Dr. Kelly has authored over 220 peer-reviewed publications published in prominent scientific journals including Science, Nature, Cell, New England Journal of Medicine, Proceedings of the National Academy of Sciences, Journal of the American Chemical Society, Biochemistry, and Journal of Medicinal Chemistry. For reprint requests, please click here.
2004:
- You S-L, Deechongkit S, Kelly JW. Solid-phase synthesis and stereochemical assignments of tenuecyclamides A-D employing heterocyclic amino acids derived from commercially available Fmoc α-amino acids. Org. Lett. 2004;6:2627-2630.
- Deechongkit S, Nguyen H, Powers ET, Dawson PE, Gruebele M, Kelly JW. Context-dependent contributions of backbone hydrogen bonding to β-sheet folding energetics. Nature 2004;430:101-105.
- Purkey HE, Palaninathan SK, Kent KC, Smith C, Safe SH, Sacchettini JC, Kelly JW. Hydroxylated polychlorinated biphenyls selectively bind transthyretin in blood and inhibit amyloidogenesis: rationalizing rodent PCB toxicity. Chemistry & Biology 2004;11:1719-1728.
- You S-L, Kelly JW. Highly efficient enantiospecific synthesis of imidazoline-containing amino acids using bis(triphenyl)oxodiphosphonium trifluoromethanesulfonate. Org. Lett. 2004;6:1681-1683.
- Hurshman AR, White JP, Powers ET, Kelly JW. Transthyretin aggregation under partially denaturing conditions is a downhill polymerization. Biochemistry 2004;43:7365-7381.
- Reixach N, Deechongkit S, Jiang X, Kelly JW, Buxbaum JN. Tissue damage in the amyloidoses: transthyretin monomers and nonnative oligomers are the major cytotoxic species in tissue culture. Proc. Natl. Acad. Sci. USA 2004;101:2817-2822.
- Zhang Q, Powers ET, Nieva J, Huff ME, Dendle MA, Bieschke J, Glabe CG, Eschenmoser A, Wentworth P, Lerner RA, Kelly JW. Metabolite-initiated protein misfolding may trigger Alzheimer's disease. Proc. Natl. Acad. Sci. USA 2004;101:4752-4757.
- Miller SR, Sekijima Y, Kelly JW. Native state stabilization by NSAIDs inhibits transthyretin amyloidogenesis from the most common familial disease variants. Lab. Invest. 2004;84:545-552.
- Deechongkit S, You S-L, Kelly JW. Synthesis of all nineteen appropriately protected chiral α-hydroxy acid equivalents of the α-amino acids for Boc solid-phase depsi-peptide synthesis. Org. Lett. 2004;6:497-500.
- You S-L, Kelly JW. Highly efficient biomimetic total synthesis and structural verification of bistratamides E and J from Lissoclinum bistratum. Chem. Eur. J. 2004;10:71-75.
- Adamski-Werner SL, Palaninathan SK, Sacchettini JC, Kelly JW. Diflunisal analogues stabilize the native state of transthyretin. Potent inhibition of amyloidogenesis. J. Med. Chem. 2004;47:355-374.
- Kelker MS, Foss TR, Peti W, Teyton L, Kelly JW, Wüthrich K, Wilson IA. Crystal structure of human triggering receptor expressed on myeloid cells 1 (TREM-1) at 1.47 Å. J. Mol. Biol. 2004;342:1237-1248.
- Page LJ, Huff ME, Kelly JW, Balch WE. Ca2+ binding protects against gelsolin amyloidosis. Biochem. Biophys. Res. Comm. 2004;322:1105-1110.
- Deechongkit S, Dawson PE, Kelly JW. Toward assessing the position-dependent contributions of backbone hydrogen bonding to β-sheet folding thermodynamics employing amide-to-ester perturbations. J. Am. Chem. Soc. 2004;126:16762-16771.
