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Current lab projects:
Multiple Sclerosis: We have discovered a novel signaling mechanism - S1P - affecting the nerve cells that are damaged in MS. Our research is currently focusing on identifying potential therapeutic targets that may slow or halt disease progression.
Reproductive Disorders: Our lab has created transgenic mice with reduced male or female fertility. We are now studying reproduction in these mice with the hope of finding new ways to overcome infertility in men and women.
Alzheimer's and Parkinson's Diseases: Currently, we are investigating the link between human neurodegenerative disorders, particularly AD and PD, and genomic diversity in the brain. This research could lead to a new understanding of how these diseases develop.
Human Childhood Brain Disorders: Much of our research is focused on studying how the brain develops, especially the neocortex. We believe this basic knowledge is important in understanding and treating many developmental brain disorders. Already, this research has uncovered possible factors in several major disorders including: polymicrogyria and microcephaly; Down syndrome; and autism.
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