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Circadian clocks enable organisms to keep track of the time of day and to adjust their physiology to recurring, and therefore predictable, daily changes in the external environment, including food availability.  Our work and others’ have demonstrated that circadian clocks are critical regulators of mammalian metabolic physiology: epidemiological evidence shows that shift workers are at increased risk of metabolic disease and genetic and biochemical studies have shown that clocks in the liver, muscle and pancreas directly modulate metabolic processes to regulate glucose production and utilization.  We are studying the molecular basis for the circadian control of metabolism to enable novel therapies to treat metabolic disease.