Employment Opportunities

Applying For Postdoctoral Positions

You may apply for a postdoctoral position by sending your cover letter and curriculum vitae to the attention of the principal investigator as listed in each job vacancy, at the respective TSRI location (Florida or California). You may use the e-mail address listed for each investigator and electronically attach your curriculum vitae, or you may send your information to the principal investigator by mail as follows:

CALIFORNIA:
The Scripps Research Institute
10550 North Torrey Pines Road
La Jolla, CA 92037

FLORIDA:
Scripps Florida
Division of The Scripps Research Institute
5353 Parkside Drive
Jupiter, FL 33458

TSRI Faculty: Please help keep the information on this page current. See the Information Page on posting a postdoctoral position.

POSTDOCTORAL POSITIONS AVAILABLE AT TSRI

Select one of the following departments to view available positions:

CANCER BIOLOGY
CELL BIOLOGY
CHEMICAL PHYSIOLOGY
CHEMISTRY
COMMITTEE ON THE NEUROBIOLOGY OF ADDICTIVE DISORDERS
IMMUNOLOGY & MICROBIAL SCIENCE
INFECTOLOGY
INFORMATICS
METABOLISM & AGING
MOLECULAR BIOLOGY
MOLECULAR & EXPERIMENTAL MEDICINE
MOLECULAR & INTEGRATIVE NEUROSCIENCES
MOLECULAR THERAPEUTICS
NEUROBIOLOGY
THE SKAGGS INSTITUTE FOR CHEMICAL BIOLOGY
TRANSLATIONAL RESEARCH INSTITUTE

CANCER BIOLOGY

Within the department of Cancer Biology, the following postdoctoral position is available:

Principal Investigator: Jun-Li Luo
E-Mail: jlluo@scripps.edu

Duties & Responsibilities: A postdoctoral position is available within the Department of Cancer Biology, Scripps Research Institute-Florida, to study signaling pathways in cancer biology. The newly established lab is focused on mechanistic and translational research in molecular signaling that connects epigenetic factors with genetic events during tumor genesis, progression and metastasis (Nature, 2007; 446(7136): 690-4. Cell, 2005; 121(7): 977-90. Cancer Cell, 2004; 6(3): 297-305.).

Requirements: The candidate should be Ph.D. or M.D. and Ph.D. with biomedical research experience. Candidate with stem cell research experience will be highly preferred. The starting time will be around August 1st, 2008. Interested applicants should submit a copy of CV, a brief statement of research skills, experiences, goals, and contact information (email address and phone number) of three references to: Dr. Jun-Li Luo, Assistant Professor in cancer biology, Email: jlluo@scripps.edu .

Location: Jupiter, FL

Principal Investigator: Tina Izard
E-Mail: izard@scripps.edu
URL: http://www.scripps.edu/florida/cancerbio/izard/

Duties & Responsibilities: A position is available for post-doctoral fellow in Protein Crystallography. The lab is focused on unraveling the regulation of cell migration and morphogenesis, which relies on the cell's ability to form specific contacts with its neighbors or with the extracellular matrix (ECM) through dedicated adhesion receptors. Contacts with the ECM are directed by integrin receptors, which are unique in directing both outside-in and inside-out signaling pathways. Activation of integrin receptors triggers the rapid reorganization of the actin cytoskeleton and this relies on the function of talin and vinculin, which were previously thought to act as scaffolds that bridge integrin receptors to the actin cytoskeleton. Surprisingly, our structural, biochemical, and cell biological studies have revealed that these proteins function as direct signaling effectors that, by undergoing dramatic changes in their structures, transmit the outside-in signal. Successful candidates will work in a cutting-edge research environment that tackles this important new arena in cancer and cell biology. The laboratory has outstanding facilities for molecular biology; protein expression, purification, and biochemistry; and protein crystallography.

Requirements: We are seeking a PhD graduate to determine the crystal structures of several important cytoskeletal proteins. Candidates should have experience in crystal structure determination as well as an interest in the biology of cytoskeletal proteins. The position provides an outstanding training program in protein biochemistry and structure, and also in molecular and cellular biology, in a highly funded, dynamic, and team-oriented research program. Please send CV, a summary of research experience and interests, and names, addresses, e-mail and telephone numbers of 3 references to: izard@scripps.edu .

Location: Jupiter, FL

CELL BIOLOGY

Within the department of Cell Biology, the following postdoctoral positions are available:

Principal Investigator: Stephen Mayfield
Maildrop: BCC-283
E-Mail: mayfield@scripps.edu

Duties & Responsibilities: The general aims of this project are to genetically engineer eukaryotic algae for the production of biofuels. The specific project is to engineer the green algae C. reinhardtii for the production of hydrocarbons by altering metabolic pathways in chloroplasts. Duties will include gene cloning, vector construction, genetic transformation and analysis of transgenic strains for enzyme activity and accumulation of biofuels.

Requirements: Ph.D. in Molecular Biology, Cell Biology, or Biochemistry with experience in general biological laboratory protocols is required. A solid working knowledge of recombinant technologies including DNA and RNA isolation, PCR, gene cloning, cell transformations, protein isolation, and western blot analysis is essential. Experience in recombinant protein expression and purification, or in metabolic engineering of eukaryotic organisms is also desirable. The successful candidate should have a solid record of achievement including publications in peer reviewed journals.Interested candidates should submit their CV and a list of at least 3 professional references to mayfield@scripps.edu.

Location: La Jolla, CA

CHEMICAL PHYSIOLOGY

Within the department of Chemical Physiology, the following postdoctoral positions are available:

Principal Investigator: Keri Mowen
Maildrop: IMM-11
E-Mail: kmowen@scripps.edu
URL: http://www.scripps.edu/chemphys/mowen/

Duties & Responsibilities: A postdoctoral position is available for an enthusiastic, motivated, and independent individual in the area of molecular immunology. Our lab interests are in determining the role of peptidylarginine deiminases (PADs) and protein arginine methyltransferases (PRMTs) in T helper cell and mast cell function. Projects include examining novel substrates of PADs and PRMTs in T helper cells and mast cells and determining pathways that regulate PAD and PRMT function in these cell types, especially in the context of autoimmune models like inflammatory arthritis (see Molecular Cell 2004 15:559).

Requirements: Ph.D. in molecular biology, immunology, biochemistry, or cell biology is required. Good communication and organizational skills are a must. Interested candidates should submit their CV and a list of at least 3 professional references to kmowen@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Martha Fedor
Maildrop: MB-35
E-Mail: mfedor@scripps.edu
URL: http://www.scripps.edu/chemphys/fedor/

Duties & Responsibilities: An NIH-funded postdoctoral research position is available immediately in the research group of Martha J. Fedor, to investigate intracellular RNA recognition and mechanisms of RNA secondary structure assembly. This position offers opportunities for postdoctoral training in the application of quantitative methods for analysis of RNA structure and function in vivo.

Requirements: Candidates with experience in yeast molecular biology are particularly encouraged to apply. Please send your CV and a list of at least 3 professional references to mfedor@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Martha Fedor
Maildrop: MB-35
E-Mail: mfedor@scripps.edu
URL:http://www.scripps.edu/chemphys/fedor/

Duties & Responsibilities: An NIH-funded postdoctoral research position is open immediately in the research group of Martha J. Fedor to investigate mechanisms of RNA catalysis. This position offers the opportunity for postdoctoral training in mechanistic enzymology and biophysical studies of RNA enzymes.

Requirements: Candidates with experience in fluorescence assays and/or RNA biochemistry are particularly encouraged to apply. Interested candidates should submit their CV and a list of at least 3 professional references to kmowen@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Hugh Rosen
Maildrop: ICND-118
E-Mail: sbrown@scripps.edu
URL: http://www.scripps.edu/chemphys/rosen/

Duties & Responsibilities: We are seeking post-doctoral candidates to participate in The Scripps Comprehensive Center for Chemical Probe Optimization. The Screening Center is part of the NIH Roadmap initiative funded Molecular Libraries Probe Production Centers Network (MLPCN) , the goal of which is to identify and optimize bioactive small molecules that provide researchers the tools to broaden their investigations. The candidate will work closely with investigators interested in accessing the MLPN. Duties will include optimization and implementation of assays for a wide variety of molecular targets including enzymes, receptors and functional cell-based assays using a wide variety of technologies such as fluorescence, FP, TRF and reporter gene assays. The successful candidate will have access to state of the art detection and liquid handling technologies and will use these in the discovery of novel chemical probes.

Requirements: We are seeking candidates with a Ph.D. and at least 2 years of related experience in high throughput assay development. Successful candidates will have a background in biochemistry or related fields. Must be able to effectively work within a multi-disciplinary group and have excellent communication and meticulous record-keeping skills. Please send CV and a list of at least three professional references to sbrown@scripps.edu.

Location: La Jolla, CA

CHEMISTRY

Within the department of Chemistry, the following postdoctoral position is available:

No positions currently available.

COMMITTEE ON THE NEUROBIOLOGY OF ADDICTIVE DISORDERS (CNAD)

Within CNAD, the following postdoctoral positions are available:

No positions currently available.

IMMUNOLOGY & MICROBIAL SCIENCE

Within the department of Immunology & Microbial Science, the following postdoctoral positions are available:

Principal Investigator: Wolfram Ruf
E-Mail: ruf@scripps.edu
URL: www.scripps.edu/imm/ruf/

Duties & Responsibilities: A postdoctoral training position is available for candidates with a strong motivation to conduct an independent research project in our program dealing with the role of protease signaling pathways in inflammation, angiogenesis and cancer. We are particularly interested to investigate the specificity of G-protein coupled, protease activated receptor (PAR) signaling proteases, genetic mouse models to study these pathways and innovative approaches to therapeutically target these pathways in the clinics. The applicant is expected to creatively utilize genetic mouse models and in vitro cell culture systems in cell signaling research. She/he should have a general interest in state-of-the-art genomic and proteonomic approaches, chemical biology or genetics, and aim to develop an area of technical expertise.

Requirements: Ph.D. in immunology, molecular biology, biochemistry, or other biological sciences. A track record of peer reviewed publications and strong laboratory skills in molecular and cell biology and/or genetic mouse models is required. Please send CV and a list of at least 3 professional references to ruf@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Gary Bokoch
Maildrop: IMM-14
E-Mail: bokoch@scripps.edu
URL: www.scripps.edu/imm/bokoch

Duties & Responsibilities: Research Associate/Postdoctoral positions available in our lab, which studies Rho GTPases, how they are regulated, and how they control various cell activities (see TSRI website for Bokoch lab). We are currently particularly interested in Rho GTPase regulation, the cytoskeleton and cell motility, formation of reactive oxygen species via NADPH oxidases (Nox's), leukocyte signaling and function, and how anthrax toxins might modulate innate immune responses. We seek motivated researchers with an interest in training in these subject areas.

Requirements: Dedicated candidates with knowledge of the cytoskeleton (actin/myosin/microtubule), live cell microscopy and imaging, NADPH oxidases, leukocyte function and signaling, protein purification and structure, and/or who are accomplished cell/molecular biologists are encouraged to apply. Please send curriculum vitae and letters of reference to: bokoch@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Cheng Liu
Maildrop: SP-233
E-Mail: chengliu@scripps.edu

Duties & Responsibilities: Postdoctoral positions are available investigating pathobiology and therapeutic interventions of cancer and atherothrombosis. Experiences with basic methodology in molecular biology, immunology, vascular biology and mouse models are preferred. Requirements: M.D. or/and Ph.D. in biomedical sciences.

Requirements: Postdoctoral degree and related experience.

Location: La Jolla, CA

Principal Investigator: Luc Teyton
Maildrop: IMM-23
E-Mail: lteyton@scripps.edu

Duties & Responsibilities: A postdoctoral position is available to study Molecular Immunology of type 1 diabetes. Through usage of recombinant proteins the candidate will address some fundemental aspects of T cell selection and pathogenicity in the NOD mouse. Knowledge of protein purification, DNA technologies, single cell PCR and RNA display are a must.

Requirements: Motivation and dedication. A Ph.D. is required. Please send CV and at least three professional references to lteyton@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Michael Zwick
Maildrop: IMM-2
E-Mail: zwick@scripps.edu

Duties & Responsibilities: A Postdoctoral position is open for a post doc who has a background in molecular biology and is interested in HIV-1 vaccine research with respect to the host's neutralizing antibody response.

Applicant will engineer HIV-1 mutagenesis libraries, isolate and characterize clones, then test the variants in HIV-1 virus binding and neutralization assays. HIV-1 Env mutagenesis, escape mutations and the aim is to:
(1) identify HIV-1 Env variants that improved characteristics required of a vaccine
(2) identify broadly neutralizing epitopes on gp41
(3) re-design and engineer Env mimetics for improved anti-HIV-1 Ab responses
(4) contribute to theories about HIV-1 Env structure-function, HIV-1 entry and neutralization mechanisms, HIV-1 Ab evasion, and vaccine development.

Requirements: Ph.D. in molecular biology, biochemistry or biophysics preferred.
Please send your CV and a list of at least 3 professional references to zwick@scripps.edu .

Location: La Jolla, CA

Principal Investigator: Tsung-Hsien Chuang
Maildrop: IMM-12
E-Mail: chuang@scripps.edu

Duties & Responsibilities: Postdoctoral positions are available in the Department of Immunology for motivated individuals to investigate molecular mechanisms in control of innate immunity, with a focus on protein degradation in Toll-like receptors , RIG-I-like receptors and NOD-like receptors signaling pathways.

Requirements: Candidates with M.D. and/or Ph.D. degree and with background in immunology and molecular biology are encouraged to apply. Experience with small animal work is a plus. Please send CV to Dr. Tsung-Hsien Chuang at chuang@scripps.edu .

Location: La Jolla, CA

Principal Investigator: Philippe Gallay
Maildrop: IMM-9
E-Mail: gallay@scripps.edu
URL: http://www.scripps.edu/research/faculty.php?rec_id=5582

Duties & Responsibilities: A postdoctoral position is available to investigate the mechanisms that control the incorporation of viral glycoproteins (gp120/41) into the human immunodeficiency virus (HIV). The goal is to generate and identify compounds that block glycoproteins incorporation into HIV rendering the virus noninfectious.

Requirements: Candidates should have a PhD and laboratory experience in HIV as well as in molecular biology (cloning). Candidates should also have perfect English knowledge and computer skills. Please send CV and three professional references to gallay@scripps.edu.

Principal Investigator: Philippe Gallay
Maildrop: IMM-9
E-Mail: gallay@scripps.edu
URL: http://www.scripps.edu/research/faculty.php?rec_id=5582

Duties & Responsibilities: A postdoctoral position is available to determine the contribution of cyclophilins to hepatitis C virus (HCV) replication. The goal is to understand how and why neutralization of intracellular cyclophilins with cyclosporine A and derivatives blocks HCV replication both in vitro and in vivo.

Requirements: Candidates with experience in the yeast 2-hybrid system and other protein-protein interaction techniques will be preferred. Candidates should also have perfect English knowledge and computer skills. Please send CV and three professional references to gallay@scripps.edu.

INFECTOLOGY

Within the department of Infectology, the following postdoctoral position is available:

Principal Investigator: Donny Strosberg
E-Mail: strosber@scripps.edu

Duties & Responsibilities: Post-Doctoral position available in Virology. Need for a well trained cell biologist with experience in molecular analysis of viruses, preferably HCV. Duties and Responsibilities will include: characterizing a new culture system for infectious HCV 1b genotype. The goal is to compare this system to previously established HCV 2a genotype system and to analyze in-vitro properties of this new research system.

Requirements: Candidates should have laboratory experience in cell and molecular biology and be familiar with HCV structure and function. Candidates should also have perfect English knowledge and computer skills. Please send CV and at least three professional references to strosber@scripps.edu .

Location: Jupiter, FL

INFORMATICS

Within the department of Informatics, the following postdoctoral position is available:

No positions currently available.

MEDICINAL CHEMISTRY

Within the department of Medicinal Chemistry, the following postdoctoral position is available:

No positions currently available.

METABOLISM & AGING

Within the department of Metabolism & Aging, the following postdoctoral position is available:

No positions currently available.

MOLECULAR BIOLOGY

Within the department of Molecular Biology, the following postdoctoral positions are available:

Principal Investigator: Geoffrey Chang
Maildrop: CB-105
E-Mail: gchang@scripps.edu

Duties & Responsibilities: A postdoctoral position is available to work with a lab subgroup in cloning and bacterial expression of eukaryotic membrane proteins. Specific duties include: buffer preparation, PCR amplification of genes from DNA clones, plasmid cloning, bacterial culture, protein expression screening with SDS-PAGE and western blots.

Requirements: Ph.D. with 1-3 years experience in molecular biology and protein biochemistry techniques. Good organizational skills. Experience in protein crystallization and x-ray crystallography a plus. Please send CV and list of at least 3 professional references to gchang@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Qinghai Zhang
Maildrop: CB-256
E-Mail: qinghai@scripps.edu

Duties & Responsibilities: Postdoctoral position is open in the field of organic synthesis and bioorganic chemistry. Experience on solution or solid phase peptide synthesis is desired but not necessary.

Requirements: The Individual should be highly self motivated, have a Ph.D. with a strong background in organic synthesis. Please send your CV, a research summary and list of 3 references to Dr. Qinghai Zhang at qinghai@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Curt Wittenberg
Maildrop: MB-3
E-Mail: lmadden@scripps.edu

Duties & Responsibilities: A postdoctoral position is available for an enthusiastic and motivated investigator in the area of molecular genetics. Our laboratory is interested in regulation of cell proliferation with a focus on transcriptional and proteolytic mechanisms. Recent work has focused on the regulation of periodic gene expression and its regulation by cell cycle checkpoints in budding and fission yeast (see Molecular Cell 23: 483 and PNAS 105: 11230).

Requirements: Ph.D. in molecular biology, genetics, biochemistry, or cell biology is required. Good communication and organization skills are a must. Experience studying gene expression, chromatin modification, or DNA damage is a plus. Interested candidates should submit their CV and a list of at least three professional references to lmadden@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Takanori Otomo
Maildrop: CB-207
E-Mail: totomo@scripps.edu
URL: http://www.scripps.edu/mb/otomo

Duties & Responsibilities: A postdoctoral position is open in the laboratory of Takanori Otomo for a highly motivated, enthusiastic and independent candidate in the area of structural biology and biochemistry. The broad interest of the group is structural and functional basis of proteins involved in cell biology. We are currently focusing on mechanisms in autophagy, which is closely related to cellular trafficking, cytoskeleton, and organelle biogenesis.

Requirements: Candidates who have training in structural biology (X-ray crystallography and/or other methods) and/or biochemistry are desired. Please send your CV, a brief summary of research accomplishments and interests, and three professional references to totomo@scripps.edu.

Location: La Jolla, CA

Principal Investigator: Jane Dyson
Maildrop: MB-2
E-Mail: dyson@scripps.edu

Duties & Responsibilities: A postdoctoral position is available immediately for reserach into the solution structure and dynamics of the inhibitor of kappa-B-alpha and its interactions with nuclear factor kappa-B using high-field NMR. Some of this work was recently published (Sue et al., J. Mol. Biol. 380,917-931,2008).

Requirements: The position requires extensive skill in the preparation and handling of large proteins and protein complexes, as well as high-resolution NMR experiences. Familiarity with labeling schemes and relaxation-optimized spectroscopy for use with large protein complexes would be an advantage. We are looking for a highlty-motivated and creative individual to move this project into some innovative new directions. Send your CV and list of at least 3 professional references to dyson@scripps.edu.

Location: La Jolla, CA

MOLECULAR & EXPERIMENTAL MEDICINE

Within the department of Molecular & Experimental Medicine, the following postdoctoral positions are available:

Principal Investigator: Laura Crisa
Maildrop: MEM-L55
E-Mail: crisa@scripps.edu

Duties & Responsibilities: A postdoctoral position is available to join a research program aiming to characterize the development of bone marrow derived endothelial progenitors in vitro and in vivo in models of retinal neovascularization.

Requirements: Ph.D. in Molecular or Cellular Biology. Must have background in molecular and cellular biology tech-niques. Previous experience in immunology & microsurgery techniques is preferred. Please send CV and a list of at least 3 professional references to crisa@scripps.edu.

Location: La Jolla, CA

Principal Investigator: James Hoch
Maildrop: MEM-116
E-Mail: hoch@scripps.edu
URL: http://www.scripps.edu/mem/cb/

Duties & Responsibilities: A postdoctoral position is available to work with and study purification and charaterization of signal proteins from bacteria.

Requirements: This position requires a Ph.D. in either biology, microbiology, bacterial genetics or biochemistry. All applicants may be required to comply with Select Agent regulations and pass Department of Justice security risk assessment. Applicants are required to have experience in microbiology, molecular biology and protein expression/purification. Please send your CV and a list of at least 3 professional references to hoch@scripps.edu

Location: La Jolla, CA

Principal Investigator: Laura Crisa
Maildrop: MEM-L55
E-Mail: crisa@scripps.edu

Duties & Responsibilities: A postdoctoral position is available to perform microsurgery techniques on mice (i.e. pancreatic islet transplants); histological assessment of transplants; derive endothelial cell lines from bone marrow progenitors and study their immunological characteristics; determine genetic profile of tissue-derived vs. bone marrow derived endothelia isolated from transplants; defining proangiogenic myeloid and non-myeloid inflammatory cells supporting transplant engraftment.

Requirements: Ph.D. required. Basic cell biology and molecular biology techniques. Some knowledge in immunology is preferred. Please send CV and a list of at least 3 professional references to crisa@scripps.edu.

Location: La Jolla, CA

MOLECULAR & INTEGRATIVE NEUROSCIENCES DEPARTMENT (MIND)

Within MIND, the following postdoctoral positions are available:

Principal Investigator: Tamas Bartfai
Maildrop: SR-307
E-Mail: mjmcrae@scripps.edu
URL: http://www.scripps.edu/research/dorriscenter/index.html

Duties & Responsibilities: This fellowship is generously donated by Ms. Helen Doris, a local philanthropist, and covers NIH level salary and benefits for 2 years. The previous fellows have gone on to promising academic careers.

The successful candidate will work within a research group on the receptor-ligand interactions and on intracellular signaling of the neuropeptide galanin (involved in Major Depression, Schizophrenia, cognition and seizure control) or of the proinflammatory cytokine Interleukin 1. We study both transcription dependent and transcription independent signaling mechanisms, and routinely use DNA chipping to examine transcriptional changes and subsequently follow up expression of gene products in various functional, physiological and behavioral tests. The work will employ biochemical, molecular biological (mutagenesis, polymorphisisms, and transgenics) and cell biological techniques, and acute and chronic methods of neuropharmacology and immunopharmacology, and will be supported by ongoing work in the laboratory by electrophysiologists, morphologists, and behavioral scientists.

The unique opportunity arises from the close collaboration within the same lab of all of these disciplines required for a depp understanding of any neurobiological problem. Our seminars and progess reports typically feature collaboration between two or more disciplines.

Requirements: M.D. or Ph.D. Interested applicants should submit a CV, brief summary of research accomplishments and interests and three professional references to mjmcrae@scripps.edu

Location: La Jolla, CA

Principal Investigator: Tamas Bartfai
Maildrop: SR-307
E-Mail: mjmcrae@scripps.edu
URL: http://www.scripps.edu/research/dorriscenter/index.html

Duties & Responsibilities: A postdoctoral position is available in the areas of investigation include aging, thermoregulation, obesity and neuro-immunology. The laboratories have strong multidisciplinary approaches to these problems using in vitro and in vivo mouse models.

Requirements: M.D. or Ph.D. Candidates with strong a background in molecular biology, biochemistry and immunohistochemistry, including in situ hybridization, are encouraged to apply. Interested applicants should submit a CV, brief summary of research accomplishments and interests and three professional references to mjmcrae@scripps.edu

Location: La Jolla, CA

MOLECULAR THERAPEUTICS

Within the department of Molecular Therapeutics, the following postdoctoral positions are available:

Principal Investigator: Roy Periana
E-Mail: rperiana@scripps.edu

Duties & Responsibilities: These postdoctoral research positions will involve the investigation of hydrocarbon oxidation chemistry and small molecule activation.

Requirements: Candidates should be experts in organometallic or inorganic synthesis and characterization. The Scripps Energy Laboratories is oriented toward problem solving with close association to industrial partners. Candidates must be motivated to work in a fast-paced, industrial-like environment. Appointments are for one year with renewal of more years with satisfactory performance. Postdoctoral financial support is dependent on experience and expertise. Candidates should send a CV and letters of recommendations to Sel_pdoc@scripps.edu.

Location: Jupiter, FL

Principal Investigator: Paul Kenny
E-Mail: pjkenny@scripps.edu

Duties & Responsibilities: This position will involve investigation of the mechanisms underlying psychiatric disorders.

Requirements: The candidate should have a strong background in molecular biology and be enthusiastic about learning in vivo behavioral tests. In particular, candidates with expertise in mouse genetics are strongly encouraged to apply. For further information and to apply, please send: (1) a short letter of intent outlining your research experience and (2) a copy of your current CV that includes the names and addresses of three references to Dr. Paul Kenny, pjkenny@scripps.edu

Location: Jupiter, FL

Principal Investigator: Patrick Griffin
E-Mail: pgriffin@scripps.edu

Duties & Responsibilities: A position is available at The Scripps Research Institute, Scripps Florida for a postdoctoral fellow wishing to gain additional training in the areas of nuclear receptor modulation and signaling. The projects focus on the mechanisms by which ligands activate nuclear receptor signaling pathways. My laboratory is utilizing structural biology techniques, high-throughput cell based screening on a genome scale (cDNA expression libraries, siRNA libraries), high-throughput small molecule screening, and proteomics to identify novel proteins and small molecules that regulate the NR pathways with an emphasis on orphan receptors.

Requirements:Candidates should have obtained or are near completion of a doctoral degree in life sciences. The individual should possess the creativity and willingness to utilize new technology to explore fundamental biological questions in nuclear receptor modulation. Candidates with prior publications and experience in cell culture, molecular, and biochemical techniques will receive preference. Prior experience in protein expression and purification is preferred but not required. Experience in assay development would be ideal. Please send CV and list of at least 3 professional references to pgriffin@scripps.edu

Location: Jupiter, FL

Principal Investigator: Patrick Griffin
E-Mail: pgriffin@scripps.edu

Duties & Responsibilities: A position is available at The Scripps Research Institute, Scripps Florida for a postdoctoral fellow wishing to gain additional training in chemical biology approaches to the study of nuclear receptor modulation and GPCR activation. The position is within the laboratory of Dr. Patrick Griffin, Professor and Chair of the Department of Molecular Therapeutics. The Griffin laboratory utilizes structural biology, high-throughput small molecule screening, and proteomics to identify novel proteins and small molecules that regulate the NR pathways.

Biological Mass Spectrometrist. This appointment will focus on the development of mass spectrometry based approaches to the study structure-function relationships of nuclear receptors and GPCRs. These methods include hydrogen/deuterium exchange (HDX) mass spectrometry analysis of ligand and coregulatory protein interactions, characterization of post-translational modifications, and mass spectrometry analysis of protein complexes. The candidate is expected to be able to contribute to the improvement of all aspects of the project including protein production, mass spectrometry automation, improvement in sensitivity for analysis, optimization of chromatography and data processing. Previous experience with HDX exchange is not required; however experience in biological mass spectrometry and liquid chromatography is preferred.

Requirements: Candidates should be near completion of a doctoral degree in life sciences. The individual should possess the creativity and willingness to utilize new technology to explore fundamental biological questions in nuclear receptor modulation and GPCR activation. Prior experience in protein expression and purification is preferred but not required. Experience in assay development would be ideal. Please send CV and list of at least 3 professional references to pgriffin@scripps.edu

Location: Jupiter, FL

NEUROBIOLOGY

Within the department of Neurobiology, the following postdoctoral positions are available:

Principal Investigator: Kathryn Crossin
Maildrop: SBR-14
E-Mail: kcrossin@scripps.edu

Duties & Responsibilities: A postdoctoral position is available to study the influence of redox state and mitochondria on signaling and differentiation in neural stem cells.

Requirements: Ph.D. in relevant biological field. Knowledge of cell biology and neural cell culture, molecular biology, and microscopic imaging are all helpful. Data analysis and statistics.Interested applicants should submit a CV, brief summary of research accomplishments and interests and three professional references to kcrossin@scripps.edu

Location: La Jolla, CA

THE SKAGGS INSTITUTE FOR CHEMICAL BIOLOGY

Within The Skaggs Institute for Chemical Biology, the following postdoctoral position is available:

No positions currently available.

TRANSLATIONAL RESEARCH INSTITUTE

Within the Translational Research Institute (TRI), the following postdoctoral positions are available:

Principal Investigator: Peter Hodder
E-mail: hodderpATscrippsDOTedu
TRI Division : Lead ID

Duties & Responsibilities: Will be responsible for developing novel biochemical and cell-based functional high-throughput screening (HTS) assays for drug discovery. Perform molecular biology techniques, including subcloning and generation of expression vectors to create stable mammalian cell lines. Perform protein labeling, expression, purification. Perform optimization of biochemical and cell-based assays. Operate and troubleshoot automated liquid handling and analytical equipment. Utilize a variety of spreadsheet and data management software systems to generate, analyze and report data from research efforts.

Requirements: Ph.D. in Biology, Chemistry, or Engineering Sciences. Background in and experience with enzyme kinetics, protein expression/purification, mammalian cell culture expression vectors and cloning. Proficiency with operation of common laboratory and analytical equipment. Candidates must have excellent communication skills and a desire to work in a fast-paced, multi-disciplinary collaborative team. Please send CV and a list of at least 3 professional references to Dr. Peter Hodder, hodderpATscrippsDOTedu.

Location: Jupiter, FL

Principal Investigator: Alex Pachori
E-mail: apachori@scripps.edu
TRI Division : Discovery Biology

Duties & Responsibilities: We are seeking experienced candidates for postdoctoral fellowship in the epartment of drug discovery, division of pharmacology. The qualified candidate will support ongoing research projects on the development of novel anti-hypertensive agents. In addition, this person will undertake basic research projects to understand signaling pathways/mechanisms in the pathogenesis of hypertension/cardiovascular diseases

Requirements: Qualified candidates will have a Ph.D. in pharmacology/physiology, animal handling experience, drug dosing, basic molecular biology skills, cloning, development of knockout/transgenic mice and investigating signal ransduction pathways. Compensation will be commensurate with experience. Please send CV and a list of at least 3 professional references to apachori@scripps.edu.

Location: Jupiter, FL

Principal Investigator: William Rousch
E-mail: cmills@scripps.edu
TRI Division : Medicinal Chemistry

Duties & Responsibilities: The Drug Discovery Program at the Scripps Research Institute in Jupiter, Florida has postdoctoral positions available for highly motivated Ph.D. graduate students with extensive organic synthesis expertise. These full-time lab positions are available starting between November 2008 and early 2009.

Requirements: Extensive Ph.D. graduate work in multi-step organic synthesis is required, with good laboratory skills and familiarity with modern synthetic techniques and instrumentation (HPLC-MS, HPLC, NMR, chromatography). Strong candidates may also have knowledge and experience in heterocyclic and medicinal chemistry and/or structure-based drug design. Excellent communication skills and interpersonal skills necessary to thrive in a fast-paced team-oriented environment are also required. Please send CV, research summary, and 3 references to cmills@scripps.edu . (Please include “Medicinal Chemistry Postdoctoral Recruiting” in the subject line.)

Location: Jupiter, FL