Dr. Kelly has authored over 220 peer-reviewed publications published in prominent scientific journals including Science, Nature, Cell, New England Journal of Medicine, Proceedings of the National Academy of Sciences, Journal of the American Chemical Society, Biochemistry, and Journal of Medicinal Chemistry. For reprint requests, please click here.
2008:
- Balch WE, Morimoto RI, Dillin A, Kelly JW. Adapting Proteostasis for Disease Intervention. Science 2008; 319:916-919.
- Bieschke J, Siegel SJ, Fu Y, Kelly JW. Alzheimer's Abeta Peptides Containing an Isostructural Backbone Mutation Afford Distinct Aggregate Morphologies but Analogous Cytotoxicity. Evidence for a Common Low-Abundance Toxic Structure(s)? Biochemistry 2008; 47:50-59.
- Gao J, Kelly W. Toward quantification of protein backbone-backbone hydrogen bonding energies: An energetic analysis of an amide-to-ester mutation in an alpha-helix within a protein. Protein Sci. 2008; 17:1096-1101.
- Hurschman Babbes AR, Powers ET, Kelly JW. Quantification of the thermodynamically linked quaternary and tertiary structural stabilities of transthyretin and its disease-associated variants: the relationship between stability and amyloidosis. Biochemistry 2008; 47:6969-84.
- Jager M, Deechongkit S, Koepf EK, Nguyen H, Gao J, Powers ET, Gruebele M, Kelly JW. Understanding the mechanism of beta-sheet folding from a chemical and biological perspective. Biopolymers 2008; 90:751-758.
- Johnson SM, Connelly S, Wilson IA, Kelly JW. Biochemical and structural evaluation of highly selective 2-arylbenzoxazole-based transthyretin amyloidogenesis inhibitors. J. Med. Chem. 2008; 51:260-270.
- Johnson SM, Connelly S, Wilson IA, Kelly JW. Toward optimization of the linker substructure common to transthyretin amyloidogenesis inhibitors using biochemical and structural studies. J. Med. Chem. 2008; 51:6348-6358.
- Liu F, Du D, Fuller AA, Davoren JE, Wipf P, Kelly JW, Gruebele M. An experimental survey of the transition between two-state and downhill protein folding scenarios. Proc. Natl. Acad. Sci. U.S.A. 2008; 105:2369-2374.
- Mu TW, Fowler DM, Kelly JW. Partial restoration of mutant enzyme homeostasis in three distinct lysosomal storage disease cell lines by altering calcium homeostasis. PLoS Biology 2008; 6:e26.
- Mu TW, Ong DST, Wang YJ, Balch WE, Yates JR III, Segatori L, Kelly JW. Chemical and biological approaches synergize to ameliorate protein-folding diseases. Cell 2008; 134:769-781.
- Palaninathan SK, Mohamedmohaideen NN, Snee WC, Kelly JW, Sacchettini JC. Structural insights into pH-induced conformational changes within the native human transthyretin tetramer. J. Biol. Chem. 2008; 382:1157-1167.
- Reixach N, Foss TR, Santelli E, Pascual J, Kelly JW, Buxbaum JN. Human-Murine Transthyretin Heterotetramers Are Kinetically Stable and Non-amyloidogenic: A lesson in the generation of transgenic models of diseases involving oligomeric proteins. J. Biol. Chem. 2008; 283:2098-2107.
- Sekijima Y, Kelly JW, Kieda S. Pathogenesis of and therapeutic strategies to ameliorate the transthyretin amyloidoses. Curr. Pharm. Design 2008; 14:3219-3230.
- Yonemoto IT, Kroon GJ, Dyson HJ, Balch WE, Kelly JW. Amylin proprotein processing generates progressively more amyloidogenic peptides that initially sample the helical state. Biochemistry 2008; 47:9900-9910.
