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The living cell is home to thousands of molecular machines that perform an astounding array of functions, each machine playing out one or more specific roles that are directly involved in the cell's survival. These nanoparticles are generally made up of one or more copies of a single or even dozens of different proteins, and can vary greatly in size and shape.Our research focuses on the structural characterization of these biological assemblies through the use of cryo-electron microscopy (cryoEM). Computational reconstruction of the cellular macromolecules imaged in the microscope enable us to explore their architecture and the manner in which they carry out their roles in biological processes.