2001) J Mol Biol 314: 1-8.

Unexpected formation of an epoxide-derived multisubstrate adduct inhibitor on the active site of GAR transformylase. SE Greasley, TH Marsilje, H Cai, S Baker, SJ Benkovic, DL Boger, IA Wilson (2001) Biochemistry 40: 13538-47.

Observation of covalent intermediates in an enzyme mechanism at atomic resolution. A Heine, G DeSantis, JG Luz, M Mitchell, CH Wong, IA Wilson (2001) Science 294: 369-74.

Global efforts in structural genomics. RC Stevens, S Yokoyama, IA Wilson (2001) Science 294: 89-92.

Getting into the groove: unusual features of peptide binding to MHC class I molecules and implications in vaccine design. V Apostolopoulos, IF McKenzie, IA Wilson (2001) Front Biosci 6: D1311-20.

Antibody catalysis of the oxidation of water. P Wentworth , LH Jones, AD Wentworth, X Zhu, NA Larsen, IA Wilson, X Xu, WA Goddard , KD Janda, A Eschenmoser, RA Lerner (2001) Science 293: 1806-11.

Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design. EO Saphire, PW Parren, R Pantophlet, MB Zwick, GM Morris, PM Rudd, RA Dwek, RL Stanfield, DR Burton, IA Wilson (2001) Science 293: 1155-9.

Crystal structure of a cocaine-binding antibody. NA Larsen, B Zhou, A Heine, P Wirsching, KD Janda, IA Wilson (2001) J Mol Biol 311: 9-15.

Tech.Sight. Industrializing structural biology. RC Stevens, IA Wilson (2001) Science 293: 519-20.

Unraveling the mysteries of γδ T cell recognition. IA Wilson, RL Stanfield (2001) Nat Immunol 2: 579-81.

The hHFE gene of browsing and grazing rhinoceroses: a possible site of adaptation to a low-iron diet. E Beutler, C West, JA Speir, IA Wilson, M Worley (2001) Blood Cells Mol Dis 27: 342-50.

Crystal structure of a bifunctional transformylase and cyclohydrolase enzyme in purine biosynthesis. SE Greasley, P Horton, J Ramcharan, GP Beardsley, SJ Benkovic, IA Wilson (2001) Nat Struct Biol 8: 402-6.

The crystal structures of K(bm1) and K(bm8) reveal that subtle changes in the peptide environment impact thermostability and alloreactivity. MG Rudolph, JA Speir, A Brunmark, N Mattsson, MR Jackson, PA Peterson, L Teyton, IA Wilson (2001) Immunity 14: 231-42.

Glycosylation and the immune system. PM Rudd, T Elliott, P Cresswell, IA Wilson, RA Dwek (2001) Science 291: 2370-6.

Crystal structure of the murine NK cell-activating receptor NKG2D at 1.95 Å. DW Wolan, L Teyton, MG Rudolph, B Villmow, S Bauer, DH Busch, IA Wilson (2001) Nat Immunol 2: 248-54.

Preliminary X-ray diffraction studies of the transcriptional inhibitory antibody Fab41.4. J Mazlo , RL Stanfield , IA Wilson , SH Hinrichs , JJ Stezowski (2001) Acta Crystallogr D Biol Crystallogr 57: 462-4.

Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-Aa. JA Speir, J Stevens, E Joly, GW Butcher, IA Wilson (2001) Immunity 14: 81-92.

Crystallization and preliminary structure determination of an intact human immunoglobulin, b12: an antibody that broadly neutralizes primary isolates of HIV-1. EO Saphire, PW Parren, CF Barbas, DR Burton, IA Wilson (2001) Acta Crystallogr D Biol Crystallogr 57: 168-71.

-- 2000 (10) --

Structural implications for the design of molecular vaccines. V Apostolopoulos, M Yu, IF McKenzie, IA Wilson (2000) Curr Opin Mol Ther 2: 29-36.

Catalysis of decarboxylation by a preorganized heterogeneous microenvironment: crystal structures of abzyme 21D8. K Hotta, H Lange, DJ Tantillo, KN Houk, D Hilvert, IA Wilson (2000) J Mol Biol 302: 1213-25.

A new functional domain of guanine nucleotide dissociation inhibitor (alpha-GDI) involved in Rab recycling. P Luan, A Heine, K Zeng, B Moyer, SE Greasely, P Kuhn, WE Balch, IA Wilson (2000) Traffic 1: 270-81.

A functional hot spot for antigen recognition in a superagonist TCR/MHC complex. M Degano, KC Garcia, V Apostolopoulos, MG Rudolph, L Teyton, IA Wilson (2000) Immunity 12: 251-61.

The I-Ag7 MHC class II molecule linked to murine diabetes is a promiscuous peptide binder. T Stratmann, V Apostolopoulos, V Mallet-Designe, AL Corper, CA Scott, IA Wilson, AS Kang, L Teyton (2000) J Immunol 165: 3214-25.

Structural requirements for antigen presentation by mouse CD1. N Burdin, L Brossay, M Degano, H Iijima, M Gui, IA Wilson, M Kronenberg (2000) Proc Natl Acad Sci U S A 97: 10156-61.

Crystallization and preliminary crystallographic investigations of avian 5-aminoimidazole-4-carboxamide ribonucleotide transformylase-inosine monophosphate cyclohydrolase expressed in Escherichia coli. VM Reyes, SE Greasley, EA Stura, GP Beardsley, IA Wilson (2000) Acta Crystallogr D Biol Crystallogr 56: 1051-4.

A structural framework for deciphering the link between I-Ag7 and autoimmune diabetes. AL Corper, T Stratmann, V Apostolopoulos, CA Scott, KC Garcia, AS Kang, IA Wilson, L Teyton (2000) Science 288: 505-11.

Using antibody catalysis to study the outcome of multiple evolutionary trials of a chemical task. A Karlstrom, G Zhong, C Rader, NA Larsen, A Heine, R Fuller, B List, F Tanaka, IA Wilson, CF Barbas, RA Lerner (2000) Proc Natl Acad Sci U S A 97: 3878-83.

Crystal structure of a gammadelta T cell receptor ligand T22: a truncated MHC-like fold. C Wingren, MP Crowley, M Degano, Y Chien, IA Wilson (2000) Science 287: 310-4.

-- 1999 (15) --

Emerging principles for T cell receptor recognition of antigen in cellular immunity. KC Garcia, M Degano, JA Speir, IA Wilson (1999) Rev Immunogenet 1: 75-90.

The molecular basis of CD1-mediated presentation of lipid antigens. DB Moody, GS Besra, IA Wilson, SA Porcelli (1999) Immunol Rev 172: 285-96.

Perspectives: protein structure. Class-conscious TCR? IA Wilson (1999) Science 286: 1867-8.

The structure, organization, activation and plasticity of the erythropoietin receptor. IA Wilson, LK Jolliffe (1999) Curr Opin Struct Biol 9: 696-704.

New insights into inhibitor design from the crystal structure and NMR studies of Escherichia coli GAR transformylase in complex with beta-GAR and 10-formyl-5,8,10-trideazafolic acid. SE Greasley, MM Yamashita, H Cai, SJ Benkovic, DL Boger, IA Wilson (1999) Biochemistry 38: 16783-93.

Evolution of shape complementarity and catalytic efficiency from a primordial antibody template. J Xu, Q Deng, J Chen, KN Houk, J Bartek, D Hilvert, IA Wilson (1999) Science 286: 2345-8.

Roles for glycosylation of cell surface receptors involved in cellular immune recognition. PM Rudd, MR Wormald, RL Stanfield, M Huang, N Mattsson, JA Speir, JA DiGennaro, JS Fetrow, RA Dwek, IA Wilson (1999) J Mol Biol 293: 351-66.

Structural basis of T cell recognition. KC Garcia, L Teyton, IA Wilson (1999) Annu Rev Immunol 17: 369-97.

Structural basis for antibody catalysis of a disfavored ring closure reaction. K Gruber, B Zhou, KN Houk, RA Lerner, CG Shevlin, IA Wilson (1999) Biochemistry 38: 7062-74.

Shared and unique determinants of the erythropoietin (EPO) receptor are important for binding EPO and EPO mimetic peptide. SA Middleton, FP Barbone, DL Johnson, RL Thurmond, Y You, FJ McMahon, R Jin, O Livnah, J Tullai, FX Farrell, MA Goldsmith, IA Wilson, LK Jolliffe (1999) J Biol Chem 274: 14163-9.

Crystal structure of an MHC class I presented glycopeptide that generates carbohydrate-specific CTL. JA Speir, UM Abdel-Motal, M Jondal, IA Wilson (1999) Immunity 10: 51-61.

Erythropoietin receptor activation by a ligand-induced conformation change. I Remy, IA Wilson, SW Michnick (1999) Science 283: 990-3.

Crystallographic evidence for preformed dimers of erythropoietin receptor before ligand activation. O Livnah, EA Stura, SA Middleton, DL Johnson, LK Jolliffe, IA Wilson (1999) Science 283: 987-90.

Molecular recognition of lipid antigens by T cell receptors. EP Grant, M Degano, JP Rosat, S Stenger, RL Modlin, IA Wilson, SA Porcelli, MB Brenner (1999) J Exp Med 189: 195-205.

-- 1998 (12) --

An antagonist peptide-EPO receptor complex suggests that receptor dimerization is not sufficient for activation. O Livnah, DL Johnson, EA Stura, FX Farrell, FP Barbone, Y You, KD Liu, MA Goldsmith, W He, CD Krause, S Pestka, LK Jolliffe, IA Wilson (1998) Nat Struct Biol 5: 993-1004.

The CD1 family of lipid antigen-presenting molecules. SA Porcelli, BW Segelke, M Sugita, IA Wilson, MB Brenner (1998) Immunol Today 19: 362-8.

A pH-dependent stabilization of an active site loop observed from low and high pH crystal structures of mutant monomeric glycinamide ribonucleotide transformylase at 1.8 to 1.9 A. Y Su, MM Yamashita, SE Greasley, CA Mullen, JH Shim, PA Jennings, SJ Benkovic, IA Wilson (1998) J Mol Biol 281: 485-99.

Structural basis of 2C TCR allorecognition of H-2Ld peptide complexes. JA Speir, KC Garcia, A Brunmark, M Degano, PA Peterson, L Teyton, IA Wilson (1998) Immunity 8: 553-62.

Alanine scanning mutagenesis of an αβ T cell receptor: mapping the energy of antigen recognition. TC Manning, CJ Schlueter, TC Brodnicki, EA Parke, JA Speir, KC Garcia, L Teyton, IA Wilson, DM Kranz (1998) Immunity 8: 413-25.

An antibody exo Diels-Alderase inhibitor complex at 1.95 Å resolution. A Heine, EA Stura, JT Yli-Kauhaluoma, C Gao, Q Deng, BR Beno, KN Houk, KD Janda, IA Wilson (1998) Science 279: 1934-40.

Crystal structures of two I-Ad-peptide complexes reveal that high affinity can be achieved without large anchor residues. CA Scott, PA Peterson, L Teyton, IA Wilson (1998) Immunity 8: 319-29.

Unusual MHC-like molecules: CD1, Fc receptor, the hemochromatosis gene product, and viral homologs. IA Wilson, PJ Bjorkman (1998) Curr Opin Immunol 10: 67-73.

Identification of a 13 amino acid peptide mimetic of erythropoietin and description of amino acids critical for the mimetic activity of EMP1. DL Johnson, FX Farrell, FP Barbone, FJ McMahon, J Tullai, K Hoey, O Livnah, NC Wrighton, SA Middleton, DA Loughney, EA Stura, WJ Dower, LS Mulcahy, IA Wilson, LK Jolliffe (1998) Biochemistry 37: 3699-710.

Engineering protein for X-ray crystallography: the murine Major Histocompatibility Complex class II molecule I-Ad. CA Scott, KC Garcia, EA Stura, PA Peterson, IA Wilson, L Teyton (1998) Protein Sci 7: 413-8.

The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF.G9 complex. M Huang, R Syed, EA Stura, MJ Stone, RS Stefanko, W Ruf, TS Edgington, IA Wilson (1998) J Mol Biol 275: 873-94.

Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. KC Garcia, M Degano, LR Pease, M Huang, PA Peterson, L Teyton, IA Wilson (1998) Science 279: 1166-72.

-- 1997 (7) --

Immune versus natural selection: antibody aldolases with enzymic rates but broader scope. CF Barbas, A Heine, G Zhong, T Hoffmann, S Gramatikova, R Björnestedt, B List, J Anderson, EA Stura, IA Wilson, RA Lerner (1997) Science 278: 2085-92.

Alphabeta T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization. KC Garcia, MD Tallquist, LR Pease, A Brunmark, CA Scott, M Degano, EA Stura, PA Peterson, IA Wilson, L Teyton (1997) Proc Natl Acad Sci U S A 94: 13838-43.

T-cell receptor structure and TCR complexes. IA Wilson, KC Garcia (1997) Curr Opin Struct Biol 7: 839-48.

Crystal structure of mouse CD1: An MHC-like fold with a large hydrophobic binding groove. Z Zeng, AR Castaño, BW Segelke, EA Stura, PA Peterson, IA Wilson (1997) Science 277: 339-45.

Sequence, specificity and crystallization of an oestrone-3-glucuronide antibody (3910). M He, M Gani, O Livnah, EA Stura, D Beale, J Coley, IA Wilson, MJ Taussig (1997) Immunology 90: 632-9.

Structure-based design of a constrained peptide mimic of the HIV-1 V3 loop neutralization site. JB Ghiara, DC Ferguson, AC Satterthwait, HJ Dyson, IA Wilson (1997) J Mol Biol 266: 31-9.

Computation of the binding of fully flexible peptides to proteins with flexible side chains. J Desmet, IA Wilson, M Joniau, M De Maeyer, I Lasters (1997) FASEB J 11: 164-72.

-- 1996 (7) --

CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. KC Garcia, CA Scott, A Brunmark, FR Carbone, PA Peterson, IA Wilson, L Teyton (1996) Nature 384: 577-81.

Structural insights into the function of the Rab GDI superfamily. SK Wu, K Zeng, IA Wilson, WE Balch (1996) Trends Biochem Sci 21: 472-6.

An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex. KC Garcia, M Degano, RL Stanfield, A Brunmark, MR Jackson, PA Peterson, L Teyton, IA Wilson (1996) Science 274: 209-19.

Functional mimicry of a protein hormone by a peptide agonist: the EPO receptor complex at 2.8 Å. O Livnah, EA Stura, DL Johnson, SA Middleton, LS Mulcahy, NC Wrighton, WJ Dower, LK Jolliffe, IA Wilson (1996) Science 273: 464-71.

Another twist to MHC-peptide recognition. IA Wilson (1996) Science 272: 973-4.

Structure and mutational analysis of Rab GDP-dissociation inhibitor. I Schalk, K Zeng, SK Wu, EA Stura, J Matteson, M Huang, A Tandon, IA Wilson, WE Balch (1996) Nature 381: 42-8.

Role of chain pairing for the production of functional soluble IA major histocompatibility complex class II molecules. CA Scott, KC Garcia, FR Carbone, IA Wilson, L Teyton (1996) J Exp Med 183: 2087-95.

-- 1995 (9) --

CTL escape viral variants. I. Generation and molecular characterization. H Lewicki, A Tishon, P Borrow, CF Evans, JE Gairin, KM Hahn, DA Jewell, IA Wilson, MB Oldstone (1995) Virology 210: 29-40.

Differential localization of the mRNA of the M and B isoforms of creatine kinase in myoblasts. IA Wilson, KM Brindle, AM Fulton (1995) Biochem J 308 ( Pt 2): 599-605.

Antigen processing and presentation. IA Wilson (1995) Clin Transplant 9: 260-1.

A Trojan horse with a sweet tooth. IA Wilson, RL Stanfield (1995) Nat Struct Biol 2: 433-6.

Towards structure-based drug design: crystal structure of a multisubstrate adduct complex of glycinamide ribonucleotide transformylase at 1.96 A resolution. C Klein, P Chen, JH Arevalo, EA Stura, A Marolewski, MS Warren, SJ Benkovic, IA Wilson (1995) J Mol Biol 249: 153-75.

Crystallization and preliminary crystallographic data for class I deoxyribose-5-phosphate aldolase from Escherichia coli: an application of reverse screening. EA Stura, S Ghosh, E Garcia-Junceda, L Chen, CH Wong, IA Wilson (1995) Proteins 22: 67-72.

Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove. DH Fremont, EA Stura, M Matsumura, PA Peterson, IA Wilson (1995) Proc Natl Acad Sci U S A 92: 2479-83.

Protein-peptide interactions. RL Stanfield, IA Wilson (1995) Curr Opin Struct Biol 5: 103-13.

Immune recognition of viral antigens. IA Wilson, RL Stanfield, DA Jewell, JB Ghiara, DH Fremont, EA Stura (1995) Infect Agents Dis 3: 155-62.

-- 1994 (12) --

Crystallization and preliminary crystallographic data for Rab guanine nucleotide dissociation inhibitor (RabGDI) from bovine brain. IJ Schalk, EA Stura, J Matteson, IA Wilson, WE Balch (1994) J Mol Biol 244: 469-73.

Antibody-antigen interactions: new structures and new conformational changes. IA Wilson, RL Stanfield (1994) Curr Opin Struct Biol 4: 857-67.

Structural analysis of antibody specificity. Detailed comparison of five Fab'-steroid complexes. JH Arevalo, CA Hassig, EA Stura, MJ Sims, MJ Taussig, IA Wilson (1994) J Mol Biol 241: 663-90.

Crystal structure of a peptide complex of anti-influenza peptide antibody Fab 26/9. Comparison of two different antibodies bound to the same peptide antigen. ME Churchill, EA Stura, C Pinilla, JR Appel, RA Houghten, DH Kono, RS Balderas, GG Fieser, U Schulze-Gahmen, IA Wilson (1994) J Mol Biol 241: 534-56.

Reverse screening. EA Stura, AC Satterthwait, JC Calvo, DC Kaslow, IA Wilson (1994) Acta Crystallogr D Biol Crystallogr 50: 448-55.

Antigen-induced conformational changes in antibodies: a problem for structural prediction and design. RL Stanfield, IA Wilson (1994) Trends Biotechnol 12: 275-9.

Covalently linked ligand stabilizes expression of heterodimeric receptor. IA Wilson (1994) Structure 2: 561-2.

Crystal structure of the principal neutralization site of HIV-1. JB Ghiara, EA Stura, RL Stanfield, AT Profy, IA Wilson (1994) Science 264: 82-5.

Routes to catalysis: structure of a catalytic antibody and comparison with its natural counterpart. MR Haynes, EA Stura, D Hilvert, IA Wilson (1994) Science 263: 646-52.

Crystallization and preliminary structural studies of a chorismate mutase catalytic antibody complexed with a transition state analog. MR Haynes, EA Stura, D Hilvert, IA Wilson (1994) Proteins 18: 198-200.

Monoclonal antibodies against progesterone: effect of steroid-carrier coupling position on antibody specificity. M Gani, J Coley, J Piron, AS Humphreys, J Arevalo, IA Wilson, MJ Taussig (1994) J Steroid Biochem Mol Biol 48: 277-82.

Structure of anti-peptide antibody complexes. IA Wilson, JB Ghiara, RL Stanfield (1994) Res Immunol 145: 73-8.

-- 1993 (7) --

Detailed analysis of the free and bound conformations of an antibody. X-ray structures of Fab 17/9 and three different Fab-peptide complexes. U Schulze-Gahmen, JM Rini, IA Wilson (1993) J Mol Biol 234: 1098-118.

Molecular basis of crossreactivity and the limits of antibody-antigen complementarity. JH Arevalo, MJ Taussig, IA Wilson (1993) Nature 365: 859-63.

Major antigen-induced domain rearrangements in an antibody. RL Stanfield, M Takimoto-Kamimura, JM Rini, AT Profy, IA Wilson (1993) Structure 1: 83-93.

Crystal structure of a human immunodeficiency virus type 1 neutralizing antibody, 50.1, in complex with its V3 loop peptide antigen. JM Rini, RL Stanfield, EA Stura, PA Salinas, AT Profy, IA Wilson (1993) Proc Natl Acad Sci U S A 90: 6325-9.

Three-dimensional structure of an anti-steroid Fab' and progesterone-Fab' complex. JH Arevalo, EA Stura, MJ Taussig, IA Wilson (1993) J Mol Biol 231: 103-18.

Structural analysis of MHC class I molecules with bound peptide antigens. IA Wilson, DH Fremont (1993) Semin Immunol 5: 75-80.

Crystal structure of phospholipase A2 from Indian cobra reveals a trimeric association. DH Fremont, DH Anderson, IA Wilson, EA Dennis, NH Xuong (1993) Proc Natl Acad Sci U S A 90: 342-6.

-- 1992 (9) --

Crystallization of murine major histocompatibility complex class I H-2Kb with single peptides. EA Stura, M Matsumura, DH Fremont, Y Saito, PA Peterson, IA Wilson (1992) J Mol Biol 228: 975-82.

Crystallization, sequence, and preliminary crystallographic data for an antipeptide Fab 50.1 and peptide complexes with the principal neutralizing determinant of HIV-1 gp120. EA Stura, RL Stanfield, GG Fieser, S Silver, M Roguska, LM Hincapie, HK Simmerman, AT Profy, IA Wilson (1992) Proteins 14: 499-508.

Crystal structure of glycinamide ribonucleotide transformylase from Escherichia coli at 3.0 A resolution. A target enzyme for chemotherapy. P Chen, U Schulze-Gahmen, EA Stura, J Inglese, DL Johnson, A Marolewski, SJ Benkovic, IA Wilson (1992) J Mol Biol 227: 283-92.

Emerging principles for the recognition of peptide antigens by MHC class I molecules. M Matsumura, DH Fremont, PA Peterson, IA Wilson (1992) Science 257: 927-34.

Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb. DH Fremont, M Matsumura, EA Stura, PA Peterson, IA Wilson (1992) Science 257: 919-27.

Intermonomer disulfide bonds impair the fusion activity of influenza virus hemagglutinin. GW Kemble, DL Bodian, J Rosé, IA Wilson, JM White (1992) J Virol 66: 4940-50.

Structural evidence for induced fit as a mechanism for antibody-antigen recognition. JM Rini, U Schulze-Gahmen, IA Wilson (1992) Science 255: 959-65.

Crystallization studies of glycosylated and unglycosylated human recombinant interleukin-2. EA Stura, P Chen, CM Wilmot, JH Arevalo, IA Wilson (1992) Proteins 12: 24-30.

Monoclonal antibodies against an identical short peptide sequence shared by two unrelated proteins. U Schulze-Gahmen, IA Wilson (1992) Pept Res 2: 322-31.

-- 1991 (2) --

Structural aspects of antibodies and antibody-antigen complexes. IA Wilson, RL Stanfield, JM Rini, JH Arevalo, U Schulze-Gahmen, DH Fremont, EA Stura (1991) Ciba Found Symp 159: 13-28; discussion 28-39.

X-ray crystallographic analysis of free and antigen-complexed Fab fragments to investigate structural basis of immune recognition. IA Wilson, JM Rini, DH Fremont, GG Fieser, EA Stura (1991) Methods Enzymol 203: 153-76.

-- 1990 (2) --

Crystal structures of an antibody to a peptide and its complex with peptide antigen at 2.8 A. RL Stanfield, TM Fieser, RA Lerner, IA Wilson (1990) Science 248: 712-9.

Structural basis of immune recognition of influenza virus hemagglutinin. IA Wilson, NJ Cox (1990) Annu Rev Immunol 8: 737-71.

-- 1989 (3) --

Preliminary crystallographic data and primary sequence for anti-peptide Fab' B13I2 and its complex with the C-helix peptide from myohemerythrin. EA Stura, RL Stanfield, TM Fieser, RS Balderas, LR Smith, RA Lerner, IA Wilson (1989) J Biol Chem 264: 15721-5.

Crystallization and preliminary X-ray diffraction studies of a complex between interleukin-2 and a soluble form of the p55 component of the high affinity interleukin-2 receptor. G Lambert, EA Stura, IA Wilson (1989) J Biol Chem 264: 12730-6.

Preliminary crystallographic investigations of glycinamide ribonucleotide transformylase. EA Stura, DL Johnson, J Inglese, JM Smith, SJ Benkovic, IA Wilson (1989) J Biol Chem 264: 9703-6.

-- 1988 (2) --

Preliminary crystallographic data, primary sequence, and binding data for an anti-peptide Fab and its complex with a synthetic peptide from influenza virus hemagglutinin. U Schulze-Gahmen, JM Rini, J Arevalo, EA Stura, JH Kenten, IA Wilson (1988) J Biol Chem 263: 17100-5.

Purification of a RAS-responsive adenylyl cyclase complex from Saccharomyces cerevisiae by use of an epitope addition method. J Field, J Nikawa, D Broek, B MacDonald, L Rodgers, IA Wilson, RA Lerner, M Wigler (1988) Mol Cell Biol 8: 2159-65.

-- 1987 (4) --

Analysis of an anti-progesterone antibody: variable crystal morphology of the Fab' and steroid-Fab' complexes. EA Stura, JH Arevalo, A Feinstein, RB Heap, MJ Taussig, IA Wilson (1987) Immunology 62: 511-21.

Anti-peptide antibodies detect steps in a protein conformational change: low-pH activation of the influenza virus hemagglutinin. JM White, IA Wilson (1987) J Cell Biol 105: 2887-96.

Crystallographic analysis of the three-dimensional structure of baboon alpha-lactalbumin at low resolution. Homology with lysozyme. SG Smith, M Lewis, R Aschaffenburg, RE Fenna, IA Wilson, M Sundaralingam, DI Stuart, DC Phillips (1987) Biochem J 242: 353-60.

Crystallization and preliminary crystallographic data for an antiprogesterone monoclonal antibody Fab' and steroid-Fab' complexes. EA Stura, A Feinstein, IA Wilson (1987) J Mol Biol 193: 229-31.

-- 1986 (2) --

Selection by site-directed antibodies of small regions of peptides which are ordered in water. HJ Dyson, KJ Cross, J Ostresh, RA Houghten, IA Wilson, PE Wright, RA Lerner (1986) Ciba Found Symp 119: 58-75.

The immunodominant site of a synthetic immunogen has a conformational preference in water for a type-II reverse turn. HJ Dyson, KJ Cross, RA Houghten, IA Wilson, PE Wright, RA Lerner (1986) Nature 318: 480-3.

-- 1985 (2) --

Identical short peptide sequences in unrelated proteins can have different conformations: a testing ground for theories of immune recognition. IA Wilson, DH Haft, ED Getzoff, JA Tainer, RA Lerner, S Brenner (1985) Proc Natl Acad Sci U S A 82: 5255-9.

Studies with monoclonal antibodies prepared against X-31 influenza virus haemagglutinin. JJ Skehel, E Brown, RS Daniels, AR Douglas, M Knossow, IA Wilson, NG Wrigley, DC Wiley (1985) Biochem Soc Trans 13: 12-4.