The Cell Adhesion Laboratory

PhD Thesis

Three Dimensional Fourier Synthesis of N-neuraminate Lyase from Escherichia coli

Abstract/ TOC	Abstract, Table of Contents, Preface, Declaration, Acknowledgements, Dedication, List of Tables, List of Figures
Chapter 1	Introduction
Chapter 2	Crystallisation
Chapter 3	Space Group Determination and Crystal Characterisation
Chapter 4	Data Collection
Chapter 5	Data Processing and Reduction
Chapter 6	The Self-Rotation Function
Chapter 7	Initial Phasing by Single Isomorphous Replacement
Chapter 8	Solvent Flattening and Molecular Envelope Determination
Chapter 9	Phase Improvement by Non-Crystallographic Symmetry Averaging with Phase Extension
Chapter 10	Interpretation of the Electron Density Map
Chapter 11	Crystallographic Refinement by Simulated Annealing
Chapter 12	Description of the Structure
Chapter 13	Homologous and Related Structures
Chapter 14	Future Prospects
Chapter 15	References
Abbrev/ Glossary	Abbreviations and Glossary of Symbols