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The Hedlund Lab

Publications

2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 1990-2002

  1. Kim, J. J., B. W. Bridle, J.-E. Ghia, H. Wang, M. M. Manocha, P. Rengasamy, M. S. Shajib, S. N. Syed, Y. Wan, P. B. Hedlund, and W. I. Khan (2013) Targeted inhibition of serotonin type 7 (5-HT7) receptor function modulates immune responses and reduces the severity of intestinal inflammation. Journal of Immunology, 190:4795-4804. [PubMed]
  2. Cates, L. A., A. J. Roberts, S. Huitron-Resendiz, and P. B. Hedlund (2013) Effects of lurasidone in behavioral models of depression. Role of the 5-HT7 receptor subtype. Neuropharmacology, 70:211-217. [PubMed]
  3. Lacivita, E., D. Patarnello, N. Stroth, A. Caroli, M. Niso, M. Contino, P. De Giorgio, P. Di Pilato, N. A. Colabufo, F. Berardi, R. Perrone, P. Svenningsson, P. B. Hedlund, and M. Leopoldo (2012) Investigations on the 1-(2-biphenyl)piperazine motif. Identification of new potent and selective ligands for the serotonin7 (5-HT7) receptor with agonist or antagonist action in vitro or ex vivo. J. Med. Chem., 55:6375–6380. [PubMed]
  4. Roberts, A. J. and P. B. Hedlund (2012) The 5-HT7 receptor in learning and memory. Importance of the hippocampus. Hippocampus, 22:762–771. [PubMed]
  5. Leopoldo, M., E. Lacivita, F. Berardi, R. Perrone, and P. B. Hedlund (2011) Serotonin 5-HT7 receptor agents: structure-activity relationships and potential therapeutic applications in central nervous system disorders. Pharmacology & Therapeutics, 129:120-148. [PubMed]
  6. Sutcliffe, J. G., P. B. Hedlund, E. A. Thomas, F. E. Bloom, and B. S. Hilbush (2011) Peripheral reduction of β-amyloid is sufficient to reduce brain Aβ: implications for Alzheimer’s disease. Journal of Neuroscience Research, 89:808-814. [PubMed]
  7. Sarkisyan, G., A. J. Roberts, and P. B. Hedlund (2010) The 5‑HT7 receptor as a mediator and modulator of antidepressant-like behavior. Behav. Brain Res., 209:99-108.
  8. Hedlund, P. B., M. Leopoldo, S. Caccia, G. Sarkisyan, C. Fracasso, G. Martelli, E. Lacivita, F. Berardi, and R. Perrone (2010) LP-211 is a brain penetrant selective agonist for the serotonin 5‑HT7 receptor. Neurosci. Lett., 481:12-16. [PubMed]
  9. Sarkisyan, G. and P. B. Hedlund (2009) The 5-HT7 receptor is involved in allocentric spatial memory information processing. Behav. Brain Res., 202:26-31.
  10. Abbas, A., P. B. Hedlund, X. P. Huang, T. B. Tran, H. Y. Meltzer, and B. L. Roth (2009) Amisulpride is a potent 5-HT7 antagonist: relevance for antidepressant actions in vivo. Psychopharmacology, 205:119-128. [PubMed]
  11. Liu, J., T. Akay, P. B. Hedlund, K. G. Pearson, and L. M. Jordan (2009) Spinal 5-HT7 receptors are critical for alternating activity during locomotion: in vitro neonatal and in vivo adult studies using 5-HT7 receptor knockout mice. J. Neurophysiol., 102:337-348. [PubMed]
  12. Hedlund, P. B. (2009) The 5‑HT7 receptor and disorders of the nervous system: an overview. Psychopharmacology, 206:345-354. [PubMed]
  13. Semenova, S., Geyer, M. A., Sutcliffe, J. G., A. Markou, and P. B. Hedlund (2008) Inactivation of the 5-HT7 receptor partially blocks PCP-induced disruption of prepulse inhibition. Biol. Psychiatry, 63:98-105. [PubMed]
  14. Jordan, L. M., J. Liu, P. B. Hedlund, T. Akay, and K. G. Pearson (2008) Descending command systems for the initiation of locomotion in mammals. Brain Res. Rev., 57:183-191. [PubMed]
  15. Hedlund, P. B. and J. G. Sutcliffe (2007) The 5-HT7 receptor influences stereotypic behavior in a model of obsessive-compulsive disorder. Neurosci. Lett., 414:247-251. [PubMed]
  16. Hedlund, P. B. and J. G. Sutcliffe (2006) 5-HT7 receptors as favorable pharmacological targets for drug discovery. In B. L. Roth (Ed.), The Serotonin Receptors: From Molecular Pharmacology to Human Therapeutics. Humana Press, Totowa, NJ, pp. 517-535.
  17. Landry E. S., N. P. Lapointe, C. Rouillard, D. Levesque, P. B. Hedlund, and P. A. Guertin (2006) Contribution of spinal 5-HT1A and 5-HT7 receptors to locomotor-like movement induced by 8-OH-DPAT in spinal cord transected mice. Eur. J. Neurosci., 24:535-546. [PubMed]
  18. Hedlund, P. B., and G. von Euler (2005) Z-analysis: A new approach to analyze stimulation curves with intrinsic basal stimulation. Biochem. Pharmacol., 70:170-175. [PubMed]
  19. Hedlund, P. B., S. Huitron-Resendiz, S. J. Henriksen, and J. G. Sutcliffe (2005) 5-HT7 receptor knockout mice exhibit antidepressed-like behavior and sleep pattern. Biol. Psychiatry, 58:831-837. [PubMed]
  20. Bonaventure, P., D. Nepomuceno, L. Hein, J. G. Sutcliffe, T. Lovenberg, and P. B. Hedlund (2004) Radioligand binding analysis of knockout mice reveals 5-hydroxytryptamine7 receptor distribution and uncovers 8-hydroxy-[N-n-dipropyl-N-(3'-iodo-2'propenyl)amino]tetraline interaction with α2 adrenergic receptors. Neurosci., 124:901-911. [PubMed]
  21. Hedlund, P. B., L. Kelly, C. Mazur, T. Lovenberg, J. G. Sutcliffe, and P. Bonaventure (2004) 8-OH-DPAT acts on both 5-HT1A and 5-HT7 receptors to induce hypothermia in rodents. Eur. J. Pharmacol., 487:125-132. [PubMed]
  22. Roberts, A. J., T. Krucker, C. L. Levy, K. A. Slanina, J. G. Sutcliffe, and P. B. Hedlund (2004) Mice lacking 5-HT7 receptors show specific impairments in contextual learning. Eur. J. Neurosci., 19:1913-1922. [PubMed]
  23. Hedlund, P. B., and J. G. Sutcliffe (2004) Functional, molecular and pharmacological advances in 5-HT7 receptor research. Trends Pharmacol. Sci., 25:481-486. [PubMed]
  24. Hedlund, P. B., P. E. Danielson, E. A. Thomas, K. Slanina, M. J. Carson, and J. G. Sutcliffe (2003) No hypothermic response to serotonin in 5-HT7 receptor knockout mice. Proc. Natl. Acad. Sci., 100:1375-1380. [PubMed]
  25. Danielson, P.E., L. N. Sautkulis, P. E. Foye, P. B. Hedlund, and M. J. Carson (2002) A novel mRNA expressed along brain ventricles. Brain Res. Gene Expression Patterns, 1:83-88. [PubMed]
  26. Narváez, J. A., Z. Díaz-Cabiale, P. B. Hedlund, J. A. Aguirre, R. Coveñas, S. Gonzáles-Barón, and K. Fuxe (2000) The galanin receptor antagonist M40 blocks the central cardiovascular actions of the galanin N-terminal fragment (1-15). Eur. J. Pharamcol., 399:197-203. [PubMed]
  27. Hedlund, P. B. and G. von Euler (1999) EasyBound — A user-friendly approach to nonlinear regression analysis of binding data. Comp. Meth. Prog. Biomed., 58:245-249. [PubMed]
  28. Hillefors, M., M. von Euler, P. B. Hedlund and G. von Euler (1999) Prominent binding of the dopamine D3 agonist [3H]PD 128907 in the caudate-putamen of the adult rat. Brain Res., 822:126-131. [PubMed]
  29. Hillefors, M., P. B. Hedlund and G. von Euler (1999) Effects of adenosine A2A receptor stimulation in vivo on dopamine D3 receptor agonist binding in the rat brain. Biochem. Pharmacol., 58:1961-1964. [PubMed]
  30. Hedlund, P. B., M. J. Carson, J. G. Sutcliffe and E. A. Thomas (1999) Allosteric regulation by oleamide on the binding properties of 5-hydroxytryptamine7 receptors. Biochem. Pharmacol., 58:1807-1813. [PubMed]
  31. Razani, H., P. B. Hedlund, A. C. Hansson, K. Fuxe and S. O. Ögren (1997) 5-HT1A receptor activation: short-term effects on the mRNA expression of the 5-HT1A receptor and galanin in the raphe nuclei. Neuroreport, 8:3565-3570. [PubMed]
  32. Hedlund, P. B. and K. Fuxe (1996) Galanin and 5-HT1A receptor interactions as an integrative mechanism in 5-HT neurotransmission in the brain. Ann. N. Y. Acad. Sci., 780:193-212. [PubMed]
  33. Fuxe, K., X.-M. Li, P. Hedlund, F. Benfenati, L. F. Agnati, and S. Ferré (1996) Integrative aspects of brain function: Receptor-receptor interactions in dopamine transmission of the basal ganglia. In T. W. Stone (Eds.), CNS neurotransmitters and neuromodulators: Dopamine. CRC Press, Boca Raton, pp. 89-106.
  34. Díaz, Z., J. A. Narváez, P. B. Hedlund, J. A. Aguirre, S. González-Barón, and K. Fuxe (1996) Centrally infused galanin-(1-15), but not galanin-(1-29), reduces the baroreceptor reflex sensitivity in the rat. Brain Res., 741:32-37. [PubMed]
  35. Dasgupta, S., S. Ferré, B. Kull, P. B. Hedlund, U.-B. Finnman, S. Ahlberg, E. Arenas, B. B. Fredholm, and K. Fuxe (1996) Adenosine A2a receptors modulate the binding characteristics of dopamine D2 receptors in stably cotransfected fibroblast cells. Eur. J. Pharmacol., 316:325-331. [PubMed]
  36. von Euler, G. and P. B. Hedlund (1995) Regional and age-dependent differences in the affinity of dopamine D2 agonist binding in the rat brain. Neurochem. Int., 26:397-410. [PubMed]
  37. Li, X.-M., P. B. Hedlund, and K. Fuxe (1995) Cholecystokinin octapeptide in vitro and ex vivo strongly modulates striatal dopamine D2 receptors in rat forebrain sections. Eur. J. Neurosci., 7:962-971. [PubMed]
  38. Fuxe, K., X.-M. Li, S. Tanganelli, P. Hedlund, W. T. O'Connor, L. Ferraro, U. Ungerstedt, and L. F. Agnati (1995) Receptor-receptor interactions and their relevance for receptor diversity. Focus on neuropeptide/dopamine interactions. Ann. N. Y. Acad. Sci., 757:365-376.
  39. Aguirre, J. A., P. B. Hedlund, J. A. Narváez, B. Bunnemann, D. Ganten, and K. Fuxe (1995) Increased vasopressor actions of intraventricular neuropeptide Y-(13-36) in spontaneously hypertensive versus normotensive Wistar-Kyoto rats. Possible relationship to increases in Y2 receptor binding in the nucleus tractus solitarius. Brain Res., 684:159-164. [PubMed]
  40. Janson, A. M., A. Møller, P. B. Hedlund, G. von Euler, and K. Fuxe (1995) Nicotine and animal models of Parkinson's disease. In P. B. S. Clarke, M. Quik, F. Adlkofer and K. Thurau (Eds.), Effects of nicotine on biological systems II. Birkhäuser, Basel, pp. 321-328.
  41. Hillefors-Berglund, M., P. B. Hedlund, and G. von Euler (1995) Effects of GCS 21680 in vivo on dopamine D2 agonist binding in the rat brain. Brain Res., 690:34-40. [PubMed]
  42. Li, X.-M., P. B. Hedlund, and K. Fuxe (1994) Cholecystokinin receptor subtypes regulate dopamine D2 receptors in rat neostriatal membranes. Involvement of D1 receptors. Ann. N. Y. Acad. Sci., 713:386-387. [PubMed]
  43. Hedlund, P. B., U.-B. Finnman, N. Yanaihara, and K. Fuxe (1994) Galanin-(1-15), but not galanin-(1-29), modulates 5-HT1A receptors in the dorsal hippocampus of the rat brain: possible existence of galanin receptor subtypes. Brain Res., 634:163-167. [PubMed]
  44. Hedlund, P. B., J. I. Koenig, and K. Fuxe (1994) Adrenalectomy alters discrete galanin mRNA levels in the hypothalamus and mesencephalon of the rat. Neurosci. Lett., 170:77-82. [PubMed]
  45. Narváez, J. A., Z. Diaz, J. A. Aguirre, S. González-Baron, N. Yanaihara, K. Fuxe, and P. B. Hedlund (1994) Intracisternally injected galanin-(1-15) modulates the cardiovascular responses of galanin-(1-29) and the 5-HT1A receptor agonist 8-OH-DPAT. Eur. J. Pharmacol., 257:257-265. [PubMed]
  46. Yang, S.-N., D. R. Fior, P. B. Hedlund, J. A. Narváez, L. F. Agnati, and K. Fuxe (1994) Coinjections of NPY(1-36) or [Leu31,Pro34]NPY with adrenaline in the nucleus tractus solitarius of the rat counteract the vasodepressor responses to adrenaline. Neurosci. Lett., 171:27-31. [PubMed]
  47. Li, X.-M., P. B. Hedlund, L. F. Agnati, and K. Fuxe (1994) Dopamine D1 receptors are involved in the modulation of D2 receptors induced by cholecystokinin receptor subtypes in rat neostriatal membranes. Brain Res., 650:289-298. [PubMed]
  48. Fior, D. R., S.-N. Yang, P. Hedlund, J. A. Narvaez, L. F. Agnati, and K. Fuxe (1994) α2/Angiotensin II receptor interactions in the nucleus tractus solitarius lead to an enhancement of angiotensin II receptor transduction. Pharm. Pharmacol. Lett., 3:237-240.
  49. Janson, A. M., P. B. Hedlund, K. Fuxe, and G. von Euler (1994) Chronic nicotine treatment counteracts dopamine D2 receptor upregulation induced by a partial meso-diencephalic hemitransection in the rat. Brain Res., 655:25-32. [PubMed]
  50. Hedlund, P. B. (1994) Galanin and 5-hydroxytryptamine receptor interactions in the brain. A biochemical and functional study. Karolinska Institutet, Stockholm.
  51. Li, X.-M., P. B. Hedlund, and K. Fuxe (1994) Strong effects of NT/NN peptides on DA D2 receptors in rat neostriatal sections. NeuroReport, 5:1621-1624. [PubMed]
  52. Fior, D. R., S.-N. Yang, P. B. Hedlund, J. A. Narváez, L. F. Agnati, and K. Fuxe (1994) Evidence for an antagonitic angiotensin II/α2-adrenoceptor interaction in the nucleus tractus solitarii. Eur. J. Pharmacol., 262:271-282. [PubMed]
  53. Billecocq, A., P. B. Hedlund, F. Bolaños-Jiménez, and G. Fillion (1994) Characterization of galanin and 5-HT1A receptor coupling to adenylyl cyclase in discrete regions of the rat brain. Eur. J. Pharmacol. Mol. Pharmacol. Sect., 269:209-217. [PubMed]
  54. Yang, S.-N., D. R. Fior, P. B. Hedlund, L. F. Agnati, and K. Fuxe (1994) Selective modulation of the NPY receptors of the Y2 subtype by α2 receptors in the nucleus tractus solitarii of the rat. A cardiovascular and quantitative receptor autoradiographical analysis. Brain Res., 654:137-144. [PubMed]
  55. Fuxe, K., X.-M. Li, B. Bjelke, P. B. Hedlund, G. Biagini, and L. F. Agnati (1994) Possible mechanisms for the powerful actions of neuropeptides. Ann. N. Y. Acad. Sci., 739:42-49. [PubMed]
  56. Yang, S.-N., D. R. Fior, P. B. Hedlund, L. F. Agnati, and K. Fuxe (1994) Antagonistic regulation of α2-adrenoceptors by neuropeptide Y receptor subtypes in the nucleus tractus solitarii. Eur. J. Pharmacol., 271:201-212. [PubMed]
  57. Fuxe, K., L. F. Agnati, B. Bjelke, P. Hedlund, A. Ueki, B. Tinner, B. Bunneman, H. Steinbusch, D. Ganten, and A. Cintra (1993) Novel aspects on central 5-hydroxytryptamine neurotransmission. Focus on the cerebellum. In P. Trouillas and K. Fuxe (Eds.), Serotonin, the cerebellum and ataxia, Raven Press, New York, pp. 1-36.
  58. Li, X.-M., G. von Euler, P. B. Hedlund, U.-B. Finnman, and K. Fuxe (1993) The C-terminal neurotensin-(8-13) fragment potently modulates rat neostriatal dopamine D2 receptors. Eur. J. Pharmacol., 234:125-128. [PubMed]
  59. Li, X.-M., U.-B. Finnman, G. von Euler, P. B. Hedlund, and K. Fuxe (1993) Neuromedin N is a potent modulator of dopamine D2 receptor agonist binding in rat neostriatal membranes. Neurosci. Lett., 155:121-124. [PubMed]
  60. Zoli, M., L. F. Agnati, P. B. Hedlund, X. M. Li, S. Ferré, and K. Fuxe (1993) Receptor-receptor interactions as an integrative mechanism in nerve cells. Mol. Neurobiol., 7:293-334. [PubMed]
  61. Fior, D. R., P. B. Hedlund, and K. Fuxe (1993) Autoradiographic evidence for a bradykinin/angiotensin II receptor-receptor interaction in the rat brain. Neurosci. Lett., 163:58-62. [PubMed]
  62. Fuxe, K., L. F. Agnati, P. Hedlund, S. O. Ögren, F. Bortolotti, C. Carani, and G. Biagini (1992) Failure of integrative mechanisms in the aging brain. In G. Racagni and J. Mendlewicz (Eds.), Treatment of age-related cognitive dysfunction: pharmacological and clinical evaluation. Int. Acad. Biomed. Drug Res., Karger, Basel, pp. 1-18.
  63. Fuxe, K., L. F. Agnati, G. von Euler, S. Tanganelli, W. T. O'Connor, S. Ferré, P. Hedlund, and M. Zoli (1992) Neuropeptide, excitatory amino acid and adenosine A2 receptors regulate D2 receptors via intramembrane receptor-receptor interactions. Relevance for Parkinson's disease and schizophrenia. Neurochem. Int., 20, Suppl.:215S-224S. [PubMed]
  64. Hedlund, P. B., N. Yanaihara, and K. Fuxe (1992) Evidence for specific N-terminal galanin fragment binding sites in the rat brain. Eur. J. Pharmacol., 224:203-205. [PubMed]
  65. Janson, A. M., P. B. Hedlund, M. Hillefors, and G. von Euler (1992) Chronic nicotine treatment decreases dopamine D2 agonist binding in the rat basal ganglia. NeuroReport, 3:1117-1120. [PubMed]
  66. Hedlund, P. and K. Fuxe (1991) Chronic imipramine treatment increases the affinity of [125I]-galanin binding sites in the tel- and diencephalon of the rat and alters the 5-HT1A/galanin receptor interaction. Acta Physiol. Scand., 141:137-138. [PubMed]
  67. Hedlund, P., B., Bjelke, J. A. Aguirre, and K. Fuxe (1991) Preferential increases of [125I]-NPY1-36 binding in the hippocampal formation produced by the NPY Y2 receptor agonist NPY13-36. Acta Physiol. Scand., 141:279-280. [PubMed]
  68. Hedlund, P., G. von Euler, and K. Fuxe (1991) Activation of 5-hydroxytryptamine1A receptors increases the affinity of galanin receptors in di- and telencephalic areas of the rat. Brain Res., 560:251-259. [PubMed]
  69. Fuxe, K., L. F. Agnati, B. Bjelke, M. Zoli, J. A. Aguirre, A. Cintra, P. Hedlund, G. von Euler, K. Andersson, and P. Eneroth (1991) Central integration of chemical signals involved in the control of prolactin and LH secretion. Focus on the medianosomes. New trends in gynaecology and obstetrics, 7:237-259.
  70. Hedlund, P. B., J. A. Aguirre, J. A. Narvaez, and K. Fuxe (1991) Centrally coinjected galanin and a 5-HT1A agonist act synergistically to produce vasodepressor responses in the rat. Eur. J. Pharmacol., 204:87-95. [PubMed]
  71. Fuxe, K., P. Hedlund, G. von Euler, K. Lundgren, M. Martire, S.-O. Ögren, P. Eneroth, and L. F. Agnati (1991) Galanin/5-HT interactions in the rat central nervous system. Relevance for depression. In T. Hökfelt, T. Bartfai, D. Jacobowitz and D. Ottosson (Eds.), Galanin: a new multifunctional peptide in the neuroendocrine system, MacMillan Press, London, pp. 221-235.
  72. Aguirre, J. A., K. Fuxe, P. Hedlund, J. A. Narváez, A. Cintra, L. Rosén, and L. F. Agnati (1991) Neuropeptide Y/Angiotensin II interactions in central cardiovascular regulation of the rat. Brain Res., 566:61-69. [PubMed]
  73. Fuxe, K., J. A. Aguirre, L. F. Agnati, G. von Euler, P. Hedlund, R. Covenas, M. Zoli, B. Bjelke, and P. Eneroth (1990) Neuropeptide Y and central cardiovascular regulation: Focus on its role as a cotransmitter in cardiovascular adrenergic neurons. Ann. N. Y. Acad. Sci., 611:111-132. [PubMed]