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The Kodadek Lab



Erharuyi O., Simanski S. McEnaney P.J., Kodadek T. (2018) Screening one bead one compound libraries against serum using a flow cytometer: Determination of the minimum antibody concentration required for ligand discovery. Bioorg Med Chem Lett. Epub ahead of print.

Hoang NT., Kodadek T. (2018) Solid-Phase Synthesis of B-amino Ketones Via DNA-Compatible Organocatalytic Mannich Reactions. ACS Comb Sci. 12:20(2):55-60.

Pels K., Dickson P., An H., Kodadek T. (2018) DNA-compatible solid-phase combinatorial synthesis of B-cyanoacrylamides and related electrophiles. ACS Comb Sci. 12:20(2):61-69.

Kodadek T. (2017) Another One (of the "Undruggable" Targets) Bites the Dust: Discovery of a Potent and Selective Inhibitor of the Histone Acetyl Transferase p300/CBP. Biochemistry. 13;57(6):899-900.

Koesema E., Kodadek T. (2017) Global analysis of gene expression mediated by OX1 orexin receptor signaling in a hypothalamic cell line. Plos One. 12(11):e0188082.

Wu Hao, An H, Mo S, Kodadek T. (2017) Asymmetric Synthesis of Vinylogous β-Amino Acids and Their Incorporation Into Mixed Backbone Oligomers. Org Biomol Chem. 15(15):3255-3264.

Trader DJ, Simanski S, Dickson P, Kodadek T. (2017) Establishment of a suite of assays that support the discovery of proteasome stimulators. Biochim Biophys Acta. 1861(4):892-899.

Mendes KR, Malone ML, Ndungu JM, Suponitsky-Kroyter I, Cavett VJ, McEnaney PJ, MacConnell AB, Doran TM, Ronacher K, Stanley K, Utset O, Walzl G, Paegel BM, Kodadek T. (2017) High-throughput Identification of DNA-Encoded IgG Ligands that Distinguish Active and Latent Mycobacterium tuberculosis Infections. ACS Chem Biol. 12(1):234-243.


Wu H, Mousseau G, Mediouni S, Valente ST, Kodadek T. (2016) Cell-Permeable Peptides Containing Cycloalanine Residues. Angew Chem Int Ed Engl. 55(41):12637-42.

Wu SY, Nin DS, Lee AY, Simanski S, Kodadek T, Chiang CM. (2016) BRD4 Phosphorylation Regulates HPV E2-Mediated Viral Transcription, Origin Replication, and Cellular MMP-9 Expression. Cell Rep. 16(6):1733-48.

Doran TM, Morimoto J, Simanski S, Koesema EJ, Clark LF, Pels K, Stoops SL, Pugliese A, Skyler JS, Kodadek T. (2016) Discovery of Phosphorylated Peripherin as a Major Humoral Autoantigen in Type 1 Diabetes Mellitus. Cell Chem. Biol. 23(5):618-28.

Gearhart TL, Montelaro RC, Schurdak ME, Pilcher CD, Rinaldo CR, Kodadek T, Park Y, Islam K, Yurko R, Marques ET Jr, Burke DS. (2016) Selection of a potential diagnostic biomarker for HIV infection from a random library of non-biological synthetic peptoid oligomers. J Immunol Methods. 435:85-9.

Sarma BK, Liu X, Kodadek T. (2016) Identification of selective covalent inhibitors of platelet activating factor acetylhydrolase 1B2 from the screening of an oxadiazolone-capped peptoid-azapeptoid hybrid library. Bioorg. Med Chem 24(17):3953-63.

Doran TM, Sarkar M, Kodadek T. (2016) Chemical Tools to Monitor and Manipulate Adaptive Immune Responses. J Am Chem Soc. 138(19):6076-94.

Clark LF, Kodadek T. (2016) The Immune System and Neuroinflammation as Potential Sources of Blood-Based Biomarkers for Alzheimer's Disease, Parkinson's Disease, and Huntington's Disease. ACS Chem Neurosci. 7(5):520-7.

Kodadek T, McEnaney PJ. (2016) Towards vast libraries of scaffold-diverse, conformationally constrained oligomers. Chem Commun (Camb.) 52(36):6038-59.

Sarkar M, Liu Y, Qi J, Peng H, Morimoto J, Rader C, Chiorazzi N, Kodadek T. (2016) Targeting Stereotyped B Cell Receptors from Chronic Lymphocytic Leukemia Patients with Synthetic Antigen Surrogates. J Biol Chem. 291(14):7558-70.


Clark LF, Kodadek T. (2015) And then there were two. Elife. Dec 30;4.

Doran TM, Morimoto J, Simanski S, McEnaney PJ, Kodadek T. (2015) Reliable diagnosis of murine type 1 diabetes using a panel of autoantigens and "antigen surrogates" mounted onto a liquid array. Mol Biosyst. 11(11):3156-63.

Mendes K, Ndungu JM, Clark LF, Kodadek T. (2015) Optimization of the Magnetic Recovery of Hits from One-Bead-One-Compound Library Screens. ACS Comb Sci. 17(9):506-17.

Li X, Patterson JT, Sarkar M, Pedzisa L, Kodadek T, Roush WR, Rader C. (2015) Site-Specific Dual Antibody Conjugation via Engineered Cysteine and Selenocysteine Residues. Bioconjug Chem. 26(11):2243-8.

Doran TM, Gao Y, Simanski S, McEnaney P, Kodadek T. (2015) High affinity binding of conformationally constrained synthetic oligomers to an antigen-specific antibody: Discovery of a diagnostically useful synthetic ligand for murine Type 1 diabetes autoantibodies. Bioorg Med Chem Lett. 25(21):4910-7.

Morimoto J, Kodadek T. (2015) Synthesis of a large library of macrocyclic peptides containing multiple and diverse N-alkylated residues. Mol Biosyst. 11(10):2770-9.

Trader DJ, Simanski S, Kodadek T. (2015) A reversible and highly selective inhibitor of the proteasomal ubiquitin receptor Rpn13 is toxic to multiple myeloma cells. J. Amer. Chem. Soc. 137(19):6312-9.

Pels K, Kodadek T. (2015) Solid-phase synthesis of diverse peptide tertiary amides by reductive amination. ACS Comb Sci17(3):152-5.

Gao, Y. and Kodadek, T. (2015) Direct comparison of linear and macrocyclic compounds as a source of protein ligands. ACS Comb. Sci. 17(3):190-5.

Cravatt BF, Kodadek T. (2015) Editorial overview: Omics: Methods to monitor and manipulate biological systems: recent advances in "omics." Curr Opin Chem Biol.

Doran, T.M., Simanski, S. and Kodadek, T. (2015) Discovery of native autoantigens via antigen surrogate technology: Application to type 1 diabetes. ACS Chem. Biol. 10(2):401-12.

Sarkar, M., Liu, Y., Morimoto, J., Peng, H., Aquino, C., Rader, C., Chiorazzi, N. and Kodadek, T. (2015) Recognition of antigen-specific B cell receptors from chronic lymphocytic leukemia patients by synthetic antigen surrogates. Chem & Biol. 21, 21(12):1670-9.

Gao, Y., Amar, S., Pahwa, S., Fields, G. and Kodadek, T. (2015) Rapid lead discovery through iterative screening of one bead one compound libraries. ACS Comb. Sci. 17(1):49-59.


Sarma BK, Liu X, Wu H, Gao Y, Kodadek T. (2014) Solid phase synthesis of 1,3,4-oxadiazin-5 (6R)-one and 1,3,4-oxadiazol-2-one scaffolds from acyl hydrazides. Org Biomol Chem. 12, 59-63.

Morimoto J, Sarkar M, Kenrick S, Kodadek T. (2014) Dextran as a Generally Applicable Multivalent Scaffold for Improving Immunoglobulin-Binding Affinities of Peptide and Peptidomimetic Ligands. Bioconjug Chem. 25, 1479-1491.

Kodadek T. (2014) Chemical tools to monitor and manipulate the adaptive immune system. Chem Biol. 21(9):1066-74.

Suwal S, Kodadek T. (2014) Solid-phase synthesis of peptoid-like oligomers containing diverse diketopiperazine units. Org Biomol Chem. 12(31):5831-4.

Doran TM, Gao Y, Mendes K, Dean S, Simanski S, Kodadek T. (2014) Utility of redundant combinatorial libraries in distinguishing high and low quality screening hits. ACS Comb Sci. 16(6):259-70.

Vanderstichele H, Kodadek T. (2014) Roadblocks for integration of novel biomarker concepts into clinical routine: the peptoid approach.  Alzheimers Res Ther. 6(2):23.

Gao Y, Kodadek T. (2014) Split-and-pool synthesis and characterization of peptide tertiary amide library. J Vis Exp. (88):e51299.

Quan J, Lakhanpal A, Reddy MM, Zaman S, Li QZ, German DC, Olsen NJ, Kodadek T, Karp DR. (2014) Discovery of biomarkers for systemic lupus erythematosus using a library of synthetic autoantigen surrogates. J Immunol Methods. 402(1-2):23-34.

Doran TM, Kodadek T. (2014) A liquid array platform for the multiplexed analysis of synthetic molecule-protein interactions. ACS Chem Biol. 9(2):339-46.


Kodadek T. (2013) A jack of all trades to combat drug-resistant Gram-negative bacteria. Chem Biol. 20(10):1202-3.

Rzuczek SG, Gao Y, Tang ZZ, Thornton CA, Kodadek T, Disney MD. (2013) Features of modularly assembled compounds that impart bioactivity against an RNA target.  ACS Chem Biol. 8(10):2312-21

Clark, L.F. and Kodadek, T. (2013) Advances in blood-based protein biomarkers for Alzheimer’s disease. Alzheimer’s Research & Therapy 5, 18-25.

Sarkar, M., Pascal, B.D., Steckler, C., Micalizio, G.C., Kodadek, T. and Chalmers, M.J. (2013) Decoding split and pool combinatorial libraries with electron transfer dissociation tandem mass spectrometry. J. Amer. Soc. Mass Spec. 24, 1026-1036.

Gao, Y. and Kodadek, T. (2013) Synthesis and Screening of Stereochemically Diverse Combinatorial Libraries of Conformationally Restrained Peptide Tertiary Amides. Chem. & Biol. 20, 360-369.

Raveendra, B., Hao, W., Baccala, R., Reddy, M.M., Schilke, J., Bennett, J.L., Theofilopoulos, A.N. and Kodadek, T. (2013) Discovery of peptoid ligands for anti-Aquaporin 4 antibodies. Chem. & Biol. 20, 351-359

Suwal, S. and Kodadek, T. (2013) Synthesis of Libraries of Peptidomimetic Compounds Containing A 2-Oxopiperazine Unit In The Main Chain. Org. Biomol. Chem. 11, 2088 – 2092.


Sarma, B.K. and Kodadek, T. (2012) Sub-Monomer Synthesis of A Hybrid Peptoid-Azapeptoid Library. ACS Comb. Sci. 14, 558-564.

Liu, X. Dix, M., Speers, A.E., Bachovchin, D.A., Zuhl, A.M., Cravatt, B.F. and Kodadek, T. (2012) Rapid Development of a Potent Photo-Triggered Inhibitor of the Serine Hydrolase RBBP9. ChemBioChem. 13, 2082-2093.

Simpson, L. and Kodadek, T. (2012) A cleavable scaffold strategy for the synthesis of one-bead one-compound cyclic peptoid libraries that can be sequenced by tandem mass spectrometry. Tet.Lett. 53, 2341-2344.

Udugamasooriya DG, Kodadek T. (2012) On-Bead Two-Color (OBTC) Cell Screen for Direct Identification of Highly Selective Cell Surface Receptor Ligands. Curr Protoc Chem Biol. 4:35-48.

Aditya, A. and Kodadek, T. (2012) Incorporation of heterocycles into the backbone of peptoids to generate diverse peptoid-inspired one bead one compound libraries. ACS Comb. Sci. 14, 164-169.


Aquino, C., Sarkar, M., Chalmers, M.J., Mendes, K., Kodadek, T. and Micalizio, G. (2011) A Biomimetic polyketide-inspired approach to small molecule ligand discovery. Nature Chemistry 4, 99-104.

Chen X, Wu J, Luo Y, Liang X, Supnet C, Kim MW, Lotz GP, Yang G, Muchowski PJ, Kodadek T, Bezprozvanny I. (2014) Expanded polyglutamine-binding peptoid as a novel therapeutic agent for treatment of Huntington's disease. Chem Biol. 18(9):1113-25.

Mendes, K. and Kodadek, T. (2011) PDZ dimerization brings proteins together. Chem. & Biol. 18, 1071-1072.

Sarma, B.K., Yousufuddin, M. and Kodadek, T. (2011) Acyl hydrazides as peptoid sub-monomers. Chem. Comm 47, 10590-10592.

Cai, D., Lee, A.Y., Chiang, C.-M. and Kodadek, T. (2011) Peptoid ligands that bind selectively to phosphoproteins. Bioorg. Med. Chem. Lett. 21, 4960-4964.

Kodadek, T. (2011) The rise, fall and reinvention of combinatorial chemistry. Chem. Comm. 47, 9757-9763.

Reddy, M.M., Wilson, R., Wilson, J., Connell, S., Gocke, A., Hynan, L., German, D. and Kodadek, T. (2011) Identification of candidate IgG biomarkers for Alzheimer’s disease via combinatorial library screening. Cell 144, 132-142.


Kodadek T, Cai D, (2010) Chemistry and biology of orexin signaling. Mol Biosyst. 6(8):1366-75

Kodadek T. (2010) Synthetic receptors with antibody-like binding affinities. Curr Opin Chem Biol. 14(6):713-20.

Kodadek T. (2010) Development of antibody surrogates for the treatment of cancers and autoimmune disease. Curr Opin Chem Biol. 14(6):721-7.

Astle, JM, Simpson LS, Huang Y. Reddy, MM, Wilson, R, Connell S, Wilson J, Kodadek T., (2010)  Seamless bead to microarray screening:  rapid identification of teh highest affinity protein ligands from large combinatorial librairies.  Chem Bio 17(1):38-45.

Lee, J., Reddy, M.M. and Kodadek, T. (2010)  Discovery of an orexin receptor positive potentiator.  Chem Sci. 1, 48-54.

Lee, J., Udugamasooriya, D.G., Lim, H.-S. and Kodadek, T. (2010) Potent and selective photo-inactivation of proteins with peptoid-ruthenium conjugates. Nature Chem. Biol. 6, 258-260.

Kodadek, T. (2010) Rethinking screening. Nature Chem. Biol. 6, 162-165.


Gocke, A. R., Udugamasooriya, D.G., Archer, C.T., Lee, J. and Kodadek, T. (2009) Isolation of antagonists of antigen-specific autoimmune T cell proliferation. Chem. & Biol. 16, 1133-1139.

Chan, Y.-C., Wu, S.-Y., Lim, H.-S., Chiang, C.-M. and Kodadek, T. (2009) Non-proteolytic regulation of p53-mediated transcription through destabilization of the activator-promoter complex by the proteasomal ATPases. J. Biol. Chem. 284, In press.

Qi, X., Astle, J. and Kodadek, T. (2009) Rapid identification of orexin receptor ligands using cell-based screening accelerated with magnetic beads. Molecular BioSystems 5, In press.

Liu, B. and Kodadek, T. (2009) Investigating the Cellular Permeability of DNA-binding Pyrrole-Imidazole Polyamides. J. Med. Chem. 52, 4604-4612.

Lim, H.-S., Reddy, M.M., Xiao, X., Wilson, J., Wilson, R., Connell, S. and Kodadek, T. (2009) Rapid identification of improved protein ligands using peptoid microarrays. Bioorganic Med. Chem. Lett. 19, 3866-3869.

Zuckermann, R.N. and Kodadek, T. (2009) Peptoids as potential therapeutics. Curr. Opin. Mol. Therapeutics. 11, 299-307.

Simpson, L.S., Burdine, L., Dutta, A.K., Feranchak, A.P. and Kodadek, T. (2009) Selective Toxin Sequestrants for the Treatment of Bacterial Infections. J. Amer. Chem. Soc. 131, 5760-5762.

Friedberg, E.C. and Kodadek, T. (2009) Nucleic Acids: Chemical Damage. Volume 3, 467-480 in Wiley Encyclopedia of Chemical Biology. John Wiley & Sons, Inc., Hoboken, N.J.


Archer, C.T., Burdine, L., Liu, B., Ferdous, A., Johnston, S.A. and Kodadek, T. (2008) Physical and functional interaction of mono-ubiquitylated transactivators with the proteasome. J. Biol. Chem. 283, 21789-21798.

Kwon, Y.-U. and Kodadek, T. (2008) Encoded combinatorial libraries for the construction of cyclic peptoid microarrays. Chem. Comm. 5704-5706.

Udugamasooriya, D.G., Dunham, G., Ritchie, C., Brekken, R.A. and Kodadek, T. (2008) The pharmacophore of a peptoid VEGF Receptor antagonist includes both side chain and main chain residues. Bioorg, Med. Chem. Lett. 18, 5892-5894.

Kodadek, T. (2008) Rise of the machines: Bruce Alberts and the biochemistry of multi-protein complexes. Mol. BioSystems. 4, 1043-1045.

Ferdous, A., O'Neal, M., Nalley, K., Sikder, D., Kodadek, T. and Johnston, S.A. (2008) Phosphorylation of the Gal4 DNA-binding domain is essential for activator mono-ubiquitylation and effeficient promoter occupancy. Mol. BioSystems. 4, 1116-1125.

Archer, C.T., Burdine, L., Liu, B., Ferdous, A., Johnston, S.A. and Kodadek, T. (2008) Physical and functional interaction of mono-ubiquitylated transactivators with the proteasome. J. Biol. Chem. 283, 21789-21798.

Astle, J.M., Udugamasooriya, D.G., Smallshaw, J.E. and Kodadek, T. (2008) A VEGFR2 antagonist and other peptoids evade immune recognition. Intl. J. Peptide Res. & Therapeutics. 14, 223-227.

Kodadek, T. (2008) Molecular cloaking devices. Nature. 453, 861-862.

Tan, N.C., Yu, P., Kwon, Y.-U. and Kodadek, T. (2008) High-throughput evaluation of relative cell permeability between peptoids and peptides. Bioorg. Med. Chem. 16, 5853-5861.

Kodadek, T. (2008) Proteomes take the electrophilic bait. Nature Chem. Biol. 4, 387-388.

Udugamasooriya, D.G., Ritchie, C., Brekken, R.A. and Kodadek, T. (2008) A Peptoid Antagonist of VEGF Receptor 2 Recognizes A Hotspot In the Extracellular Domain Distinct From The Hormone-Binding Site. Bioorg. & Med. Chem. 16, 6338-6343.

Hanaoka, K., Lubag, A.J.M., Castillo-Muzquiz, A., Kodadek, T. and Sherry, A.D. (2008) The detection limit of a Gd3+-based T1 agent is substantially reduced when targeted to a protein microdomain. Mag. Res. Imaging. 26, 608-617.

Udugamasooriya, D.G., Dineen, S.P., Brekken, R.A. and Kodadek, T. (2008) A peptoid antibody surrogate that antagonizes VEGF Receptor 2 activity. J. Amer. Chem. Soc. 130, 5744-52.

Archer, C.T., Delahodde, A., Gonzalez, F., Johnston, S.A. and Kodadek, T. (2008) Activation domain-dependent mono-ubiquitylation of Gal4 protein is essential for promoter binding in vivo. J. Biol. Chem. 283, 12614-12623.

Shores, K.S., Udugamasooriya, D.G., Kodadek, T. and Knapp, D.R. (2008) Use of peptide analog diversity library beads for increased depth of proteomic analysis: Application to cerebrospinal fluid. J. Proteome Res. 7, 1922-1931.

Marthandan, N., Klyza, S., Li, S., Kodadek, T. and Garner, H.R. (2008) Construction and evaluation of an automated light directed protein-detecting microarray synthesizer. IEEE Transactions in NanoBioscience. 7, 20-27.

Lim, H.-S., Archer, C.T., Kim, Y.-C., Hutchens, T. and Kodadek, T. (2008) Rapid identification of the pharmacophore in a peptoid inhibitor of the proteasome regulatory particle. Chem. Comm. 1064-1066.

Lee, J., Yu, P., Xiao, X. and Kodadek, T. (2008) A General System for Evaluating the Efficiency of Chromophore-Assisted Light Inactivation (CALI) of Proteins Reveals Ru(II) tris-bipyridyl As An Unusually Efficient Warhead. Molecular BioSystems. 4, 59-65.


Astle, J. Ferguson, JT. German, JB. Harrigan, GG. Kelleher, NL. Kodadek, T. Parks, BA. Roth, MJ. Singletary, KW. Wenger, CD. Mahady, G.B. (2007) Characterization of proteomic and metabolomic responses to dietary factors and supplements. J. of Nutrition. 137, 2787-2793.

Yu, P. and Kodadek, T. (2007) Dynamics of the Hypoxia-Inducible Factor-1-VEGF promoter complex. J. Biol. Chem. 282, 35035 – 35045.

Lim, H.-S., Cai, D. and Kodadek, T. (2007) Chemical cross-linking reveals Sug2/Rpt4 as the molecular target of a peptoid inhibitor of the 19S proteasome regulatory particle. J. Amer. Chem. Soc. 129, 12936-12937.

Sikder, D. and Kodadek, T. (2007) The neurohormone orexin stimulates hypoxia-inducible factor-1 activity. Genes & Devel. 21, 2995-3005

Liu, B., Archer, C.T., Burdine, L., Gillette, T.G. and Kodadek, T. (2007) Label transfer chemistry for the characterization of protein-protein interactions. J. Amer. Chem. Soc. 129, 12348-12349.

Kwon, Y.-U. and Kodadek, T. (2007) Quantitative comparison of the relative cell permeability of cyclic and linear peptides. Chem. & Biol. 14, 671-677.

Lim, H.-Y., Archer, C.T. and Kodadek, T. (2007) Identification of a peptoid inhibitor of the proteasome 19S regulatory particle. J. Amer. Chem. Soc. 129, 7750-7751.

Xiao, X., Yu, P., Lim, H.-Y., Sikder, S. and Kodadek, T. (2007) Design and synthesis of a cell permeable transcription factor mimic. J. Comb. Chem. 9, 592-600.

Xiao, X., Yu, P., Lim, H.-S., Sikder, D. and Kodadek, T. (2007) A cell permeable transcription factor mimic. Angew. Chem. Intl. Ed. 46, 2865-2868.

Yu, P. and Kodadek, T. (2007) A convenient, high-throughput strategy for measuring the relative cell permeability of synthetic compounds. Nature Protocols. 2, 23-30.

Kwon, Y.-U. and Kodadek, T. (2007) Quantitative evaluation of the relative cell permeability of peptoids and peptides. J. Amer. Chem. Soc. 129, 1508-1509.

Ferdous, A., Sikder, D., Gillette, T., Nalley, K., Kodadek, T. and Johnston, S.A. (2007) The Role of the Proteasomal ATPases and Activator Mono-Ubiquitylation in Regulating Gal4 Binding to Promoters. Genes & Dev. 21, 112-123.


Liu, B., Burdine, L. and Kodadek, T. (2006) Chemistry of periodate-mediated cross-linking of 3,4-dihydroxyphenlalanine (DOPA)-containing molecules to proteins. J. Amer. Chem. Soc. 128, 15228-15235.

Page, T., Sikder, D. Yang, L. Pluta, L., Wolfinger, R.D., Kodadek, T. and Thomas, R.S. (2006) Genome-wide analysis of human HSF1 signaling reveals a transcriptional program linked to cellular adaptation and survival. Molecular BioSystems. 2, 627-639.

Kodadek, T., Sikder, D. and Nalley, K. (2006) Keeping transcriptional activators under control. Cell. 127, 261-264.

Sikder, D., Johnston, S.A. and Kodadek, T. (2006) Widespread, but non-identical, association of proteasomal 19S and 20S proteins with yeast chromatin. J. Biol. Chem. 281, 27346-27355.

Nalley, K., Johnston, S.A. and Kodadek, T. (2006) Proteolytic turnover of Gal4 is not required for function in vivo. Nature. 442, 1054-1057.

Alluri, P., Liu, B., Yu, P., Xiao, X. and Kodadek, T. (2006) isolation and chearacterization of coactivator-binding peptoids from a combinatorial library. Molecular Biosystems. 2, 568-579.

Sulahian, R., Sikder, D., Johnston, S.A. and Kodadek, T. (2006) The Proteasomal ATPase Complex Is Required For Stressed-Induced Trasncription in Yeast. Nucl. Acids Res. 34, 1351-1357.

Sikder, K. and Kodadek, T. (2006) Optimized protocols for the isolation of specific protein-binding peptides or peptoids from combinatorial libraries displayed on beads. Molecular BioSystems. 2, 25-35.


Archer, C., Burdine, L. and Kodadek, T. (2005) Identification of Gal4 transactivation domain binding proteins in the 26S proteasome by perioddate-triggered cross-linking. Molecular BioSystems. 1, 366-372.

Liu, B., Yu, P., Alluri, P.G. and Kodadek, T. (2005) Simple reporter gene-based assays for hairpin polyamide conjugate permeability and DNA-binding activity in living cells. Molecular BioSystems. 1, 307-317.

Reddy, M.M. and Kodadek, T. (2005) Protein 'fingerprinting' in complex mixtures using peptoid microarrays.  Proc. Natl. Acad. Sci. USA 102, 12672-12677.

Liu, B., Alluri, P., Yu, P. and Kodadek, T. (2005) A KIX-binding peptoid functions as a transactivation domain in mammalian cells.  J. Amer. Chem. Soc. 127, 8254-8255.

Yu, P., Liu, B. and Kodadek, T. (2005) A high-throughput assay for assessing the cell permeability of combinatorial libraries. Nature Biotechnol. 23, 746-751.

Li, S., Marthandan, N., Bowerman, D., Garner, H.R. and Kodadek, T. (2005) Photolithographic synthesis of cyclic peptide arrays using a differential deprotection strategy. Chem. Comm. (5): 581-583.


Gillette, T., Gonzalez, F.G., Delahodde, A., Johnston, S.A. and Kodadek, T. (2004) Physical and Functional Association of RNA Polymerase II and the Proteasome. Proc. Natl. Acad. Sci. USA 101, 5904-5909.


Gonzalez, F., Delahoude, A., Kodadek, T. and Johnston, S.A. (2002) A sub-complex of the 19S proteasome regulatory complex is recruited to an activated promoter. Science. 296, 548-550.


Ferdous, A., Gonzalez, F., Sun, L., Kodadek, T. and Johnston, S.A. (2001) The 19S regulatory particle of the proteasome is required for efficient transcription elongation by RNA polymerase II. Mol. Cell. 7, 981-991.