RESEARCH

Antibodies and Infectious Disease:
The perception of man as the easy victor over microbes has changed dramatically in the last decade. Vaccination has offered protection against a number of viral pathogens, but it is increasingly recognized that the strategies used in the past will not be successful against all viruses. More understanding of viral pathogenesis and the interaction of viruses with the immune system are required. We are focused on the interplay of antibodies and viruses in humans. We make particular use of combinatorial antibody technology, which gives ready access to human antibodies. The viruses we are studying are human immunodeficiency virus type 1 (HIV-1), respiratory syncytial virus (RSV), herpes simplex virus (HS-1, HSV-2), and Ebola Virus.

 

Animation: Molecular model of Fab b12 binding
into CD4bs of HIV-1 gp120.