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Selected Publications since 2000


  1. Akasaki Y, Reicach N, Matsuzaki T, Alvarez-Garcia O, Olmer M, Iwamoto Y, Buxbaum JN, LOTZ MK. Transthyretin deposition in articular cartilage: A novel mechanism in the pathogenesis of osteoarthritis. Arthritis Rheumatol. 2015. [Epub ahead of print].

  2. Yamanaka Y, Ali Faghihi MA, Magistri M, Alvarez-Garcia O, LOTZ M, Wahlestedt C. Antisense RNA controls LRP1 sense transcript expression through interaction with a chromatin-associated protein, HMGB2. Cell Rep S2211-1247, 2015. [Epub ahead of print].

  3. Wang Y, Zhao X, LOTZ M, Terkeltaub R, Liu-Bryan R. Mitrochondrial biogenesis is impaired in osteoarthritic chondrocytes but reversible via peroxisome proliferator-activated receptor-γ coactivator 1α. Arthritis Rheumatol. 2015 May 4. [Epub ahead of print].

  4. López de Figueroa, LOTZ M, Blanco F, Caramés B. Autophagy activation protects from mitochondrial dysfunction in human chondrocytes. Arthritis Rheumatol 67:966-76, 2015.

  5. Hoshiyama Y, Otsuki S, LOTZ MK. Chondrocyte clusters adjacent to sites of cartilage degeneration have characteristics of progenitor cells. J Orthop Res 33:548-55, 2015.

  6. Caramés B, Olmer M, Kiosses WB, LOTZ M. The relationship of autophagy defects and cartilage damage during joint aging in a mouse model. Arthritis Rheumatol, 2015 Feb 23 [Epub ahead of print].

  7. Otabe K, Nakahara H, Hasegawa A, Matsukawa T, Ayabe Fm Onizuka N, Inui , Takada S, Ito Y, Sekiya I, Muneta T, LOTZ MK. Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo. J Orthop Res 33:1-8, 2015.

  8. Zhao X, Petursson F, Viollet B, LOTZ M, Terkeltaub R, Liu-Bryan R. PGC-1a and FOXO3a mediate chondroprotection by AMP-activated Protein Kinase. Arthritis Rheumatol. 2014 Jul 21.

  9. Kato T, Miyaki S, Ishitobi H, Nakamura Y, Nakasa T, LOTZ MK, Ochi M. Exosomes from IL-1b stimulated synovial fibroblasts induce osteoarthritis changes in articular chondrocytes. Arthritis Res Ther 16:R163, 2014.

  10. Alvarez-Garcia O, Rogers NH, Smith RG, LOTZ MK. Palmitate has proapoptotic and proinflammatory effects on articular cartilage and synergizes with interleukin-1. Arthritis Rheumatol 66:1779-88, 2014.

  11. Akasaki Y, Hasegawa A, Saito M, Asahara H, Iwamoto Y, LOTZ MK. Dysregulated FOXO transcription factors in articular cartilage in aging and osteoarthritis. Osteoarthritis Cartilage 22:162-170, 2014.

  12. Shapiro I, Layfield R, LOTZ M, Settembre C, Whitehouse C. Boning up on autophagy. The role of autophagy in skeletal biology. Autophagy 10:1-13, 2013.

  13. Grogan S, Chen X, Sovani S, Taniguchi N, Colwell C Jr, LOTZ M, D'Lima D. Influence of cartilage extacellular matrix molecules on cell phenotype and neocartilage formation. Tissue Eng Part A 20:264-74, 2013.

  14. van Loosdregt J, Spreafico R, Rossetti M, Prakken BJ, LOTZ M, Albani S. Hydroxychloroquine preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: A possible mechanism for therapeutic modulation of T cells. J Allergy Clin Immunol 131:1443-6, 2013.

  15. Grogan SP, Chung PH, Soman P, Chen P, LOTZ MK, Chen S, D'Liima DD. Digital-Micromirror-Device projection printing system for meniscus tissue enginenering. Acta Biomater 9:7218-26, 2013.

  16. Caramés B, Kiosses, WB, Akasaki Y, Brinson D, Koziol J, LOTZ M. Glucosamine activates autophagy in virtro and in vivo. Arth Rheum 65:1843-52, 2013.

  17. LOTZ M, Martel-Pelletier J, Christiansen C, Brandi M-L, Bruyere O, et al. Value of biomarkers in osteoarthritis: current status and perspectives. Ann Rheum Dis 72:1756-63, 2013.

  18. Yoshitaka T, Kawai A, Miyaki S, Numoto K, Kikuta K, Ozaki T, LOTZ M, Asahara H. Analysis of microRNAs expressions in chondrocarsoma. J Ortho Res 31:1992-8, 2013. [Epub ahead of print]

  19. Onizuki N, Ito Y, Takada S, Nakahara H, LOTZ M, Toyama Y, Asahara H. The mohawk homeobox transcription factor regulates the differentiation of tendons, tendon sheaths and volar plates. J Orthop Sci. 2013 Oct 29 [Epub ahead of print].

  20. Nakahara H, Hasegawa A, Otabe K, Ayabe F, Matsukawa T, Onizuka N, Ito Y, LOTZ MK, Asahara H. Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation. Arth Rheum 65:2081-9, 2013.

  21. Petursson F, Husa M, June R, LOTZ M, Terkeltaub T, Liu-Bryan R. Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes. Arth Res Ther 15:R77 [Epub ahead of print]. 2013.

  22. Grogan S, Chen X, Sovani S, Taniguchi N, Colwell C Jr., LOTZ M, D'Lima D. Influence of cartilage extracellular matrix molecules on cell phenotype and neocartilage formation. [Epub ahead of print].

  23. Matsukawa T, Nakahara H, Sakai T, Yonezawa Hiraiwa H, Hamada T, Nakashima M, Ono Y, Ishizuka S, Nakahara H, LOTZ MK, Asahara H. MicroRNA-125b regulates the expression of aggrecanase-1 (ADAMTS-4) in human osteoarthritis chondrocytes. Arth Res Ther 15:R2, 2013.

  24. Hasegawa A, Nakahara H, Asahara H, Kinoshita M, Koziol J, LOTZ MK. Cellular and extracellular matrix changes in anterior cruciate ligament during human knee aging and osteoarthritis. Arthritis Res Ther 15:R29, 2013.

  25. Grogan SP, Duffy S, Pauli C, Koziol JA, Su A, D’Lima DD, LOTZ MK. Zone specific gene expression patterns in articular cartilage. Arthritis Rheum 65:418-28, 2013.

  26. Levy Y, Hasegawa A, Patil S, Koziol J, LOTZ MK, D'Lima D. Histopathological changes in the human posterior cruciate ligament during aging and osteoarthritis. Annals Rheum Dis 72:271-7, 2012.

  27. LOTZ M, Loeser R. Effects of aging on articular cartilage homeostasis. Bone 51:241-8, 2012.

  28. Cui X, Hasegawa A, LOTZ M, D’Lima D. Structured three-dimensional co-culture of mesenchymal stem cells with meniscus cells promotes meniscal phenotype without hypertrophy. Biotechnol Bioeng 109:2369-80, 2012.

  29. Chan EF, Harjanto R, Asahara H, Nozomu I,Masuda K, Bugbee WD, Firestein GS, Hosalkar H, LOTZ M, Sah RL. Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice. Orthop Clin North Am 43:173-85, 2012.

  30. LOTZ M, Caramés B. Autophagy, a new therapeutic target in cartilage injury and osteoarthritis. J Am Acad Orthop Surg 20:261-2, 2012.

  31. Pauli C, Lee M, Bae W, LOTZ M, Bydder G, D’Lima D, Chung C, Du J. Ultrashort-echo time MR Imaging of the patella with bicomponent analysis: Correlation with histopathologic and polarized light microscopic findings. Radiology 264:484-93, 2012.

  32. Cui X, Boland T, D'Lima DD, LOTZ MK. Thermal inkjet printing in Tissue Engineering and regenerative medicine. Recent Pat Drug Deliv Formul 6:149-55, 2012.

  33. Monemdjou R, Vasheghani F, Fahmi H, Perez G, Blati M, Taniguchi N, LOTZ M, St-Arnaud R, Pelletier JP, Martel-Pelletier J, Beier F, Kapoor M. Association of cartilage-specific deletion of peroxisome proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and development in a murine model. Arthritis Rheum 64:1551-61, 2012.

  34. Grogan SP, Sovani S, Pauli C, Chen J, Hartmann A, Colwell CW, LOTZ MK, D’Lima DD. Effects of perfusion and dynamic loading on human neocartilage formation in alginate hydrogels. Tissue Engineering 18:1784-92, 2012.

  35. Cui X, Breitenkamp K, LOTZ M, D'Lima D. Synergistic Action of Fibroblast Growth Factor-2 and Transforming Growth Factor-beta1 Enhances Bioprinted Human Neocartilage Formation. Biotechnol Bioeng 109:2357-88, 2012.

  36. Cui X, Breitenkamp K, Finn MG, LOTZ M, D'Lima D. Direct human cartilage repair using three-dimensional bioprinting technology. Tissue Eng Part A 18:1304-12, 2012.

  37. Levy YD, Hasegawa A, Patil S, Koziol J, LOTZ MK, D’Lima D. Histopathological changes in the human posterior cruciate ligament during aging and osteoarthritis. Ann Rheum Dis 72:271-7, 2012.

  38. Grogan SP, Pauli C, Chen P, Du J, Chung CB, Kong SD, Colwell JR CW, LOTZ M, Jin S, D'Lima DD. In situ tissue engineering using magnetically guided 3D cell patterning. Tissue Eng Part C Methods 18:496-506, 2012. 

  39. LOTZ M. Osteoarthritis year 2011 in review: biology. Osteoarthritis Cartilage 20:192-6, 2012.

  40. Caramés B, Hasegawa A, Taniguchi N, Blanco F, LOTZ M. Autophagy activation by rapamycin reduces severity of experimental osteoarthritis.Ann Rheum Dis 71:575-81, 2012.

  41. Caramés B, Taniguchi N, Seino D, Blanco F, D’Lima DD, LOTZ M. Mechanical injury suppresses autophagy regulators and its pharmacological activation results in chondroprotection. Arthritis Rheum 64:1182-92, 2012.

  42. Taniguchi N, Carames B, Hsu E, Cherqui S, Kawakami Y, LOTZ M. Expression patterns and function of chromatin protein HMGB2 during Mesenchymal stem cell differentiation. J Biol Chem 286:41489-98, 2011.

  43. Hasegawa A, Otsuki S, Pauli C, Miyaki S, Patil S, Steklov N, Kinoshita M, Koziol J, D’Lima DD, LOTZ M. Anterior cruciate ligament changes in human joint in aging and osteoarthritis.  Arthritis Rheum 64:696-704, 2012.

  44. Pauli C, Grogan SP, Patil S, Otsuki S, Koziol J, LOTZ MK, D'Lima DD. Macroscopic and histopathologic analysis of human knee menisci in aging and osteoarthritis. Osteoarthritis Cartilage 19:1132-42, 2011.  

  45. LOTZ M, Caramés B. Autophagy and cartilage homeostasis mechanisms in joint health, aging and osteoarthritis. Nature Rev Rheumatol 7:579-87, 2011.

  46. Terkeltaub R, Yang B, LOTZ M, Liu-Bryan R. Chondrocyte AMP-activated protein kinase activity suppresses matrix degradation responses to inflammatory cytokines IL-1β and TNFα. Arthritis Rhem 63:1928-37, 2011.  

  47. Itou J, Taniguchi N, Oishi I, Kawakami H, LOTZ M, Kawakami Y. HMGB factors are required for posterior digit development through enhancing ß-catenin pathway activity, Dev Dyn 240:1151-62, 2011.  

  48. Schelwies M, Brinson D, Hong Y-H, Lotz M, Wong C-H, Hanson S. Glucosamine-6-sulfamate analogues of heparan sulfate as inhibitors of endosulfatases. ChemBioChem 11:2393-97, 2010.

  49. Otsuki S, Grogan SP, Miyaki S, Kinoshita M, Asahara H, Lotz M. Tissue neogenesis and STRO-1 expression in immature and mature articular cartilage. J Orthop Res 28:96-102, 2010.

  50. Haudenschild DR, Chen J, Pang N, Lotz M, D’Lima DD. Rho kinase-dependent activation of SOX9 in chondrocytes. Arthritis Rheum 62:191-200, 2010.

  51. Bae WC, Payanal MM, Chen AC, Hsieh-Bonassera ND, Ballard BL, Lotz M, Coutts RD, Bugbee WD, Sah RL. Topographic patterns of cartilage lesions in knee osteoarthritis. Cartilage 1:10-19, 2010.

  52. Higashiyama R, Miyaki S, Yamashita S, Yoshitaka T, Lindman G, Ito Y, Sasho T, Takahashi K, Lotz M, Asahara H. Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. Modern Rheumatol 20:11-17, 2010. 

  53. Caramés B, Taniguchi N, Otsuki S, Blanco F, Lotz M. Autophagy is a protective mechanism in normal cartilage and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum, 62:791-01, 2010. 

  54. Oyama Y, Hashiguchi T, Taniguchi T, Tancharoen S, Uchimura T, Biswas KK, Kawahara K, Nitanda T, Umekita Y, Lotz M, Maruyama I. High-mobility group box-1 protein promotes granulomatous nephritis in adenine-induced nephropathy. Lab Invest, 90:853-66, 2010. 

  55. Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, Kato Y, Takemoto F, Nakasa T, Yamashita S, Takada S, Lotz M, Ueno-Kudo H, Asahara H. MicroRNA-140 plays dual roles both in cartilage development and homeostasis. Genes Dev, 24:1173-85, 2010. 

  56. Otsuki S, Hanson SR, Miyaki S, Grogan SP, Kinoshita M, Asahara H, Wong C-H, Lotz M. Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways. Proc Natl Acad Sci USA, 107:10202-07, 2010.  

  57. Haudenschild, D, Chen J, Steklov N, Grogan S, Lotz M, D’Lima DD. Vimentin contributes to changes in chondrocyte stiffness in osteoarthritis. J Orthop Res 20:20-25, 2010. 

  58. Lotz M, Otsuki S, Grogan SP, Sah R, Terkeltaub R, D’Lima D. Cartilage cell clusters. Arthritis Rheum 62:2206-18, 2010.   

  59. Lotz M, Kraus V. Posttraumatic Osteoarthritis: Pathogenesis and pharmacological treatment options. Arthritis Res Ther. 2010 Jun 28;12(3):2110. 

  60. Garcia-Gonzalez A, Lotz M, Ochoa JL. Anti-inflammatory activity of superoxide dismutase obtained from from Debaryomyces hansenii on type II collagen induced arthritis in rats. Rev Invest Clin 61:212-20, 2009.  

  61. Taniguchi N, Caramés B, Ronfani L, Ulmer U, Komiya S, Bianchi ME, Lotz M. Aging-related loss of the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis. Proc Natl Acad Sci U S A 106:1181-6, 2009.  

  62. Steklov N, Srivastava A, Sung KLP, Chen PC, Lotz M, D’Lima DD. Aging-related differences in chondrocyte viscoelastic properties. Mol Cell Biomech 6:113-20, 2009.  

  63. Grogan SP, Miyaki S, Asahara H, D’Lima DD, Lotz M. Mesenchymal progenitor cell markers in human articular cartilage: normal distribution and changes in osteoarthritis. Arthritis Res Ther 11:R85, 2009.

  64. Haudenschild DR, Chen J, Steklov N, Lotz M, D’Lima DD. Characterization of the chondrocyte actin cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli. Mol Cell Biomech 6:135-44, 2009.

  65. Shikhman AR, Brinson DC, Valbracht J, Lotz M. Differential metabolic effects of glucosamine and N-acetylglucosamine in human articular chondrocytes. Osteoarthritis Cartilage 17:1022-8, 2009.  

  66. Miyaki S, Nakasa T, Otsuki S, Grogan SP, Higashiyama R, Inoue A, Kato Y, Sato T, Lotz M, Asahara H. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1 responses. Arthritis Rheum 60:2723-30, 2009.

  67. Ito T, Yadav N, Lee J, Furumatsu T, Yamashita S, Yoshida K, Taniguchi N, Hashimoto M, Tsuchiya M, Ozaki T, Lotz M, Bedford MT, Asahara H. Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. BMC Dev Biol 9:47, 2009.

  68. Taniguchi N, Caramés B, Kawakami Y, Amendt BA, Komiya S, Lotz M. Chromatin protein HMGB2 regulates articular cartilage surface maintenance via beta-catenin pathways. Proc Natl Acad Sci U S A 106:16817-22, 2009.

  69. Temple-Wong MM, Bae WC, Chen MQ, Bugbee WD, Amiel D, Coutts RD, Lotz M, Sah RL. Biomechanical, structural, and biochemical indices of degenerative and osteoarthritic deterioration of adult human articular cartilage of the femoral condyle. Osteoarthritis Cartilage 17:1469-76, 2009.

  70. Otsuki S, Nakajima M, Lotz M, Kinoshita M. Hyaluronic acid and chondroitin sulfate content of osteoarthritic human knee cartilage: site-specific correlation with weight-bearing force based on femorotibial angle measurement. J Orthop Res 26:1194-8, 2008.

  71. Otsuki S, Brinson DC, Creighton L, Kinoshita M, Sah RL, D’Lima D, Lotz M. The effect of glycosaminoglycan loss on chondrocyte viability: a study on porcine cartilage explants. Arthritis Rheum 58:1076-85, 2008.

  72. Grogan SP, Olee T, Hiraoka K, Lotz M. Repression of chondrogenesis through binding of notch signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site. Arthritis Rheum 58:2754-63, 2008.

  73. Otsuki S, Taniguchi N, Grogan SP, D’Lima D, Kinoshita M, Lotz M. Expression of novel extracellular sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage. Arthritis Res Ther 10:R61, 2008.

  74. Wong BL, Bae WC, Chun J, Gratz KR, Lotz M, Sah RL. Biomechanics of cartilage articulation: effects of lubrication and degeneration on shear deformation. Arthritis Rheum 58:2065-74, 2008.

  75.  Haudenschild DR, Nguyen B, Chen J, D’Lima DD, Lotz M. Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes. Arthritis Rheum 58:2735-42, 2008.

  76. Mishima Y, Lotz M. Chemotaxis of human articular chondrocytes and mesenchymal stem cells. J Orthop Res 26:1407-12, 2008.

  77. Haudenschild DR, D’Lima DD, Lotz M. Dynamic compression of chondrocytes induces a Rho kinase-dependent reorganization of the actin cytoskeleton. Biorheology, 45:219-228, 2008.

  78. Taniguchi N, Yoshida K, Ito T, Tsuda M, Mishima Y, Furumatsu T, Ronfani L, Abeyama K, Kawahara K, Komiya S, Maruyama I, Lotz M, Bianchi ME, Asahara H. Stage-specific secretion of HMGB1 in cartilage regulates endochondral ossification. Mol Cell Biol 27:5650-63, 2007.

  79. Temple MM, Bae WC, Chen MQ, Lotz M, Amiel D, Coutts RD, Sah RL. Age- and site-associated biomechanical weakening of human articular cartilage of the femoral condyle. Osteoarthritis Cartilage 15:1042-52, 2007.

  80. Lotz M. Nitric oxide and other radicals in the pathogenesis of osteoarthritis. In: Osteoarthritis, Inflammation and Degradation: A Continuum. Buckwalter J, Lotz M, Stoltz JF [Eds.] IOS Press, p. 182-91, 2007.

  81. Stoltz JF, Lotz M, Buckwalter J. Cartilage engineering. In: Osteoarthritis, Inflammation and Degradation: A Continuum. Buckwalter J, Lotz M, Stoltz JF [Eds.] IOS Press, p. 280-86, 2007.

  82. Buckwalter J, Lotz M, Stoltz JF. Therapeutics and osteoarthritis. In: Osteoarthritis, Inflammation and Degradation: A Continuum. Buckwalter J, LOTZ M, Stoltz JF [Eds.] IOS Press, p. 287-98, 2007.

  83. D'Lima D, Hermida J, Hashimoto S, Colwell C, Lotz M. Caspase inhibitors reduce severity of cartilage lesions in experimental osteoarthritis. Arthritis Rheum 54:1814-21, 2006.

  84. Hiraoka K, Grogan S, Olee T, Lotz M. Mesenchymal progenitor cells in adult human articular cartilage. Biorheology 43:447-54, 2006.

  85. Shikhman AR, Amiel D, D’Lima D, Hwang SB, Hu C, Xu A, Hashimoto S, Kobayashi K, Sasho T, Lotz M. Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis. Ann Rheum Dis 64:89-94, 2005.

  86. Kinney RC, Schwartz Z, Week K, Lotz M, Boyan BD. Human articular chondrocytes exhibit sexual dimorphism in their responses to 17beta-estradiol. Osteoarthritis Cartilage 13:330-7, 2005.

  87. Kawakami Y, Tsuda M, Takahashi S, Taniguchi N, Esteban CR, Zemmyo M, Furumatsu T, Lotz M, Belmonte JC, Asahara H. Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association with Sox9. Proc Natl Acad Sci U S A 102:2414-9, 2005.

  88. Cecil DL, Johnson K, Rediske J, Lotz M, Schmidt AM, Terkeltaub R. Inflammation-induced chondrocyte hypertrophy is driven by receptor for advanced glycation end products. J Immunol 175:8296-302, 2005.

  89. Daouti S, Latario B, Nagulapalli S, Buxton F, Uziel-Fusi S, Chirn GW, Bodian D, Song C, Labow M, Lotz M, Quintavalla J, Kumar C. Development of comprehensive functional genomic screens to identify novel mediators of osteoarthritis. Osteoarthritis Cartilage 13:508-18, 2005.

  90. Shikhman AR, Brinson DC, Lotz M. Distinct pathways regulate facilitated glucose transport in human articular chondrocytes during anabolic and catabolic responses. Am J Physiol Endocrinol Metab 286:E980-5, 2004.

  91. Kühn K, D’Lima DD, Hashimoto S, Lotz M. Cell death in cartilage. Osteoarthritis Cartilage 12:1-16, 2004.

  92. Alsalameh S, Amin R, Gemba T, Lotz M. Identification of mesenchymal progenitor cells in normal and osteoarthritic human articular cartilage. Arthritis Rheum 50:1522-32, 2004.

  93. D'Lima DD, Kuhn K, Lotz M. Detection of apoptosis in cartilage in situ and in isolated chondrocytes. Methods Mol Med 100:275-90, 2004.

  94. Sen M, Cheng YH, Goldring MB, Lotz M, Carson DA. WISP3-dependent regulation of type II collagen and aggrecan production in chondrocytes. Arthritis Rheum 50:488-97, 2004.

  95. D’Lima D, Lotz M, Colwell CW Jr. Cartilage mechanical properties after injury. J ASTM Intl 67-76, 2004.

  96. D’Lima DD, Bergula A, Chen PC, Colwell CW Jr, Lotz M. Age related differences in chondrocyte viability and biosynthetic response to mechanical injury. J ASTM Intl 77–83, 2004.

  97. Lotz M. Neuropeptides, free radicals and nitric oxide. In: Rheumatology, 3rd Edition. Hochberg M et al [Eds.]. Keyword Publishing Services Ltd, Essex UK, 2003.

  98. Kühn K, Shikhman AR, Lotz M. Role of nitric oxide, reactive oxygen species, and p38 MAP kinase in the regulation of human chondrocyte apoptosis. J Cell Physiol 197:379-87, 2003.

  99. Zemmyo M, Meharra EJ, Kühn K, Creighton-Achermann L, Lotz M. Accelerated, aging-dependent development of osteoarthritis in alpha 1 integrin-deficient mice. Arthritis Rheum 48:2873-80, 2003.

  100. Kühn K, Lotz M. Mechanisms of sodium nitroprusside-induced death in human chondrocytes. Rheumatol Intl 23:241-7, 2003.

  101. Seitz M, Valbracht J, Quach J, Lotz M. Gold sodium thiomalate and chloroquine inhibit cytokine production in monocytic THP-1 cells through distinct transcriptional and posttranslational mechanisms. J Clin Immunol 23:477-84, 2003.

  102. Yamada K, Healy R, Amiel D, Lotz M, Coutts R. Subchondral bone of the human knee joint in aging and osteoarthritis. Osteoarthritis Cartilage 10:360-9, 2002.

  103. Hashimoto S, Creighton-Achermann L, Takahashi K, Amiel D, Coutts RD, Lotz M. Development and regulation of osteophyte formation during experimental osteoarthritis. Osteoarthritis Cartilage 10:180-7, 2002.

  104. Gemba T, Valbracht J, Alsalameh S, Lotz M. Focal adhesion kinase and mitogen-activated protein kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragment. J Biol Chem 277:907-11, 2002.

  105. Jin G, Sah RL, Li YS, Lotz M, Shyy JY, Chien S. Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes. J Orthop Res 18:899-908, 2001.

  106. Lotz M. Cytokines and their Receptors. In: Arthritis and Allied Conditions. Koopman W. [Ed.] Lippincott Williams & Wilkins, New York, 436-77, 2001.

  107. Johansen JS, Olee T, Price PA, Hashimoto S, Ochs RL, Lotz M. Regulation of YKL-40 production by human articular chondrocytes. Arthritis Rheum 44:826-37, 2001.

  108. Shikhman AR, Kühn K, Alaaeddine N, Lotz M. N-acetylglucosamine prevents IL-1 beta-mediated activation of human chondrocytes. J Immunol 166:5155-60, 2001.

  109. Liu J, Shikhman AR, Lotz MK, Wong CH. Hexosaminidase inhibitors as new drug candidates for the therapy of osteoarthritis. Chem Biol 8:701-11, 2001.

  110. Alaaeddine N, Olee T, Hashimoto S, Creighton-Achermann L, Lotz M. Production of the chemokine RANTES by articular chondrocytes and role in cartilage degradation. Arthritis Rheum 44:1633-43, 2001.

  111. Kühn K, Lotz M. Regulation of CD95 (Fas/Apo-1)-induced apoptosis in human chondrocytes. Arthritis Rheum 44:1644-53, 2001.

  112. Lotz M. Cytokines in cartilage injury and repair. Clin Orthop Relat Res 391:S108-15, 2001.

  113. Kobayashi K, Mishima H, Hashimoto S, Goomer RS, Harwood FL, Lotz M, Moriya H, Amiel D. Chondrocyte apoptosis and regional differential expression of nitric oxide in the medial meniscus following partial menisectomy. J Orthop Res 19:802-8, 2001.

  114. Komuro H, Olee T, Kühn K, Quach J, Brinson DC, Shikhman A, Valbracht J, Creighton-Achermann L, Lotz M. The osteoprotegerin/receptor activator of nuclear factor kappaB/receptor activator of nuclear factor kappaB ligand system in cartilage. Arthritis Rheum 44:2768-76, 2001.

  115. Shikhman AR, Brinson DC, Valbracht J, Lotz M. Cytokine regulation of facilitated glucose transport in human articular chondrocytes. J Immunol 167:7001-8, 2001.

  116. Takahashi K, Hashimoto S, Kubo T, Hirasawa Y, Lotz M, Amiel D. Hyaluronan suppressed nitric oxide production in the meniscus and synovium of rabbit osteoarthritis model. J Orthop Res 19:500-3, 2001.

  117. D’Lima DD, Hashimoto S, Chen PC, Colwell CW Jr, Lotz M. Human chondrocyte apoptosis in response to mechanical injury. Osteoarthritis Cartilage 9:712-9, 2001.

  118. D'Lima DD, Hashimoto S, Chen PC, Colwell CW Jr, Lotz M. Impact of mechanical trauma on matrix and cells. Clin Orthop Relat Res 391:S90-9, 2001.

  119. D’Lima DD, Hashimoto S, Chen PC, Lotz M, Colwell CW Jr. Cartilage injury induces chondrocyte apoptosis. J Bone Joint Surg Am 83-A Suppl:19-21, 2001.

  120. D’Lima DD, Hashimoto S, Chen PC, Lotz M, Colwell CW Jr. In vitro and in vivo models of cartilage injury. J Bone Joint Surg Am 83-A Suppl 2:22-24, 2001.

  121. D’Lima DD, Hashimoto S, Chen PC, Lotz M, Colwell CW Jr. Prevention of chondrocyte apoptosis. J Bone Joint Surg 83-A Suppl 2:25-6, 2001.

  122. Johnson K, Hashimoto S, Lotz M, Pritzker K, Goding J, Terkeltaub R. Up-regulated expression of the phosphodiesterase nucleotide pyrophosphatase family member PC-1 is a marker and pathogenic factor for knee meniscal cartilage matrix calcification. Arthritis Rheum 44:1071-81, 2001.

  123. Colwell CW Jr, D'Lima DD, Hoenecke HR, Fronek J, Pulido P, Morris BA, Chung C, Resnick D, Lotz M. In vivo changes after mechanical injury. Clin Orthop Relat Res 391:S116-23, 2001.

  124. Johnson K, Hashimoto S, Lotz M, Pritzker K, Terkeltaub R. Interleukin-1 induces pro-mineralizing activity of cartilage tissue transglutaminase and factor XIIIa. Am J Pathol 159:149-63, 2001.

  125. Kühn K, Hashimoto S, Lotz M. IL-1 beta protects human chondrocytes from CD95-induced apoptosis. J Immunol 164:2233-9, 2000.

  126. Shikhman AR, Brinson DC, Lotz M. Profile of glycosaminoglycan-degrading glycosides and glycoside sulfatases secreted by human articular chondrocytes in homeostasis and inflammation. Arthritis Rheum 43:1307-14, 2000.

  127. Dudler J, Renggli-Zulliger N, Busso N, Lotz M, So A. Effect of interleukin-17 on proteoglycan degradation in murine knee joints. Ann Rheum Dis 59:529-32, 2000.

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