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The Cell Adhesion Laboratory

Publications

Rangarajan ES, Izard T* (2012). The Cytoskeletal Protein α-Catenin unfurls upon binding to vinculin. Journal of Biological Chemistry 287:18492-18499

Yogesha SD, Rangarajan ES, Vonrhein C, Bricogne G, Izard T* (2012). Crystal structure of vinculin in complex with vinculin binding site 50 (VBS50), the integrin binding site 2 (IBS2) of talin. Protein Science 21:583-588

Yogesha SD, Sharff AJ, Giovannini M, Bricogne G, Izard T* (2011). Unfurling of the band 4.1, ezrin, radixin, moesin (FERM) domain of the merlin tumor suppressor. Protein Science 20:2113-2120

Park H, Lee JH, Gouin E, Cossart P, Izard T* (2011). The rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin. Journal of Biological Chemistry 286:35096-35103

Pilati C, Amessou M, Bihl MP, Balabaud C, Nhieu JT, Paradis V, Nault JC, Izard T, Bioulac-Sage P, Couchy G, Poussin K, Zucman-Rossi J (2011). Somatic mutations activating STAT3 in human inflammatory hepatocellular adenomas. Journal of Experimental Medicine 208:1359-1366

Yogesha SD, Sharff A, Bricogne G, Izard T* (2011). Intermolecular versus intramolecular interactions of the vinculin binding site 33 of talin. Protein Science 20:1471-1476

Rangarajan ES, Lee JH, Izard T* (2011). Apo raver1 structure reveals distinct RRM domain orientations. Protein Science 20:1464-1470

Park H, Valencia-Gallardo C, Sharff A, Tran Van Nhieu G, Izard T* (2011). Novel vinculin binding site of the IpaA invasin of Shigella. Journal of Biological Chemistry 286:23214-23221

Rangarajan ES, Izard T* (2010). Improving the diffraction of full-length human selenomethionyl metavinculin crystals by streak-seeding. Acta Crystallogr Sect F Struct Biol Cryst Commun 66:1617-1620

Rangarajan ES, Lee JH, Yogesha SD, Izard T* (2010). A helix replacement mechanism directs metavinculin functions. PLoS One 5:e10679

Park H, Rangarajan ES, Sygusch J, Izard T* (2010). Dramatic improvement of crystal quality for low-temperature-grown rabbit muscle aldolase. Acta Crystallogr Sect F Struct Biol Cryst Commun 66:595-600

George EM, Izard T, Anderson SD, Brown DT (2010). The nucleosome interaction surface of linker histone H1c is distinct from that of H10. Journal of Biological Chemistry 285:20891-20896

Rangarajan ES, Park H, Fortin E, Sygusch J, Izard T* (2010). Mechanism of aldolase control of sorting nexin 9 function in endocytosis. Journal of Biological Chemistry 285:11983-11990

Lee JH, Rangarajan ES, Yogesha SD, Izard T* (2009). Raver1 interactions with vinculin and RNA suggest a feed-forward pathway in directing mRNA to focal adhesions. Structure 17:833-842

Rebouissou S, Amessou M, Couchy G, Poussin K, Imbeaud S, Pilati C, Izard T, Balabaud C, Bioulac-Sage P, Zucman-Rossi J (2009). Frequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours. Nature 457:200-204

Nhieu GT, Izard T* (2007). Vinculin binding in its closed conformation by a helix addition mechanism. EMBO J 26:4588-4596

St-Jean M, Izard T, Sygusch J (2007). A hydrophobic pocket in the active site of glycolytic aldolase mediates interactions with Wiskott-Aldrich syndrome protein. Journal of Biological Chemistry 282:14309-14315

Ramarao N, Le Clainche C, Izard T, Bourdet-Sicard R, Ageron E, Sansonetti PJ, Carlier MF, Tran Van Nhieu, G (2007). Capping of actin filaments by vinculin activated by the Shigella IpaA carboxyl-terminal domain. FEBS Letters 581:853-857

Izard T, Tran Van Nhieu G, Bois PR (2006). Shigella applies molecular mimicry to subvert vinculin and invade host cells. Journal of Cell Biology 175:465-475

Bois PR, O'Hara BP, Nietlispach D, Kirkpatrick J, Izard T* (2006). The vinculin binding sites of talin and α-actinin are sufficient to activate vinculin. Journal of Biological Chemistry 281:7228-7236

Brown DT, Izard T, Misteli T (2006). Mapping the interaction surface of linker histone H1(0) with the nucleosome of native chromatin in vivo. Nature Structural & Molecular Biology 13:250-255

Bois PRJ, Borgon RA, Vonrhein C, Izard T* (2005). Structural dynamics of α-actinin-vinculin interactions. Molecular and Cellular Biology 25:6112-6122

Morris VK, Izard T* (2004). Substrate-induced asymmetry and channel closure revealed by the apoenzyme structure of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase. Protein Science 13:2547-2552

Borgon RA, Vonrhein C, Bricogne G, Bois PRJ, Izard T* (2004). Crystal structure of human vinculin. Structure 12:1189-1197

Izard T*, Vonrhein C (2004). Structural basis for amplifying vinculin activation by talin. Journal of Biological Chemistry 279:27667-27678

Rush CL, Izard T* (2004). Rhombohedral crystals of the human vinculin head domain in complex with a vinculin-binding site of talin. Acta Crystallographica D60:945-947

Izard T*, Evans G, Borgon RA, Rush CL, Bricogne G, Bois PRJ (2004). Vinculin activation by talin through helical bundle conversion. Nature 427:171-175

Izard T, Sygusch J. (2004). Induced fit movements and metal cofactor selectivity of class II aldolases: Structure of thermus aquaticus fructose-1,6-bisphosphate aldolase. Journal of Biological Chemistry 279:11825-11822

Brown KL, Morris VK, Izard T* (2004). Rhombohedral crystals of Mycobacterium tuberculosis phosphopantetheine adenylyltransferase. Acta Crystallographica D60:195-196

Izard T* (2003). A novel adenylate binding site confers phosphopantetheine adenylyltransferase interactions with Coenzyme A. Journal of Bacteriology 185:4174-4080

Hurlbert J, Izard T* (2002). Crystallization of HLA-DR4 complexed with a collagen II peptide. Acta Crystallographica D58:1749-1751

Izard T* (2002). The crystal structures of phosphopantetheine adenylyltransferase with bound substrates reveal the enzyme's catalytic mechanism. Journal of Molecular Biology 315:487-495

Izard T* (2001). Structural basis for chloramphenicol tolerance in Streptomyces venezuelae by chloramphenicol phosphotransferase activity. Protein Science 10:1508-1513

Izard T*, Blackwell N (2000). Crystal structures of the metal-dependent 2-dehydro-3-deoxy-galactarate aldolase suggest a novel reaction mechanism. The EMBO Journal 19:3849-3856

Izard T*, Ellis J (2000). The crystal structures of chloramphenicol phosphotransferase reveal a novel inactivation mechanism. The EMBO Journal 19:2690-2700

Blackwell NC, Cullis PM, Cooper RA, Izard T* (1999). Rhombohedral crystals of 2-dehydro-3-deoxy glucarate aldolase Escherichia coli. Acta Crystallographica D55:1368-1369

Izard T*, Geerlof A, Lewendon A, Barker JJ (1999). Cubic crystals of phosphopantetheine adenylyltransferase from Escherichia coli. Acta Crystallographica D55:1226-1228

Ellis J, Campopiano DJ, Izard T* (1999). Cubic crystals of chloramphenicol phosphotransferase from Streptomyces venezuelae. Acta Crystallographica D55:1086-1088

Izard T*, Geerlof A (1999). The crystal structure of a novel bacterial adenylyltransferase reveals half of sites reactivity. The EMBO Journal 18:2021-2030

Izard T, Ævarsson A, Allen MD, Westphal AH, Perham RN, de Kok A, Hol WGJ (1999). Principles of quasi-equivalence and euclidean geometry govern the assembly of cubic and dodecahedral cores of pyruvate dehydrogenase complexes. Proceedings of the National Academy of Sciences USA 96:1240-1245

Izard T, Sarfaty S, de Kok A, Westphal A, Hol WGJ (1997). Improvement of diffraction quality upon rehydration of dehydrated icosahedral E. faecalis pyruvate dehydrogenase core crystals. Protein Science 6:913-915

Izard T, Lawrence MC, Malby RL, Lilley, GG, Colman PM (1994). The three-dimensional structure of N-acetylneuraminate lyase from Escherichia coli. Structure 2:361-369

Lawrence MC, Izard T, Beuchat M, Blagrove RJ, Colman PM (1994). The structure of phaseolin at 2.2 Å resolution: Implications for a common vicilin/legumin structure and the genetic engineering of seed storage proteins. Journal of Molecular Biology 238:748-776

Izard T, Fol B, Pauptit RA, Jansonius JN (1990). Trigonal crystals of porcine mitochondrial aspartate aminotransferase. Journal of Molecular Biology 215:341-344

PhD Thesis: "Three Dimensional Fourier Synthesis of N-neuraminate Lyase from Escherichia coli."

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