The Scripps Research Institute


We study functionally important protein conformational changes pertinent to protein recognition, interaction and catalysis to provide a detailed understanding of how proteins work. Major research areas include protein photosensing, enzymatic control of reactive oxygen and nitrogen species, the coupling of metal-site chemistry and electron transfer for catalysis, and protein networks involved in circadian rhythms.

We integrate results from high-resolution protein crystallography; computational and computer graphics analysis; protein design cycles; small angle X-ray scattering; biochemical and spectroscopic analyses; and molecular biology to address fundamental questions of interest.


Protein Structures, Activities and Regulation:  The functioning of Molecular Machines