Dr. Kelly has authored over 220 peer-reviewed publications published in prominent scientific journals including Science, Nature, Cell, New England Journal of Medicine, Proceedings of the National Academy of Sciences, Journal of the American Chemical Society, Biochemistry, and Journal of Medicinal Chemistry. For reprint requests, please click here.
2009:
- Bieschke J, Cohen E, Murray A, Dillin A, Kelly JW. A Kinetic Assessment of the C.elegans Amyloid Disaggregation Activity Enables Uncoupling of Disassembly and Proteolysis. Protein Sci. 2009; 18:2231-2241.
- Bunagan MR, Gao J, Kelly JW, Gai F. Probing the Folding Transition State Structure of the Villin Headpiece Subdomain via Sidechain and Backbone Mutagenesis. J. Am. Chem. Soc. 2009; 131:7470-7476.
- Choi S, Reixach N, Connelly S, Johnson SM, Wilson IA, Kelly JW. A Substructure Combination Strategy to Create Potent and Selective Transthyretin Kinetic Stabilizers that Prevent Amyloidogenesis and Cytotoxicity. J. Am. Chem. Soc. 2009; 132:1359-1370.
- Cohen E, Cohen T-B, Paulsson JF, Du D, Estepa G, Pham HM, Kelly JW, Masliah E, Dillin A. Reduced IGF-1 Signaling Delays Age-associated Proteotoxicity in Mice. Cell 2009; 139:1157-1169.
- Fowler DM, Kelly JW. Aggregating Knowledge about Prions and Amyloid. Cell 2009; 137:20-22.
- Fuller AA, Du D, Liu F, Davoren JE, Kroon G, Powers ET, Wipf P, Gruebele M, Kelly JW. Evaluating β-turn Mimics as β-sheet Folding Nucleators. Proc. Natl. Acad. Sci. 2009; 106:11067-11072.
- Gao J, Bosco DA, Powers ET, Kelly JW. Localized Thermodynamic Coupling between Hydrogen Bonding and Microenvironment Polarity Significantly Stabilizes Proteins. 2009; 16:684-690.
- Hanson SR, Culyba EK, Hsu T-L, Wong C-H, Kelly JW, Powers ET. The Core Trisaccharide of an N-linked Glycoprotein Intrinsically Accelerates Folding and Enhances Stability. Proc. Natl. Acad. Sci. 2009; 106:3131-3136.
- Jager M, Dendle M, Kelly JW. Sequence Determinants of Thermodynamic Stability in a WW domain–an all β-sheet protein. Protein Sci. 2009; 18:1806-1813.
- Johnson SW, Connelly S, Wilson IA, Kelly JW. Toward Optimization of the Second Aryl Substructure Common to Transthyretin Amyloidogenesis Inhibitors Using Biochemical and Structural Studies. J. Med. Chem. 2009; 52:1115-1125.
- Page LJ, Suk J-Y, Bazhenova L, Fleming SM, Wood M, Guo LT, Misizin AP, Kisilevsky R, Shelton DG, Balch WE, Kelly JW. Secretion of Amyloidogenic Gelsolin Progressively Compromises Protein Homeostasis Leading to the Intracellular Aggregation of Proteins. Proc. Natl. Acad. Sci. 2009; 106:11125-11130.
- Powers ET, Morimoto RI, Dillin A, Kelly JW, Balch WE. Biological and Chemical Approaches to Diseases of Proteostasis Deficiency. Ann. Rev. Biochem. 2009; 78;959-91.
- Solomon JP, Yonemoto IT, Murray AN, Price JL, Powers ET, Kelly JW. Plasma Gelsolin 5 and 8 kDa Fragments Form Amyloid by a Nucleated Polymerization Mechanism, while the 68 kDa Fragment is Not Amyloidogenic. Biochemistry2009; 48:11370-11380.
- Usui K, Hulleman JD, Paulsson JF, Siegel SJ, Powers ET, Kelly JW. Site-specific modification of Alzheimer’s peptides by cholesterol oxidation products enhance aggregation energetics and neurotoxicity. Proc. Natl. Acad. Sci. 2009; 106:18563-18568.
- Watt B, van Niel G, Fowler DM, Hurbain I, Luk KC, Stayrook SE, Lemmon MA, Raposo G, Shorter J, Kelly JW, Marks MS. N-Terminal Domains Elicit Formation of Functional Pmel17 Amyloid Fibrils. J. Biol. Chem. 2009; 284:35543-35555.
- Yonemoto IT, Wood MR, Balch WE, Kelly JW. A General Strategy for the Bacterial Expression of Amyloidogenic Peptides using BCL-XL-1/2 Fusions. Protein Sci. 2009; 18:1978-1986.
