Dr. Kelly has authored over 220 peer-reviewed publications published in prominent scientific journals including Science, Nature, Cell, New England Journal of Medicine, Proceedings of the National Academy of Sciences, Journal of the American Chemical Society, Biochemistry, and Journal of Medicinal Chemistry. For reprint requests, please click here.
2006:
- Wang X, Venable J, LaPointe P, Hutt DM, Koulov AV, Coppinger J, Gurkan C, Kellner W, Matteson J, Plutner H, Riordan JR, Kelly JW, Yates JR III, Balch WE. Hsp90 cochaperone Aha1 downregulation rescues misfolding of CFTR in cystic fibrosis. Cell 2006;127:803-815.
- Tojo K, Sekijima Y, Kelly JW, Ikeda S-i. Diflunisal stabilizes familial amyloid polyneuropathy-associated transthyretin variant tetramers in serum against dissociation required for amyloidogenesis. Neuroscience Res. 2006;56:441-449.
- Fu Y, Gao J, Bieschke J, Dendle MA, Kelly JW. Amide-to-E-olefin versus amide-to-ester backbone H-bond perturbations: evaluating the O-O repulsion for extracting H-bond energies. J. Am. Chem. Soc. 2006;128:15948-15949.
- Zhang Y, Kim Y, Genoud N, Gao J, Kelly JW, Pfaff SL, Gill GN, Dixon JE, Noel JP. Determinants for dephosphorylation of the RNA polymerase II C-terminal domain by Scp1. Mol. Cell 2006;24:759-770.
- Reixach N, Adamski-Werner SL, Kelly JW, Koziol J, Buxbaum JN. Cell based screening of inhibitors of transthyretin aggregation. Biochem. Biophys. Res. Comm. 2006;348:889-897.
- Cordeiro Y, Kraineva J, Suarez MC, Tempesta AG, Kelly JW, Silva JL, Winter R, Foguel D. Fourier transform infrared spectroscopy provides a fingerprint for the tetramer and for the aggregates of transthyretin. Biophys. J. 2006;91:957-967.
- Bieschke J, Zhang Q, Bosco DA, Lerner RA, Powers ET, Wentworth P, Kelly JW. Small molecule oxidation products trigger disease-associated protein misfolding. Acc. Chem. Res. 2006;39:611-619.
- Kelly JW. Proteins downhill all the way. Nature 2006;442:255-256.
- Cohen E, Bieschke J, Perciavalle RM, Kelly JW, Dillin A. Opposing activities protect against age onset proteotoxicity. Science 2006;313:1604-1610.
- Sekijima Y, Dendle MA, Kelly JW. Orally administered diflunisal stabilizes transthyretin against dissociation required for amyloidogenesis. Amyloid 2006;13:236-249.
- Jager M, Zhang Y, Bieschke J, Nguyen H, Dendle M, Bowman M, Noel JP, Gruebele M, Kelly JW. The structure-function-folding relationship in a WW domain. Proc. Natl. Acad. Sci. USA 2006;103:10648-10653.
- Sawkar AR, Schmitz M, Zimmer K-P, Reczek D, Edmunds T, Balch WE, Kelly JW. Chemical chaperones and permissive temperatures alter the cellular localization of Gaucher disease associated glucocerebrosidase variants. ACS Chem. Biol. 2006;1:235-251.
- Kelly JW, Balch WE. The integration of cell and chemical biology in protein folding. Nat. Chem. Biol. 2006;2:224-227.
- Sörgjerd K, Ghafouri B, Jonsson B-H, Kelly JW, Blond SY, Hammarström P. Retention of misfolded mutant transthyretin by the chaperone BiP/GRP78 mitigates amyloidogenesis. J. Mol. Biol. 2006;356:469-482.
- Bosco DA, Fowler DM, Zhang Q, Nieva J, Powers ET, Wentworth P, Lerner RA, Kelly JW. Elevated levels of oxidized cholesterol metabolites in Lewy body disease brains accelerate α-synuclein fibrilization. Nat. Chem. Biol. 2006;2:249-253.
- Sawkar AR, D'Haeze W, Kelly JW. Therapeutic strategies to ameliorate lysosomal storage disorders - a focus on Gaucher disease. Cell. Mol. Life Sci. 2006;63:1179-1192.
- Sekijima Y, Dendle MT, Wiseman RL, White JT, D'Haeze W, Kelly JW. R104H may suppress transthyretin amyloidogenesis by thermodynamic stabilization, but not by the kinetic mechanism characterizing T119M interallelic trans-suppression. Amyloid 2006;13:57-66.
- Deechongkit S, Nguyen H, Jäger M, Powers ET, Gruebele M, Kelly JW. β-sheet folding mechanisms from perturbation energetics. Curr. Opin. Struct. Biol. 2006;16:94-101.
- Suk JY, Zhang F, Balch WE, Linhardt R, Kelly JW. Heparin accelerates gelsolin amyloidogenesis. Biochemistry 2006;45:2234-2242.
- Fowler DM, Koulov AV, Alory-Jost C, Marks MS, Balch WE, Kelly JW. Functional amyloid formation within mammalian tissue. PLoS Biol. 2006;4:e6.
