movies

Cell Movies

Movie 1:

Chemotaxis of human neutrophils towards a micropipette (shadow at left) dispensing a chemoattractant gradient of fMLP. See
Gardiner et al Current Biol. 12: 2029, 2002 and Pestonjamasp et al Blood 108: 2814, 2006. Movie prepared by Hui Zhang, Ph.D.

Movie 2 : Movie 3 : Movie 4 :

Analysis of actin dynamics at the cell edge of Ptk1 kidney epithelial cells using fluorescent speckle microscopy (FSM). The presence of active RacQ61L causes a widening of the lamellipodia and increased retrograde actin flow. This effect is blocked when the downstream effector, p21-activated kinase 1 (PAK1) is inhibited by expressing of the (auto)inhibitory domain (PID). See Delorme et al (2007) – in press.

(Movies prepared by Violaine Delorme, Ph.D)

Movie 5:

Normal HeLa cell undergoing cell division. See Birkenfeld et al Dev. Cell. May 8, 2007. Vol 12, Issue 5, pages 699-712.

(Movie prepared by Joerg Birkenfeld, Ph.D.)

Movie 6 :

Cells undergoing division: note the cell to the left fails to divide properly due to the enhanced cofilin activity caused by overexrpression of the cofilin phosphatase Chronophin (CIN), discovered in our laboratory. See Gohla et al Nature Cell Biol. 7: 21, 2005.

(Movie prepared by Céline DerMardirossian, Ph.D.)