About TSRI
Research & Faculty
News & Publications
Scientific Calendars
Scripps Florida
PhD Program
Campus Services
Work at TSRI
TSRI in the Community
Giving to TSRI
Directory
Library
Contact
Site Map & Search
TSRI Home
 

.
Selected Publications

1. de Parseval, A., U. Chatterji, G. Morris, P.Sun and J.H. Elder. (2005) Structural mapping of CD134 residues critical for interaction with FIV. Nat Struct Mol Biol. 12:60-66, PMID: 15592478.
2. de Parseval, A., M.D. Bobardt, J.H. Elder, G. David, S. Zolla-Pazner, D.R. Burton, J. Sodroski, M.R. Farzan, T-H. Lee and P.A. Gallay. (2005) A Highly Conserved Arginine in Gp120 Governs HIV-1 Binding to Both CCR5 and Syndecans Via a Sulfated Motif. J. Biol. Chem. 280:39493-504, PMID: 16157597.
3. Brik, A., J. Alexandratos, Y-C. Lin, J.H. Elder, A.J. Olson, A. Wlodawer, D.S. Goodsell and C-H. Wong. (2005) 1,2,3-Triazole as a Peptide Surrogate in the Rapid Synthesis of HIV-1 Protease Inhibitors. ChemBioChem. 6:1167-1169, PMID: 15934050.
4.

Liang, F-S., A. Brik, Y-C. Lin, J.H. Elder and C-H. Wong. (2006) Epoxide Opening in the Water and Screening In Situ for Rapid Discovery Enzyme Inhibitors in Microtiter Plate. Bioorganic & Medicinal Chemistry. 14(4):1058-62, PMID: 16275107.

5.

Gonzalez-Lira, B., P.E. Rueda-Orozco, O. Galicia, C.J. Montes-Rodriguez, K. Guzman, M. Guevara-Martinez, J.H. Elder and O. Prospero. (2006) Nicotine prevents HIVgp120-caused electrophysiological and motor disturbances in rats. Neuroscience Letters. 394(2):136-9, PMID: 16269213.

6.

Whiting, M., J. Muldoon, Y-C. Lin, S.M. Silverman, W. Lindstrom, A. Olson, H.C. Kolb, M.G. Finn, K.B. Sharpless, J.H Elder and V.V. Fokin. (2006) Inhibitors of HIV-1 Protease through In Situ Click Chemistry. Angew. Chem. Int. Ed. 44:1-5.

7.

Heaslet, H., V. Kutilek, G. Morris, Y.-C.Lin, J.H. Elder, B.E. Torbett, C.D. Stout. (2006) Structural Insights into the Mechanisms of Drug Resistance in HIV-1 Protease NL4-3. Journal of Molecular Biology. 356(4):967-81.

8.

de Parseval, A., C.K. Grant, J. Sastry, J.H. Elder. (2006) Sequential CD1334-CXCR4 Interactions in Feline Immunodeficiency Virus (FIV): Soluble CD134 Activates FIV Env for CXCR-4 dependent Entry and Reveals a Cryptic Neutralization Epitope. Journal of Virology. 80(6):3088-91, PMCID: PMC1395450.

9.

Binley J.M., S. Ngo-Abdalla, P. Moore, M. Bobardt, Chatterji, U., P. Gallay, D.R. Burton, I.A. Wilson, J.H. Elder, A. de Parseval. (2006) Inhibition of HIV Env binding to cellular receptors by monoclonal antibody 2G12 as probed by Fc-tagged gp120. Retrovirology. 3:39; correction (2007)
4:23, PMID: 16817962.

10.

Lin, Y.C., A. Brik, A. de Parseval, K. Tam, B.E. Torbett, C.H. Wong, J.H. Elder. (2006) Altered gag polyprotein cleavage specificity of feline immunodeficiency virus/human immunodeficiency virus mutant proteases as demonstrated in a cell-based expression system. Journal of Virology.80(16):7832-43, PMCID: PMC1563824.

11. Whiting, M., J.C. Tripp, Y.C. Lin, W. Lindstrom, A.J. Olson, J.H. Elder, K.B. Sharpless, V.V.Fokin. (2006) Rapid discovery and structure-activity profiling of novel inhibitors of human immunodeficiency virus type 1 protease enabled by the copper(I)-catalyzed synthesis of 1,2,3-triazoles and their further functionalization. J. Med. Chem. 49, 7697-7710.
12.

Heaslet, H., Y.C. Lin, K. Tam, B.E. Torbett, J.H. Elder, C.D. Stout. (2007) Crystal structure of an FIV/HIV chimeric protease complexed with the broad-based inhibitor, TL-3. Retrovirology 4:1, PMCID: PMC1781954.

13.

30. Manuell, A.L., M.V. Beligni, J.H. Elder, D.T. Siefker, M. Tran, A. Weber, T.L. McDonald, S.P. Mayfield. (2007) Robust expression of a bioactive mammalian protein in Chlamydomonas chloroplast. Plant Biotechnology Journal, 5.

14.

Sundstrom M, Chatterji U, Schaffer L, de Rozières S, Elder JH. (2008) Feline immunodeficiency virus OrfA alters gene expression of splicing factors and proteasome-ubiquitination proteins. Virology.20;371(2):394-404, PMID: 18289701.

15.

Elder JH, Sundstrom M, de Rozieres S, de Parseval A, Grant CK, Lin YC. (2008) Molecular mechanisms of FIV infection. Vet Immunol Immunopathol. 2008 May 15;123(1-2):3-13 PMCID: PMC2409060.

16.

de Rozières S, Thompson J, Sundstrom M, Gruber J, Stump DS, de Parseval AP, Vandewoude S, Elder JH. (2008) Replication Properties of Clade A/C Chimeric FIVs and Evaluation of Infection Kinetics in the Domestic Cat. J Virol. 82:7953-7963, PMID: 18550665.

17. Sundstrom M, White RL, de Parseval A, Sastry KJ, Morris G, Grant CK, Elder JH. (2008) Mapping of the CXCR4 Binding site within Variable Region 3 of the Feline Immunodeficiency Virus Surface Glycoprotein. J Virol. 2008 Jul 2, PMID: 18596086.
   
   
   
   
   
   
   

 
















 

Home

Research

Publications

Group Members