Dr. Kelly has authored over 220 peer-reviewed publications published in prominent scientific journals including Science, Nature, Cell, New England Journal of Medicine, Proceedings of the National Academy of Sciences, Journal of the American Chemical Society, Biochemistry, and Journal of Medicinal Chemistry. For reprint requests, please click here.
1999:
- Koepf EK, Petrassi HM, Ratnaswamy G, Huff ME, Sudol M, Kelly JW. Characterization of the structure and function of W --> F WW domain variants: identification of a natively unfolded protein that folds upon ligand binding. Biochemistry 1999;38:14338-14351.
- Lashuel HA, Wurth C, Woo L, Kelly JW. The most pathogenic transthyretin variant, L55P, forms amyloid fibrils under acidic conditions and protofilaments under physiological conditions. Biochemistry 1999;38:13560-13573.
- Koo EH, Lansbury PT, Kelly JW. Amyloid diseases: abnormal protein aggregation in neurodegeneration. Proc. Natl. Acad. Sci. USA 1999;96:9989-9990.
- Bekele H, Fendler JH, Kelly JW. Self-assembling peptidomimetic monolayer nucleates oriented CdS nanocrystals. J. Am. Chem. Soc. 1999;121:7266-7267.
- Oza VB, Petrassi HM, Purkey HE, Kelly JW. Synthesis and evaluation of anthranilic acid-based transthyretin amyloid fibril inhibitors. Bioorg. Med. Chem. Lett. 1999;9:1-6.
- Ratnaswamy G, Koepf E, Bekele H, Yin H, Kelly JW. The amyloidogenicity of gelsolin is controlled by proteolysis and pH. Chemistry & Biology 1999;6:293-304.
- Baures PW, Oza VB, Peterson SA, Kelly JW. Synthesis and evaluation of inhibitors of transthyretin amyloid formation based on the non-steroidal anti-inflammatory drug, flufenamic acid. Bioorg. Med. Chem. 1999;7:1339-1347.
- Chitnumsub P, Fiori WR, Lashuel HA, Diaz H, Kelly JW. The nucleation of monomeric parallel β-sheet-like structures and their self-assembly in aqueous solution. Bioorg. Med. Chem. 1999;7:39-59.
- Koepf EK, Petrassi HM, Sudol M, Kelly JW. WW: an isolated three-stranded antiparallel β-sheet domain that unfolds and refolds reversibly; evidence for a structured hydrophobic cluster in urea and GdnHCl and a disordered thermal unfolded state. Prot. Science 1999;8:841-853.
