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Selected References


Lyumkis D., Doamekpor, S.K., Bengtson, M.H., Lee, J.W., Toro, T.B., Petroski, M.D., Lima, C.D., Potter, C.S., Carragher, B., and Joazeiro, C.A.P. 2013. Single-particle EM reveals extensive conformational variability of the Ltn1 E3 ligase.
Proceedings of the National Academy of Sciences of the USA  vol. 110: 1702-1707

Bengtson, M.H., and Joazeiro, C.A.P. 2010. Role of a ribosome-associated E3 ubiquitin ligase in protein quality control.
Nature 467: 470-473.

Chu, J., Hong, N., Masuda, C., Jenkins, B., Nelms, K., Goodnow, C., Glynne, R., Wu, H., Masliah, E., Joazeiro, C.A.P. and Kay, S.A. 2009. A mouse forward genetics screen identifies LISTERIN as an E3 ubiquitin ligase involved in neurodegeneration.
Proceedings of the National Academy of Sciences of the USA  vol. 106: 2097-2103

Deshaies, R.J. and Joazeiro, C.A.P. 2009. RING Domain E3 Ubiquitin Ligases.
Annual Review of Biochemistry  vol. 78: 399-434

Li, W., Bengtson, M., Ulbrich, A., Matsuda, A., Orth, A., Chanda, S., Batalov, S. and Joazeiro, C.A.P. 2008. Genome-wide and Functional Annotation of Human E3 Ubiquitin Ligases Identifies MULAN, a Mitochondrial E3 that Regulates the Organelle's Dynamics and Signaling.
PLoS ONE  vol. 3:e1487

Zhang, Q., Liu, Y., Gao, F., Ding, Q., Cho, C., Hur, W.-Y., Jin, Y., Uno, T., Joazeiro, C.A.P. and Gray, N. 2006. Discovery of EGFR-Selective 4,6-Disubstituted Pyrimidines from a Combinatorial Kinase-Directed Heterocycle Library.
Journal of the American Chemical Society  vol. 128:2182-2183

Joazeiro, C.A.P., Anderson, K.C. and Hunter, T. 2006. Proteasome inhibitor drugs on the rise.
Cancer Research  vol. 66:7840-7842

Takagi, Y., Masuda, C., Chang, W.-H., Komori, H., Wang, D., Hunter, T., Joazeiro, C.A.P.# and Kornberg, R.D.# 2005. Ubiquitin Ligase Activity of Transcription Factor IIH and the Transcriptional Response to DNA Damage.
Molecular Cell  vol. 18: 237-243. #co-senior authors
(please see News and Views article about this work, Nature Cell Biol. 2005, 7: 553-555)

Li, W., Chanda, S., Micik, I. and Joazeiro, C.A.P. 2005. Methods for the functional genomic analysis of ubiquitin ligases.
Methods in Enzymology  vol. 398:280-291

Donaldson, K., Yin, H., Gekakis, N., Supek, F. and Joazeiro, C.A.P. 2003. Ubiquitin signals protein trafficking via interaction with a novel ubiquitin-binding domain in the membrane fusion regulator, Vps9p.
Current Biology  vol. 13: 258-262

Donaldson, K.M., Li, W., Ching, K.A., Batalov, S., Tsai, C.-C. and Joazeiro, C.A.P. 2003. Ubiquitin-mediated sequestration of normal cellular proteins into polyglutamine aggregates.
Proceedings of the National Academy of Sciences of the USA  vol. 100: 8892-8897

Verdecia, M.A., Joazeiro, C.A.P., Wells, N.J., Ferrer, J., Bowman, M.E., Hunter, T. and Noel, J.P. 2003. Conformational Flexibility Underlies Ubiquitin Ligation Mediated by the WWP1 HECT Domain E3 Ligase.
Molecular Cell  vol. 11: 249-259

Fang, D., Elly, C., Gao, B., Fang, N., Altman, Y., Joazeiro, C., Hunter, T., Copeland, N., Jenkins, N. and Liu, Y.-C. 2002. Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation.
Nature Immunology  vol. 3(3):281-287

Lu, Z., Xu, S., Joazeiro, C., Cobb, M.H. and Hunter, T. 2002. The PHD Domain of MEKK1 Acts as an E3 Ubiquitin Ligase and Mediates Ubiquitination and Degradation of ERK1/2.
Molecular Cell  vol. 9:945-956

Bays, N., Gardner, R., Seelig, L., Joazeiro, C.A.P. and Hampton, R. 2001. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation.
Nature Cell Biology  vol. 3:24-29

Joazeiro, C.A.P. and Weissman, A. 2000. RING Finger Proteins: Mediators of Ubiquitin Ligase Activity.
Cell  vol. 102: 549-552

Joazeiro, C.A.P. and Hunter, T. 2000. Ubiquitination: More than Two to Tango.
Science  vol. 289:2061-2062

Joazeiro, C.A.P., Wing, S.S., Huang, H.-k., Leverson, J.D., Hunter, T. and Liu, Y.-C. 1999. The tyrosine kinase negative regulator, c-Cbl, as a RING-type, E2-dependent ubiquitin-protein ligase.
Science  vol. 286: 309-312
(please see comment on Barinaga M. A new finger on the protein destruction button. Science. 1999 286:223-225)