Dr. Kelly has authored over 220 peer-reviewed publications published in prominent scientific journals including Science, Nature, Cell, New England Journal of Medicine, Proceedings of the National Academy of Sciences, Journal of the American Chemical Society, Biochemistry, and Journal of Medicinal Chemistry. For reprint requests, please click here.
2001:
- Jiang X, Buxbaum JN, Kelly JW. The V122I cardiomyopathy variant of transthyretin increases the velocity of rate-limiting tetramer dissociation resulting in accelerated amyloidosis. Proc. Natl. Acad. Sci. USA 2001;98:14943-14948.
- White JT, Kelly JW. Support for the multigenic hypothesis of amyloidosis: The binding stoichiometry of retinol-binding protein, vitamin A, and thyroid hormone influences transthyretin amyloidogenicity in vitro. Proc. Natl. Acad. Sci. USA 2001;98:13019-13024.
- Chen C-D, Huff ME, Matteson J, Page L, Phillips R, Kelly JW, Balch WE. Furin initiates gelsolin familial amyloidosis in the Golgi through a defect in Ca2+ stabilization. EMBO J. 2001;20:6277-6287.
- Hammarström P, Schneider F, Kelly JW. Trans-suppression of misfolding in an amyloid disiease. Science 2001;293:2459-2461.
- Jäger M, Nguyen H, Crane JC, Kelly JW, Gruebele M. The folding mechanism of β-sheet: the WW domain. J. Mol. Biol. 2001;311:373-393.
- Hammarström P, Jiang X, Deechongkit S, Kelly JW. Anion shielding of electrostatic repulsions in transthyretin modulates stability and amyloidosis: insight into the chaotrope unfolding dichotomy. Biochemistry 2001;40:11453-11459.
- Jiang X, Smith CS, Petrassi HM, Hammarström P, White JT, Sacchettini JC, Kelly JW. An engineered transthyretin monomer that is nonamyloidogenic, unless it is partially denatured. Biochemistry 2001;40:11442-11452.
- Schneider F, Hammarström P, Kelly JW. Transthyretin slowly exchanges subunits under physiological conditions: a convenient chromatographic method to study subunit exchange in oligomeric proteins. Protein Sci. 2001;10:1606-1613.
- Jiang, X, Kowalski J, Kelly JW. Increasing protein stability using a rational approach combining sequence homology and structural alignment: Stabilizing the WW domain. Prot. Science 2001;10:1454-1465.
- Kaul R, Angeles AR, Jäger M, Powers ET, Kelly JW. Incorporating β-turns and a turn mimetic out of context in loop 1 of the WW domain affords cooperatively folded β-sheets. J. Am. Chem. Soc. 2001;123:5206-5212.
- Purkey HE, Dorrell MI, Kelly JW. Evaluating the binding selectivity of transthyretin amyloid fibril inhibitors in blood plasma. Proc. Natl. Acad. Sci. USA 2001;98:5566-5571.
- Ratnaswamy G, Huff ME, Su AI, Rion S, Kelly JW. Destabilization of Ca2+-free gelsolin may not be responsible for proteolysis in Familial Amyloidosis of Finnish Type. Proc. Natl. Acad. Sci. USA 2001;98:2334-2339.
- Petrassi HM, Sharpless KB, Kelly JW. The copper-mediated cross-coupling of phenylboronic acids and N-hydroxyphthalimide at room temperature: synthesis of aryloxyamines. Org. Lett. 2001;3:139-142.
- Powers ET, Kelly JW. Medium-dependent self-assembly of an amphiphilic peptide: direct observation of peptide phase domains at the air-water interface. J. Am. Chem. Soc. 2001;123:775-776.
