Dr. Kelly has authored over 220 peer-reviewed publications published in prominent scientific journals including Science, Nature, Cell, New England Journal of Medicine, Proceedings of the National Academy of Sciences, Journal of the American Chemical Society, Biochemistry, and Journal of Medicinal Chemistry. For reprint requests, please click here.
2002:
- Kelly JW. Towards an understanding of amyloidogenesis. Nat. Struct. Biol. 2002;9:323-325.
- Sawkar AR, Cheng W-C, Beutler E, Wong C-H, Balch WE, Kelly JW. Chemical chaperones increase the cellular activity of N370S β-glucosidase: a therapeutic strategy for Gaucher disease. Proc. Natl. Acad. Sci USA 2002;99:15428-15433.
- Kaul R, Deechongkit S, Kelly JW. Synthesis of a negatively charged dibenzofuran-based β-turn mimetic and its incorporation into the WW miniprotein-enhanced solubility without a loss of thermodynamic stability. J. Am. Chem. Soc. 2002;124:11900-11907.
- Hammarström P, Jiang X, Hurshman AR, Powers ET, Kelly JW. Sequence-dependent denaturation energetics: a major determinant in amyloid disease diversity. Proc. Natl. Acad. Sci. USA 2002;99:16427-16432.
- Liu K, Kelly JW, Wemmer DE. Native state hydrogen exchange study of suppressor and pathogenic variants of transthyretin. J. Mol. Biol. 2002;320:821-832.
- McCammon MG, Scott DJ, Keetch CA, Greene LH, Purkey HE, Petrassi HM, Kelly JW, Robinson CV. Screening transthyretin amyloid fibril inhibitors: characterization of novel multiprotein, multiligand complexes by mass spectrometry. Structure 2002;10:851-863.
- Deechongkit S, Kelly JW. The effect of backbone cyclization on the thermodynamics of β-sheet unfolding: stability optimization of the PIN WW domain. J. Am. Chem. Soc. 2002;124:4980-4986.
- Kowalski JA, Liu K, Kelly JW. NMR solution structure of the isolated Apo Pin1 WW domain: comparison to the X-ray crystal structures of Pin1. Biopolymers 2002;63:111-121.
- Sacchettini JC, Kelly JW. Therapeutic strategies for human amyloid diseases. Nat. Rev. Drug Discov. 2002;1:267-275.
- Oza VB, Smith C, Raman P, Koepf EK, Lashuel HA, Petrassi HM, Chiang KP, Powers ET, Sacchettini J, Kelly JW. Synthesis, structure, and activity of diclofenac analogues as transthyretin amyloid fibril formation inhibitors. J. Med. Chem. 2002;45:321-332.
- Powers ET, Yang SI, Lieber CM, Kelly JW. Ordered Langmuir-Blodgett films of amphiphilic β-hairpin peptides imaged by atomic force microscopy. Angew. Chem. Int. Ed. 2002;41:127-130.
