Selected Publications

• Alam, S.M., Travers, P.J., Wung, J.L., Nasholds, W., Redpath, S., Jameson, S.C., and Gascoigne, N.R.J. (1996). T cell receptor affinity and thymocyte positive selection. Nature 381: 616-620
• Sim, B.-C., Zerva, L., Greene, M.I., and Gascoigne, N.R.J. (1996). Control of MHC restriction by TCR Vα CDR1 and CDR2. Science 273: 963-966
• Zal, T., Zal, M.A.,and Gascoigne, N.R.J. (2002). Inhibition of T-cell receptor-coreceptor interactions by antagonist ligands visualized by live FRET imaging of the T-hybridoma immunological synapse. Immunity 16: 521-534
• Niederberger, N.,Holmberg, K., Alam, S.M., Sakati, W., Naramura, M., Gu, H., and Gascoigne, N.R.J. (2003). Allelic exclusion of the T cell receptor α-chain is an active process requiring TCR-mediated signaling and c-Cbl. J. Immunol. 170: 4557-4563
• Holmberg, K., Mariathasan, S., Ohteki, T., Ohashi, P.S. and Gascoigne, N.R.J. (2003). TCR binding kinetics measured with MHC class I tetramers reveal a positive selecting peptide with relatively high affinity for TCR. J. Immunol. 171: 2427-2434
• Zal, T. and Gascoigne,N.R.J. (2004). Photobleaching-corrected FRET efficiency imaging of live cells. Biophys. J. 86: 3923-3939
• Gronski, M.A., Boulter, J.M., Moskophidis, D., Nguyen, L.T., Holmberg, K., Elford, A.R., Deenick, E.K., Kim, H.O., Penninger, J.M., Odermatt, B., Gallimore, A., Gascoigne, N.R.J. and Ohashi, P.S. (2004). TCR affinity and negative regulation limit autoimmunity. Nature Med. 10: 1234-1239
• Niederberger, N., Buehler, L., Ampudia, J. and Gascoigne, N.R.J. (2005). Thymocyte stimulation by anti-TCR-β, but not by anti-TCR-α, leads to induction of developmental transcription program. J. Leukocyte Biol. 77(1)
• Yachi, P.P., Ampudia, J., Gascoigne, N.R.J. , Zal, T. (2005).Nonstimulatory peptides contribute to antigen-induced CD8-T cell receptor interaction at the immunological synapse. Nature Immunol. 2005 Aug;6(8):785-92.
• Yachi, P.P., Ampudia, J., Zal, T., Gascoigne, N.R.J. (2006). Altered peptide ligands induce delayed CD8-T cell receptor interaction--a role for CD8 in distinguishing antigen quality. Immunity. 2006 Aug;25(2):203-11.
• Yachi P.P, Lotz C., Ampudia J., Gascoigne NR.(2007). T cell activation enhancement by endogenous pMHC acts for both weak and strong agonists but varies with differentiation state. J Exp Med. 2007 Oct 29;204(11):2747-57

Reviews

• Sim, B.-C., Lo, D., and Gascoigne, N.R.J. (1998). Preferential expression of TCR Vα regions in CD4/CD8 subsets: Class discrimination or co-receptor recognition? Immunol. Today 19: 276-282
• Gascoigne, N.R.J. and Alam, S.M. (1999). Allelic exclusion of the TCR α-chain: developmental regulation of a post-translational event. Semin. Immunol. 11: 337-347
• Gascoigne, N.R.J., Zal, T., and Alam, S.M. (2001). T-cell receptor binding kinetics in T-cell development and activation. Expert Rev. Mol. Med. Feb. 12; 2001: 1-17 (http://www-ermm.cbcu.cam.ac.uk/01002502h.htm)
• Gascoigne, N.R.J. and Zal, T. (2004). Molecular interactions at the T cell-APC interface. Curr. Op. Immunol. 16: 114-119
• Zal, T. and Gascoigne, N.R.J. (2004). Using live FRET imaging to reveal early protein-protein interactions during T cell activation. Curr. Op. Immunol. 16: 418-427