Havran Laboratory- Research
 
   

Publications

Boismenu, R., Havran, W.L. Modulation of epithelial cell growth by intraepithelial γδ T cells. Science 266:1253, 1994. PubMed

Boismenu, R., Chen, Y., and Havran, W.L. The role of intraepithelial γδ T cells: A gut feeling. Microbes and Infection 1:235, 1999. Pubmed

Havran, W.L. A role for epithelial γδ T cells in tissue repair. Immunol. Res. 21/2-3:63, 2000. Pubmed

Witherden, D., Boismenu, R., and Havran, W.L. CD81 and CD28 costimulate T cells through distinct pathways. J. Immunol. 165:1902, 2000. Pubmed

Witherden, D., Rieder, S.E., Boismenu, R., and Havran, W.L. A role for epithelial γδ T cells in tissue repair. Springer Seminars in Immunopathology. 22:265, 2000. Pubmed

Jameson, J., Ugarte, K., Chen, N., Yachi, P., Fuchs, E., Boismenu, R., and Havran, W.L. A role for skin γδ T cells in wound healing. Science 296:747-749, 2002. Pubmed

Chen, Y., Chou, K., Fuchs, E., Havran, W.L., and Boismenu, R. Protection of the intestinal mucosa by intraepithelial γδ T cells. Proc. Nat. Acad. Sci. USA, 99:14338, 2002. Pubmed

Jameson, J., Witherden, D., and Havran, W.L. T cell effector mechanisms: γδ and CD1-restricted subsets. Current Opinion in Immunology 15:349, 2003. Pubmed

Jameson, J., Cauvi, G., Witherden, D., and Havran, W.L. A keratinocyte-responsive γδ TCR is necessary for dendritic epidermal T cell activation by damaged keratinocytes and maintenance in the epidermis. J. Immunol., 172:3573, 2004. Pubmed

Jameson, J.M., Sharp, L., Witheren, D.A., and Havran, W.L. Regulation of skin cell homeostasis by γδ T cells. Frontiers in Bioscience, 9:2640, 2004. Pubmed

Yui, M., Sharp, L.L., Havran, W.L., and Rotherberg, E.V. Preferential activation of an IL-2 regulatory sequence transgene in TCR γδ and NKT cells: subset-specific differences in IL-2 regulation. J. Immunol., 172:4691, 2004. Pubmed

Sharp, L.*, Jameson, J.*, Cauvi, G., and Havran, W.L. Dendritic epidermal T cells regulate skin homeostasis through local production of Insulin Like Growth Factor-1. Nature Immunol. 6:73-79, 2004. *contributed equally Pubmed

Baccala, R.*, Witherden, D.*, Gonzalez-Quintial, R., Dummer, W., Surh, C.D., Havran, W.L., and Theofilopoulos, A.N. γδ T cell homeostasis is controlled by interleukins 7 and 15 together with subset-specific ligands. J. Immunol., 174(8):4604-12, 2005. *contributed equally Pubmed

Sharp, L., Jameson, J., Witherden, D., Komori, H.K., and Havran, W.L. Activation requirements for dendritic epidermal γδ T cells. Critical Rev. Immunol., 25(1):1-18, 2005. Pubmed

Jameson, J., Cauvi, G., Sharp, L., Witherden, D., and Havran, W.L. γδ T cells induce hyaluronan production by epithelial cells: A mechanism for regulating inflammation. J. Exp. Med., 201(8):1269-19, 2005. Pubmed

Havran, WL, Jameson JM, Witherden DA. Epithelial cells and their neighbors. III. Interactions between intrapepithelial lymphocytes and neighboring epithelial cells. Am J Physiol Gastrointest Liver Physiol. 289(4) G627-10, 2005. Pubmed

Komori, HK, Meehan, RF, Havran WL. Epithelial and mucosal γδ T cells. Curr Opin Immunol. 18(5):534-8. 2006. Pubmed

Kronenberg M, Havran WL. Frontline T cells: γδ T cells and intrapithelial lymphocytes. Immunol Rev. 215:5-7. 2007. Pubmed

Jameson J, Havran WL. Skin γδ T cell functions in homeostasis and wound healing. Immunol Rev. 215:114-22. 2007. Pubmed

Yu D, Cook MC, Shin DM, Silva DG, Marshall J, Toellner KM, Havran WL, Caroni P, Cooke MP, Morse HC, MacLennan IC, Goodnow CC, Vinuesa CG Axon growth and guidance genes identify T-dependent germinal centre B cells.Immunol Cell Biol. 86(1):3-14. 2008. Pubmed

Kim CH, Witherden DA, Havran WL. Characterization and TCR variable region gene use of mouse resident nasal gammadelta T lymphocytes. J Leukoc Biol. 84(5):1259-63. 2008 Pubmed

Toulon A, Breton L, Taylor KR, Tenenhaus M, Bhavsar D, Lanigan C, Rudolph R, Jameson J, Havran WL. A role for human skin-resident T cells in wound healing. J Exp Med. 206(4):743-50, 2009. Pubmed

Havran WL, Jameson JM. Epidermal T cells and wound healing. J. Immunol. 184(10):5423-8, 2010. Pubmed

Witherden DA, Verdino P, Rieder SE, Garijo O, Mills RE, Teyton L, Fischer WH, Wilson IA, Havran WL. The junctional adhesion molecule JAML is a costimulatory receptor for epithelial gammadelta T cell activation. Science 3;329(5996):1205-10, 2010. Pubmed (See link(s) below for access to this Science article).

Abstract: http://www.sciencemag.org/cgi/content/abstract/329/5996/1205?ijkey=eOQ6g7ewwfX4U&keytype=ref&siteid=sci
Reprint: http://www.sciencemag.org/cgi/rapidpdf/329/5996/1205?ijkey=eOQ6g7ewwfX4U&keytype=ref&siteid=sci
Full Text: http://www.sciencemag.org/cgi/content/full/329/5996/1205?ijkey=eOQ6g7ewwfX4U&keytype=ref&siteid=sci 

Verdino P, Witherden DA, Havran WL, Wilson I. The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science 3;329(5996):1210-4, 2010.
Pubmed


 


      10550 N Torrey Pines Rd, La Jolla CA, 92037