TSRI Logo

Template Laboratory
Laboratory Home | Research | Publications | Personnel

Selected peer-reviewed publications.

  1. Edgington, T.S., Glassock, R.J., Dixon, F.J. Autologous immune-complex pathogenesis of experimental allergic glomerulonephritis. Science 155:1432-4, 1967.
  2. Edgington, T.S., Ritt, D.J. Intrahepatic expression of serum hepatitis virus-associated antigens. J. Exp. Med. 134:871-85, 1971.
  3. Plow, E.F., Edgington, T.S. Discriminating neoantigenic differences between fibrinogen and fibrin derivatives. Proc. Natl. Acad. Sci. USA 70:1169-73, 1973.
  4. Edgington, T.S., Astarita, R.W., Plow, E.F. Association of an isomeric species of carcinoembryonic antigen with neoplasia of the gastrointestinal tract. N. Engl. J. Med. 293:103-7, 1975.
  5. Plow, E.F., Edgington, T.S. Isolation and characterization of a homogeneous isomeric species of carcinoembryonic antigen (CEA-S). Int. J. Cancer 15:748-61, 1975.
  6. Loskutoff, D.J., Edgington, T.S. Synthesis of a fibrinolytic activator and inhibitor by endothelial cells. Proc. Natl. Acad. Sci. USA 74:3903-7, 1977.
  7. Marguerie, G.A., Plow, E.F., Edgington, T.S. Human platelets possess an inducible and saturable receptor specific for fibrinogen. J. Biol. Chem. 254:5357-63, 1979.
  8. Leung, J.P., Nelson-Rees, W.A., Moore, G.E., Cailleau, R., Edgington, T.S. Characteristics of membrane and cytosol forms of the mammary tumor glycoprotein molecule MTGP in human breast carcinoma cell cultures and tumors. Int. J. Cancer 28:35-42, 1981.
  9. Soule, H.R., Linder E., Edgington, T.S. Membrane 126-kilodalton phospho-glycoprotein associated with human carcinomas identified by a hybridoma antibody to mammary carcinoma cells. Proc. Natl. Acad. Sci. USA 80:1332-6, 1983.
  10. Sun, N.C.J., Edgington, T.S., Carpentier, C.L., McAfee, W., Terry, R., Bateman, J. Immunohistochemical localization of carcinoembryonic antigen (CEA), CEA-S, and nonspecific cross-reacting antigen (NCA) in carcinomas of lung. Cancer 52:1632-41, 1983.
  11. Khaw, B.A., Strauss, H.W., Cahill, S.L., Soule, H.R., Edgington, T., Cooney, J. Sequential imaging of Indium-lll-labeled monoclonal antibody human mammary tumors hosted in nude mice. J. Nucl. Med. 25:592-603, 1984.
  12. Lando, P.A., Edgington, T.S. An innate host response to the neoplastic cell: Syngeneic rat tumor cells can elicit a rapid de novo lymphoid procoagulant response. J. Immunol. 135:3587-95, 1985.
  13. Morrissey, J.H., Fakhrai, H., Edgington, T.S. Molecular cloning of the cDNA for tissue factor, the cellular receptor for the initiation of the coagulation protease cascade. Cell 50:129-35, 1987.
  14. Mackman, N., Morrissey, J.H., Fowler, B., Edgington, T.S. Complete sequence of the human tissue factor gene, a highly regulated cellular receptor that initiates the coagulation protease cascade. Biochemistry 28:1755-62, 1989.
  15. Fan, S.-T., Edgington, T.S. Sufficiency of the CD8+ T cell lineage to mount an effective tumoricidal response to a syngeneic tumor bearing novel class I MHC antigen. J. Immunol. 143:4287-91, 1989.
  16. Altieri, D.C., Edgington, T.S. Identification of EPR-1: A leukocyte distributed receptor for serine proteases. J. Immunol. 145:246-53, 1990.
  17. Altieri, D.C., Etingin, O.R., Fair, D.S., Brunck, T.K., Geltosky, J.E., Hajjar, D.P., Edgington, T.S. Structural homologous ligand binding of integrin Mac-1 and viral glycoprotein C receptors. Science 254:1200-2, 1991.
  18. Mueller, B.M., Reisfeld, R.A., Edgington, T.S., Ruf, W. Expression of tissue factor by melanoma cells promotes efficient hematogenous metastasis. Proc. Natl. Acad. Sci. USA 89:11832-6, 1992.
  19. Carmeliet, P., Mackman, N., Moons, L., Luther, T., Gressens,P., Van Vlaenderen, I., Demunck, H., Kasper, M., Breier, G., Evrard, P., Müller, M., Risau, W., Edgington, T., Collen, D. Role of tissue factor in blood vessel development. Nature 383:73-5, 1996.
  20. Huang, X., Molema, G., King, S., Watkins, L., Edgington, T.S., Thorpe, P.E. Tumor infarction in mice by antibody-directed targeting of tissue factor to tumor vasculature. Science 275:547-50, 1997.
  21. Huang, M., Syed, R., Stura, E.A., Stone, M.J., Stefanko, R.S., Ruf, W., Edgington, T.S., Wilson, I.A. The mechanism of an inhibitory antibody on TF-initiated blood coagulation revealed by the crystal structures of human tissue factor, Fab 5G9 and TF-5G9 complex. J. Mol. Biol. 275:873-94, 1998.
  22. Liu, C., Huang, H., Doñate, F., Dickinson, C., Santucci, R., EL-Sheikh, A., Vessella, R., Edgington, T.S. Prostate-specific membrane antigen directed selective thrombotic infarction of tumors. Cancer Res. 62:5470-5, 2002.
  23. EL-Sheikh, A., Liu, C., Huang, H., Edgington, T.S. A novel VEGF heparin binding domain substructure binds to glycosaminoglycans in vivo, and localizes to tumor microvascular endothelium. Cancer Res. 62:7118-23, 2002.
  24. Liu, C., Sun, C., Huang, H., Janda, K., Edgington, T. Over-expression of legumain in tumors is significant for invasion/metastasis and a candidate enzymatic target for prodrug therapy. Cancer Res. 63:2957-64, 2003.
  25. Huang, H., Norledge, B.V., Liu, C., Olson, A.J., Edgington, T.S. Selective attenuation of the extrinsic limb of the tissue factor driven coagulation protease cascade by occupancy of a novel peptidyl docking site on tissue factor. Biochemistry 42(36):10619-26, 2003.
  26. Liu, C., Bhattacharjee, G., Boisvert, W., Dilley, R., Edgington, T.S. In vivo interrogation of the molecular display of atherosclerotic lesion surfaces. Am. J. Pathol. 163(5):1859-71, 2003.
  27. Liu, C., Dickinson, C., Shobe, J. Donate, F., Ruf, W., Edginton T.S. A hybrid fibronectin motif protein as an integrin targeting selective tumor vascular thrombogen. Mol. Cancer Therap. 3(7):793-801, 2004.
  28. Bhattacharjee, G., Ahamed, J., Pedersen, B., El-Sheikh, A., Mackman, N., Ruf, W., Edgington, T.S. Regulation of tissue factor mediated initiation of the coagulation cascade by cell surface Grp78. Arterioscler. Thromb. Vasc. Biol. 25:1737-43, 2005.
  29. El-Sheikh, A., Borgstrom, P., Bhattacharjee, G., Belting, M., Edgington, T.S. A selective tumor microvasculature thrombogen that targets a novel receptor complex in the tumor angiogenic microenvironment. Cancer Res. 65:11109-1117, 2005.
  30. Wu, W., Luo, Y., Sun, C., Liu, Y., Kuo, P., Varga, J., Xiang, R., Reisfeld, R., Janda, K.D., Edgington, T.S., and Liu, C. Targeting cell-impermeable prodrug activation to tumor microenvironment eradicates multiple drug resistant neoplasms. Cancer Res., in press, January 2006.