My research interest is applying protein crystallographic techniques to understanding the mode of regulation and activity of key proteins implicated in human diseases.

Recent Publications:

Horsman, G.P., Bhowmik, S., Seah, S.Y.K., Kumar, P., Bolin, J.T., and Eltis, L.D. (2007). The tautomeric half-reaction of BphD, a C-C bond hydrolase: kinetic and structural evidence supporting a key role for Histidine 265 of the catalytic triad. J. Biol. Chem., 282(27):19894-904.

Bhowmik, S., Horsman, G.P., Bolin, J.T., and Eltis, L.D. (2007). Molecular basis for inhibition of BphD, a C-C bond hydrolase involved in PCB degradation: large 3-substituents prevent tautomerization. J. Biol. Chem., 282(50): 36377-85.