The Kirill Maretmyanov Laboratory at the Scripps Research Institute Florida

Publications

PubMed

The following articles were published by Kirill Martemyanov, his lab members and his collaborators. You may view the entire article by clicking on the abstract link at the end of the corresponding title. The link will redirect you to the PubMed.gov website.

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2017

 
Spicer TP, Hubbs C, Vaissiere T, Collia D, Rojas C, Kilinc M, Vick K, Madoux F, Baillargeon P, Shumate J, Martemyanov KA, Page DT, Puthanveettil S, Hodder P, Davis R, Miller CA, Scampavia L, Rumbaugh G. (2017) Improved Scalability of Neuron-Based Phenotypic Screening Assays for Therapeutic Discovery in Neuropsychiatric Disorders. Mol Neuropsychiatry 3,141-150. https://doi.org/10.1159/000481731
   
Martemyanov, K.A., Sampath, A.P. (2017) The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease. Ann Rev Vis Sci. 3, 25-51. Pubmed
   
J Biol Chem
Carmon, K.S., Gong, X., Yi, J., Wu, L., Thomas, A., Moore, C.M., Masuho, I., Timson, D.J., Martemyanov, K.A., Liu, Q.J. (2017) LGR5 receptor promotes cell-cell adhesion in stem cells and colon cancer cells via the IQGAP1-Rac1 pathway. J Biol Chem. 292, 14989-15001. Pubmed
   
Neuillé, M., Cao, Y., Caplette, R., Guerrero-Given, D., Thomas, C., Kamasawa, N., Sahel, J.A., Hamel, C.P., Audo, I., Picaud, S., Martemyanov, K.A., Zeitz, C. (2017) LRIT3 Differentially Affects Connectivity and Synaptic Transmission of Cones to ON- and OFF-Bipolar Cells. Invest Opthalmol Vis Sci. 58, 1768-1778. PubMed
   
Wang, Y., Fehlhaber, K.E., Sarria, I., Cao, Y., Ingram, N.T., Guerrero-Given, D., Throesch, B., Baldwin, K., Kamasawa, N., Ohtsuka, T., Sampath, A.P., Martemyanov, K.A. (2017) The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors. Neuron 93, 1359-1374. PubMed
   
Lohmann, K., Masuho, I., Patil, D.N., Baumann, H., Hebert, E., Steinrücke, S., Trujillano, D., Skamangas, N.K., Dobricic, V., Hüning, I., Gillessen-Kaesbach, G., Westenberger, A., Savic-Pavicevic, D., Münchau, A., Oprea, G., Klein, C., Rolfs, A., Martemyanov, K.A.(2017) Novel GNB1 mutations disrupt assembly and function of G protein heterotrimers and cause global developmental delay in humans. Hum Mol Genet. doi: 10.1093/hmg/ddx018. PubMed
   

2016

 
Aguado, C., Orlandi, C., Fajaro-Serrano, A., Gil-Minguez, M., Martemyanov, K.A., Lujan, R. (2016) Cellular and Subcellular Localization of the RGS7/Gβ5/R7BP Complex in the Cerebellar Cortex. Front Neuroanat. 10:114. PubMed
   
Xie, K., Colgan, L.A., Dao, M.T., Muntean, B.S., Sutton, L.P., Orlandi, C., Boye, S.L., Boye, S.E., Shih, C.C., Li, Y., Xu, B., Smith, R.G., Yasuda, R., Martemyanov, K.A. (2016) NF1 is a direct protein effector essential for opioid signaling to Ras in the striatum. Curr. Biol. 26, 2992-3003. (PubMed)
   
Victoria, N.C., Marron, Fernandez de Velasco, E., Ostrovskaya, O., Metzger, S., Xia, Z., Kotecki, L., Benneyworth, M.A., Zink, A.N., Martemyanov, K.A., Wickman, K. (2016) G protein-gated K+ channel ablation in forebrain pyramidal neurons selectively impairs fear learning. Biol. Psychiatry. 80, 796-806. (PubMed)
   
Shamseldin, H.E., Masuho, I., Alenizi, A., Alyamani, S., Patil, D.N., Ibrahim, N., Martemyano, K.A., Alkuraya, F.S. (2016) GNB5 mutation causes a novel neuropsychiatric disorder featuring attention deficit hyperactivity disorder, severely impaired language development and normal cognition. Genome Biol. 17, 195. (PubMed)
   
Sutton, L.P., Ostrovskaya, O., Dao, M., Xie, K., Orlandi, C., Smith, R., Wee, S., Martemyanov, K.A. (2015) Regulator of G-Protein Signaling 7 Regulates Reward Behavior by Controlling Opioid Signaling in the Striatum. Biol. Psychiatry. 80, 235-245. PubMed
   
Science Signaling
Chen, Y., Palczewska, G., Masuho, I., Gao, S., Jin, H., Dong, Z., Gieser, L., Brooks, M.J., Kiser, P.D., Kern, T.S., Martemyanov, K.A., Swaroop, A., Palczewski, K. (2016) Synergistically acting agonists and antagonists of G protein-coupled receptors prevent photoreceptor cell degeneration. Sci. Signal. 9(438):ra74. (PubMed)
   
Masuho, I., Fang, M., Geng, C., Zhang, J., Jiang, H., Özgul, R.K., Yılmaz, D.Y., Yalnızoğlu, D., Yüksel, D., Yarrow, A., Myers, A., Burn, S.C., Crotwell, P.L., Padilla-Lopez, S., Dursun, A., Martemyanov, K.A., Kruer, M.C. (2016) Homozygous GNAL mutation associated with familial childhood-onset generalized dystonia. Neurol. Genet. 2(3):e78. (PubMed)
   
Dos Santos, C.O., Masuho, I., da Silva-Júnior, F.P., Barbosa, E.R., Silva, S.M., Borges, V., Ferraz, H.B., Rocha, M.S., Limongi, J.C., Martemyanov, K.A., de Carvalho Aguiar, P. (2016) Screening of GNAL variants in Brazilian patients with isolated dystonia reveals a novel mutation with partial loss of function. J. Neurol. 263, 665-668. PubMed
   
Sci Reports
Xu, Y., Orlandi, C., Cao, Y., Yang, S., Choi, C.I., Pagadala, V., Birnbaumer, L., Martemyanov, K.A., Vardi, N (2016) The TRPM1 channel in ON-bipolar cells is gated by both the α and the βγ subunits of the G-protein Go. Sci. Rep. 6:20940. PubMed
   
J Biol Chem
Tayou, J., Wang, Q., Jang, G.F., Pronin, A.N., Orlandi, C., Martemyanov, K.A., Crabb, J.W., Slepa,k V.Z. (2016) Regulator of G-protein Signaling 7 (RGS7) can exist in a homo-oligomeric form that is regulated by Gαo and R7-binding protein. J. Biol. Chem. 291, 9133-47. PubMed
   
J neuro
Sarria, I., Orlandi, C., McCall, M.A., Gregg, R.G., Martemyanov, K.A. (2016) Intermolecular Interaction between Anchoring Subunits Specify Subcellular Targeting and Function of RGS Proteins in Retina ON-Bipolar Neurons. J. Neurosci. 36, 2915-2925. PubMed
   
Journal of Biological Chemistry
Muntean, B.S., Martemyanov, K.A. (2016) Association with the Plasma Membrane Is Sufficient for Potentiating Catalytic Activity of Regulators of G Protein Signaling (RGS) Proteins of the R7 Subfamily. J. Biol. Chem. 291, 7195-7204. PubMed
   
bioessays
Salaga, M., Storr, M., Martemyanov, K.A., Fichna, J. (2016) RGS proteins as targets in the treatment of intestinal inflammation and visceral pain: New insights and future perspectives. Biosessays 38, 344-354. PubMed
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2015

 
   
Masuho, I., Ostrovskaya, O., Kramer, G.M., Jones, C.D., Xie, K., Martemyanov, K.A. (2015 ) Distinct profiles of functional discrimination among G proteins determine the actions of G protein-coupled receptors. Sci Signal. 8(405):ra123. PubMed
   
Xie, K., Masuho, I., Shih, C.C., Cao, Y., Sasaki, K., Lai, C.W., Han, P.L., Ueda, H., Dessauer, C.W., Ehrlich, M.E., Xu, B., Willardson, B.M., Martemyanov, K.A. (2015) Stable G protein-effector complexes in striatal neurons: mechanism of assembly and role in neurotransmitter signaling. Elife e10451. Pubmed
   
Cao, Y., Sarria, I., Fehlhaber, K.E., Kamasawa, N., Orlandi, C., James, K.N., Hazen, J.L., Gardner, M.R., Farzan, M., Lee, A., Baker, S., Baldwin, K., Sampath, A.P., Martemyanov, K.A. (2015 )Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision. Neuron 87, 1248-1260. PubMed
   
Masuho, .I, Martemyanov, K.A., Lambert, N.A. (2015) Monitoring G Protein Activation in Cells with BRET. Methods Mol. Biol. 1335, 107-113. PubMed
   
Neuillé, M., Morgans, C.W., Cao, Y., Orhan, E., Michiels, C., Sahel, J.A., Audo, I., Duvoisin, R.M., Martemyanov, K.A., Zeitz, C. (2015) LRIT3 is essential to localize TRPM1 to the dendritic tips of depolarizing bipolar cells and may play a role in cone synapse formation. Eur. J. Neurosci. 42, 1966-1975. PubMed
   
Sarria, I., Pahlberg, J., Cao, Y., Kolesnikov, A.V., Kefalov, V.J., Sampath, A.P., Martemyanov, K.A. (2015) Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior. Elife e06358. PubMed
   
Orlandi, C., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Martemyanov, K.A. (2015) Orphan Receptor GPR158 is an Allosteric Modulator of Regulator of G Protein Signaling 7 (RGS7) Catalytic Activity with Essential Role in Dictating its Expression and Localization in the Brain. J. Biol. Chemi. 290, 13622-13639. PubMed
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2014

 
Kumar, K.R., Martemyanov, K.A., Lohmann, K. (2014) GNAL mutations and dystonia--reply. JAMA Neurol. 71(8):1053-4. PubMed
   
Martemyanov, K.A. (2014) G protein signaling in the retina and beyond: the cogan lecture.. Invest. Opthalmol. Vis. Sci. 55, 8201-07. PubMed
   
Ray, T.A., Heath, K.M., Hasan, N., Noel, J.M., Samuels, I.S., Martemyanov, K.A., Peachey, N.S., McCall, M.A., Gregg, R.G. (2014) GPR179 Is Required for High Sensitivity of the mGluR6 Signaling Cascade in Depolarizing Bipolar Cells. J. Neurosci. 34, 6334-43. PubMed
   
Ostrovskaya, O., Xie, K., Masuho, I., Fajardo-Serrano, A., Lujan, R., Wickman, K., Martemyanov, K.A. (2014) RGS7/Gβ5/R7BP complex regulates synaptic plasticity and memory by modulating hippocampal GABABR-GIRK signaling. Elife 3:e02053. PubMed
   
Kumar, K.R., Lohmann, K., Masuho, I., Miyamoto, R., Ferbert, A., Lohnau, T., Kasten, M., Hagenah, J., Brüggemann, N., Graf, J., Münchau, A., Kostic, V.S., Sue, C.M., Domingo, A.R., Rosales, R.L., Lee, L.V., Freimann, K., Westenberger, A., Mukai, Y., Kawarai, T., Kaj,i R., Klein, C., Martemyanov, K.A., Schmidt, A. (2014) Mutations in GNAL: A Novel Cause of Craniocervical Dystonia. JAMA Neurol. 71(4):490-4. PubMed
   
Wydeven, N., Posokhova, E., Xia, Z., Martemyanov, K.A., Wickman, K. (2014) RGS6, but not RGS4, is the dominant regulator of G protein signaling (RGS) modulator of the parasympathetic regulation of mouse heart rate. J. Biol. Chemi. 289(4):2440-9. PubMed
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2013

 
Posokhova, E., NG, D., Opel, A., Masuho, I., Tinker, A., Biesecker, L.G., Wickman, K., Martemyanvo, K.A. (2013) Essential role of the m2R-RGS6-IKACh pathway in controlling intrinsic heart rate variability. PLoS One 8, e76973 . PubMed
   
Orlandi, C., Cao, Y., Martemyanov, K.A. (2013) Orphan Receptor GPR179 Forms Macromolecular Complexes With Components of Metabotropic Signaling Cascade in Retina ON-Bipolar Neurons. Invest. Opthalmol. Vis. Sci. 54, 7153-61. PubMed
   
Masuho, I., Xie, K., Martemyanov, K.A. (2013) Macromolecular composition dictates receptor and G protein selectivity of regulator of G protein signaling (RGS) 7 and 9-2 protein complexes in living cells. J. Biol. Chem. 288, 25129-42. PubMed
   
Fajardo-Serrano, A., Wydeven, N., Young, D., Watanabe, M., Shigemoto, R., Martemyanov, K.A., Wickman K., Lujan, R. (2103) Association of Rgs7/Gβ5 complexes with girk channels and GABAB receptors in hippocampal CA1 pyramidal neurons. Hippocampus doi: 10.1002/hipo.22161. PubMed
 
Fuchs, T., Saunders-Pullman, R., Masuho, I., San Luciano, M., Raymond, D., Factor, S., Lang, A.E., Liang, T-W, Trosch, R.M., White, S., Ainehsazan, E., Herve, D., Sharma, N., Ehrlich, M.E., Martemyanov, K.A., Bressma, S.B., Ozelius, L.J. (2013) Mutations in GNAL cause primary torsion dystonia. Nat. Genetics 45, 88-92. PubMed
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2012

 
Xie, K., Masuho, I., Brand, C., Dessauer, C.W., Martemyanov, K.A. (2012) The Complex of G Protein Regulator RGS9-2 and Gβ5 Controls Sensitization and Signaling Kinetics of Type 5 Adenylyl Cyclase in the Striatum. Sci. Signal. 5(239):ra63. PubMed
   
Orlandi C., Posokhova E., Masuho I., Ray T.A., Hasan N., Gregg R.G., Martemyanov K.A. (2012) GPR158/179 regulate G protein signaling by controlling localization and activity of the RGS7 complexes. J. Cell. Biol. 197:711-719. PubMed
   
Cao Y., Pahlberg J., Sarria I., Kamasawa N., Sampath A.P., Martemyanov K.A. (2012) Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons. Proc. Natl. Acad. Sci. USA 109:7905-7910. PubMed
 
Xie K., Ge S., Collins V.E., Haynes C.L, Renner K.J., Meisel R.L., Lujan R., Martemyanov K.A. (2012) Gβ5-RGS complexes are gatekeepers of hyperactivity involved in control of multiple neurotransmitter systems. Psychoparmacology 219:823-834. PubMed
   
Terzi D., Cao Y., Agrimaki I., Martemyanov K.A., and Zachariou V. (2012) R7BP Modulates Opiate Analgesia and Tolerance but not Withdrawal. Neuropsychopharmacology 37:1005-1012. PubMed
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2011

 
Xie K. and Martemyanov K.A. (2011) Control of striatal signaling by g protein regulators. Front. Neuroanat. 5:49. PubMed
   
Cao Y., Posokhova E., and Martemyanov K.A. (2011) TRPM1 Forms Complexes with Nyctalopin In Vivo and Accumulates in Postsynaptic Compartment of ON-Bipolar Neurons in mGluR6-Dependent Manner. J. Neurosci. 31:11521-11526. PubMed
   
Gopalakrishna K.N., Doddapuneni K., Boyd K.K., Masuho I, Martemyanov K.A., and Artemyev N.O. (2011) Interaction of Transducin with Uncoordinated 119 Protein (UNC119): Implications for the model of transducin trafficking in rod photoreceptors. J. Biol. Chem. 286: 28954-289546262. PubMed
   
Masuho I., Wakasugi-Masuho H., Posokhova E.N., Patton J.R., and Martemyanov K.A. (2011) Type 5 G protein beta subunit (Gbeta5) controls the interaction of regulator of G protein signaling 9 (RGS9) with membrane anchors. J. Biol. Chem. 286:21806-21813. PubMed
   
Posokhova E., Song H., Belcastro M., Higgins L., Bigley L.R., Michaud N.A., Martemyanov K.A., and Sokolov M. (2011) Disruption of the chaperonin containing TCP-1 function in rods affects multiple protein networks and arrests outer segment morphogenesis. Mol. Cell. Proteom. 10: M110.000570 PubMed
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2010

 
Porter M.Y., Xie K., Pozharski E., Koelle M.R., and Martemyanov K.A. (2010) A conserved protein interaction interface on the type 5 G protein beta subunit controls proteolytic stability and activity of R7 family regulator of G protein signaling proteins. J. Biol. Chem. 285: 41100-41112. PubMed
   
Posokhova E., Wydeven N., Allen K.L., Wickman K., and Martemyanov K.A. (2010) RGS6/Gbeta5 complex accelerates IKACh gating kinetics in atrial myocytes and modulates parasympathetic regulation of heart rate. Circ. Res. 107: 1350-1354 PubMed
   
Cao Y., Kolesnikov A.V., Masuho I., Kefalov V.J., and Martemyanov K.A. (2010) Membrane anchoring subunits specify selective regulation of RGS9-Gbeta5 GAP complex in photoreceptor neurons. J. Neurosci. 30: 13784-13793. PubMed
   
Xie K., Allen K.L., Kourrich S., Colón-Saez J., Thomas, M.J., Wickman K., and Martemyanov K.A. (2010) Gbeta5 recruits R7 RGS proteins to GIRK channels to regulate the timing of neuronal inhibitory signaling. Nat. Neurosci. 13: 661-663. PubMed
   
Panicker L.M., Zhang J.H., Posokhova E., Gastinger M.J., Martemyanov K.A., and Simonds W.F. (2010) Nuclear localization of the G protein beta5/R7-regulator of G protein signaling protein complex is dependent on R7 binding protein. J. Neurochem. 113: 1101-1112 PubMed
   
Posokhova E., Uversky V., and Martemyanov K.A. (2010) Proteomic Identification of Hsc70 as a Mediator of RGS9-2 Degradation by In Vivo Interactome Analysis. J. Prot. Res. 9: 1510-1521. PubMed
   
Roloff A.M., Anderson G.R., Martemyanov K.A., and Thayer S.A. (2010) Homer 1a gates the induction mechanism for endocannabinoid-mediated synaptic plasticity. J. Neurosci. 30: 3072-3081 PubMed
   
Anderson G.R., Cao Y., Davidson S., Truong H.V., Pravetoni M., Thomas M.J., Wickman K., Giesler G.J. Jr., and Martemyanov K.A. (2010) R7BP Complexes With RGS9-2 and RGS7 in the Striatum Differentially Control Motor Learning and Locomotor Responses to Cocaine. Neuropsychopharmacology 35(4):1040-1050. PubMed
   
Masuho I., Celver J., Kovoor A., and Martemyanov K.A. (2010) Membrane Anchor R9AP Potentiates GTPase-accelerating Protein Activity of RGS11/Gbeta5 Complex and Accelerates Inactivation of the mGluR6-Go Signaling. J. Biol. Chem. 285(7): 4781-4787. PubMed
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2009

 
Anderson , G.R., Posokhova E., and Martemyanov K.A. (2009) The R7 RGS protein family: multi-subunit regulators of neuronal G protein signaling. Cell. Biochem. Biophys. 54:33-46. PubMed
   
Martemyanov K.A. and Arshavsky V.Y. (2009) Biology and functions of the RGS9 isoforms. In Progress in Molecular Biology and Translational Science (Fisher, R. Ed.), Elsevier volume 86007: 201-273. PubMed
   
Cao Y., Masuho I., Okawa H., Xie K, Asami J., Kammermeier P., Furukawa T., Inoue Y., Sampath A.P., and Martemyanov K.A. (2009) Retina specific GTPase accelerator RGS11/Gbeta5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons. J. Neurosci. 29:9301-9313. PubMed
   
Anderson G.R., Lujan R., and Martemyanov K.A. (2009) Changes in striatal signaling induce remodeling of RGS complexes containing Gbeta5 and R7BP subunits. Mol. Cell Biol. 11:3033-3044. PubMed
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2008

 
Martemyanov K.A., Krispel C.M., Lishko P.V., Burns M.E., and Arshavsky V.Y. (2008) Functional comparison of RGS9 splice isoforms in a living cell. Proc. Natl. Acad. Sci. USA 105:20988-20993. PubMed
   
Hooks S., Martemyanov K., and Zachariou V. (2008) A role of RGS proteins in drug addiction. Biochem. Pharmacol. 75:76-84. PubMed
   
Kim H.J., Martemyanov K.A., and Thayer S.A. (2008) Human immunodeficiency virus protein Tat induces synapse loss via a reversible process that is distinct from cell death. J. Neurosci. 28:12604-12613. PubMed
   
Cao Y., Song H., Okawa H., Sampath A.P., Sokolov M., and Martemyanov K.A. (2008) Targeting of RGS7/G5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP. J. Neurosci. 28: 10443:10449. PubMed
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2007

 
Anderson G.R., Lujan R., Semenov A., Pravetoni M., Posokhova E.N., Song J.H., Uversky V., Chen C-K., Wickman K., and Martemyanov K.A. (2007) Expression and Localization of RGS9-2/Gbeta5/R7BP Complex In Vivo Is Set by Dynamic Control of Its Constitutive Degradation by Cellular Cysteine Proteases. J. Neurosci. 27:14117-14127. PubMed
   
Song J.H., Song H., Wensel T.G., Sokolov M., and Martemyanov K.A. (2007) Localization and differential interaction of R7 RGS proteins with their membrane anchors R7BP and R9AP in neurons of vertebrate retina. Mol. Cell. Neurosci. 35:311-319. PubMed
   
Anderson G.R., Semenov A., Song J.H., and Martemyanov K.A. (2007) The membrane anchor R7BP controls the proteolytic stability of the striatal specific RGS protein, RGS9-2. J. Biol. Chem. 282(7):4772-4781. PubMed
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2006

 
Song J.H., Waataja J.J., and Martemyanov K.A. (2006) Subcellular targeting of RGS9-2 is controlled by multiple molecular determinants on its membrane anchor, R7BP. J. Biol. Chem. 281(22):15361-15369. PubMed