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The Heeb Laboratory


Burstyn-Cohen, T., Heeb, M.J., Lemke, G., Lack of protein S in mice causes embryonic lethal coagulopathy and vascular dysgenesis. J. Clin. Invest. 119:2942, 2009.

Heeb, M.J., Prashun, D., Griffin, J.H., Bouma, B.N. Plasma protein S contains zinc essential for efficient activated protein C-independent anticoagulant activity and binding to factor Xa, but not for efficient binding to tissue factor pathway inhibitor. FASEB J., 23:2244-2253, 2009.

Fernandez, J.A.*, Heeb, M.J.*, Xu, X., Singh, L., Zlokovic, B.V., Griffin, J.H. Species-specific anticoagulant and mitogenic activities of murine protein S. Hematologica, 94:1721-1731, 2009. * These authors contributed equally.

Heeb, M.J. Role of the ProS1 gene in thrombosis: lessons and controversies. Expert Rev. Hematol. 1:9, 2008.

Heeb, M.J., Gandrille, S., Fernández, J.A., Griffin, J.H., Fedullo, P. Late onset thrombosis in a case of severe protein S deficiency due to compound heterozygosity for PROS1 mutations. J. Thromb. Haemost. 6:1235, 2008.

Keywords: Antithrombotics, Blood coagulation, Factor Xa, Protein S, Protein Z, Stroke, Thrombosis, Tissue factor pathway inhibitor, Zinc metalloprotein