WELCOME TO THE McHEYZER-WILLIAMS LAB
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Michael McHeyzer-Williams, PhD |
Associate Professor
Department of Immunology
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Phone: (858) 784-8259
Fax: (858) 784-8350
Email: mcheyzer@scripps.edu
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BRIEF BIOGRAPHY
Michael McHeyzer-Williams received a PhD in Immunology in 1991 from the Walter and Eliza Hall Institute of Medicine, University of Melbourne, Australia. As a Lucille P. Markey Fellow, Michael undertook post-doctoral work in the Immunology Department at Stanford University Medical Center in 1992. In 1995, he was appointed Assistant Professor in Immunology at Duke University Medical Center in Durham, NC. Since 2001, Michael has continued his work at The Scripps Research Institute in La Jolla, CA as Associate Professor in Immunology.
RESEARCH FOCUS
Regulating Adaptive Immunity. Helper T cells are the master regulators of adaptive immunity that control the development of antigen-specific B cell immunity. Our research seeks to define the cellular and molecular details of the major developmental checkpoints that regulate these cell fate decisions in vivo. We have recently extended our studies into the earliest innate immune events that initiate and shape this adaptive immune response. If we can understand the rules that control adaptive immunity, it will be possible to design safe and effective protein sub-unit vaccines.
RECENT PUBLICATIONS
Fazilleau, N.R., Eisenbraun, M.D., Malherbe, L.P., Ebright, J.N., McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. (2007) Lymphoid reservoirs of antigen-specific memory T helper cells. Nature Immunology 8:753-761 PubMed Abstract
Fazilleau, N.R. McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. (2007) Local development of effector and memory T helper cells. Curr. Opin. Immunol. 19 (3) 259-267 PubMed Abstract
McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. Antigen-Specific Memory B Cell Development. (2005) Annual Reviews Immunol. Vol. 23:487-513. PubMed Abstract
Malherbe L, Hausl C, Teyton L, McHeyzer-Williams MG. Clonal selection of helper T cells is determined by an affinity threshold with no further skewing of TCR binding properties. (2004) Immunity 21(5):669-79. PubMed Abstract
McHeyzer-Williams, L.J. and McHeyzer-Williams, M.G. Developmentally-distinct Th cells control plasma cell production in vivo. (2004) Immunity 20:231-242 PubMed Abstract
Shapiro-Shelef, M.A., Lin, K-I., McHeyzer-Williams, L.J., Liao, J., McHeyzer-Williams, M.G. and Calame, K. Blimp-1 is required for the formation of immunoglobulin secreting plasma cells and pre-plasma memory B cells. (2003) Immunity 19:607-620. PubMed Abstract
TSRI STORIES
