Chun Lab logo
Chun home
Chun Research
Publications
Chun Members
Giving
Contact Chun Lab
aneuploidy cell signaling cortical development
Chun Lab Publications
By Year
For selected publications by subject area, click here
2009
Articles/Letters
169. Chun J, Hartung H-P. Mechanism of action of oral Fingolimod (FTY720) in multiple sclerosis. Clin. Neuropharm. in press, 2009.
168. Zhao Y, Tong J, He D, Pendyala S, Evgeny B, Chun J, Sperling AI, Natarajan V. (2009) Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma. Respiratory Res. 10:114.
167. Ma L, Uchida H, Nagai J, Inoue M, Chun J, Aoki J, Ueda H. (2009) Lysophosphatidic acid-3 receptor-mediated feed-foward production of lysophosphatidic acid: An initiator of nerve injury-induced neuropathic pain. Mol. Pain. 5:64.
166. Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, Cyster JG, Chun J. (2009) T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. J Exp Med. 206, 2469-2481.
165. Lin S, Yeruva S, He P, Singh AK, Zhang H, Chen M, Lamprecht G, de Jonge HR, Tse M, Donowitz M, Hogema BM, Chun J, Seidler U, Yun CC. Lysophosphatidic acid stimulates the intestinal brush border Na+/H+ exchanger 3 and fluid absorption via LPA5 and NHERF2. Gastroenterology, epub ahead of print 30 Sep 2009.
164. Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, Birchmeier C, Wiese S, Sendtner M, Kawabe H, Kishimoto-Suga M, Brose N, Baumgart J, Geist B, Aoki J, Savaskan NE, Brauer AU, Chun J, Ninnemann O, Schmitz D, Nitsch R. (2009) Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell. 138, 1222-1235.
163. Takuwa N, Ohkura SI, Takashima SI, Ohtani K, Okamoto Y, Tanaka T, Hirano K, Usui S, Wang F, Du W, Yoshioka K, Banno Y, Sasaki M, Ichi I, Okamura M, Sugimoto N, Mizugishi K, Nakanuma Y, Ishii I, Takamura M, Kaneko S, Kojo S, Satouchi K, Mitumori K, Chun J, Takuwa Y. S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. Cardiovasc Res, epub ahead of print 15 Sep 2009.
162. Santin L, Bilbao A, Pedraza C, Matas-Rico E, Lopez-Barroso D, Castilla-Ortega E, Sanchez-Lopez J, Riquelme R, Varela-Nieto I, de la Villa P, Suardiaz M, Chun J, Rodriguez-Fonseca F, Estivill-Torrus G. (2009) Behavioral phenotype of maLPA1-null mice: Increased anxiety-like behavior and spatial memory deficits. Genes, Brain Behav, in press.
161. Nieuwenhuis B, Luth A, Chun J, Huwiler A, Pfeilschifter J, Schafer-Korting M, Kleuser B. (2009) Involvement of the ABC-transporter ABCC1 and the sphingosine 1-phosphate receptor subtype S1P(3) in the cryoprotection of human fibroblasts by the glucocorticoid dexamethasone. J Mol Med. 87, 645-657.
160. Westra JW, Barral S, Chun J. A reevaluation of tetraploidy in the Alzheimer's disease brain. Neuro-degen Dis, epub ahead of print 9 Sep 2009.
159. Lin S, Wang D, Iyer S, Ghaleb AM, Shim H, Yang VW, Chun J, Yun CC. (2009) The absence of LPA(2) attenuates tumor formation in an experimental model of colitis-associated cancer. Gastroenterology. 136, 1711-1720.
158. Ikeda H, Watanabe N, Ishii I, Shimosawa T, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Iitsuka S, Fujita R, Omata M, Chun J, Yatomi Y. (2009) Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2. J Lipid Res. 50, 556-564.
Reviews and Book Chapters
157. Ye X, Chun J. Lysophosphatidic acid (LPA) signaling in vertebrate reproduction. Trends Endocrinol Metab epub ahead of print 15 Oct 2009.
156. Yung YC, Kennedy G, Chun J. (2009) Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR. In Current Protocols in Neuroscience, Unit 3.8, Taylor G (Ed.), John Wiley & Sons.
155. Teo ST, Yung YC, Herr DR, Chun J. (2009) Lysophosphatidic acid in vascular development and disease. IUBMB Life. 61, 791-799.
154. Lin M-E, Herr DR, Chun J. Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance. Prostagland Lipid Mediators, in press 2009.
153. Mutoh T, Chun J. Lysophosphatidic acid and sphingosine 1-phosphate activation of G protein-coupled receptors. In: Bradshaw RA and Dennis EA (eds.) Handbook of Cell Signaling, Second Edition, Elsevier, Inc., in press 2009.
152. Noguchi K, Herr D, Mutoh T, Chun J. (2009) Lysophosphatidic acid (LPA) and its receptors. Curr. Opin. Pharmacol. 9, 15-23.
151. Paczkowski C, Chun J. (2009) Genomic Disorder and Gene Expression in the Developing CNS. In: Squire LR (ed.) Encyclopedia of Neuroscience, volume 4, pp. 679-684. Oxford: Academic Press.
2008
Articles/Letters
150. Xie W, Matsumoto M, Chun J, Ueda H. (2008) Involvement of spinal input through Abeta-fibers in mice with partial sciatic nerve injury. Mol. Pain. 4, 46.
149. Matas-Rico E, Garcia-Diaz B, Llebrez-Zayas P, Lopez-Barroso D, Santin L, Pedraza C, Smith-Fernandez A, Fernandez-Llebrez P, Tellez T, Redondo M, Chun J, Rodriguez de Fonseca F, Estivill-Torrus G. (2008) Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus. Mol. Cell Neurosci. 39, 342-355.
148. Panchatcharam M, Miriyala S, Yang F, Rojas , Valiant C, Dong A, Lynch K, Chun J, Morris AJ, Smyth SS. (2008) Lysoposphatidic acid receptors 1 and 2 play roles in regulation of vasuclar injury responses but not blood pressure. Circ. Res. 103, 662-670.
147. Tölle M, Pawlak A, Schuchardt M, Kawamura A, Tietge UJ, Lorkowski S, Keul P, Assmann G, Chun J, Levkau B, van der Giet M, Nofer JR. (2008). HDL-associated lysosphingolipids inhibit NAD(P)H oxidase-dependent monocyte chemoattractant protein-1 production.  Arterioscler. Thromb. Vasc. Biol. 28, 1542-1548.
146. Ye X, Skinner MK, Kennedy G, Chun J.  (2008). Age-dependent loss of sperm production in mice via impaired lysophosphadtidic acid signaling.  Biol. Reprod. 79, 328-336.
145. Choi JW, Lee CW, Chun J. (2008). Biological roles of lysophospholipid receptors revealed by genetic null mice: an update. Biochem. Biophys. Acta. 1781, 531-539.
144. Inoue M, Xie W, Matsushita Y, Chun J, Aoki J, Ueda H. (2008) Lysophosphatidylcholine induces neuropathic pain through an action of autotaxin to generate lysophosphatidic acid. Neurosci. 152, 296-298.
143. Means CK, Miyamoto S, Chun J, Brown JH.  (2008) S1P1 receptor localization confers selectivity for Gi mediated cAMP and contractile responses.  J. Biol. Chem. 283, 11954-11963.
142. Niessen F, Schaffner F, Furlan-Freguia C, Pawlinksi R, Bhattacharjee G, Chun J, Derian CK, Andrade-Gordon P, Rosen H, Ruf W. (2008) Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature. 452, 654-658.
141. Inoue M, Ma L, Aoki J, Chun J, Ueda H. (2008) Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain. Mol. Pain. 4, 6.
140. Spohr TC, Choi JW, Gardell SE, Herr D, Rehen SK, Gomes FC, Chun J. (2008). LPA receptor-dependent secondary effects via astrocytes promote neuronal differentiation. J. Biol. Chem. 283, 7470-7479.
139. Lee CW, Kim NH, Choi HK, Sun Y, Nam JS, Rhee HJ, Chun J, Huh SO. (2008). Lysophosphatidic acid-induced c-fos up-regulation involves cyclic AMP response element-binding protein activated by mitogen- and stress-activated protein kinase-1. J. Cell. Biochem. 104, 785-794.
138. Westra JW, Peterson SE, Yung YC, Mutoh T, Barral S, Chun J. (2008). Aneuploid mosaicism in the developing and adult cerebellar cortex. J. Comp. Neurol. 507, 1944-1951.
137. Salomone S, Potts EM, Tyndall S, Ip PC, Chun J, Brinkmann V, Waeber C. (2008). Analysis of sphingosine 1-phosphate receptors involved in constriction of isolated cerebral arteries with receptor null mice and pharmacological tools. Br. J. Pharmacol. 153, 140-147.
136. Tager AM, LaCamera P, Shea BS, Campanella GK, Selman M, Zhao Z, Polosukhin Z,  Wain J, Karimi-Shah BA, Kim ND, Hart WK,  Pardo A, Blackwell TS, Xu Y, Chun J, Luster AD.  (2008). The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis  to lung injury by mediating fibroblast recruitment and vascular leak.  Nat. Med. 14, 45-54.
135. Shano S, Moriyama R, Chun J, Fukushima N. (2008). Lysophosphatidic acid stimulates astrocyte proliferation through LPA1. Neurochem. Intl. 52, 216-220.
134. Estivill-Torrus G, Llebrez-Zayas P, Matas-Rico E, Santin L, Pedraza C, De Diego I, Del Arco I, Fernandez-Llebrez P, Chun J, Rodriguez De Fonseca F. (2008). Absence of LPA1 signaling results in defective cortical development. Cerebral Cortex. 18, 938-950.
Reviews and Book Chapters
133. Mutoh T, Chun J. (2008) Lysophospholipid activation of G protein-coupled receptors. Subcell. Biochem. 49, 269-297.
132. Peterson S, Rehen S, Westra W, Yung Y, Chun J. (2008) Spectral karyotyping and fluorescent in situ hybridization. In Human Stem Cell Manual: A Laboratory Guide, Chapter 6, pp. 71-84. Loring JF, Esselschmidt RI, Schwartz PH (eds.). Elsevier.
131. Peterson SE, Westra JW, Paczkowski CM, Chun J.  (2008) Chromosomal mosaicism in neural stem cells.  In Neural Stem Cells Methods and Protocols, Chapter 16, pp. 197-204.  Weiner LP (ed.). Humana Press.
2007
Articles/Letters
130. Hama K, Aoki J, Inoue A, Endo T, Amano T, Motoki R, Kanai M, Ye X, Chun J, Matsuki N, Suzuki H, Shibasaki M, Arai H. (2007). Embryo spacing and implantation timing are diffentially regulated by LPA3-mediated lysophosphatidic acid signaling. Biol. Reprod. 77, 954-959.
129. Chun J. (2007). How the lysophospholipid got its receptor. The Scientist. 21, 48-54.
128. Chan LC, Peters W, Xu Y, Chun J, Farese Jr. RV, Cases S. (2007). LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA). J. Leukocyte. Biol. 82, 1193-1200.
127. Pradere J-P, Klein J, Gres S, Guigne C, Neau E, Valet P, Calise D, Chun J, Bascands J-L, Saulnier-Blache J-S, Schanstra JP. (2007). LPA1 receptor activation promotes renal interstitial fibrosis. J. Am. Soc. Nephrology. 18, 3110-3118.
126. Chun J. (2007). The sources of a lipid conundrum. Science. 316, 208-210.
125. Serriere-Lanneau V, Teixeira-Clerc F, Li L, Schippers M, de Wries W, Julien B, Tran-Van-Nhieu J, Manin S, Poelstra K, Chun J, Carpentie S, Levade T, Mallat A, Lotersztajn S. (2007). The sphingosine-1-phosphate receptor S1P2 triggers hepatic wound healing. FASEB J. 21, 2005-2013.
124. Means CK, Xiao CY, Li Z, Zhang T, Omens JH, Ishii I, Chun J, Brown JH. (2007). Sphingosine-1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. Am. J. Physiol. Heart Circ. Physiol. 292, H2944-H2951.
123. Walter DH, Rochwalsky U, Reinhold J, Seeger F, Aicher A, Urbich C, Spyridolpoulos I, Chun J, Brinkmann V, Keul P, Levkau B, Zeiher AM, Dimmeler S, Haendeler J. (2007). Spingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CxCR4-dependent signaling pathway via the S1P3 receptor. Arterioscler. Thromb.
Vasc. Biol. 27, 275-282.
122. Herr D, Grillet N, Schwander M, Rivera R, Muller U, Chun J. (2007). Sphingosine 1-phosphate signaling is required for maintenance of hair cells largely via activation of S1P2. J. Neurosci. 27, 1474-1478.
121. Lee CW, Rivera R, Dubin AE, Chun J. (2007). LPA4/GPR23 is a lysophospatidic acid (LPA) receptor utilizing Gs, Gq/Gi-mediated calcium signaling and G12/13-mediated Rho activation. J. Biol. Chem. 281, 23589-23597.
120. Rajendran RS, Zupanc MM, Losche A, Westra J, Chun J, Zupanc GKH. (2007). Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish. Dev. Neurobiol. 67, 1334-1347.
119. Keller CD, Gil PR, Tolle M, van der Giet M, Chun,J, Radeke HH, Schafer-Korting M, Kleuser B. (2007). Immunomodulator FTY720 induces myofibroblast differentiation via the lysophospholipid receptor S1P3 and Smad3 signaling. Am. J. Path. 170, 281-292.
Reviews and Book Chapters
118. Rivera R, Chun J. (2007). Potential therapeutic roles of lysophospholipid signaling in autoimmune-related disease. Future Lipidol. 2, 535-545.
117. Herr D, Chun J. (2007). Effects of LPA and S1P on the nervous system and implications for their involvement in disease. Cur. Drug Targ. 8, 155-167.
116. Chun J. (2007). “Extracellular Lipid Signals,” in Wiley Encyclopedia of Chemical Biology, accepted.
2006
Articles/Letters
115. Rehen SK, Kingsbury MA, Almeida BSV, Herr D, Peterson S, Chun J. (2006). A new method of embryonic culture for assessing global changes in brain organization. J. Neurosci. Meth. 158, 100-108.
114. Fukushima N, Shano S, Moriyama R, Chun J. (2006). Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-Gi/o pathway. Neurochem. Int. 50, 302-307.
113. Inoue M, Yamaguchi A, Kawakami M, Chun J, Ueda H. (2006). Loss of substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain. Mol. Pain 2, 25.
112. Theilmeier G, Schmidt C, Jörg Herrmann J, Keul P, Schäfers M, Herrgott I, Mersmann J, Larmann J, Hermann S, Stypmann J, Schober O, Hildebrand R, Schulz R, Heusch G, Haude M, von Wnuck Lipinski K, Herzog C, Schmitz M, Erbel R, Chun J, Levkau B. (2006). High-density lipoproteins and their constituent sphingosine-1-phosphate directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. Circulation 114, 1403-1409.
111. Lee C-W, Rivera R, Gardell S, Dubin AE, Chun J. (2006). GPR92 as a new G12/13 and Gq coupled lysophosphatidic acid receptor that increases cAMP: LPA5. J. Biol. Chem. 281, 23589-23597.
110. Chao C, Herr D, Chun J, Xu Y. (2006). Ser18 and Ser23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. EMBO J. 25, 2615-2222.
Reviews and Book Chapters
109. Birgbauer E, Chun J. (2006). New developments in the biological functions of lysophospholipids. Cell. Mol. Life Sci. 63, 2695-2701.
108. Kingsbury MA, Yung YC, Peterson SE, Westra JW, Chun J. (2006). Aneuploidy in the normal and diseased brain. Cell. Mol. Life Sci. 63, 2626-2641.
107. Rivera R, Chun J. (2006). Biological effects of lysophospholipids. Rev. Physiol. Biochem. Pharmacol.
106. Gardell SE, Dubin AE, Chun J. (2006). Emerging medicinal roles for lysophospholipid receptors. Trends in Molecular Med. 12, 65-75.
105. Chun J, Rosen H. (2006). Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases. Cur. Pharm. Design. 12, 161-171.
2005
Articles/Letters
104. Ye X, Hama K, Contos JJ, Anliker B, Inoue A, Skinner MK, Suzuki H, Amano T, Kennedy G, Arai H, Aoki J, Chun J. (2005). LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature. 435, 104-8.
(see also News & Views)
103. Barbeito L, Chun J, Binder LI, Neto VM, Perry G, Scazzochio C, Violini G. (2005). The end of a Chilean institute. Science. 308,792-3.
102. Kingsbury MA, Friedman B, McConnell MJ, Rehen SK, Yang AH, Kaushal D, Chun J. (2005). Aneuploid neurons are functionally active and integrated into brain circuitry. Proc. Natl. Acad. Sci. USA. 102, 6143-7.
101. Rehen SK, Yung YC, McCreight MP, Yang AH, Almeida BSV, Kingsbury MA, Cabral KMS, Kaushal D, McConnell MJ, Anliker B, Fontanoz M, Chun J. (2005). Constitutional aneuploidy in the normal human brain. J. Neurosci. 25, 2176-2180. (cover art)
100. Tölle M, Levkau B, Keul P, Brinkmann V, Giebing G, Schönfelder G, Schäfers M, von Wnuck Lipinski K, Jankowski J, Jankowski V, Chun J, Zidek W, van der Giet M. (2005). The immunomodulator FTY720 induces eNOS-dependent arterial vasodilation via the lysophospholipid receptor S1P3. Circ. Res. 96, 913-920.
99. Goparaju SK, Jolly PS, Watterson KR, Bektas M, Alvarez S, Sarkar S, Mel L, Ishii I, Chun J, Milstien S, Spiegel S. (2005). The S1P2 Receptor negatively regulates PDGF-induced motility and proliferation. Mol. Cell. Biol. 25, 4237-49.
98. Li H, Ye X, Mahanivong C, Bian D, Chun J, Huang S. (2005). Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells. J Biol Chem. 280, 10564-71.
97. Simon MF, Daviaud D, Pradere JP, Gres S, Guigne C, Wabitsch M, Chun J, Valet P, Saulnier-Blache JS. (2005). Lysophosphatidic acid inhibits adipocyte differentiation via lysophosphatidic acid 1 receptor-dependent down-regulation of peroxisome proliferator-activated receptor gamma2. J Biol Chem .280, 14656-62.
Reviews and Book Chapters
96. Chun J. (2005). Lysophospholipids in the nervous system. J. Prostagland. Lipid Mediators. 77, 46-51.
95. Rehen S, Chun J. (2005). Cell Death (during development of the central nervous system), Chapter 5, pp. 73-90 in Brain Development: Normal Processes and the Effects of Alcohol and Nicotine, Ed. by Michael W. Miller, Oxford University Press.
2004
Articles/Letters
94. Girkontaite I, Sakk V, Wagner M, Borggrefe T, Tedford K, Chun J, Fischer K-D. (2004). The sphingosine-1-phosphate lysophospholipid receptor S1P3 regulates MAdCAM-1+ endothelial cells in splenic marginal sinus organization. J. Exp. Med. 200, 1491-1501.
93. Levkau B, Hermann S, Theilmeier G, van der Giet M, Chun J, Otmar Schober O, Schäfers M. (2004). HDL stimulates myocardial perfusion in vivo. Circulation. 110, 3355-3359.
92. McConnell MJ, Kaushal,D, Yang AH, Kingsbury MA, Rehen SK, Treuner K, Helton R, Annas EG, Chun J, Barlow C. (2004). Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in Atm-deficient but not the Trp53-deficient adult cerebral cortex. J. Neurosci. 24, 8090-8096.
91. Webb M, Tham CS, Lin FF, Lariosa-Willingham K, Yu N, Hale J, Mandala S, Chun J, Rao TS. (2004). Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice. J. Neuroimmunol. 153, 108-121.
90. Inoue M, Rashid H, Fujita R, Contos JJA, Chun J, Ueda H. (2004). Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling.  Nature Med. 10, 712-718.
89. Rao TS, Lariosa-Willingham KD, Lin F-F, Yu N, Tham C-S, Chun J, Webb M. Growth factor pre-treatment differentially regulates phosphoinositide turnover downstream of lysophospholipid receptor and metabotropic glutamate receptors in cultured rat cerebrocortical astrocytes. Int. J. Devel. Neurosci. 22, 131-135.
88. Hama K, Aoki J, Fukay M, Kishi Y, Ohta H, Sakai T, Suzuki R, Watanabe M, Chun J, Arai H. (2004). Autotaxin and lysophosphatidic acid stimulate cell motility of neoplastic and non-neoplastic cells through LPA1. J. Biol. Chem. 279, 17634-17639.
87. Sanna G, Alfonso A, Liao J, Ahn M-Y, Peterson MS, Jo E, Webb B, Lefebvre S, Chun J, Gray N, Rosen H. (2004). Distinct S1P receptor subtypes S1P1 and S1P3 respectively regulate lymphocyte recirculation and heart rate. J. Biol. Chem. 279, 13839-13848.
86. Nofer J-R, van der Giet M, Tölle M, Wolinska I, Sokoll A, von Wnuck-Lipinski K, Baba HA, Gödecke A, Ishii I, Kleuser B, Volker W, Fobker M, Zidek W, Assmann G, Chun J, Levkau B. (2004). HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3: role of HDL-associated lysophospholipids. J. Clin. Invest. 113, 569-581.
85. Baudhuin LM, Ying J, Zaslavsky A, Ishii I, Chun J, Yan Xu Y. (2004). S1P3-mediated Akt activation and crosstalk with platelet-derived growth factor receptor (PDGFR). FASEB J. 18, 341-343.
Reviews and Book Chapters
84. Chun J. (2004). Choices, choices, choices. Nature Neurosci. 7, 323-5.
83. Anliker B, Chun J. (2004). Lysophospholipid receptors: an update. J. Biol. Chem. 279, 20555-20558.
82. Anliker B, Chun J. (2004). Cell surface receptors in lysophospholipid signaling. Sem. Cell and Devel. Biol. 15, 457-465.
81. Ishii I, Fukushima N, Ye X, Chun J. (2004). Lysophospholipid receptors: signaling and biology. Ann. Rev. Biochemistry. 73, 321-354.
80. Kingsbury MA, Rehen SK, Ye X, Chun J. (2004). Genetics and cell biology of lysophosphatidic acid receptor-mediated signaling during cortical neurogenesis. J. Cell. Biochem. 92, 1004-1012.
2003
Articles/Letters
79. Kingsbury MA, Rehen SK, Contos JJA, Higgins C, Chun J. (2003). Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding. Nature Neurosci. 6, 1292-1299.
(see also News & Views)
78. Yang AH, Kaushal D, Rehen SK, Kriedt K, Kingsbury MA, McConnell MJ, Chun J. (2003). Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells. J. Neurosci. 23, 10454-10462.
77. Olivera A, Rosenfeldt H, Bektas M, Wang F, Ishii I, Chun J, Milstien S, Spiegel S. (2003). Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation yet promotes growth and survival independent of G protein coupled receptors. J. Biol. Chem. 278, 46452-46460.
76. Rao TS, Lariosa-Willingham KD, Lin F-F, Palfreyman EL, Yu N, Chun J, Webb M. (2003). Pharmacological characterization of lysophospholipid receptor signal transduction pathways in rat cerebrocortical astrocytes. Brain Res. 990, 182-194.
75. Liu H, Toman RE, Goparaju S, Maceyka M, Nava VE, Sankala H, Payne SG, Bektas M, Ishii I, Chun J, Milstien S, Spiegel S. (2003). Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. J. Biol. Chem. 278, 40330-6.
74. Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, Lein ES, Eadie BD, Willhoite AR, Muotri AR, Summers RG, Chun J, Lee K-F, Gage FH. (2003). Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc. Natl. Acad. Sci. USA. 100, 6777-6782.
73. Kaushal D, Contos JJA, Treuner K, Yang AH, Kingsbury MA, Rehen SK, McConnell MJ, Okabe M, Barlow C, Chun J. (2003). Alteration of gene expression by chromosome loss in the postnatal mouse brain. J. Neurosci. 23, 5599-5606.
2002
Articles/Letters
72. McGiffert C, Contos JJA, Friedman B, Chun J. (2002). Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p1 in neurogenesis and s1p1-3 in angiogenesis. FEBS Lett. 531, 103-108.
71. Contos JJA, Ye X, Sah V, Chun J. (2002). Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p4/lpC1/Edg6) gene. FEBS Lett. 531, 531, 99-102.
70. Contos JJA, Ishii I, Fukushima I, Kingsbury MA, Ye X, Kawamura S, Brown JH, Chun J. (2002). Characterization of LPA2 (EDG-4) and LPA1/LPA2 (EDG-2/EDG-4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to LPA2. Mol. Cell Biol. 22: 6921-6929.
69. Ishii I, Ye X, Friedman B, Kawamura S, Contos JJA, Kingsbury MA, Yang AH, Zhang G, Brown JH, Chun J. (2002). Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate receptors, S1P2/LPB2/EDG-5 and S1P3/LPB3/EDG-3. J. Biol. Chem. 277, 25152-25159.
68. Fukushima N, Ishii I, Habara Y, Allen CB, Chun J. (2002). Dual Regulation of Actin Rearrangement through Lysophosphatidic Acid Receptor in Neuroblast Cell Lines. Mol. Biol. Cell. 13, 2692-2705.
67. Fukushima N, Weiner JA, Kaushal J, Contos JJA, Rehen SK, Kingsbury MA, Kim KY, Chun J. (2002). Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons. Mol. Cell. Neurosci., 20, 271-282.
66. Ishii I, Chun J. (2002). Anandamide-induced neuroblastoma cell rounding via the CB1 cannabinoid receptors. Neuroreport. 13, 593-596.
Reviews and Book Chapters
65. Ye X, Fukushima N, Kingsbury MA, Chun J. (2002). Lysophosphatidic acid in neural signaling. Neuroreport 13, 2169-2175.
64. Ye X, Ishii I, Kingsbury MA, Chun J. (2002). Lysophosphatidic acid as a novel cell survival/apoptotic factor. Biochim. Biophys. Acta. 1585, 108-113.
63. Fukushima N, Ye X, Chun J. (2002). Neurobiology of lysophosphatidic acid signaling. The Neuroscientist. 8,540-550.
62. Yang AH, Ishii I, Chun J. (2002). In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice. Biochim. Biophys. Acta. 1582, 197-203.
61. Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J. (2002). Genetic mosaicism in the brain: a new paradigm for neuronal diversity. Directions in Science. 1, 53-55.
60. Chun J, Goetzl EJ, Hla TL, Igarashi Y, Lynch KR, Moolenaar WH, Pyne S, Tigyi G. (2002). International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacol. Rev. 54, 265-269.
2001
Articles/Letters
59. Rehen SK, McConnell MJ, Kaushal D, Kingsbury MA, Yang AH, Chun J. (2001). Chromosomal variation in neurons of the developing and adult mammalian nervous system. Proc. Natl. Acad. Sci. USA, 98: 13361-13366.

(See comment in Nature Reviews Neuroscience, 2, 853, 2001, The Scientist, 16, 35, 2002, Revista Ciencia Hoje, 19-21, March 2002, Clin Genet., 61, 169-175, 2002)
http://www.nature.com/nsu/021216/021216-2.html; http://in.news.yahoo.com/021217/139/1z72u.html
58. Ishii I, Friedman B, Ye X-Q, Kawamura S, McGifffert C, Contos JJA, Kingsbury M, Zhang G, Brown JH, Chun J. (2001). Selective loss of sphingosine 1-phosphate signaling with no obvious phenotypic abnormality in mice lacking its G protein-coupled receptor, LPB3/EDG-3. J. Biol. Chem. 276: 33,697-33,704.
57. Weiner JAW, Fukushima N, Contos JJA, Scherer SS, Chun J. (2001). Regulation of Schwann cell morphology and adhesion by receptor-mediated lysophosphatidic acid signaling. J. Neurosci. 21: 7069-7078.
56. Moeller T, Contos JJ, Musante DB, Chun J, Ransom BR. (2001). Expression and function of lysophosphatidic acid receptors in cultured rodent microglial cells. J. Biol. Chem. 276: 25,946-25,952.
55. Contos JJA, Chun J. (2001). The mouse lpA3/Edg7 lysophosphatidic acid receptor gene: sequence, genomic structure, chromosomal location and expression pattern. Gene. 267: 243-253.
54. Kimura Y, Schmitt A, Fukushima N, Ishii I, Kimura H, Nebreda AR, Chun J. (2001). Two novel Xenopus homologs of mammalian LPA1/edg-2 function as lysophosphatidic acid receptors in Xenopus oocytes and mammalian cells. J. Biol. Chem. 276, 15028-15215.
Reviews and Book Chapters
53. Fukushima N, Chun J. (2001). The LPA Receptors. J. Prostagland Lipid Mediators. 64, 21-31.
52. Fukushima N, Ishii I, Contos JJA, Weiner JA, Chun J. (2001). Lysophospholipid receptors. Ann. Rev. Pharmacol. Toxicol. 41, 507-534.
51. Chun J. (2001). Selected comparison of immune and nervous system development. Adv. Immunol. 77, 297-322.
2000
Articles/Letters
50. Hagihara K, Watanabe K, Chun J, Yamaguchi Y. (2000). Glypican-4 is an FGF2-binding heparan sulfate proteoglycan expressed in neural precursor cells. Dev. Dyn. 219, 353-367.
49. Contos JJA, Ishii I, Chun J. (2000). Lysophosphatidic acid receptors. Mol. Pharmacol. 58, 1188-1196.
48. Contos JJA, Weiner JA, Fukushima N, Kaushal D, Chun J. (2000). Requirement for the lpA1 lysophosphatidic acid receptor gene in normal suckling behavior. Proc. Natl. Acad. Sci. USA. 97, 13384-13389.
47. Fukushima N, Weiner JA, Chun J. (2000). Lysophosphatidic acid (LPA) is a novel extracellular regulator of cortical neuroblast morphology. Dev. Biol. 228, 6-18.
46. Ishii I, Contos JJA, Fukushima N, Chun J. (2000). Functional comparisonsof the lysophosphatidic acid receptors, LPA1, LPA2 and LPA3 in neuronal cell lines using a retrovirus expression system. Mol. Pharmacol. 58, 895-902.
45. Pompeiano M, Blaschke AJ, Flavell RA, Srinivasan A, Chun J. (2000). Decreased apoptosis in proliferative and postmitotic regions of the caspase 3 deficient embryonic CNS. J. Comp. Neurol. 423,1-12.
44. Contos JJA, Chun J. (2000) Genomic characterization of the lysophosphatidic acid receptor gene, lpA2/Edg4, and identification of a frameshift mutation in a previouslycharacterized cDNA. Genomics 64, 155-169.
43. Gu Y, Sekiguchi J, GaoY, Dikkes P, Frank K, Ferguson D, Hasty P, Chun J, Alt FW. (2000). Defective embryoic neurogenesis in ku, but not DNA-PKcs, deficient mice. Proc. Natl. Acad. Sci., USA. 97, 2668-2673.
Reviews and Book Chapters
42. Chun J. (2000). An alternative view of cell death, DNA breaks and possible rearrangements. Trends in Neurosci. 23, 407-408.
41. Chun J, Weiner JA, Fukushima N, Contos JJA, Zhang G, Kumura Y, Dubin A, Ishii I, Hecht JH, Akita C, Kaushal D. (2000). Neurobiology of receptor-mediated lysophospholipid signaling: From the first lysophospholipid (LP) receptor to roles in nervous system function and development. Ann. N.Y. Acad. Sci. 905, 110-117.
1995-1999
Articles/Letters
40. Marszalek JR, Weiner JA, Farlow SJ, Chun J, Goldstein LSB. (1999). Novel dendritic kinesin sorting identified by different process targeting of two related kinesins: KIF21A and KIF21B. J. Cell Biol. 145, 469-479.
39. Weiner JA, Chun J. (1999). Schwann cell survival mediated by the signaling phospholipid lysophosphatidic acid. Proc. Natl. Acad. Sci. 96, 5233-5238.
38. Dubin AE, Bahnson T, Weiner JA, Fukushima N, Chun J. (1999). Lysophosphatidic acid (LPA) stimulates neurotransmitter-like conductance changes that precede GABA and L-glutamate in early, presumptive cortical neuroblasts. J. Neurosci. 19, 1371-1381.
37. Nagai Y, Onodera O, Chun J, Strittmatter WJ, Burke JR. (1999). Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network. Exp. Neurol. 155, 195-203.
36. Zhang G, Contos JJA, Weiner JA, Fukushima N, Chun J. (1999). Comparative analysis of three murine G-protein coupled receptors activated by sphingosine-1-phosphate. Gene. 227, 89-99.
35. Contos JJA, Chun J. (1998). Complete cDNA sequence, genomic structure and chromosomal localization of the LPA receptor gene, vzg-1/lpA1/Gpcr26. Genomics. 51, 364-378.
34. Weiner JA, Hecht JH, Chun J. (1998) The lysophosphatidic acid receptor gene vzg-1/lpA1/edg-2 is expressed by mature oligodendrocytes during myelination in the postnatal murine brain. J. Comp. Neurol. 398, 587-589.
33. Pompeiano M, Hvala M, Chun J. (1998). Onset of apoptotic DNA fragmentation can precede cell elimination by days in the small intestinal vilus. Cell Death and Diff. 5, 702-709.
32. Fukushima N, Kimura Y, Chun J. (1998). A single receptor encoded by vzg-1/lpa1/edg-2 couples to G-proteins and mediates multiple cellular responses to lysophosphatidic acid (LPA). Proc. Natl. Acad. Sci. USA. 95, 6151-6156.
31. Blaschke AJ, Weiner JA, Chun J. (1998). Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the CNS. J. Comp. Neurol. 396, 39-50.
30. Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS. (1997). D-AKAP2, a novel protein kinase A Anchoring Protein that contains a potential RGS doman. Proc. Natl. Acad. Sci. USA. 94, 11184-11189.
29. McWhirter JR, Goulding M, Weiner J, Chun J, Murre C. (1997). A novel fibroblast growth factor gene expressed in the developing nervous system is a downstream target of the chimeric homeodomain oncoprotein E2A-Pbx1. Development. 124, 3221-3232.
28. Bain G, Engel I, Maandag ECR, te Riele HPJ, Voland JR, Sharp LL, Chun J, Huey B, Pinkel D, Murre C. (1997). E2A deficient mice rapidly develop T cell leukemias. Mol. Cell Biol. 17, 4782-4791.
27. Weiner JA, Chun J. (1997). Maternally-derived immunoglobulin light chain is present in the fetal mammalian CNS. J. Neurosci. 17, 3148-3156.
26. Weiner JA, Chun J. (1997). Png-1, a nervous system-specific zinc finger gene, identifies regions containing postmitotic neurons during mammalian embryonic development. J. Comp Neurol. 381, 130-142.
25. Huang LJ, Durick K, Weiner JA, Chun J, Taylor SS. (1997). Identification of a novel dual specificity protein kinase A anchoring protein that binds both type I and type II regulatory subunits. J. Biol. Chem. 272, 8057-8064.
24. Staley K, Blaschke AJ, Chun J. (1997). Apoptotic DNA fragmentation is detected by a semi-quantitative ligation-mediated PCR of blunt DNA ends. Cell Death and Differen. 4, 66-75.
23. Hecht JH, Weiner JA, Post SR, Chun J. (1996). Ventricular zone gene -1 (Vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. J. Cell Biol. 135, 1071-1083.
22. Chun J, Jaenisch R. (1996). Clonal cell lines produced by birth-date targeting of neocortical neuroblasts using multiple oncogenes transduced by retroviruses. Mol. Cell. Neurosci. 7, 304-321.
21. Blaschke AJ, Staley K, Chun J. (1996). Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development. 122, 1165-1174. (see comment in Neuron 16, 693, 1996).
Reviews and Book Chapters
20. Chun J. (1999). Developmental neurobiology: a genetic Cheshire cat? Cur. Biol. 9, 651-654.
19. Chun J. (1999). Lysophospholipid receptors: Implications for neural signaling. Crit. Rev. Neurobiol. 13, 151-168.
18. Chun J. (1999). The first cloned and identified lysophospholipid (LP) receptor gene, vzg-1: implications for the nervous system and related receptors. Adv. Exp. Med. Biol. 469:357-362.
17. Chun J, Schatz DG. (1999). Developmental neurobiology: alternative “ends” to a familiar story? Curr. Biol. 9, R251-R253.
16. Chun J, Contos JJA, Munroe D. (1999). A growing family of receptor genes for lysophosphatidic acid (LPA) and other lysophospholipids (LPs). Cell Biochem. and Biophys. 30, 213-242.
15. Chun J, Schatz DG. (1999). Rearranging views on neurogenesis: neuronal death in the absence of DNA end-joining proteins. Neuron. 22, 7-10.
14. Chun J. (1998). Detection of cells undergoing programmed cell death using in situ end labeling plus (ISEL+) in Biotechniques book, Apoptosis Detection, CHAPTER 5, pp. 35-45, in “Apoptosis detection and assay methods,” L Zhu and J Chun, eds, BioTechniques Books, Natick, MA.
13. Chun J. (1998). Apoptotic DNA fragmentation detection using ligation mediated PCR (LMPCR) in Biotechniques book, Apopotosis Detection, CHAPTER 4, pp. 23-33, in “Apoptosis detection and assay methods,” L Zhu and J. Chun, eds, BioTechniques Books, Natick, MA.
12. Chun J, Blaschke AJ. (1997). Unit 3.8, Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR. In Current Protocols in Neuroscience, C. Gerfen and R. Mckay, eds. John Wiley and Sons, Inc.
< 1995
Articles/Letters
11. Chun JJM. (1993). A protocol using retrovirally-introduced multiple oncogenes in the production of neuron-like cell lines from the murine central nervous system. NeuroProtocols 3, 214-221.
10. Turka LA, Schatz DG, Oettinger MA, Chun JJM, Gorka C, Lee K, McCormack WT, Thompson CB. (1991). Thymocyte expression of the recombination activating genes RAG-1 and RAG-2 can be terminated by T-cell receptor stimulation in vitro. Science. 253, 778-781.
9. Chun JJM, Schatz DG, Oettinger MA, Jaenisch R, Baltimore D. (1991). The Recombination activating gene-1 (RAG-1) transcript is present in the murine central nervous system. Cell. 64, 189-200.
8. Chun JJM, Shatz CJ. (1989b). The earliest-generated neurons of the cat cerebral cortex: characterization by MAP2 and neurotransmitter immunohistochemistry during fetal life. J. Neurosci. 9, 1648-1667.
7. Chun JJM, Shatz CJ. (1989a). Interstitial cells of the adult neocortical white matter are the remnant of the early generated subplate neuron population. J. Comp. Neurol. 282, 555-569.
6. Chun JJM, Shatz CJ. (1988b). Redistribution of synaptic vesicle antigens is correlated with the disappearance of a transient synaptic zone in the developing cerebral cortex. Neuron. 1, 297-310.
5. Chun JJM, Shatz CJ. (1988a). A fibronectin-like molecule is present in the developing cat cerebral cortex and is correlated with subplate neurons. J. Cell Biol. 106, 857-872.
4. Chun JJM, Nakamura MJ, Shatz CJ. (1987). Transient cells of the developing mammalian telencephalon are peptide-immunoreactive neurons. Nature. 325, 617-620.
Reviews and Book Chapters
3. Chun JJM, Schatz DG. (1993). Recombination activating gene -1 (RAG-1) transcription in the mammalian CNS. Chapter 22. In Neuronal Cell Death and Repair, Vol. 6, A. C. Cuello, ed. Elsevier Science Publishers, Amsterdam.
2. Schatz DG, Chun JJM. (1992). V(D)J recombination and the transgenic brain blues. New Biologist. 4, 188.
1. Shatz CJ, Chun JJM, Luskin MB. (1988). The role of the subplate in the development of the mammalian telencephalon. In Development of the Cerebral Cortex, Vol. 7, A. Peters and E.G. Jones, eds. Plenum publishing corp., New York.
The Chun Lab
ICND 118 - The Scripps Research Institute
10550 N. Torrey Pines Rd., La Jolla, CA 92037
Phone: 858-784-7039; FAX: 858-784-7084

For Scientists
For Nonscientists

Chun Lab Outreach
Donating to Chun Lab

Current Members

Past Members
By Year
By Topic