•   Mailing Address
    The Scripps Research Institute - Scripps Florida
    130 Scripps Way, #2C1
    Jupiter, FL 33458

  •    Shipping Address
    The Scripps Research Institute - Scripps Florida
    130 Scripps Way, #2C1
    Jupiter, FL 33458

  •    Physical Address
    The Scripps Research Institute- Scripps Florida
    130 Scripps Way, #2C1
    Jupiter, FL 33458
  •   Phone and Fax Numbers
    Lab      (561) 228-2146
    Admin  (561) 228-3249
    Fax      (561) 228-2415
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Publications


15. Cabanos C, Wang M, Han X, Hansen SB "A Soluble Flourescent Binding Assay Reveals PIP2 Antagonism of TREK-1 Channels." Cell Rep 2017 Aug 8:20(6):1287-1294

14. Petersen EN, Chung H-W, Nayebosadri A, Hansen SB "Kinetic disruption of lipid rafts is a mechanosensor for phospholipase D." 2016  Nat Commun 7:13873.

13. Hansen SB “Lipid agonism; the PIP2 paradigm of ligand gated ion channels” Biochim Biophys Acta 2015 May 1851 (5): 620-628 Invited Review

12. Hansen SB, Xiao Tao, Roderick MacKinnon “Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2” Nature 2011, 477:495-98 PMCID: PMC3324908

11. Hansen SB, Wang, HL, Taylor P, and Sine SM “An Ion-Selectivity Filter in the Extracellular Domain of Cys-loop Receptors Reveals Determinants for Ion Conductance. J Biol Chem. 2008 Dec 26:283(52):36066-70 PMCID: PMC2031909

10. Hansen SB and Taylor P “Galanthamine and Non-competitive Inhibitor Binding to ACh-binding Protein: Evidence for a Binding Site on Non-a-subunit Interfaces of Heteromeric Neuronal Nicotinic Receptors” J. Mol. Biol. 2007 June 369, 895-901 PMCID: PMC2031909

9. Gao F, Mer G, Tonelli M, Hansen SB, Burghart TP, Taylor P, Sine SM. “Solution NMR of Acetycholine Binding Protein Reveals ACh-mediated Conformational Change of the C-loop” Mol Pharmacol. 2006 Oct 70(4): 1230-5

8. Hansen SB, Sulzenbacher G, Huxford T, Marchot P, Taylor P, and Bourne Y “Structures of Aplysia AChBP complexes with agonists and antagonists reveal distinctive binding interfaces and conformations” Embo J 2005, 24:3635-46

7. Gao F, Bren N, Burghardt TP, Hansen SB, Henchman RH, Taylor P, McCammon JA, Sine SM. “Agonist-mediated conformational changes in acetylcholine-binding protein revealed by simulation and intrinsic tryptophan fluorescence” J Biol Chem. 2005 Mar 4;280(9):8443-51

6. Hibbs RE, Johnson DA, Shi J, Hansen SB, and Taylor P “Structural Dynamics of the a-Neurotoxin-Acetylcholine Binding Protein Complex: Hydrodynamic and Fluorescence Anisotropy Decay Analyses” Biochemistry 2005, 44:16602-11

5. Bourne Y, Talley TT, Hansen SB, Taylor P and Marchot P “Crystal structure of a Cbtx-AChBP complex reveals essential interaction between snake a-neurotoxins and nicotinic receptors” Embo J 2005, 24: 1512-22

4. Bouzat C, Gumilar F, Spitzmaul G, Wang HL, Rayes D, Hansen SB, Taylor P, and Sine SM “Coupling of agonist binding to channel gating in an ACh-binding protein linked to an ion channel” Nature 2004 Aug 19:430:896-900 PMCID: PMC1276711

3. Hansen SB, Talley TT, Radic Z, and Taylor P. “Structural and ligand recognition characteristics of an acetylcholine binding protein from Aplysia californicaJ Biol Chem. 2004 Jun 4:279(23):24197-202

2. Gao F, Bern N, Little A, Wang HL, Hansen SB, Talley TT, Taylor P, and Sine SM. “Curariform antagonists bind in different orientations to acetylcholine-binding protein” J Biol Chem. 2003 Jun 20;278(25):23020-6.

1. Hansen SB, Radic Z, Talley TT, Molles BE, Deerinck T, Tsigelny I, and Taylor P. “Tryptophan fluorescence reveals conformational changes in the acetylcholine binding protein” J Biol Chem. 2002 Nov 1;277(44):41299-302.