Genetics

A.A. Brzezinska, J.L. Johnson, D.B. Munafo, K. Crozat, B. Beutler, W.B. Kiosses, B.A. Ellis, S.D. Catz.  The Rab27a Effectors JFC1/Slp1 and Munc13-4 Regulate Exocytosis of Neutrophil Granules.  Traffic, Epub ahead of print, (2008).

B.A. Croker, B.R. Lawson, M. Berger, C. Eidenschenk, A.L. Blasis, E.M. Moresco, S. Sovath, L. Cengia, L.D. Shultz, A.N. Theofilopoulos, S. Pettersson, B.A. Beutler.  Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger. Proc Natl Acad Sci U S A, 105:15028-33, (2008).

X. Du, M. Schwander, E.M. Moresco, P. Viviani, C. Haller, M.S. Hildebrand, K. Pak, L. Tarantino, A. Roberts, H. Richardson, G. Koob, H. Najmabadi, A.F. Ryan, R.J. Smith, U. Muller, B. Beutler. A catechol-O-methyltransferase that is essential for auditory function in mice and humans. Proc Natl Acad Sci U S A, 105:14609-14614, (2008).

B.A. Beutler. TLRs and innate immunity. Blood, Epub ahead of print, (2008).

J. Chaix, M.S. Tessmer, K. Hoebe, N. Fuseri, B. Ryffel, M. Dalod, L. Alexopoulou B. Beutler, L. Brossay, E. Vivier, T. Walzer. Cutting Edge: Priming of NK cells by IL-18. J Immunol., 181:1627-31, (2008).

B. Beutler, I.W. Milsark, A.C. Cerami. Passive immunization against cachectin/tumor necrosis factor protects mice from lethal effect of endotoxin. J Immunol., 181:7-9, (2008).

B. Beutler, E.M. Moresco. The forward genetic dissection of afferent innate immunity. Curr Top Microbiol Immunol., 321:3-26, (2008).

B. Beutler. Immunology, phenotype first. Preface. Curr Top Microbiol Immunol., 321:v-viii, (2008).

K. Kiemer, R.L. Senaratne, L.W. Riley, K. Tabeta, B. Beutler, and B. L. Zuraw. Suppressed activation of human macrophage TLR9 by DNA from virulent mycobacteria. Journal of Innate Immunity, In Press, (2008).

X. Du, E. She, T. Gelbart, J. Truksa, P. Lee, Y. Xia, K. Khovananth, S. Mudd, N. Mann, E. M. Moresco, E. Beutler and B. Beutler. The serine protease TMPRSS6 is required to sense iron deficiency. Science, 320:1088-92, (2008).

P. Georgel, X. Du, K. Hoebe, B. Beutler. ENU Mutagenesis in Mice. Methods Mol Biol., 415:1-16, (2008).

M.A. Freudenberg, S. Tchaptchet, S. Keck, G. Fejer, M. Huber, N. Schutze, B. Beutler, C. Galanos. Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity. Immunobiology, 213:193-203, (2008).

K. Hoebe and B. Beutler. Forward genetic analysis of TLR-signaling pathways: An evaluation. Adv Drug Deliv Rev., 60:824-9, (2008).

C.H. Xia, H. Liu, D. Cheung, M. Wang, C. Cheng, X. Du, B. Chang, B. Beutler, X. Gong. A model for familial exudative vitreoretinopathy caused by LPR5 mutations. Hum Mol Genet., 17:1605-12, (2008).

B. Beutler and E. M. Moresco. Akirins vs. Infection. Nature Immunology, 9:7-9, (2008). 

B. Beutler. Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease. Immunological Reviews, 220:113-28, (2007).

J. Koehn, D. Huesken, M. Jaritz, A. Rot, M. Zurini, A. Dwertmann, B. Beutler, and U. Korthäuer. Assessing the function of human UNC-93B in TLR signaling and MHC II response. Human Immunology, 68:871-78, (2007).

B. Croker, K. Crozat, M. Berger, Y. Xia, S. Sovath, L. Schaffer, I. Eleftherianos, J.L. Imler, and B. Beutler. ATP-Sensitive Potassium channels mediate survival during infection in mammals and insects. Nature Genetics, 39:1453-60, (2007).

B. Beutler, C. Eidenschenk, K. Crozat, J. Imler, J. Hoffman, O. Takeuchi, and S. Akira. Genetic Analysis of Resistance to Viral Infection. Nature Reviews Immunology, 7:753-766, (2007).

J. H. Han, S. Akira, K. Calame, B. Beutler, E. Selsing, and T. Imanishi-Kari. Class Switch Recombination and Somatic Hypermutation in Early Mouse B Cells Are Mediated by B Cell and Toll-like Receptors. Immunity, 1:64-75, (2007)

B. Beutler, X. Du, Y. Xia. Precis on gorward genetics in mice. Nature Immunology, 8:659-664, (2007).

D. B. Munafó, J. L. Johnson, B. A. Ellis, S. Rutschmann, B. Beutler and S. D. Catz. Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes. Biochemical Journal, 402:229-239, (2007).

P. Georgel, Z. Jiang, S. Kunz, E. Janssen, J. Mols, K. Hoebe, S. Bahram, M.B.A. Oldstone, and B. Beutler. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology, 362:304-313, (2007).

K.R. Taylor, K. Yamasaki, K. A. Radek, A. Di Nardo, H. Goodarzi, D. Golenbock, B. Beutler, and R. L. Gallo. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on TLR4, CD44, and MD-2. Journal of Biological Chemistry, 282:18265-75, (2007).

D. Togbe, L. Schofield, G.E. Grau, B. Schnyder, V. Boissay, S. Charron, S. Rose, B. Beutler, V.F.J. Quesniaux, and B. Ryffel. Murine cerebral malaria development is independent of Toll-like receptor signaling. American Journal of Pathology, 170:1640-1648, (2007).

K. Crozat, K. Hoebe, S. Ugolini, N. A. Hong, E. Janssen, S. Rutschmann, S. Mudd, S. Sovath, E. Vivier, and B. Beutler. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. Journal of Experimental Medicine, 204: 853-863, (2007).

B. Beutler. The Toll-like Receptors. In: Genetic Susceptibility to Infection. Kaslow, R.L.,McNicholl, J., and Hill, A.V.S., eds. Oxford University Press, in press, (2007).

M.M. Brinkmann, E. Spooner, K. Hoebe, B. Beutler, H.L. Ploegh, and Y-M. Kim. The interaction between the ER membrane protein UNC93B and TLRs 3, 7 and 9 is crucial for TLR signaling. Journal of Cell Biology, 177:265-275, (2007).

R. Baccala, K. Hoebe, D.H. Kono, B. Beutler, and A. N. Theofilopoulos. Toll-like receptor-dependent and independent pathways of Type I interferon induction in systemic autoimmunity. Nature Medicine, 13:543-551, (2007).

S.O. Kim, S.D. Ha, S. Lee, S. Stanton, B. Beutler, and J. Han. Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells. Biotechniques, 42: 493-501, (2007).

M. Otsuka, Q. Jing, P. Georgel, New, J. Chen, J. Mols, Y.J. Kang, Z. Jiang, S. C. Das, A. K. Pattnaik, J. Carlos de la Torre, B. Beutler and J. Han. Hypersusceptibility to vesicular stomatitis virus infection in Dicer-deficient mice is due to impaired miR24 and miR93 expression. Immunity, 27:123-124, (2007).