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The Gill Lab at Scripps Florida

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The focus of the lab is to characterize the effects of small molecules on lifespan determination in the nematode Caenorhabditis elegans, with a view to identifying new molecular mechanisms that affect the aging process. 

Aging is the single most important factor determining the onset of human disease in developed countries. Current demographic trends indicate that the number of individuals over the age of 65 in the US will rise from 35 million in the year 2000 to 70 million in the year 2030.  This means that there will be an increasing health care burden for diseases such as diabetes, cancer, and neurodegenerative conditions such as Alzheimer’s and Parkinson’s diseases.

Research into the basic biology of aging in model organisms, such as yeast, worms and flies has shown that many interventions that extend lifespan also ameliorate or prevent phenotypes associated with age-related disease.  Thus it is possible that a therapy that promotes healthy aging will be able to simultaneously prevent or delay the onset of many, if not all, of the diseases of aging. 

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