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Selected Chun Lab Publications
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| Lysophospholipids |
| Articles/Letters |
| Ye X, Skinner MK, Kennedy G, Chun J. (2008). Age-dependent loss of sperm production in mice via impaired lysophosphadtidic acid signaling. Biol. Reprod. in press. |
| Chun J. (2007). How the lysophospholipid got its receptor. The Scientist, 21, 48-54. |
| Chun J. (2007). The sources of a lipid conundrum. Science, 316, 208-210. |
| Herr D, Schwander M, Rivera R, Muller U, Chun J. (2007). Sphingosine 1-phosphate signaling is required for maintenance of hair cells largely via activation of S1P2. J. Neurosci., 27, 1474-1478. |
Lee CW, Rivera R, Dubin AE, Chun J. (2007). LPA4/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing Gs, Gq/Gi-mediated calcium signaling and G12/13-mediated Rho activation. J. Biol. Chem., 281, 23589-23597.  |
| Fukushima N, Shano S, Moriyama R, Chun J. (2006). Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-Gi/o pathway. Neurochem. Int., 50, 302-307. |
| Lee C-W, Rivera R, Gardell S, Dubin AE, Chun J. (2006). GPR92 as a new G12/13 and Gq coupled lysophosphatidic acid receptor that increases cAMP: LPA5. J. Biol. Chem., 281, 23589-23597. |
Ye X, Hama K, Contos JJ, Anliker B, Inoue A, Skinner MK, Suzuki H, Amano T, Kennedy G, Arai H, Aoki J, Chun J. (2005). LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature 435, 104-8.
(see also News & Views.) |
| Webb M, Tham CS, Lin FF, Lariosa-Willingham K, Yu N, Hale J, Mandala S, Chun J, Rao TS. (2004). Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. J. Neuroimmunol., 153, 108-121. |
| Inoue M, Rashid H, Fujita R, Contos JJA, Chun J, Ueda H. (2004). Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nature Med., 10, 712-718. |
| Rao TS, Lariosa-Willingham KD, Lin FF, Yu N, Tham CS, Chun J, Webb M. Growth factor pre-treatment differentially regulates phosphoinositide turnover downstream of lysophospholipid receptor and metabotropic glutamate receptors in cultured rat cerebrocortical astrocytes. Int. J. Devel. Neurosci., 22, 131-135. |
Kingsbury MA, Rehen SK, Contos JJA, Higgins C, Chun J. (2003). Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding. Nature Neurosci., 6, 1292-1299.
(see also News & Views) |
| Rao TS, Lariosa-Willingham KD, Lin FF, Palfreyman EL, Yu N, Chun J, Webb M. (2003). Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes. Brain Res., 990, 182-194. |
| McGiffert C, Contos JJA, Friedman B, Chun J. (2002). Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1-3 in angiogenesis. FEBS Lett., 531, 103-108. |
| Contos JJA, Ye X, Sah V, Chun J. (2002). Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p4/lpC1/Edg6) gene. FEBS Lett., 531, 99-102. |
| Contos JJA, Ishii I, Fukushima I, Kingsbury MA, Ye X, Kawamura S, Brown JH, Chun J. (2002). Characterization of LPA2 (EDG-4) and LPA1/LPA2 (EDG-2/EDG-4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to LPA2. Mol. Cell Biol., 22: 6921-6929. |
| Ishii I, Ye X, Friedman B, Kawamura S, Contos JJA, Kingsbury MA, Yang AH, Zhang G, Brown JH, Chun J. (2002). Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3. J. Biol. Chem., 277, 25152-25159. |
| Fukushima N, Ishii I, Habara Y, Allen CB, Chun J. (2002). Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines. Mol. Biol. Cell, 13, 2692-2705. |
| Fukushima N, Weiner JA, Kaushal J, Contos JJA, Rehen SK, Kingsbury MA, Kim KY, Chun J. (2002). Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons. Mol. Cell. Neurosci., 20, 271-282. |
| Ishii I, Chun J. (2002). Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors. Neuroreport, 13, 593-596. |
| Ishii I, Friedman B, Ye X-Q, Kawamura S, McGifffert C, Contos JJA, Kingsbury M, Zhang G, Brown JH, Chun J. (2001). Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LPB3/EDG-3. J. Biol. Chem., 276, 33697-33704. |
| Weiner JAW, Fukushima N, Contos JJA, Scherer SS, Chun J. (2001). Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling. J. Neurosci., 21, 7069-7078. |
| Contos JJA, Chun J. (2001). The mouse lpA3/Edg7 lysophosphatidic acid receptor gene: sequence, genomic structure, chromosomal location and expression pattern. Gene, 267, 243-253. |
| Kimura Y, Schmitt A, Fukushima N, Ishii I, Kimura H, Nebreda AR, Chun J. (2001). Two novel Xenopus homologs of mammalian LPA1/edg-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells. J. Biol. Chem., 276, 15028-15215. |
| Contos JJA, Ishii I, Chun J. (2000). Lysophosphatidic acid receptors. Mol. Pharmacol., 58, 1188-1196. |
| Contos JJA, Weiner JA, Fukushima N, Kaushal D, Chun J. (2000). Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc. Natl. Acad. Sci. USA, 97, 13384-13389. |
| Fukushima N, Weiner JA, Chun J. (2000). Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology. Dev. Biol., 228, 6-18. |
| Ishii I, Contos JJA, Fukushima N, Chun J. (2000). Functional comparisonsof the lysophosphatidic acid receptors, LPA1, LPA2 and LPA3 in neuronal cell lines using a retrovirus expression system. Mol. Pharmacol., 58, 895-902. |
| Contos JJA, Chun J. (2000). Genomic characterization of the lysophosphatidic acid receptor gene, lpA2/Edg4, and identification of a frameshift mutation in a previouslycharacterized cDNA. Genomics, 64, 155-169. |
| Weiner JA, Chun J. (1999). Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid. Proc. Natl. Acad. Sci., 96, 5233-5238. |
| Dubin AE, Bahnson T, Weiner JA, Fukushima N, Chun J. (1999). Lysophosphatidic acid (LPA) stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts. J. Neurosci., 19, 1371-1381. |
| Zhang G, Contos JJA, Weiner JA, Fukushima N, Chun J. (1999). Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene, 227, 89-99. |
| Contos JJA, Chun J. (1998). Complete cDNA sequence, genomic structure and chromosomal localization of the LPA receptor gene, vzg-1/lpA1/Gpcr26. Genomics, 51, 364-378. |
| Weiner JA, Hecht JH, Chun J. (1998) The lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. J. Comp. Neurol., 398, 587-589. |
| Fukushima N, Kimura Y, Chun J. (1998). A single receptor encoded by vzg-1/lpa1/edg-2 couples to G-proteins and mediates multiple cellular responses to lysophosphatidic acid (LPA). Proc. Natl. Acad. Sci. USA, 95, 6151-6156. |
| Hecht JH, Weiner JA, Post SR, Chun J. (1996). Ventricular zone gene -1 (Vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J. Cell Biol., 135, 1071-1083. |
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| Reviews and Book Chapters |
| Rivera R, Chun J. (2007). Potential therapeutic roles of lysophospholipid signaling in autoimmune-related disease. Future Lipidol., 2, 535-545. |
| Herr D, Chun J. (2007). Effects of LPA and S1P on the nervous system and implications for their involvement in disease. Cur. Drug Targ., 8, 155-167. |
| Chun J. (2007). “Extracellular Lipid Signals” in Wiley Encyclopedia of Chemical Biology, in press. |
| Birgbauer E, Chun J. (2006). New developments in the biological functions of lysophospholipids. Cell. Mol. Life Sci., 63, 2695-2701. |
| Rivera R, Chun J. (2006). Biological effects of lysophospholipids. Rev. Physiol. Biochem. Pharmacol. |
| Gardell SE, Dubin AE, Chun J. (2006). Emerging medicinal roles for lysophospholipid receptors. Trends in Molecular Med., 12, 65-75. |
| Chun J, Rosen H. (2006). Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases. Cur. Pharm. Design, 12, 161-171. |
| Chun J. (2005). Lysophospholipids in the nervous system. J. Prostagland. Lipid Mediators, 77, 46-51. |
| Anliker B, Chun J. (2004). Lysophospholipid receptors: an update. J. Biol. Chem., 279, 20555-20558. |
| Anliker B, Chun J. (2004). Cell surface receptors in lysophospholipid signaling. Sem. Cell and Devel. Biol., 15, 457-465. |
| Ishii I, Fukushima N, Ye X, Chun J. (2004). Lysophospholipid receptors: signaling and biology. Ann. Rev. Biochemistry, 73, 321-354. |
| Kingsbury MA, Rehen SK, Ye X, Chun J. (2004). Genetics and cell biology of lysophosphatidic acid receptor-mediated signaling during cortical neurogenesis. J. Cell. Biochem., 92, 1004-1012. |
| Ye X, Fukushima N, Kingsbury MA, Chun J. (2002). Lysophosphatidic acid in neural signaling. Neuroreport, 13, 2169-2175. |
| Ye X, Ishii I, Kingsbury MA, Chun J. (2002). Lysophosphatidic acid as a novel cell survival/apoptotic factor. Biochim. Biophys. Acta, 1585, 108-113. |
| Fukushima N, Ye X, Chun J. (2002). Neurobiology of lysophosphatidic acid signaling. The Neuroscientist, 8,540-550. |
| Yang AH, Ishii I, Chun J. (2002). In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice. Biochim. Biophys. Acta, 1582, 197-203. |
| Chun J, Goetzl EJ, Hla TL, Igarashi Y, Lynch KR, Moolenaar WH, Pyne S, Tigyi G. (2002). International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol. Rev., 54, 265-269. |
| Fukushima N, Chun J. (2001). The LPA receptors. J. Prostagland Lipid Mediators, 64, 21-31. |
| Fukushima N, Ishii I, Contos JJA, Weiner JA, Chun J. (2001). Lysophospholipid receptors. Ann. Rev. Pharmacol. Toxicol., 41, 507-534. |
| Chun J, Weiner JA, Fukushima N, Contos JJA, Zhang G, Kumura Y, Dubin A, Ishii I, Hecht JH, Akita C, Kaushal D. (2000). Neurobiology of receptor-mediated lysophospholipid signaling: From the first lysophospholipid (LP) receptor to roles in nervous system function and development. Ann. N.Y. Acad. Sci., 905, 110-117. |
| Chun J. (1999). Lysophospholipid receptors: implications for neural signaling. Crit. Rev. Neurobiol., 13, 151-168. |
| Chun J. (1999). The first cloned and identified lysophospholipid (LP) receptor gene, vzg-1: implications for the nervous system and related receptors. Adv. Exp. Med., Biol. 469:357-362. |
| Chun J, Contos JJA, Munroe D. (1999). A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs). Cell Biochem. and Biophys., 30, 213-242. |
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| Cortical Development |
| Articles/Letters |
| Estivill-Torrus G, Llebrez-Zayas P, Matas-Rico E, Santin L, Pedraza C, De Diego I, Del Arco I, Fernandez-Llebez P, Chun J, Rodriguez De Fonseca F. (2007). Absence of LPA1 signaling results in defective cortical development. Cerebral Cortex, in press. |
| Fukushima N, Shano S, Moriyama R, Chun J. (2007). Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-Gi/o pathway. Neurochem. Int., 50, 302-307. |
| Rehen SK, Kingsbury MA, Almeida BSV, Herr D, Peterson S, Chun J. (2006). A new method of embryonic culture for assessing global changes in brain organization. J. Neurosci. Meth., 158, 100-108. |
Kingsbury MA, Rehen SK, Contos JJA, Higgins C, Chun J. (2003). Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding. Nature Neurosci., 6, 1292-1299.
(see also News & Views.) |
| Yang AH, Kaushal D, Rehen SK, Kriedt K, Kingsbury MA, McConnell MJ, Chun J. (2003). Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells. J. Neurosci., 23, 10454-10462. |
| Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, Lein ES, Eadie BD, Willhoite AR, Muotri AR, Summers RG, Chun J, Lee K-F, Gage FH. (2003). Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc. Natl. Acad. Sci. USA, 100, 6777-6782. |
| Kaushal D, Contos JJA, Treuner K, Yang AH, Kingsbury MA, Rehen SK, McConnell MJ, Okabe M, Barlow C, Chun J. (2003). Alteration of gene expression by chromosome loss in the postnatal mouse brain. J. Neurosci., 23, 5599-5606. |
| McGiffert C, Contos JJA, Friedman B, Chun J. (2002). Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1-3 in angiogenesis. FEBS Lett., 531, 103-108. |
| Fukushima N, Ishii I, Habara Y, Allen CB, Chun J. (2002). Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines. Mol. Biol. Cell, 13, 2692-2705. |
| Fukushima N, Weiner JA, Kaushal J, Contos JJA, Rehen SK, Kingsbury MA, Kim KY, Chun J. (2002). Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons. Mol. Cell. Neurosci., 20, 271-282. |
| Ishii I, Chun J. (2002). Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors. Neuroreport, 13, 593-596. |
| Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J. (2001). Chromosomal variation in neurons of the developing and adult mammalian nervous system. Proc. Natl. Acad. Sci. USA, 98: 13361-13366.
(See comment in Nature Reviews Neuroscience, 2, 853, 2001, The Scientist, 16, 35, 2002, Revista Ciencia Hoje, 19-21, March 2002, Clin Genet., 61, 169-175, 2002)
http://www.nature.com/nsu/021216/021216-2.html; http://in.news.yahoo.com/021217/139/1z72u.html
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| Fukushima N, Weiner JA, Chun J. (2000). Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology. Dev. Biol., 228, 6-18. |
| Pompeiano M, Blaschke AJ, Flavell RA, Srinivasan A, Chun J. (2000). Decreased apoptosis in proliferative and postmitotic regions of the caspase 3 deficient embryonic CNS. J. Comp. Neurol., 423, 1-12. |
| Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW. (2000). Defective embryoic neurogenesis in ku, but not DNA-PKcs, deficient mice. Proc. Natl. Acad. Sci. USA, 97, 2668-2673. |
| Dubin AE, Bahnson T, Weiner JA, Fukushima N, Chun J. (1999). Lysophosphatidic acid (LPA) stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts. J. Neurosci., 19, 1371-1381. |
| Blaschke AJ, Weiner JA, Chun J. (1998). Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the CNS. J. Comp. Neurol., 396, 39-50. |
| McWhirter JR, Goulding M, Weiner J, Chun J, Murre C. (1997). A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development, 124, 3221-3232. |
| Weiner JA, Chun J. (1997). Maternally-derived immunoglobulin light chain is present in the fetal mammalian CNS. J. Neurosci., 17, 3148-3156. |
| Weiner JA, Chun J. (1997). Png-1, a nervous system-specific zinc finger gene, identifies regions containing postmitotic neurons during mammalian embryonic development. J. Comp Neurol., 381, 130-142. |
| Hecht JH, Weiner JA, Post SR, Chun J. (1996). Ventricular zone gene -1 (Vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J. Cell Biol., 135, 1071-1083. |
| Chun J, Jaenisch R. (1996). Clonal cell lines produced by birth-date targeting of neocortical neuroblasts using multiple oncogenes transduced by retroviruses. Mol. Cell. Neurosci., 7, 304-321. |
| Blaschke AJ, Staley K, Chun J. (1996). Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development, 122, 1165-1174. (See comment in Neuron 16, 693, 1996.) |
| Chun JJM. (1993). A protocol using retrovirally-introduced multiple oncogenes in the production of neuron-like cell lines from the murine central nervous system. NeuroProtocols, 3, 214-221. |
| Chun JJM, Schatz DG, Oettinger MA, Jaenisch R, Baltimore D. (1991). The Recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. Cell, 64, 189-200. |
| Chun JJM, Shatz CJ. (1989b). The earliest-generated neurons of the cat cerebral cortex: characterization by MAP2 and neurotransmitter immunohistochemistry during fetal life. J. Neurosci., 9, 1648-1667. |
| Chun JJM, Shatz CJ. (1989a). Interstitial cells of the adult neocortical white matter are the remnant of the early generated subplate neuron population. J. Comp. Neurol., 282, 555-569. |
| Chun JJM, Shatz CJ. (1988b). Redistribution of synaptic vesicle antigens is correlated with the disappearance of a transient synaptic zone in the developing cerebral cortex. Neuron, 1, 297-310. |
| Chun JJM, Shatz CJ. (1988a). A fibronectin-like molecule is present in the developing cat cerebral cortex and is correlated with subplate neurons. J. Cell Biol., 106, 857-872. |
| Chun JJM, Nakamura MJ, Shatz CJ. (1987). Transient cells of the developing mammalian telencephalon are peptide-immunoreactive neurons. Nature, 325, 617-620. |
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| Reviews and Book Chapters |
| Herr D, Chun J. (2007). Effects of LPA and S1P on the nervous system and implications for their involvement in disease. Cur. Drug Targ. 8, 155-167. |
| Rehen S, Chun J. (2005). Cell Death (during development of the central nervous system), Chapter 5, pp. 73-90 in Brain Development: Normal Processes and the Effects of Alcohol and Nicotine, Ed. by Michael W. Miller, Oxford University Press. |
| Chun J. (2004). Choices, choices, choices. Nature Neurosci., 7, 323-5. |
| Kingsbury MA, Rehen SK, Ye X, Chun J. (2004). Genetics and cell biology of lysophosphatidic acid receptor-mediated signaling during cortical neurogenesis. J. Cell. Biochem., 92, 1004-1012. |
| Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J. (2002). Genetic mosaicism in the brain: a new paradigm for neuronal diversity. Directions in Science, 1, 53-55. |
| Chun J. (2001). Selected comparison of immune and nervous system development. Adv. Immunol., 77, 297-322. |
| Chun J. (2000). An alternative view of cell death, DNA breaks and possible rearrangements. Trends in Neurosci., 23, 407-408. |
| Chun J, Weiner JA, Fukushima N, Contos JJA, Zhang G, Kumura Y, Dubin A, Ishii I, Hecht JH, Akita C, Kaushal D. (2000). Neurobiology of receptor-mediated lysophospholipid signaling: From the first lysophospholipid (LP) receptor to roles in nervous system function and development. Ann. N.Y. Acad. Sci., 905, 110-117. |
| Chun J. (1999). Developmental neurobiology: a genetic Cheshire cat? Cur. Biol., 9, 651-654. |
| Chun J. (1999). The first cloned and identified lysophospholipid (LP) receptor gene, vzg-1: implications for the nervous system and related receptors. Adv. Exp. Med. Biol., 469, 357-362. |
| Chun J, Schatz DG. (1999). Developmental neurobiology: alternative “ends” to a familiar story? Curr. Biol., 9, R251-R253. |
| Chun J, Schatz DG. (1999). Rearranging views on neurogenesis: neuronal death in the absence of DNA end-joining proteins. Neuron, 22, 7-10. |
| Chun J. (1998). Detection of cells undergoing programmed cell death using in situ end labeling plus (ISEL+) in Biotechniques book, Apoptosis Detection, CHAPTER 5, pp. 35-45, in “Apoptosis detection and assay methods,” L Zhu and J. Chun, eds, BioTechniques Books, Natick, MA. |
| Chun J, Blaschke AJ. (1997). Unit 3.8, Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR. In Current Protocols in Neuroscience, C. Gerfen and R. Mckay, eds. John Wiley and Sons, Inc. |
| Chun JJM, Schatz DG. (1993). Recombination activating gene -1 (RAG-1) transcription in the mammalian CNS. Chapter 22. In Neuronal Cell Death and Repair, Vol. 6, A. C. Cuello, ed. Elsevier Science Publishers, Amsterdam. |
| Schatz DG, Chun JJM. (1992). V(D)J recombination and the transgenic brain blues. New Biologist, 4, 188. |
| Shatz CJ, Chun JJM, Luskin MB. (1988). The role of the subplate in the development of the mammalian telencephalon. In Development of the Cerebral Cortex, Vol. 7, A. Peters and E.G. Jones, eds. Plenum publishing corp., New York. |
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| Aneuploidy |
| Articles/Letters |
| Westra JW, Peterson SE, Yung YC, Barral S, Chun J. (2008). Aneuploid mosaicism in the developing and adult cerebellar cortex. J. Comp. Neurol. 507, 1944-1951 (epub ahead of print 13 Feb 2008). |
| Rajendran RS, Zupanc MM, Losche A, Westra J, Chun J, Zupanc GKH. (2007). Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish. Dev. Neurobiol., 67, 1334-1347. |
| Kingsbury MA, Friedman B, McConnell MJ, Rehen SK, Yang AH, Kaushal D, Chun J. (2005). Aneuploid neurons are functionally active and integrated into brain circuitry. Proc. Natl. Acad. Sci. USA, 102, 6143-6147. |
| Rehen SK, Yung YC, McCreight MP, Yang AH, Almeida BSV, Kingsbury MA, Cabral KMS, Kaushal D, McConnell MJ, Anliker B, Fontanoz M, Chun J. (2005). Constitutional aneuploidy in the normal human brain. J. Neurosci., 25, 2176-2180. (cover art) |
| McConnell MJ, Kaushal D, Yang AH, Kingsbury MA, Rehen SK, Treuner K, Helton R, Annas EG, Chun J, Barlow C. (2004). Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in Atm-deficient but not the Trp53-deficient adult cerebral cortex. J. Neurosci., 24, 8090-8096. |
| Yang AH, Kaushal D, Rehen SK, Kriedt K, Kingsbury MA, McConnell MJ, Chun J. (2003). Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells. J. Neurosci., 23, 10454-10462. |
| Kaushal D, Contos JJA, Treuner K, Yang AH, Kingsbury MA, Rehen SK, McConnell MJ, Okabe M, Barlow C, Chun J. (2003). Alteration of gene expression by chromosome loss in the postnatal mouse brain. J. Neurosci., 23, 5599-5606. |
| Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J. (2001). Chromosomal variation in neurons of the developing and adult mammalian nervous system. Proc. Natl. Acad. Sci. USA, 98, 13361-13366.
(See comment in Nature Reviews Neuroscience, 2, 853, 2001, The Scientist, 16, 35, 2002, Revista Ciencia Hoje, 19-21, March 2002, Clin Genet., 61, 169-175, 2002.)
http://www.nature.com/nsu/021216/021216-2.html; http://in.news.yahoo.com/021217/139/1z72u.html
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| Reviews and Book Chapters |
| Peterson SE, Westra JW, Paczkowski CM, Chun J. (2008) Chromosomal mosaicism in neural stem cells. In Neural Stem Cells Methods and Protocols, Chapter 16, pp. 197-204. Weiner LP (ed.). Humana Press, 2008. |
| Kingsbury MA, Yung YC, Peterson SE, Westra JW, Chun J. (2006). Aneuploidy in the normal and diseased brain. Cell. Mol. Life Sci., 63, 2695-2701. |
| Rehen S, Chun J. (2005). Cell Death (during development of the central nervous system), Chapter 5, pp. 73-90 in Brain Development: Normal Processes and the Effects of Alcohol and Nicotine. Miller EW (ed.), Oxford University Press. |
| Chun J. (2004). Choices, choices, choices. Nature Neurosci., 7, 323-325. |
| Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J. (2002). Genetic mosaicism in the brain: a new paradigm for neuronal diversity. Directions in Science, 1, 53-55. |
| Chun J. (2000). An alternative view of cell death, DNA breaks and possible rearrangements. Trends in Neurosci., 23, 407-408. |
| Earlier Studies |
| Chun J. (2001). Selected comparison of immune and nervous system development. Adv. Immunol. 77, 297-322. |
| Pompeiano M, Blaschke AJ, Flavell RA, Srinivasan A, Chun J. (2000). Decreased apoptosis in proliferative and postmitotic regions of the caspase 3 deficient embryonic CNS. J. Comp. Neurol. 423, 1-12. |
| Gu Y, Sekiguchi J, Gao Y, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW. (2000). Defective embryonic neurogenesis in ku, but not DNA-PKcs, deficient mice. Proc. Natl. Acad. Sci., USA. 97, 2668-2673. |
| Chun J. (2000). An alternative view of cell death, DNA breaks and possible rearrangements. Trends in Neurosci. 23, 407-408. |
| Pompeiano M, Hvala M, Chun J. (1998). Onset of apoptotic DNA fragmentation can precede cell elimination by days in the small intestinal vilus. Cell Death and Diff. 5, 702-709. |
| Blaschke AJ, Weiner JA, Chun J. (1998). Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the CNS. J. Comp. Neurol. 396, 39-50. |
| Staley K, Blaschke AJ, Chun J. (1997). Apoptotic DNA fragmentation is detected by a semi-quantatitive ligation-mediated PCR of blunt DNA ends. Cell Death and Differen. 4, 66-75. |
| Blashke AJ, Staley K, Chun J. (1996). Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development. 122, 1165-1174. (See comment in Neuron 16, 693, 1996). |
| Chun J. (1999). Developmental neurobiology: a genetic Cheshire cat? Cur. Biol. 9, 651-654. |
| Chun J, Schatz DG. (1999). Developmental neurobiology: alternative "ends" to a familiar story? Curr. Biol. 9, R251-R253. |
| Chun J, Schatz DG. (1999). Rearranging views on neurogenesis: neuronal death in the absence of DNA end-joining proteins. Neuron. 22, 7-10. |
| Chun J. (1999). Detection of cells undergoing programmed cell death using in situ end labeling plus (ISEL+), in Apoptosis Detection and Assay methods, Chapter 5, pp. 33-45. Zhu L and Chun J (eds.), BioTechniques Books, Natick, MA. |
| Chun J. (1998). Apoptotic DNA fragmentation detection using ligation mediated PCR (LMPCR), in Apoptosis Detection and Assay methods, Chapter 4, pp. 23-33. Zhu L and Chun J (eds.), BioTechniques Books, Natick, MA. |
| Chun J, Blaschke AJ. (1997). Unit 3.8, Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR. In Current Protocols in Neuroscience, Gerfen C and Mckay R (eds.), John Wiley and Sons, Inc. |
| Chun JJM, Schatz DG. (1993). Recombination activating gene-1 (RAG-1) transcription in the mammalian CNS. Chapter 22. In Neuronal Cell Death and Repair, Vol. 6, Cuello AC (ed.), Elsevier Science Publishers, Amsterdam. |
| Schatz DG, Chun JJM. (1992). V(D)J recombination and the transgenic brain blues. New Biologist. 4, 188. |
| Turka LA, Schatz DG, Oettinger MA, Chun JJM, Gorka C, Lee K, McCormack WT, Thompson CB. (1991). Thymocyte expression of the recombination activating genes RAG-1 and RAG-2 can be terminated by T-cell receptor stimulation in vitro. Science. 253, 778-781. |
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