We have a long-term interest in interactions between intraepithelial γδ T cells and their neighboring epithelial cells. We focus on interactions in the thymus, skin, and intestine. We are investigating the development, specificity, and function of these γδ T cells. Our results have defined unique properties of these cells and support a specialized role for intraepithelial γδ T cells in immune surveillance, wound repair, inflammation, and protection from malignant tumors.