SELECTED PUBLICATIONS

Present - 1992

 

Herman, D., Jenssen, K., Burnett, R., Soragni, E., Perlman, S.L., J.M. Gottesfeld. Histone deacetylase inhibitors reverse gene silencing in Friedreich’s ataxia. Nat. Chem. Bio., 2:551-558, 2006.

Alvarez, D., Chou, C.J., Latell, L., Zeitlin, S.G., Ku, S., Puri, P.L. Dervan, P.B., J.M. Gottesfeld. A Two-Hit Mechanism for Pre-Mitotic Arrest of Cancer Cell Proliferation by a Polyamide Alkylator Conjugate. Cell Cycle, 5:1537-1548, 2006.

Burnett, R., Melander, C., Puckett, J.W., Son., L.S., Wells, R.D., Dervan, P.B., J.M. Gottesfeld. DNA sequence-specific polyamide alleviate transcription inhibition associated with long GAA TTC repeats in Friedreich’s ataxia. Proc. Natl. Acad. Sci., 103:11497-11502, 2006.

Trzupek JD, Gottesfeld JM, Boger DL. Alkylation of duplex DNA in nucleosome core particles by
duocarmycin SA and yatakemycin. Nat Chem Biol. 2:79-82, 2006.

Beltran, A.C., Dawson, P.E., J.M. Gottesfeld. Role of DNA Sequence in the Binding Specificity of Synthetic Basic-Helix-Loop-Helix Domains. ChemBioChem, 6:104-113, 2005.

Gearhart, M.D., L. Dickinson, J. Ehley, C. Melander, P.B. Dervan, P.E. Wright, J.M. Gottesfeld. Inhibition of DNA Binding by Human Estrogen-Related Receptor 2 and Estrogen Receptor alpha with Minor Groove Binding Polyamides. Biochemistry, 44:4196-203, 2005.

Edayathumangalam, R.S., P. Weyermann, P.B. Dervan, J.M. Gottesfeld, and K.Luger. Nucleosomes in Solution exist as a Mixture of Twist-Defect States. J. Mol. Biol., 345:103-14, 2005.

Dickinson, L.A., R. Burnett, C. Melander, B.S. Edelson, P.S. Arora, P.B. Dervan, and J.M. Gottesfeld. Arresting Cancer Proliferation by Small-Molecule Gene Regulation. Chem. & Biol., 11:1583-94, 2004.

Edayathumangalam, R.S., P. Weyermann, J.M. Gottesfeld, P.B. Dervan, and K. Luger. Molecular recognition of the nucleosomal “supergroove”. Proc. Natl. Acad. Sci. USA, 101:6864-6869, 2004.

Thastrom, A., J.M. Gottesfeld, K. Luger, and J. Widom. Histone-DNA Binding Free Energy Cannot Be Measured in Dilution-Driven Dissociation Experiments. Biochemistry, 43:736-741, 2004.

Dervan, P.B., E.J. Fechter, B.S. Edelson, and J.M.Gottesfeld. Regulation of Gene Expression with Pyrrole-Imidazole Polyamides, Pseudo Peptides in Drug Development, ed. P.E. Neilsen (Wiley Europe), 121-152, 2003.

Dudouet, B., R. Burnett, L.A. Dickinson, M.R. Wood, C. Melander, J.M. Belitsky, B. Edelson, N. Wurtz, C. Briehn, P.B. Dervan, and J.M. Gottesfeld. Accessibility of Nuclear Chromatin by DNA-Binding Polyamides. Chem. & Biol., 10:859-867, 2003.

Gottesfeld, J.M., J.M. Belitsky, C. Melander, P.B. Dervan and K. Luger. Blocking Transcription Through a Nucleosome with Synthetic DNA Ligands. J. Mol. Biol., 321:249-263, 2002.

Suto, R.K., R.W. Edayathumangalam, C.L. White, C. Melander, J.M. Gottesfeld, P.B. Dervan, and K. Luger. Crystal Structures of Nucleosome Core Particles in Complex with Minor Groove DNA-binding Ligands. J. Mol. Biol., 326:371-380, 2003.

Dickinson, L.A., A.J. Edgar, J. Ehley and J.M. Gottesfeld. Cyclin L: an RS Domain Protein Involved in Pre-mRNA Splicing. J. Biol. Chem., 277:25465-25473, 2002.

Gottesfeld, J.M. and K. Luger. Energetics and Affinity of the Histone Octamer for Defined DNA Sequences. Biochemistry, 40:10927-10933, 2001.

Gottesfeld, J.M., C. Melander, R.K. Suto, H. Raviol, K. Luger, and P.B. Dervan. Sequence-specific Recognition of DNA in the Nucleosome by Pyrrole-Imidazole Polyamides. J. Mol. Biol., 309:615-629, 2001.

Gottesfeld, J.M., J.M. Turner, and P.B. Dervan. Chemical Approaches to Control Gene Expression. Gene Expression, 9:71-91, 2000.

Winston, R.L., J.A. Ehley, E.E. Baird, P.B. Dervan, and J.M. Gottesfeld. Asymmetric DNA Binding by a Homodimeric bHLH Protein. Biochemistry, 39:9092-9098, 2000.

Winston, R.L. and J.M. Gottesfeld. Rapid Identification of Key Amino Acid-DNA Contacts through Combinatorial Peptide Synthesis. Chem. & Biol., 7:245-251, 2000. Reviewed by S. Nair & S. Burley in Nature "News and Views," Vol. 404, April 13, 2000, pp. 715-718.

Dickinson, L.A., J.W. Trauger, E.E. Baird, P. Ghazal, P.B. Dervan, and J.M. Gottesfeld. Anti-Repression of Polymerase II Transcription by a Designed Ligand. Biochemistry, 38:10801-10807, 1999.

Dickinson, L.A., J.W. Trauger, E.E. Baird, P.B. Dervan, B.J. Graves, and J.M. Gottesfeld. Inhibition of Ets-1 DNA Binding and Ternary Complex Formation Between Ets-1, NF-kB, and DNA by a Designed DNA-Binding Ligand. J. Biol. Chem., 274:12765-12773, 1999.

Dickinson, L.A., R.J. Gulizia, J.W. Trauger, E.E. Baird, D.E. Mosier, J.M. Gottesfeld, and P.B. Dervan. Inhibition of RNA Polymerase II Transcription in Human Cells by Synthetic DNA-Binding Ligands. Proc. Natl. Acad. Sci. USA, 95:12890-12895, 1998.

Long, J.J., A. Leresche, R.W. Kriwacki, and J.M. Gottesfeld. Repression of TFIIH Transcriptional Activity and TFIIH-Associated Cdk7 Kinase Activity at Mitosis. Mol. Cell. Biol., 18:1467-1476, 1998.

Wuttke, D.S., M.P. Foster, D.A. Case, J.M. Gottesfeld, and P.E. Wright. Solution Structure of the First Three Zinc Fingers of TFIIIA Bound to the Cognate DNA Sequence: Determinants of Affinity and Sequence Specificity. J. Mol. Biol., 273:183-206, 1997.

Foster, M.P., D.S. Wuttke, I. Radhakrishnan, D.A. Case, J.M. Gottesfeld, and P.E. Wright. Domain Packing and Dynamics in the DNA Complex of the N-Terminal Zinc Fingers of TFIIIA. Nature Struct. Biol., 4:605-608, 1997.

Gottesfeld, J.M. and D.J. Forbes. Mitotic Repression of the Transcriptional Machinery. Trends Biochem. Sci., 22:197-202, 1997.

Gottesfeld, J.M., L. Neely, J.W. Trauger, E.E. Baird, and P.B. Dervan. Regulation of Gene Expression by Small Molecules. Nature, 387:202-205, 1997.

Gottesfeld, J.M., V.J. Wolf, T. Dang, D.J. Forbes, and P. Hartl. Mitotic Repression of RNA Polymerase III Transcription in Vitro Mediated by Phosphorylation of a TFIIIB Component. Science, 263:81-84, 1994.

Clemens, K.R., V. Wolf, S.J. McBryant, P. Zhang, X. Liao, P.E. Wright, and J.M. Gottesfeld. Molecular Basis for Specific Recognition of both RNA and DNA by a Zinc Finger Protein. Science, 260:530-533, 1993.

Clemens, K.R., X. Liao, V.J. Wolf, P.E. Wright, and J.M. Gottesfeld. Definition of the Binding Sites of Individual Zinc Fingers in the TFIIIA-5S RNA Gene Complex. Proc. Natl. Acad. Sci. USA, 89:10822-10826, 1992.

Liao, X., K.R. Clemens, L.L. Tennant, P.E. Wright, and J.M. Gottesfeld. Specific Interaction of the First Three Fingers of TFIIIA with the Internal Control Region of the Xenopus 5S RNA Gene. J. Mol. Biol., 223:857-871, 1992.