Genetics

M.J. Jimenez-Dalmaroni, N. Xiao, A.L. Corper, P. Verdino, G.D. Ainge, D.S. Larsen, G.F. Painter, P.M. Rudd, R.A. Dwek, K. Hoebe, B. Beutler, I.A. Wilson.  Soluble CD36 ectodomain binds negatively charged diacylglycerol ligands and acts as a co-receptor for TLR2, PLoS One, 4(10):e7411, (2009). PMCID: 2760212

H. Liu, M. Wang, C. Xia, X. Du, J.G. Flannery, K.D. Ridge, B. Beutler and X. Gong. A Novel Rhodopsin Mutation Causes Severe Retinal Degeneration. Investigative Ophthalmology & Visual Science Epub ahead of print, (2009).

E. Slack, S. Hapfelmeier, B. Stecher, Y. Velykoredko, M. Stoel, M.A. Lawson, M.B. Geuking, B. Beutler, T.F. Tedder, W.D. Hardt, P. Bercik, E.F. Verdu, K.D. McCoy and A.J. Macpherson. Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. Science 325:617-620, (2009).

R. Baccala, R. Gonzalez-Quintial, B.R. Lawson, M.E. Stern, D.H. Kono, B. Beutler and A.N. Theofilopoulos. Sensors of the innate immune system: their mode of action. Nat Rev Rheumatol. 5(8):448-56, (2009).

E.L. Denchi. Give me a break: How telomeres suppress the DNA damage response. DNA Repair 8(9):1118-26, (2009).

M.A. Gronski, J.M. Kinchen, I.J. Juncadella, N.C. Franc and K.S. Ravichandran. An essential role for calcium flux in phagocytes for apoptotic cell engulfment and the anti-inflammatory response. Cell Death Differ. 16(10):1323-31, (2009).

K. Flür, R. Allam, D. Zecher, O.P. Kulkarni1, J. Lichtnekert, M. Schwarz1, B. Beutler, V. Vielhauer and H.J. Anders. Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5. Implications for viral infection-associated glomerulonephritis. The American Journal of Pathology, 175(5):2014-22, (2009).

J. Truksa, T. Gelbart, H. Peng, E. Beutler, B. Beutler and P. Lee. Suppression of the hepcidin-encoding gene Hamp1 permits iron overload in mice lacking both hemojuvelin and matriptase-2/TMPRSS6. British Journal of Haematology,147(4):571-81, (2009).

O. Osborn, M. Sanchez-Alavez, S.E. Brownell, B. Ross, J. Klaus, J. Dubins, B. Beutler, B. Conti and T. Bartfai. Metabolic Characterization of a Mouse Deficient in All Known Leptin Receptor Isoforms. Cell Mol Neurobiol. Epub ahead of print, (2009).

D.H. Kono, M.K. Haraldsson, B.R. Lawson, K.M. Pollard, Y.T. Koh, X. Du, C.N. Arnold, R. Baccala, G.J. Silverman, B.A. Beutler and A.N. Theofilopoulos. Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus. Proc Natl Acad Sci U S A 106(29):12061-6, (2009). PMCID: PMC2715524

R. Fukui, S. Saitoh, F. Matsumoto, H. Kozuka-Hata, M. Oyama, K. Tabeta, B. Beutler and K. Miyake. Unc93B1 biases Toll-like receptor responses to nucleic acid in dendritic cells toward DNA- but against RNA-sensing. J Exp Med. 206(6):1339-50, (2009). PMCID: PMC2715051

P. Borelli, F.E. Barros, K. Nakajima, S.L. Blatt, B. Beutler, J. Pereira, M. Tsujita, G.M. Favero and R.A. Fock. Protein-energy malnutrition halts hemopoietic progenitor cells in the G0/G1 cell cycle stage, thereby altering cell production rates. Braz J Med Biol Res. 42(6):523-30, (2009).

S.C. Pflugfelder, M.E. Stern; Symposium Participants. Immunoregulation on the ocular surface: 2nd Cullen Symposium.  Ocul Surf 7(2):67-77, Review, (2009).

P. Krebs, M.J. Barnes, K. Lampe, K. Whitley, K.S. Bahjat, B. Beutler, E. Janssen and K. Hoebe. NK cell-mediated killing of target cells triggers robust antigen-specific T cell-mediated and humoral responses. Blood 113(26):6593-602, (2009). PMCID: PMC2710917

B.A. Beutler. TLRs and innate immunity. Blood 113(7): 1399–1407, (2009). PMCID: PMC2644070

J. Lichtnekert, V. Vielhauer, D. Zecher, O.P. Kulkarni, S. Clauss, S. Segerer, V. Hornung, T.N. Mayadas, B. Beutler, S. Akira and H.J. Anders. Dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif in immune complex glomerulonephritis. Am J Physiol Renal Physiol. 296(4):F867-74, (2009).

M.J. Barnes, P. Krebs, C. Eidenschenk, R. Gonzalez-Quintial, C.N. Arnold, K. Crozat, S. Sovath, E.M. Moresco, A. N. Theofilopoulos, B. Beutler and K. Hoebe. Commitment to the regulatory T cell lineage requires CARMA1 in the thymus but not in the periphery. PLoS Biology 3;7(3):e51, (2009). PMCID: PMC2650725

A.L. Blasius, K. Brandl, K. Crozat, Y. Xia, K. Khovananth, P. Krebs, N.G. Smart, A. Zampolli, Z.M. Ruggeri and B.A. Beutler. Mice with mutations of Dock7 have generalized hypopigmentation and white-spotting but show normal neurological function. Proc Natl Acad Sci USA 106(8):2706-11, (2009). PMCID: PMC2650330

K. Brandl, S. Rutschmann, X. Li, X. Du, N. Xiao, B. Schnabl, D.A. Brenner and B. Beutler.  Enhanced sensitivity to DSS colitis caused by a hypomorphic Mbtps1 mutation disrupting the ATF6-driven unfolded protein response. Proc Natl Acad Sci U S A 3;106(9):3300-5, (2009). PMCID: PMC2651297

A.K. Kiemer, R.H. Senaratne, J. Hoppstadter, B. Diesel, L.W. Riley, K. Tabeta, S. Bauer, B. Beutler and B.L. Zuraw. Attenuated Activation of Macrophage TLR9 by DNA from Virulent Mycobacteria. Journal of Innate Immunity 1:29-45, (2009).

B. Beutler. Microbe sensing, positive feedback loops, and the pathogenesis of inflammatory diseases.  Immunological Reviews 227:248-263, (2009). PMCID: PMC2713013

A.A. Brzezinska, J.L. Johnson, D.B. Munafo, K. Crozat, B. Beutler, W.B. Kiosses, B.A. Ellis and S.D. Catz.  The Rab27a Effectors JFC1/Slp1 and Munc13-4 Regulate Exocytosis of Neutrophil Granules.  Traffic9(12):2151-2164, (2008).

B.A. Croker, B.R. Lawson, M. Berger, C. Eidenschenk, A.L. Blasis, E.M. Moresco, S. Sovath, L. Cengia, L.D. Shultz, A.N. Theofilopoulos, S. Pettersson and B.A. Beutler.  Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U S A 105:15028-33, (2008). PMCID: PMC2567487

X. Du, M. Schwander, E.M. Moresco, P. Viviani, C. Haller, M.S. Hildebrand, K. Pak, L. Tarantino, A. Roberts, H. Richardson, G. Koob, H. Najmabadi, A.F. Ryan, R.J. Smith, U. Muller and B. Beutler. A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proc Natl Acad Sci U S A 105:14609-14614, (2008). PMCID: PMC2567147

J. Chaix, M.S. Tessmer, K. Hoebe, N. Fuseri, B. Ryffel, M. Dalod, L. Alexopoulou B. Beutler, L. Brossay, E. Vivier and T. Walzer. Cutting Edge: Priming of NK cells by IL-18. J Immunol. 181:1627-31, (2008).

B. Beutler, I.W. Milsark and A.C. Cerami. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. J Immunol. 181:7-9, (2008).

B. Beutler and E.M. Moresco. The forward genetic dissection of afferent innate immunity. Curr Top Microbiol Immunol. 321:3-26, (2008).

B. Beutler. Immunology, phenotype first. Preface. Curr Top Microbiol Immunol. 321:v-viii, (2008).

X. Du, E. She, T. Gelbart, J. Truksa, P. Lee, Y. Xia, K. Khovananth, S. Mudd, N. Mann, E.M. Moresco, E. Beutler and B. Beutler. The serine protease TMPRSS6 is required to sense iron deficiency. Science 320:1088-92, (2008). PMCID: PMC2430097

P. Georgel, X. Du, K. Hoebe and B. Beutler. ENU Mutagenesis in Mice. Methods Mol Biol. 415:1-16, (2008).

M.A. Freudenberg, S. Tchaptchet, S. Keck, G. Fejer, M. Huber, N. Schutze, B. Beutler and C. Galanos. Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity. Immunobiology 213:193-203, (2008).

K. Hoebe and B. Beutler. Forward genetic analysis of TLR-signaling pathways: An evaluation. Adv Drug Deliv Rev. 60:824-9, (2008).

C.H. Xia, H. Liu, D. Cheung, M. Wang, C. Cheng, X. Du, B. Chang, B. Beutler and X. Gong. A model for familial exudative vitreoretinopathy caused by LPR5 mutations. Hum Mol Genet. 17:1605-12, (2008).

B. Beutler and E.M. Moresco. Akirins vs. Infection. Nature Immunology 9:7-9, (2008). 

B. Beutler. The Toll-like Receptors. In: Genetic Susceptibility to Infection. R.L. Kaslow, J. McNicholl and A.V.S. Hill, eds. Oxford University Press pg. 165, (2008).

B. Beutler. Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease. Immunological Reviews 220:113-28, (2007).

J. Koehn, D. Huesken, M. Jaritz, A. Rot, M. Zurini, A. Dwertmann, B. Beutler and U. Korthäuer. Assessing the function of human UNC-93B in TLR signaling and MHC II response. Human Immunology 68:871-78, (2007).

B. Croker, K. Crozat, M. Berger, Y. Xia, S. Sovath, L. Schaffer, I. Eleftherianos, J.L. Imler and B. Beutler. ATP-Sensitive Potassium channels mediate survival during infection in mammals and insects. Nature Genetics39:1453-60, (2007).

B. Beutler, C. Eidenschenk, K. Crozat, J. Imler, J. Hoffman, O. Takeuchi and S. Akira. Genetic Analysis of Resistance to Viral Infection. Nature Reviews Immunology 7:753-766, (2007).

J.H. Han, S. Akira, K. Calame, B. Beutler, E. Selsing and T. Imanishi-Kari. Class Switch Recombination and Somatic Hypermutation in Early Mouse B Cells are Mediated by B Cell and Toll-like Receptors. Immunity 1:64-75, (2007).

B. Beutler, X. Du and Y. Xia. Precis on forward genetics in mice. Nature Immunology 8:659-664, (2007).

D.B. Munafó, J.L. Johnson, B.A. Ellis, S. Rutschmann, B. Beutler and S.D. Catz. Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes. Biochemical Journal 402:229-239, (2007).

P. Georgel, Z. Jiang, S. Kunz, E. Janssen, J. Mols, K. Hoebe, S. Bahram, M.B.A. Oldstone and B. Beutler. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology 362:304-313, (2007).

K.R. Taylor, K. Yamasaki, K.A. Radek, A. Di Nardo, H. Goodarzi, D. Golenbock, B. Beutler and R.L. Gallo. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on TLR4, CD44, and MD-2. Journal of Biological Chemistry 282:18265-75, (2007).

D. Togbe, L. Schofield, G.E. Grau, B. Schnyder, V. Boissay, S. Charron, S. Rose, B. Beutler, V.F.J. Quesniaux and B. Ryffel. Murine cerebral malaria development is independent of Toll-like receptor signaling. American Journal of Pathology 170:1640-1648, (2007).

K. Crozat, K. Hoebe, S. Ugolini, N.A. Hong, E. Janssen, S. Rutschmann, S. Mudd, S. Sovath, E. Vivier and B. Beutler. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. Journal of Experimental Medicine 204: 853-863, (2007).

M.M. Brinkmann, E. Spooner, K. Hoebe, B. Beutler, H.L. Ploegh and Y.M. Kim. The interaction between the ER membrane protein UNC93B and TLRs 3, 7 and 9 is crucial for TLR signaling. Journal of Cell Biology 177:265-275, (2007).

R. Baccala, K. Hoebe, D.H. Kono, B. Beutler and A.N. Theofilopoulos. Toll-like receptor-dependent and independent pathways of Type I interferon induction in systemic autoimmunity. Nature Medicine 13:543-551, (2007).

S.O. Kim, S.D. Ha, S. Lee, S. Stanton, B. Beutler and J. Han. Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells. Biotechniques 42:493-501, (2007).

M. Otsuka, Q. Jing, P. Georgel, L. New, J. Chen, J. Mols, Y.J. Kang, Z. Jiang, S.C. Das, A.K. Pattnaik, J. Carlos de la Torre, B. Beutler and J. Han. Hypersusceptibility to vesicular stomatitis virus infection in Dicer-deficient mice is due to impaired miR24 and miR93 expression. Immunity 27:123-124, (2007).