Employment Opportunities

Applying For Postdoctoral Positions

You may apply for a postdoctoral position by sending your cover letter and curriculum vitae to the attention of the principal investigator as listed in each job vacancy, at the respective TSRI location (Florida or California). You may use the e-mail address listed for each investigator and electronically attach your curriculum vitae, or you may send your information to the principal investigator by mail as follows:

CALIFORNIA:
The Scripps Research Institute
10550 North Torrey Pines Road
La Jolla, CA 92037

FLORIDA:
Scripps Florida
Division of The Scripps Research Institute
130 Scripps Way
Jupiter, FL 33458

TSRI Faculty: Please help keep the information on this page current. See the Information Page on posting a postdoctoral position.

POSTDOCTORAL POSITIONS AVAILABLE AT TSRI

Select one of the following departments to view available positions:

CANCER BIOLOGY
CELL BIOLOGY
CHEMICAL PHYSIOLOGY
CHEMISTRY
COMMITTEE ON THE NEUROBIOLOGY OF ADDICTIVE DISORDERS
GENETICS
IMMUNOLOGY & MICROBIAL SCIENCE
INFECTOLOGY
INFORMATICS
METABOLISM & AGING
MOLECULAR BIOLOGY
MOLECULAR & EXPERIMENTAL MEDICINE
MOLECULAR & INTEGRATIVE NEUROSCIENCES
MOLECULAR THERAPEUTICS
NEUROBIOLOGY
THE SKAGGS INSTITUTE FOR CHEMICAL BIOLOGY
TRANSLATIONAL RESEARCH INSTITUTE

CANCER BIOLOGY

Within the department of Cancer Biology, the following postdoctoral position is available:

Principal Investigator: John Cleveland
E-Mail: jcleve@scripps.edu

Research Description: An endowed postdoctoral fellowship in cancer biology is immediately available in the laboratory of Dr. John Cleveland (Professor and Chairman, Department of Cancer Biology, The Scripps Research Institute [TSRI]) at the Scripps Florida campus of TSRI. The lab is focused on defining new targets for cancer prevention and therapeutics (e.g., those that control tumor cell metabolism and autophagy) and uses mouse cancer models as platforms for discovery and for testing the efficacy of novel anti-cancer agents. The lab is targeting a number of malignancies, including lymphoma and leukemia, neuroblastoma, multiple myeloma and melanoma, and breast and lung cancer. Many of the targets that are being evaluated lie downstream of Myc oncoproteins, which are activated in 70% of rapidly dividing malignancies, and another focus of the lab is to define the mechanisms by which Myc licenses the activation of select tumor suppressor pathways in different cell contexts.

Requirements: Outstanding PhD and/or MD candidates are sought for this endowed fellowship. Candidates must have experience in molecular and cellular biology and experience in mouse models is preferred. Successful candidates will work in a cutting-edge research environment that greatly facilitates target discovery and anti-cancer drug development. This includes the unique Cell-Based Screening Core, The Ultra High-Throughput Screening Center, the Drug Discovery and DMPK components of the Translational Research Institute, and the state-of-the-art synthetic and medicinal chemistry and chemical biology programs of Scripps Florida. The laboratory has outstanding facilities and provides a unique training environment for fellows, and has an outstanding track record for placing fellows in faculty positions in academia. Interested applicants should submit a copy of CV, a brief statement of research skills, experiences, goals, and contact information (email address and phone number) of three references to: jcleve@scripps.edu.

Location: Jupiter, FL

Principal Investigator: Tina Izard
E-Mail: izard@scripps.edu
URL: http://www.scripps.edu/florida/cancerbio/izard/

Research Description: A position is available for post-doctoral fellow in Protein Crystallography. The lab is focused on unraveling the regulation of cell migration and morphogenesis, which relies on the cell's ability to form specific contacts with its neighbors or with the extracellular matrix (ECM) through dedicated adhesion receptors. Contacts with the ECM are directed by integrin receptors, which are unique in directing both outside-in and inside-out signaling pathways. Activation of integrin receptors triggers the rapid reorganization of the actin cytoskeleton and this relies on the function of talin and vinculin, which were previously thought to act as scaffolds that bridge integrin receptors to the actin cytoskeleton. Surprisingly, our structural, biochemical, and cell biological studies have revealed that these proteins function as direct signaling effectors that, by undergoing dramatic changes in their structures, transmit the outside-in signal. Successful candidates will work in a cutting-edge research environment that tackles this important new arena in cancer and cell biology. The laboratory has outstanding facilities for molecular biology; protein expression, purification, and biochemistry; and protein crystallography.

Requirements: We are seeking a PhD graduate to determine the crystal structures of several important cytoskeletal proteins. Candidates should have experience in crystal structure determination as well as an interest in the biology of cytoskeletal proteins. The position provides an outstanding training program in protein biochemistry and structure, and also in molecular and cellular biology, in a highly funded, dynamic, and team-oriented research program. Please send CV, a summary of research experience and interests, and names, addresses, e-mail and telephone numbers of 3 references to: izard@scripps.edu .

Location: Jupiter, FL

CELL BIOLOGY

Within the department of Cell Biology, the following postdoctoral positions are available:

Principal Investigator: Velia Fowler
E-Mail: velia@scripps.edu
URL: http://actin-ends.scripps.edu/

Research Description: Actin cytoskeleton regulation of cell shape and tissue patterning during development; how perturbations in the actin cytoskeleton compromise tissue function. Projects center on molecular, cellular and functional studies of transgenic and knockout mice missing the actin filament capping protein, tropomodulin, and its binding partner, tropomyosin. Model systems include hexagonal packing geometry of epithelial and fiber cells in the eye lens, biogenesis of the membrane skeleton in red blood cells, and myofibril assembly and contraction in striated muscle. Approaches utilize histological analysis and in vivo imaging of fluorescent-tagged cells and proteins in mouse tissues, together with high-resolution visualization of cell shapes and actin cytoskeleton architecture using 3D reconstruction and quantitative image analysis software. Complementary studies in cultured cells using shRNA knockdowns are used to test molecular and cellular hypotheses of actin cytoskeleton regulation. Molecular mechanisms are also investigated using actin polymerization and protein-protein interaction assays, subcellular fractionation and western blotting, proteomics, and RNA-expression profiling. Functional and physiological consequences are tested using approaches specific for each cell and tissue system.

Requirements: Experience required in at least three of the following areas: molecular biology, cell culture, transfection, protein biochemistry, immunofluorescence and confocal microscopy, live cell microscopy, image analysis, histology, targeting vector technology, mouse genetics and embryonic development, primary cell isolation and culture from mouse tissues. Experience in cytoskeletal research desirable. Applicant will be expected to apply for a postdoctoral fellowship.

Ph.D. required in a biology-related discipline such as molecular/cell biology, developmental biology, biochemistry or genetics.

Please send your CV and a list of at least three professional references to velia@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Claudio Joazeiro
Maildrop: CB-163
E-Mail: joazeiro@scripps.edu

Research Description: Research in the laboratory addresses the role of E3 ubiquitin ligases in biology and disease. We are currently studying the regulation of signaling and cell growth by MULAN, a mitochondria-anchored E3, and elucidating the mechanism by which LISTERIN, a novel E3 we identified, leads to neurodegeneration. We have also annotated the human E3-encoding genes and used this information to generate plate-arrayed, genome-wide E3 cDNA and siRNA collections that are being used in the lab for functional screens.
The position available is to study a new E3 that appears to act as a tumor suppressor. Work will include identifying the E3's critical substrates, studying the mechanisms involved in its regulation, and elucidation of its role in cancer biology. Depending on the candidate's background and interests, the project may also include generating genetically-modified mice.

Requirements: The candidate should have strong conceptual and experimental background in biochemistry and molecular biology, as well as on the mechanistic dissection of signaling; background in cancer biology and signaling is also desirable; he/she should be independent, proactive, hard working and productive, and should enjoy working in team efforts; the most competitive candidates will have at least one first-author publication (or article in press) and will have the potential and commitment to become self-funded in the short-term.

Please send CV, a brief statement of current and future research interests and three references to joazeiro@scripps.edu.

Location: La Jolla, CA

Principal Investigator: James Quiqley
E-Mail: jquigley@scripps.edu
URL: http://www.scripps.edu/research/faculty.php?rec_id=6974

Research Description: A postdoctoral position in the Department of Cell Biology at The Scripps Research Institute for late 2009/early 2010 to study newly-identified proteins that have functional roles in cancer metastasis. The proteins include multi-domain transmembrane proteins and multi-domain proteolytic enzymes.

Requirements: Candidates must have a Ph.D. degree with strong biochemical and molecular training. The chosen applicant will receive additional training in cancer cell biology, using a number of quantitative in vivo model systems that recapitulate the steps in tumor progression. An expected lead role in molecular approaches to metastasis with possible translational application will be part of this position. In addition to a background in biochemical and molecular approaches, suitable candidates should have excellent communication skills and be highly-motivated individuals. Applicants should send a cover letter, curriculum vitae and a minimum of three references to: James Quigley, Ph.D: jquigley@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Velia Fowler, Clint Potter, Bridget Carragher
E-Mail: velia@scripps.edu
URL: http://actin-ends.scripps.edu/ and http://nramm.scripps.edu/

Research Description: A postdoctoral position in cellular and structural biology approaches to translational medicine is available immediately in the Fowler/Carragher/Potter Laboratories in the Department of Cell Biology at The Scripps Research Institute in La Jolla, CA. The successful candidate will focus on cellular and structural analysis of endothelial cells in peripheral blood of patients at risk for myocardial infarction. This project will develop novel technologies in correlative fluorescence and electron microscopy to define a unique morphological signature for circulating endothelial cells released from the endothelium in patients at risk for myocardial infarction. The successful candidate will work in a translational science team of physicians, physicists, cell biologists and structural biologists to develop new approaches in the detection and characterization of circulating endothelial cells. He/she will be part of a collegial supportive environment and will enjoy state-of-the art facilities and collaborative interdisciplinary opportunities.

Requirements: Candidates (PhD and/or MD) should have experience with cell culture, fluorescence and/or electron microscopy, and a strong background in cell biology. Strong training and participation in projects with lead roles is preferred. Suitable candidates must also have excellent organizational and communication skills and must be self-motivated and detail oriented. This is a two year position that is funded by the American Recovery and Reinvestment Act of 2009. Applicants should send a cover letter, curriculum vitae and a minimum of three references to: Velia Fowler, PhD: velia@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Peter Kuhn
Maildrop: GAC-1200
E-Mail: pkuhn@scripps.edu
URL: http://kuhn.scripps.edu

Research Description: A postdoctoral position in translational medicine is available immediately in the Kuhn Laboratory, Cell Biology, at The Scripps Research Institute in La Jolla, CA. The successful candidate will focus on the dynamics of cancer over time in correlation with cell signaling events through receptor tyrosine kinases including EGFR, HER2, EphA2 and EphB4 using cell biology and biophysical approaches. The candidate will use existing approaches in the lab to identify and characterize circulating tumor cells isolated from the blood of cancer patients. He/she will be part of a collegial supportive environment and will enjoy state-of-the art facilities and vast collaborative interdisciplinary opportunities.

Requirements: Candidates (PhD and/or MD) must have experience with immunochemistry assay development, and a strong background in cancer biology as well as biophysical tools. Strong training and participation in projects with lead roles is preferred. Suitable candidates must also have excellent organizational and communication skills and must be self-motivated and detail oriented. Applicants should send a cover letter indicating research skills, experience, goals, and contact information (email address and phone number), curriculum vitae and a minimum of three references to: pkuhn@scripps.edu .

Location: La Jolla, CA

Principal Investigator: Peter Kuhn
Maildrop: GAC-1200
E-Mail: pkuhn@scripps.edu
URL: http://kuhn.scripps.edu

Research Description: A postdoctoral position in translational medicine is available immediately in the Kuhn Laboratory, Cell Biology, at The Scripps Research Institute in La Jolla, CA. The successful candidate will focus on the identification and characterization of rare cell populations of endothelial and epithelial origins in the peripheral blood of patients.
The successful candidate will work in a in a translational science team of physicians, physicists and life scientists to develop a new approach in the detection and characterization of circulating endothelial cells. This project will capitalize on and extend the impact of existing technologies in the laboratory for the detection of circulating tumor cells.

Requirements: Candidates (PhD and/or MD) must have experience with immunochemistry assay development, and a strong background in cell biology as well as biophysical tools. He/she will be part of a collegial supportive environment and will enjoy state-of-the art facilities and vast collaborative interdisciplinary opportunities. Strong training and participation in projects with lead roles is preferred. Suitable candidates must also have excellent organizational and communication skills and must be self-motivated and detail oriented. Applicants should send a cover letter indicating research skills, experience, goals, and contact information (email address and phone number), curriculum vitae and a minimum of three references to pkuhn@scripps.edu .

Location: La Jolla, CA

CHEMICAL PHYSIOLOGY

Within the department of Chemical Physiology, the following postdoctoral positions are available:

Principal Investigator: Keri Mowen
Maildrop: IMM-11
E-Mail: kmowen@scripps.edu
URL: http://www.scripps.edu/chemphys/mowen/

Research Description: A postdoctoral position is available for an enthusiastic, motivated, and independent individual in the area of molecular immunology. Our lab interests are in determining the role of peptidylarginine deiminases (PADs) and protein arginine methyltransferases (PRMTs) in T helper cell and mast cell function. Projects include examining novel substrates of PADs and PRMTs in T helper cells and mast cells and determining pathways that regulate PAD and PRMT function in these cell types, especially in the context of autoimmune models like inflammatory arthritis (see Molecular Cell 2004 15:559).

Requirements: Ph.D. in molecular biology, immunology, biochemistry, or cell biology is required. Good communication and organizational skills are a must. Interested candidates should submit their CV and a list of at least 3 professional references to kmowen@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Martha Fedor
Maildrop: MB-35
E-Mail: mfedor@scripps.edu
URL: http://www.scripps.edu/chemphys/fedor/

Research Description: An NIH-funded postdoctoral research position is available immediately in the research group of Martha J. Fedor, to investigate intracellular RNA recognition and mechanisms of RNA secondary structure assembly. This position offers opportunities for postdoctoral training in the application of quantitative methods for analysis of RNA structure and function in vivo.

Requirements: Candidates with experience in yeast molecular biology are particularly encouraged to apply. Please send your CV and a list of at least 3 professional references to mfedor@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Martha Fedor
Maildrop: MB-35
E-Mail: mfedor@scripps.edu
URL:http://www.scripps.edu/chemphys/fedor/

Research Description: An NIH-funded postdoctoral research position is open immediately in the research group of Martha J. Fedor to investigate mechanisms of RNA catalysis. This position offers the opportunity for postdoctoral training in mechanistic enzymology and biophysical studies of RNA enzymes.

Requirements: Candidates with experience in fluorescence assays and/or RNA biochemistry are particularly encouraged to apply. Interested candidates should submit their CV and a list of at least 3 professional references to mfedor@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Enrique Saez
Maildrop: SR-212
E-Mail: esaez@scripps.edu

Research Description: A postdoctoral position is available immediately for a highly enthusiastic and motivated individual to study the genetic basis of nutrient signaling and metabolic disorders in mammals. Our lab uses a variety of chemical and functional genomics and proteomics tools to study the transcriptional control of physiology, and the regulation of adipose tissue formation and function. Our ultimate goal is to identify novel therapeutic targets for the treatment of obesity, diabetes, and atherosclerosis.

Requirements: A Ph.D. in molecular biology, biochemistry, cell biology, genetics or a related area is required. Experience with high-throughput assays, mouse models, and nuclear receptor and adipose tissue biology preferred. Candidates should be independent, creative. They must have a strong interest and commitment to research, excellent organizational and communication skills, and a knack for teamwork. Please send CV and a list of at least three professional references to esaez@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Hugh Rosen
Maildrop: ICND-118
E-Mail: sbrown@scripps.edu
URL: http://www.scripps.edu/chemphys/rosen/

Research Description: We are seeking post-doctoral candidates to participate in The Scripps Comprehensive Center for Chemical Probe Optimization. The Screening Center is part of the NIH Roadmap initiative funded Molecular Libraries Probe Production Centers Network (MLPCN) , the goal of which is to identify and optimize bioactive small molecules that provide researchers the tools to broaden their investigations. The candidate will work closely with investigators interested in accessing the MLPN. Duties will include optimization and implementation of assays for a wide variety of molecular targets including enzymes, receptors and functional cell-based assays using a wide variety of technologies such as fluorescence, FP, TRF and reporter gene assays. The successful candidate will have access to state of the art detection and liquid handling technologies and will use these in the discovery of novel chemical probes.

Requirements: We are seeking candidates with a Ph.D. and at least 2 years of related experience in high throughput assay development. Successful candidates will have a background in biochemistry or related fields. Must be able to effectively work within a multi-disciplinary group and have excellent communication and meticulous record-keeping skills. Please send CV and a list of at least three professional references to sbrown@scripps.edu.

Location: La Jolla, CA

CHEMISTRY

Within the department of Chemistry, the following postdoctoral position is available:

No positions currently available.

COMMITTEE ON THE NEUROBIOLOGY OF ADDICTIVE DISORDERS (CNAD)

Within CNAD, the following postdoctoral positions are available:

Principal Investigator: Barbara Mason
Maildrop: TPC-5
E-Mail: mason@scripps.edu

Research Description: We are seeking a post-doctoral researcheer to conduct human laboratory studies and clinical trials in alcoholism and addictions. This position will also be involved in grant development and manuscript preparation.

Requirements: Must have completed a PhD, MD, or equivalent degree in a relevant discipline. Clinical trials experience is preferred; excellent writing and statistical skills; computer skills including proficiency in MS Word, Excel, and PowerPoint, and in medical literature searches. Please send CV and a list of at least three professional references to mason@scripps.edu.

Location: La Jolla, CA

GENETICS

Within the department of Genetics, the following postdoctoral positions are available:

No positions currently available.

IMMUNOLOGY & MICROBIAL SCIENCE

Within the department of Immunology & Microbial Science, the following postdoctoral positions are available:

Principal Investigator: Philippe Gallay
Maildrop: IMM-9
E-Mail: gallay@scripps.edu

Research Description: Postdoctoral position available immediately. Candidates will have the responsibility to generate a second generation of peptides using C5A as the archetype in order to optimize the in vitro and in vivo safety and potency of C5A against HIV.

In the absence of a vaccine, there is an urgent need for the development of safe and effective topical microbicides to prevent the sexual transmission of the human immunodeficiency virus (HIV). Topical microbicides are defined as genitally applied products that prevent male-to-female or female-to-male transmission of HIV infectious particles. We recently identified a short peptide, called C5A, which efficiently blocks HIV infection by disrupting the integrity of the viral membrane. Our goal is to fully explore the possibility that C5A represents a novel class of microbicidal candidates.

Requirements: Candidates with a Ph.D. and with a strong background in Biochemistry and/or Chemistry are encouraged to apply. Extensive expertise in peptide synthesis and peptide modification is absolutely required. Please send CV and three professional references to gallay@scripps.edu .

Location: La Jolla, CA

Principal Investigator: Karsten Sauer
Maildrop: IMM-24
E-Mail: ksauer@scripps.edu

Research Description: We are seeking an outstanding postdoctoral fellow with strong expertise in cellular and molecular immunology and an excellent publication record in internationally renowned journals. The successful candidate will use our unique mouse models along with primary or tissue culture cell based assays to
analyze the functions and molecular mechanisms of action of novel genes that we identified in forward genetic screens in mice, or in cell-based RNAi-screens, and hypothesize to be important for immunocyte development or function. In particular, the candidate will investigate the functions of
selected genes in swine-flu or LCMV infections and pathology.

For more details, see Science 316, 886-889 (2007), Molecular Cell 33, 43-52 (2009) and www.scripps.edu/ims/sauer.

Requirements: Substantial expertise in relevant techniques, including analyses of responses to virus infections (LCMV, Influenza etc.) in mouse models, analyses of immune system development or peripheral lymphocyte function in mouse models, RNAi studies in mice or tissue culture cells,
retro- and lentiviral transduction techniques, biochemistry, in vivo and in vitro assays for CD4 effector/memory T cell, TH1/2/17, Treg or cytotoxic CD8 T cell function. Strong expertise in analyzing cytokine, effector and memory responses to chronic or acute viral infections will be a particular advantage.

In addition to outstanding scientific credentials, very strong work ethics and a proven ability to work independently with minimal supervision, the successful candidate will have a pleasant, friendly personality and enjoy working in a fast-paced, multidisciplinary but focused academic team environment. S/he will have an excellent, fluent oral and written command of the English language and enjoy to actively participate in scientific discussions in a challenging and stimulating research environment.

For consideration, please submit your CV, the names and contact information of three references, and a brief outline of your research interestes to: ksauer@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Ann Feeney
Maildrop: IMM-22
E-Mail: feeney@scripps.edu

Research Description: A postdoctoral position is available for studies on B cell repertoire formation, B cell differentiation pathways with particular emphasis on marginal zone B cell differentiation, and analyses of the marginal zone B cell repertoire. Molecular biological and cellular approaches will be used.

Requirements: Candidates with a Ph.D. (and/or M.D.) and with a strong background in immunology are encouraged to apply. Experience with molecular biological techniques, flow cytometry and animal work is desirable. Interested candidates should submit their CV and the names and contact information for at least three references to feeney@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Philippe Gallay
Maildrop: IMM-9
E-Mail: gallay@scripps.edu
URL: http://www.scripps.edu/research/faculty.php?rec_id=5582

Research Description: In the absence of a vaccine, there is an urgent need for the development of safe and effective topical microbicides to prevent the sexual transmission of the human immunodeficiency virus (HIV). Topical microbicides are defined as genitally applied products that prevent male-to-female or female-to-male transmission of HIV infectious particles.

A postdoctoral position is immediately available to identify novel anti-HIV microbicidal candidates. S/he will be responsible for culturing and infecting cervical, rectal and penile human tissue explants to study HIV-host cellular interactions that occur in the context of complex tissue architecture and to evaluate a panel of compounds for anti-HIV activity. Compounds that prevent HIV infection of genital tissue explants not only represent potent anti-HIV microbicidal candidates, but also represent ideal tools to unravel the still poorly understood mechanisms that control the early steps of HIV transmission.

Requirements: Candidates should have a PhD and laboratory experience in HIV as well as in molecular biology (cloning). Candidates should have a strong expertise in HIV infection of ex vivo cervical and/or rectal tissue explants.. Please send CV and three professional references to gallay@scripps.edu.

Location: La Jolla, CA

INFECTOLOGY

Within the department of Infectology, the following postdoctoral position is available:

Principal Investigator: Susana Valente
E-Mail: svalente@scripps.edu

Research Description: Postdoctoral position available immediately for outstanding and motivated scientists. Candidates will join a highly motivated junior faculty that focuses on the interplay of HIV with the host cellular machinery.
We have previously identified two cellular proteins that block HIV RNA expression at different levels of the viral life cycle. The candidate will study the mechanism by which these cellular proteins restrict retroviral replication and further extend the knowledge of new cellular factors that block HIV expression by means of genetic screens.

Valente, S. T., Gilmartin, G. M., Venkataraman, K., Arriagada, G., & Goff, S. P. (2009) HIV-1 mRNA 3’ end processing is distinctively regulated by eIF3f, CDK11, and splice factor 9G8. Mol Cell 2009 Oct 23;36(2):279-89

Valente, S. T., Gilmartin, G. M., Mott, C., Falkard, B., & Goff, S. P. (2009) Inhibition of HIV-1 replication by eIF3f. Proc Natl Acad Sci U S A 106:4071-4078.
Valente, S. & Goff, S. P. (2006) Inhibition of HIV-1 Gene Expression by a Fragment of hnRNP U. Mol Cell 23:597-605.

Requirements: A PhD with strong background in molecular biology, virology, tissue culture and biochemistry. Candidates with a strong background in RNA biochemistry will receive strong consideration. The successful candidate will be required to work in the BSL3 facility with fully competent HIV-1. Interested candidates should send curriculum vitae, letter of interest, and names of three references to: svalente@scripps.edu.

Location: Jupiter, FL

INFORMATICS

Within the department of Informatics, the following postdoctoral position is available:

No positions currently available.

MEDICINAL CHEMISTRY

Within the department of Medicinal Chemistry, the following postdoctoral position is available:

No positions currently available.

METABOLISM & AGING

Within the department of Metabolism & Aging, the following postdoctoral position is available:

Principal Investigator: Courtney A. Miller
E-Mail: cmiller@scripps.edu

Research Description: Postdoctoral fellowships in the neurobiology of memory disorders are available in the laboratory of Dr. Courtney A. Miller in the Departments of Neuroscience and Metabolism & Aging.

Project goals: To investigate the epigenetic and synaptic contributions to disorders of memory (e.g. cognitive decline with aging and relapse in drug addiction). Specific areas of interest include molecular biology, protein biochemistry, intra-CNS delivery of small molecule inhibitors/viruses and animal models of behavior.

Requirements: PhD and experience with murine models of behavior, protein biochemistry and molecular biology (e.g. real-time PCR). Please send CV and list of at least 3 professional references to cmiller@scripps.edu.

Location: Jupiter, FL

Principal Investigator: William Ja
E-Mail: hollie@scripps.edu

Research Description: A postdoctoral position is available immediately in the laboratory of Prof. William Ja at The Scripps Research Institute (Jupiter, Florida) in the Department of Metabolism and Aging. The candidate will be part of an interdisciplinary effort to investigate the interactions of gut microorganisms with their host, using the fruit fly, Drosophila, as a model organism. These studies will establish the relationship between the fly microbiome, nutrition, and host health and aging. Projects include phylogenetic and genomic studies, experiments on host and bacterial gene expression, and genetic and biochemical studies of candidate host mechanisms for modulating the gut microbiota.

Requirements: Candidates will have a PhD and experience in a subset of fields including microbial ecology, virology, and nutritional science to complement existing laboratory expertise in Drosophila genetics and biochemistry. The ideal candidate will be capable of establishing independent research projects and work well with scientific colleagues from diverse backgrounds. Interested candidates should send a letter of interest, curriculum vitae, and contact information for at least two references to Hollie Alkema hollie@scripps.edu.

Location: La Jolla, CA

MOLECULAR BIOLOGY

Within the department of Molecular Biology, the following postdoctoral positions are available:

Principal Investigator: Geoffrey Chang
Maildrop: CB-105
E-Mail: gchang@scripps.edu
URL: http://www.scripps.edu/mb/chang/

Research Description: A postdoctoral position is available to work with a lab subgroup in cloning and expression of eukaryotic membrane proteins. Specific duties include: buffer preparation, PCR amplification of genes from DNA clones, plasmid cloning, bacterial culture, protein expression screening with SDS-PAGE and western blots.

Requirements: Ph.D. with 1-3 years experience in molecular biology and protein biochemistry techniques. Good organizational skills. Experience in protein crystallization and x-ray crystallography a plus. Please send CV and list of at least 3 professional references to gchang@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Jane Dyson
Maildrop: MB-2
E-Mail: dyson@scripps.edu

Research Description: A postdoctoral position is available to work in Biomolecular NMR of large protein complexes.

Requirements: Ph.D. with experience in High-resolution NMR and/or preparation of labeled proteins for NMR. Experience in Protein NMR(multidimensional spectroscopy resonance assignment, structure determination, protein relaxation dynamics) and in preparation of uniformly and specifically labeled proteins for NMR spectroscopy are required. Send your CV and a list of least 3 professional references to dyson@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Qinghai Zhang
Maildrop: CB-256
E-Mail: qinghai@scripps.edu

Research Description: Postdoctoral position is open in the field of synthetic organic chemistry or bioorganic chemistry. The candidate will be involved in the design and synthesis of novel chemical reagents for the studies of small molecule-protein interaction. The project involves multidisciplinary collaboration.

Requirements: Ph. D. in chemistry. The candidate must be highly motivated in doing research and have good writing and communication skills. Experienced on computational modeling is desired but not necessary. Please send your CV and list of 3 references to qinghai@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Raymond Stevens
Maildrop: CB-207
E-Mail: stevens@scripps.edu
URL: http://stevens.scripps.edu/

Research Description: Membrane Protein Postdoctoral Research Associate position in the area of membrane biochemistry and membrane protein crystallography. Access to novel expression/stabilization technologies, high throughput nanovolume crystallization, automated imaging, and automated beamline synchrotron facilities should greatly accelerate discovery of membrane protein crystallization and structure determination.

Requirements: Applicants must have successful experience with membrane proteins from a purification to crystallization or crystallization to structure background. Please send your CV and a list of at least three professional references to stevens@scripps.edu.

Location: La Jolla, CA

MOLECULAR & EXPERIMENTAL MEDICINE

Within the department of Molecular & Experimental Medicine, the following postdoctoral positions are available:

Principal Investigator: Stephanie Cherqui
Maildrop: MEM-241
E-Mail: scherqui@scripps.edu

Research Description: A post-doctoral position is available in the area of stem and gene therapy within the Molecular and Experimental Medicine department at The Scripps Research Institute, California. The lab is focused on stem and gene therapy for a lysosomal storage disease, cystinosis. The project covers two aspects of developing a therapy for cystinosis: the systemic treatment of the disease using genetically modified bone marrow cell transplantation, and the specific renal treatment by kidney-targeted gene therapy. These therapies are tested on the mouse model for cystinosis.

Requirements: The candidate should be Ph.D and/or M.D with molecular and cell biology experience. Candidates must be highly motivated. Candidates with stem cell research, virology and mice handling experiences will be preferred. Interested applicants should submit a cover letter, curriculum vitae and three references to: scherqui@scripps.edu .

Location: La Jolla, CA

Principal Investigator: R. Luke Wiseman
Maildrop: MEM-220
E-Mail: wiseman@scripps.edu

Research Description: A postdoctoral position is immediately available in the Wiseman lab for an innovative, enthusiastic, independent individual to study protein folding in vivo. Protein folding in the crowded intracellular environment is facilitated by the continuous partitioning of polypeptides between biological pathways associated with folding and degradation. Exposure to genetic or environmental factors that disrupt this partitioning predispose individuals to numerous human disorders collectively referred to as protein misfolding diseases. We are interested in exploring the physical, chemical, and biological factors that dictate intracellular protein folding to identify novel therapeutic strategies to ameliorate protein misfolding disease. Potential projects in the lab include 1) identification and characterization of mitochondrial proteins whose folding pathways are compromised in neurodegenerative disease, 2) quantification of the impact of Unfolded Protein Response signaling on protein folding efficiency in the early secretory pathway, or 3) elucidation of the biogenesis pathways for components of the protein folding and degradation pathways involved in maintaining intracellular folding environments. The successful candidate will explore protein folding both in vivo and in vitro using a variety of experimental approaches including proteomics, cell biology, and biophysical chemistry.

Requirements: Candidates should have either a Ph.D. or M.D. in biochemistry, cell biology, molecular biology, biophysical chemistry, or related field with experience working with proteins either in vivo or in vitro and basic molecular biology skills. Additionally, the candidate should possess good oral and written communication skills and be proficient with basic computer programs (e.g. Word, Powerpoint, Excel, etc). Experience working with yeast or mammalian cell culture is preferred. Please submit a CV and contact information for three professional references to wiseman@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Jeff Friedman
Maildrop: MEM-131
E-Mail: friedman@scripps.edu

Research Description: We are offering a postdoctoral fellowship to define the causes of hereditary hemolytic anemia in patients (mostly young) who present with this disorder. Our primary approach will utilize proteomics to define changes in protein expression or patterns of oxidative damage to proteins in red blood cells. Candidate proteins will be identified, and the corresponding genomic DNA will be evaluated for novel mutations. The lab has a general interest in the role of oxidative damage in both normal and pathologic red cell turnover, and we have devised several new approaches to measure and quantify oxidative damage. Candidate proteins/genes implicated in causing anemia will be evaluated in cell culture models to understand their normal function, with an emphasis on cellular redox status or resistance to oxidative challenge. The successful candidate will employ a wide range of approaches to study gene/protein function. These approaches will include retroviral or lentiviral transduction of cells for expression of candidate genes/proteins, as well as RNAi mediated knockdown of target genes.

Requirements: PhD in Biology, Biochemistry, Biophysics or related field; prior experience in protein chemistry and/or protein analysis; good basic molecular biology--DNA constructs, RNA purification, PCR; mammalian cell culture experience. Must be familiar with word, excel, powerpoint or equivalent. Must be familiar with statistical analysis program such as Prism or equivalent.

Bioinformatics skills are a definite asset, particularly DNA and protein sequence analysis experience.

Please send CV and a list of at least 3 professional references to: friedman@scripps.edu .

Location: La Jolla, CA

Principal Investigator: Xiaohua Wu
Maildrop: MEM-265
E-Mail: xiaohwu@scripps.edu
URL: http://www.scripps.edu/mem/wu/

Research Description: Our lab focuses on the mechanisms of cell cycle checkpoints and DNA damage repair in mammalian cells. First, biochemical, cellular and molecular approaches are used to investigate the role of tumor suppressor genes, including ATM, Nbs1 and Brca1, in the pathways of DNA damage response and repair, and to address how these critical players in the maintenance of genome stability and prevention of cancer. Second, we investigate the mechanisms of DNA repair in cancer stem cells and search for therapeutic targets that can be used to eradicate cancer stem cells specifically for better treatment. We are also developing mouse models to study DNA repair activities in stem cells and in somatic cells during the process of aging. Third, we are studying the mechanisms underlying chromosomal translocation, which is highly relevant to hematological cancers.

Requirements:The individuals should be highly motivated and enthusiastic about research, and be able to work effectively. The candidates must hold a Ph.D. or M.D. with strong background in molecular biology.
Please send your CV and a list of at least three professional references to xiaohwu@scripps.edu.
Location: La Jolla, CA

Principal Investigator: Nicholas Schork
Maildrop: SGM-300
E-Mail: nschork@scripps.edu
URL: http://www.stsiweb.edu

Research Description: The Scripps Translational Science Institute located at The Scripps Research Institute in La Jolla, California, is seeking qualified individuals for a two-year post-doctoral fellowship in statistical genomics to develop novel analysis tools and algorithms for analyzing and interpreting large scale datasets generated by next-generation sequencing.

Requirements:The candidate will have a PhD and participate in the development of methods and software for analyzing DNA sequencing datasets generated by sequence-based case-control association studies and population sequencing of bacterial genomes. The Scripps Translational Science Institute has several ongoing projects to study the genomics of cancer, obesity, healthy aging, etc., using high-throughput sequencing methods. The candidate will with work with other members of the group on these projects and contribute to writing up of results for publication.
Previous programming experience in a UNIX/Linux environment will be ideal. Strong programming skills in a high-level programming language such as C, C++ or Java and a scripting language such as Perl or Python are essential. Previous experience of bioinformatics tools and methods is desirable. Please send your CV and a list of at least three professional references to nschork@scripps.edu.
Location: La Jolla, CA

Principal Investigator: James Hoch
Maildrop: MEM-116
E-Mail: hoch@scripps.edu
URL: http://www.scripps.edu/mem/hoch/

Research Description: This is a position to study the regulatory mechanisms of pathogenesis in Bacillus anthracis with emphasis on the control of toxin synthesis and interaction with host cells. A major aim is the discovery of host factors that activate the synthesis of virulence determinants.

Requirements: A doctoral degree in Microbiology or Biochemistry. Please send your CV and a list of at least 3 professional references to hoch@scripps.edu.

Location: La Jolla, CA

MOLECULAR & INTEGRATIVE NEUROSCIENCES DEPARTMENT (MIND)

Within MIND, the following postdoctoral positions are available:

Principal Investigator: Pietro Sanna
Maildrop: SP-2300
E-Mail: psanna@scripps.edu

Research Description: A post-doctoral position is available immediately for a motivated individual to join a dynamic multidisciplinary research team at The Scripps Research Institute to study the neurobiological bases of drug addiction with emphasis on genomic of drug and alcohol abuse. Research projects will involve gene expression assay by DNA microarrays and other molecular biological techniques. This NIH-funded position offers a competitive pay and benefits package.

Requirements:Applicants will have a Ph.D., MD or equivalent degree and have a strong background in behavioral pharmacology, or metabolism. Interested applicants should submit a CV, brief summary of research accomplishments and interests and three professional references to psanna@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Bruno Conti
Maildrop: SR-307
E-Mail: bconti@scripps.edu
URL: http://dorriscenter.scripps.edu/

Research Description: A postdoctoral position available to investigate the role of temperature regulation in modulating energy homeostasis and aging in mouse. The position is for an initial period of 1 year and is available immediately.

Requirements: Ph.D. with a background in neuroscience, molecular biology and biochemistry is required. Interest in neuro-immunology is a plus. Please send your CV and a list of at least three professional references to bconti@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Donna Gruol
Maildrop: SGM-300
E-Mail: gruol@scripps.edu
URL: http://www.scripps.edu/np/gruol/

Research Description: The research involves studies on interactions between alcohol and neuroimmune factors that alter synaptic transmission in the hippocampus. The studies involve field potential recordings from the in vitro slice preparation (hippocampus) from transgenic and wild type mice.

Requirements: Ph.D or M.D. degree. Demonstrated background in Neuroscience and especially synaptic transmission. Experience with electrophysiological recordings highly preferred. Please send your CV and a list of at least three professional references to gruol@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Claes Wahlestedt
E-Mail: clawah@scripps.edu

Research Description: Scripps Florida is seeking highly motivated individuals with proven research track records for post-doctoral fellowship positions. This is a great opportunity for individuals interested in leading-edge careers within academia as well as biotechnology or pharmaceutical companies. Projects are pursued in vitro as well as in vivo and will mostly concern functional characterization of disease gene candidates in Alzheimer’s disease or in schizophrenia. Our laboratory also has a strong interest in noncoding RNA. Fellows will work in a multidisciplinary, highly interactive environment with molecular biologists, pharmacologists, chemists, engineers and bioinformaticians.

Requirements: Successful applicants will have a Ph.D. (and/or MD) in pharmacology, molecular biology, cell biology, neurobiology and/or biochemistry, and 0-5 years postdoctoral experience. In addition, candidates should possess excellent communication skills, and work effectively both on teams and as an independent investigator. Applicants are requested to email their CV to Prof. C. Wahlestedt at clawah@scripps.edu.

Location: Jupiter, FL

Principal Investigator: Pietro Sanna
Maildrop: SP-2300
E-Mail: psanna@scripps.edu

Research Description: A post-doctoral position is available immediately for a motivated individual to join a dynamic multidisciplinary research team at The Scripps Research Institute to study gene regulation in neurobiology with DNA microarrays and next generation sequencing with a focus on drug and alcohol abuse. This NIH-funded position offers a competitive pay and benefits package.

Requirements: Applicants will have a Ph.D., MD or equivalent degree and have a strong background in genomics, molecular biology, behavioral pharmacology, or neurochemistry. Interested applicants should submit a CV, brief summary of research accomplishments and interests and three professional references to psanna@scripps.edu.

Location: La Jolla, CA

MOLECULAR THERAPEUTICS

Within the department of Molecular Therapeutics, the following postdoctoral positions are available:

Principal Investigator: Roy Periana
E-Mail: rperiana@scripps.edu

Research Description: These postdoctoral research positions will involve the investigation of hydrocarbon oxidation chemistry and small molecule activation.

Requirements: Candidates should be experts in organometallic or inorganic synthesis and characterization. The Scripps Energy Laboratories is oriented toward problem solving with close association to industrial partners. Candidates must be motivated to work in a fast-paced, industrial-like environment. Appointments are for one year with renewal of more years with satisfactory performance. Postdoctoral financial support is dependent on experience and expertise. Candidates should send a CV and letters of recommendations to Sel_pdoc@scripps.edu.

Location: Jupiter, FL

Principal Investigator: Donald G. Phinney
E-Mail: dphinney@scripps.edu

Research Description: A post-doctoral position is available to study the molecular signaling pathways that regulate self-renewal and lineage specification of mesenchymal stem cells derived from adult bone marrow. A variety of molecular and cell-based approaches will be used to identify and perturb these pathways to evaluate their role in MSC specification, thereby providing a diversified training experience.

Requirements:Applicants with proficiency in culture of primary cells, cell transduction technologies, and gene expression analysis will be given close consideration; expertise in siRNA and CHIP technologies are also highly desirable. Funding is available for up to 3 years but it is anticipated that the candidate will also compete for funding from external sources. The Department of Molecular Therapeutics at Scripps Florida provides a unique environment where researchers with both academic and industry experience work collaboratively, thereby providing excellent training opportunities for young scientists interested in pursuing a wide range of career paths. Please send a cover letter discussing your interests in the laboratory as well as your CV and list of 3 individuals as references to dphinney@scripps.edu.

Location: Jupiter, FL

Principal Investigator: Laura Bohn
E-Mail: lbohn@scripps.edu

Research Description: An NIH funded post-doctoral position is available to study G protein coupled receptor regulation and signaling in genetically modified mouse models. A variety of technical approaches will be used to ascertain the contribution of receptor regulation to drug responsiveness in vivo and ex vivo providing training opportunities in diverse research techniques.

Requirements: Applicants with proficiency in animal physiology or behavioral analyses will be given close consideration; expertise in immunohistochemistry is highly desirable. The Department of Molecular Therapeutics at Scripps Florida provides a unique environment where researchers with both academic and industry experience work collaboratively. This allows for an excellent training opportunity for the candidate undecided between an academic or industrial research track. Funding is in place for up to 5 years. Please send a cover letter discussing your interests in the laboratory as well as your CV and list of 3 individuals as references to lbohn@scripps.edu.

Location: Jupiter, FL

Principal Investigator: Patrick Griffin
E-Mail: pgriffin@scripps.edu

Research Description: We are currently seeking a postdoctoral fellow to work within the laboratory of Professor Patrick R. Griffin. The lab is focused on the study of protein dynamics and chemical biology of nuclear receptors and GPCRs. The technical challenges related to development of high-throughput protein-ligand interaction characterization by hydrogen/deuterium exchange mass spectrometry requires substantial effort in protein cloning, expression, purification and analysis. An appropriate post doctoral fellow candidate would have experience in both protein chemistry and analytical chemistry. The fellow will be dedicated to detailed characterization of chemical probes that emerge from MLPCN probe development programs that are focused on disruption of protein-protein interactions. The goal would be to provide HDX maps to determine putative binding sites on the target proteins and this information would aid in mutagenesis studies and chemical optimization of the probes.

Requirements: Applicants with proficiency in structural biology and mass spectrometry will be given close consideration; expertise in molecular biology is highly desirable. The Department of Molecular Therapeutics at Scripps Florida provides a unique environment where researchers with both academic and industry experience work collaboratively. This allows for an excellent training opportunity for the candidate undecided between an academic or industrial research track. Funding is in place for up to 2 years. Please send a cover letter discussing your interests in the laboratory as well as your CV and list of 3 individuals as references to pgriffin@scripps.edu.

Location: Jupiter, FL

Principal Investigator: Juliana Conkright
E-Mail: juliejc@scripps.edu

Research Description: We are currently seeking a postdoctoral fellow to work within the laboratory of Dr. Juliana Conkright. The lab is focused on cell signaling and transcription pathways including GPCRs and nuclear receptors. Will work on the development of cell based assays for large genomic screens, execute screens on large cDNA and siRNA genomic platforms, screen small chemical libraries, program and operate automation robotics and perform data analysis. This is an industry-related fellowship, which will provide training and skills marketable for pharmaceutical and biotechnology job opportunities.

Requirements: Seeking PhD and/or MD candidates with experience in mammalian tissue culture, biological readouts in microtiter formats and molecular biology experience including PCR and restriction enzyme cloning. A background in transcription or signal transduction, cell biology and experience with cell based reporter assay systems is preferred as well as bioinformatic and robotics experience. Interested applicants should submit a CV, a brief statement of research skills, experiences, goals, and contact information (email address and phone number) of three references to: juliejc@scripps.edu

Location: Jupiter, FL

Principal Investigator: Paul Kenny
E-Mail: pjkenny@scripps.edu

Research Description: This position will involve investigation of the mechanisms underlying psychiatric disorders.

Requirements: The candidate should have a strong background in molecular biology and be enthusiastic about learning in vivo behavioral tests. In particular, candidates with expertise in mouse genetics are strongly encouraged to apply. For further information and to apply, please send: (1) a short letter of intent outlining your research experience and (2) a copy of your current CV that includes the names and addresses of three references to Dr. Paul Kenny, pjkenny@scripps.edu

Location: Jupiter, FL

NEUROBIOLOGY

Within the department of Neurobiology, the following postdoctoral positions are available:

No positions currently available.

THE SKAGGS INSTITUTE FOR CHEMICAL BIOLOGY

Within The Skaggs Institute for Chemical Biology, the following postdoctoral position is available:

No positions currently available.

TRANSLATIONAL RESEARCH INSTITUTE

Within the Translational Research Institute (TRI), the following postdoctoral positions are available:

Principal Investigator: Peter Hodder
E-mail: hodderpATscrippsDOTedu
TRI Division : Lead ID

Research Description: Will be responsible for developing and implementing novel biochemical and cell-based functional high-throughput screening (HTS) assays for drug discovery. Depending on the candidates expertise, perform enzymology, cell biology, or molecular biology techniques necessary to develop and implement HTS assays. This includes subcloning and generation of expression vectors to create stable mammalian cell lines, mammalian/bacterial protein expression and purification, mammalian/bacterial culture, determination of enzymatic parameters. Perform optimization of biochemical and cell-based assays. Operate and troubleshoot automated liquid handling and analytical equipment. Utilize a variety of spreadsheet and data management software systems to generate, analyze and report data from research efforts.

Requirements: Ph.D. in Biology, Chemistry, Microbiology, or Engineering Sciences. Background in and experience with enzyme kinetics, protein expression, protein purification (especially Äkta FPLC), and/or mammalian/bacterial culture, cloning and expression. Proficiency with operation of common equipment/instrumentation found in an enzymology, (e.g. stop-flow instrumentation) cell biology (e.g. tissue culture/transfection technology), molecular biology (e.g. gel electrophoresis/ western blots), microbiology and/or an analytical (e.g. LC-MS) laboratory. Candidates must have excellent communication skills and a desire to work in a fast-paced, multi-disciplinary collaborative team in a production-oriented setting similar to that found in the pharmaceutical industry. Specific HTS background not required. Please send CV and a list of at least 3 professional references to Dr. Peter Hodder, hodderpATscrippsDOTedu.

Location: Jupiter, FL

Principal Investigator: Derek Duckett
E-mail: ducketdr@scripps.edu
TRI Division : Discovery Biology

Research Description: A position is available at The Scripps Research Institute, Scripps Florida for a highly motivated and creative postdoctoral research fellow. Working within The Translational Research Institute at Scripps Florida the candidate will focus on the basic biology of primary central nervous system cancers and aspects of neurodegeneration.

Requirements: Candidates should have obtained or are near completion of a doctoral degree in the life sciences. Prior experience in molecular and cell biology, confocal microscopy and in vivo tumor models would be an advantage. Please send CV, research summary and a list of references to ducketdr@scripps.edu.

Location: Jupiter, FL

Principal Investigator: Alex Pachori
E-mail: apachori@scripps.edu
TRI Division : Discovery Biology

Research Description: We are seeking experienced candidates for postdoctoral fellowship in the epartment of drug discovery, division of pharmacology. The qualified candidate will support ongoing research projects on the development of novel anti-hypertensive agents. In addition, this person will undertake basic research projects to understand signaling pathways/mechanisms in the pathogenesis of hypertension/cardiovascular diseases

Requirements: Qualified candidates will have a Ph.D. in pharmacology/physiology, animal handling experience, drug dosing, basic molecular biology skills, cloning, development of knockout/transgenic mice and investigating signal ransduction pathways. Compensation will be commensurate with experience. Please send CV and a list of at least 3 professional references to apachori@scripps.edu.

Location: Jupiter, FL