Lab Home

Lab Members

Research

Publications

Meetings

Alumni

Genetics Affinity Group Seminars

Genetics Home

Mutagenetix

TSRI Home

Publications as of May 07, 2008

1998 | 1999 | 2000 | 2001 | 2002 | 2003 | 2004 | 2005 | 2006 | 2007 | 2008

2008 (7 articles)
K. Kiemer, R.L. Senaratne, L.W. Riley, K. Tabeta, B. Beutler, and B. L. Zuraw. Suppressed activation of human macrophage TLR9 by DNA from virulent mycobacteria. Journal of Innate Immunity, In Press, (2008).
X. Du, E. She, T. Gelbart, J. Truksa, P. Lee, Y. Xia, K. Khovananth, S. Mudd, N. Mann, E. Moresco, E. Beutler and B. Beutler.  The serine protease TMPRSS6 is required to sense iron deficiency. Science, 320:1088-92, (2008).
P. Georgl, X. Du, K.Hoebe, B. Beutler. ENU Mutagenesis in Mice. Methods Mol Biol., 415:1-16, (2008).
M.A. Freudenbert, S. Tchaptchet, S. Kech, G. Fejer, M. Huber, N. Schutze, B. Beutler, C. Galanos. Lipopolysaccharide sensing an important factor in the innate immune response to Gram-negative bacterial infections: Benefits and hazards of LPS hypersensitivity. Immunobiology, 213:193-203, (2008).
K. Hoebe and B. Beutler. Forward genetic analysis of TLR-signaling pathways: An evaluation. Adv Drug Deliv Rev., 60:824-9, (2008).
C.H. Xia, H. Liu, D. Cheung, M. Wang, C. Cheng, X. Du, B. Chang, B. Beutler, X. Gong. A model for familial exudative vitreoretinopathy caused by LPR5 mutations. Hum Mol Genet., 17:1605-12, (2008).
B. Beutler and E. Moresco. Akirins vs. Infection. Nat Immunol., 9:7-9, (2008).
2007 (16 articles)
B. Beutler.  The Toll-like Receptors.  In: Genetic Susceptibility to Infection. R.L Kaslow, J. McNicholl, and A.V.S. Hill, eds.  Oxford University Press, in press, (2007).
J. Koehn, D. Huesken, M. Jaritz, A. Rot, M. Zurini, A. Dwertmann, B. Beutler, and U. Korthäuer. Assessing the function of human UNC-93B in TLR signaling and MHC II response. Human Immunol., 68:871-78, (2007).
B. Croker, K. Crozat, M. Berger, Y. Xia, S. Sovath, L. Schaffer, I. Eleftherianos, J.L. Imler, and B. Beutler. ATP-Sensitive Potassium channels mediate survival during infection in mammals and insects. Nat. Genet., 39:1453-60, (2007).
B. Beutler. Neo-ligands for innate immune receptors and the etiology of sterile inflammatory disease. Immunol Rev., 220:113-28, (2007).
B. Beutler, C. Eidenschenk, K. Crozat, J. Imler, J. Hoffman, O. Takeuchi, and S. Akira. Genetic Analysis of Resistance to Viral Infection. Nat. Rev. Immunol. 7:753-766, (2007).
J. H. Han, S. Akira, K. Calame, B. Beutler, E. Selsing, and T. Imanishi-Kari. Class Switch Recombination and Somatic Hypermutation in Early Mouse B Cells Are Mediated by B Cell and Toll-like Receptors. Immunity 1:64-75, (2007).
Z. Georgel, S. Jiang, E. Kunz, J. Janssen, K. Mols, K. Hoebe, S. Bahram, M.B.A. Oldstone, and B. Beutler. Vesicular stomatitis virus glycoprotein G activates a specific antiviral Toll-like receptor 4-dependent pathway. Virology 362:304-313, (2007).
K. R. Taylor, K. Yamasaki, K. A. Radek, A. Di Nardo, H. Goodarzi, D. Golenbock, B. Beutler, and R. L. Gallo. Recognition of hyaluronan released in sterile injury involves a unique receptor complex dependent on TLR4, CD44, and MD-2. J. Biol.Chem., 282:18265-75, (2007).
D. Togbe, L. Schofield, G.E. Grau, B. Schnyder, V. Boissay, S. Charron, S. Rose, B. Beutler, V.F.J. Quesniaux, and B. Ryffel. Murine cerebral malaria development is independent of Toll-like receptor signaling. Am. J. Pathol. 170:1640-1648, (2007).
K. Crozat, K. Hoebe, S. Ugolini, N. A. Hong, E. Janssen, S. Rutschmann, S. Mudd, S. Sovath, E. Vivier, and B. Beutler. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis. J. Exp. Med. 204:853-863, (2007).
M.M. Brinkmann, E. Spooner, K. Hoebe, B. Beutler, H.L. Ploegh, and Y-M. Kim. The interaction between the ER membrane protein UNC93B and TLRs 3, 7, and 9 is crucial for TLR signaling. J. Cell Biol. 177:265-275, (2007).
R. Baccala, K. Hoebe, D.H. Kono, B. Beutler, and A. N. Theofilopoulos.  Toll-like receptor-dependent and independent pathways of Type I interferon induction in systemic autoimmunity. Nat. Med. 13:543-551, (2007).
D.B. Munafó, J.L. Johnson, B.A. Ellis, S. Rutschmann, B. Beutler and S.D. Catz. Rab27a is a key component of the secretory machinery of azurophilic granules in granulocytes. Biochem. J. 402:229-39, (2007).
S.O. Kim, S.D. Ha, S. Lee, S. Stanton, B. Beutler, and J. Han.  Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells.  Biotechniques 42: 493-501, (2007).
B. Beutler, X. Du, Y. Xia. Precis on gorward genetics in mice. Nat. Immunol. 8:659-664 (2007).
M. Otsuka, Q. Jing, P. Georgel, L. New, J. Chen, J. Mols, Y.J. Kang, Z. Jiang, S.C. Das, A.K. Pattnaik, J. Carlos de la Torre, B. Beutler and J. Han. Hypersusceptibility to vesicular stomatitis virus infection in Dicer-deficient mice is due to impaired miR24 and miR93 expression. Immunity 27:123-124, (2007).
2006 (21 articles)
M. Huber, C. Kalis, S. Keck, Z. Jiang, P. Georgel, X. Du, L. Shamel, S. Sovath, S. Mudd, B. Beutler, C. Galanos, and M.A. Freudenberg. R-form LPS, the master key to the activation of TLR4/MD2 positive cells. Eur. J. Immunol. 36:701‑711, (2006).
B. Beutler, Z. Jiang, P. Georgel, K. Crozat, B. Croker, S. Rutschmann, X. Du and K. Hoebe. Genetic analysis of host resistance: Toll-like receptor signaling and immunity at large. Annu. Rev. Immunol. 24:353-389, (2006).
E. M. Janssen, K. Tabeta, M. Barnes, S. McBride, S. Schoenberger, A.N. Theofilopoulos, B. Beutler, and K. Hoebe. Efficient T cell activation via a toll-interleukin 1 receptor-independent pathway. Immunity 24:787-799, (2006).
K. Tabeta, K. Hoebe, E.M Janssen, X. Du, P. Georgel, K. Crozat, S. Mudd, N. Mann, S. Sovath, J. Goode, L. Shamel, A. Herskovits, D. Portnoy, M. Cooke, L.M. Tarantino, T. Wiltshire, B.E. Steinberg, S. Grinstein, and B. Beutler. The Unc93b1 mutation 3d disrupts exogenous antigen presentation signaling via Toll-like receptors 3, 7, and 9. Nat. Immunol. 7:156-164, (2006).
S. Rutschmann, K. Hoebe, J. Zalevsky, X. Du, N. Mann, B.I. Dahiyat, P. Steed, and B. Beutler. PanR1, a dominant negative missense allele of Tumor Necrosis Factor α , does not impair lymphoid development. J. Immunol. 176:7525-7532, (2006).
K. Crozat, P. Georgel, S. Rutschmann, N. Mann, X. Du, K. Hoebe, and B. Beutler. Analysis of the MCMV resistome by ENU mutagenesis. Mamm. Genome 17:398-406, (2006).
Z. Jiang, P. Georgel, C. Li, J. Choe, K. Crozat, S. Rutschmann, X. Du, T. Bigby, S. Mudd, S. Sovath, I.A. Wilson, A. Olson, and B. Beutler. Details of Toll-like receptor: adapter interaction revealed by germline mutagenesis. Proc. Natl. Acad. Sci. U.S.A., 103:10961-10966, (2006).
D. Nemazee, A.L. Gavin, K. Hoebe, and B. Beutler. Commentary: The TLR independence of antibody responses. Nature 441: E4, (2006).
K. Hoebe, Z. Jiang, K. Tabeta, X. Du, P. Georgel, K. Crozat, and B. Beutler. Genetic analysis of innate immunity. Adv. in Immunol. 91:175-226, (2006).
K. Hoebe, Z. Jiang, P. Georgel, K. Tabeta, E. Janssen, X. Du, and B. Beutler. TLR signaling pathways: Opportunities for activation and blockade in pursuit of therapy. Curr. Pharm. Des. 12: 4123-4134, (2006).
H. Fischer, M. Yamamoto, S. Akira, B. Beutler, and C. Svanborg. Mechanism of pathogen-specific TLR4 activation in the mucosa: fimbriae, recognition receptors and adaptor protein selection. Eur. J. Immunol. 36:267-277, (2006).
C.H. Xia, H. Liu, D. Cheung, C. Cheng, E. Wang, X. Du, and B. Beutler. Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. Development, 133: 2033-2040, (2006).
K. Hoebe and B. Beutler. TRAF3: a new component of the TLR-signaling apparatus. Trends Mol Med. 12:187-189, (2006).
L. Gitlin, W. Barchet, S. Gilfillan, M. Cella, B. Beutler, R.A. Flavell, M.S. Diamond, and M. Colonna. Essential role of mda-5 in type I IFN responses to polyriboinosinic: polyribocytidylic acid and encephalomyocarditis picornavirus. Proc. Natl. Acad. Sci. U.S.A. 103:8459-8464, (2006).
Y. Kinjo, E. Tupin, D.Wu, M. Fujio, R. Garcia-Navarro, M.R-E-I. Benhnia, D.M. Zajonc, G. Ben-Menachem, G.D. Ainge, G.F. Painter, A. Khurana, K. Hoebe, S.M. Behar, B. Beutler, I.A. Wilson, M. Tsuji, T.J. Sellati, C-H. Wong, and M. Kronenberg. Natural killer T cells recognize diacylglycerol antigens from pathogenic bacteria. Nat. Immunol. 7:978-986, (2006).
A. Casrouge, S-Y Zhang, C. Eidenschenk, E. Jouanguy, A. Puel, K. Yang, A. Alcais, C. Picard, N. Mahfoufi, N. Nicolas, L. Lorenzo, S. Plancoulaine, B. Senechal, F. Geissmann, K. Tabeta, K. Hoebe, X. Du, R. L. Miller, B. Heron, C. Mignot, T. B. de Villemeur, P. Lebon, O. Dulac, F. Rozenberg, B. Beutler, M. Tardieu, L. Abel, J-L. Casanova. Herpes simplex virus encephalitis in human UNC-93B deficiency. Science 314:308-12, (2006).
D. Togbe, G. Aurore, N. Noulin, V.F. Quesnizux, S. Schnyder-Candrian, B. Schnyder , V.Vasseur, S. Akira, K. Hoebe, B. Beutler, B. Ryffel and I. Couillin. Nonredundant roles of TIRAP and MyD88 in airway response to endotoxin, independent of TRIF, IL-1 and IL-18 pathways. LabInvest. 86:1126-1135, (2006).
T.P. Meehan, K. Tabeta, X. Du, L.S. Woodward, K. Firozi, B. Beutler and M.J.Justice. Point mutations in the melanocortin-4 receptor cause variable obesity in mice. Mamm. Genome 17:1162-1171, (2006).
A.L. Gavin, B. Duong, T. Ota, K. Hoebe, B. Beutler, and D. Nemazee. Adjuvant-enhanced antibody responses in the absence of toll-like receptor signaling. Science 314:1936-1938, (2006).
B. Beutler. Fighting malaria: mosquitoes know how. Immunity 25:530-531, (2006).
C.H. Xia, H. Liu, M. Wang, D. Heung, A. Park, Y. Yang, X. Du, B. Chang, B. Beutler, and X. Gong. Characterization of mouse mutants with abnormal RPE cells. Adv. Exp. Med. Biol. 572:95-100, (2006).
2005 (20 articles)
A.N. Theofilopoulos, R. Baccala, B. Beutler, and D.H. Kono. Type I interferons (α/β) in immunity and autoimmunity. Annu. Rev. of Immunol., 23:307-335, (2005).
B. Beutler, K. Hoebe, P. Georgel, and X. Du. Forward genetic analysis of TLR pathways: A shared system for the detection of endotoxin and viral infection. Editor: T. Rich. In:Toll and Toll-like receptors: an immunologic perspective . Kluwer Academic/Plenum publishers, New York, NY, pages 168-177, (2005).
K. Hoebe, P. Georgel, S. Rutschmann, X. Du, S. Mudd, K. Crozat, S. Sovath, L. Shamel, T. Hartung,U. Zahringer, and B. Beutler. CD36 is a sensor of diacylglycerides. Nature 433:523-527, (2005).
T.R. Hawn, A. Verbon, M. Janer, L.P. Zhao, B. Beutler, and A. Aderem. Toll-like receptor 4 polymorphisms are associated with resistance to Legionnaires disease. Proc. Natl. Acad. Sci. U.S.A. 102:2487-2489, (2005).
B. Beutler, K. Crozat, J.A. Koziol and P. Georgel. Genetic dissection of innate immunity to infection: The mouse cytomegalovirus model. Curr. Opin. Immunol. 17:36-43, (2005).
J. Mattner, K.L. DeBord, N. Ismail, R.D. Goff, C. Cantu III, D. Zhou, P. Sait-Mezard, V. Wang, Y. Gao, N. Yin, K. Hoebe, O. Schneewind, D. Walker, B. Beutler, L. Teyton, P.B. Savage, and A. Bendelac. Both exogenous and endogenous glycolipid antigens activate NKT cells during microbial infections. Nature 434:525-529, (2005).
P. Georgel, K. Crozat, X. Lauth, S. Sovath, K. Hoebe, X. Du, S. Rutschmann, Z. Jiang, T. Bigby, V. Nizet, and B. Beutler. A TLR2-responsive lipid effector pathway protects mammals against Gram-positive bacterial infections. Infect. Immun.73:4512-4521, (2005).
Z. Zhou, K. Hoebe, X. Du, Z. Jiang, L. Shamel, and B. Beutler. Antagonism between MyD88- and TRIF-dependent signals in B7RP-1 upregulation. Eur. J. Immunol. 35:1918-1927, (2005).
Z. Jiang, P. Georgel, X. Du, L. Shamel, S. Sovath, S. Mudd, and B. Beutler. CD14 is required for MyD88-independent LPS signaling. Nat. Immunol. 6:565-570, (2005).
K. Hoebe and B. Beutler. Unraveling innate immunity using large scale ENU mutagenesis. Tissue Antigens 65:395-401, (2005).
B. Beutler and J-L. Casanova. New frontiers in immunology: Workshop on the Road Ahead: Future directions in fundamental and clinical immunology. EMBO Rep. 6:620-623, (2005).
B. Beutler, K. Hoebe, P. Georgel, K. Tabeta, X. Du. Genetic analysis of innate immunity: identification and function of the TIR adapter proteins. Adv. Exp. Med. Biol. 560:29-39 (2005).
K.I. Kim, O. Malakhova, K. Hoebe, M. Yan, B. Beutler, and D-E. Zhang. Enhanced anti-bacterial potential in UBP43-deficient mice against Salmonella typhimurium infection by up-regulation type I IFN-signaling. J. Immunol. 175:847-854, (2005).
B. Beutler. The Toll-like receptors: Analysis by forward genetic methods. Immunogenetics 57:385-392, (2005).
C.W. Wieland, S. Florquin, N.A. Maris, K. Hoebe, B. Beutler, K. Takeda, S. Akira, T. van der Poll. The MyD88 dependent but not the MyD88 independent pathway of Toll-like receptor 4 signaling is important in clearing non-typeable Haemophilus influenzae from the mouse lung. J. Immunol. 175:6042-6049, (2005).
X. Du, K. Tabeta, K. Hoebe, N. Mann, K. Crozat, S. Mudd, and B. Beutler. An essential role for Rxr α in Th2 development. Eur. J. Immunol . 35:3414-3423, (2005).
B. Beutler. Innate Immunity. In: Williams Hematology, 7th Edition . Lichtman, M.A., Beutler, E., Kipps, T.J., Seligsohn, U., Kaushansky, K., and Prchal, J.T., eds. McGraw-Hill Medical Press, New York, NY, pp. 231-238, (2005).
B. Beutler, P. Georgel, B. Croker, and K. Crozat. Genetic analysis of innate resistance to mouse cytomegalovirus (MCMV). Brief. Funct. Genomic Proteomic 4:203-213, (2005).
H.Q. Liu, X. Du, M. Wang, Q.L. Huang, L.L. Ding, H.W. McDonald, J.R. Yates, B. Beutler, J. Horwitz, and X.H. Gong. Crystallin gamma B-14F mutant protein binds to alpha-crystallin and affects lens transparency. J.Biol.Chem. 280:25071-25078, (2005).
B. Beutler. Microbial Pathogenesis and the discovery of Toll-like receptor function. In: Vaccine Adjuvants: Immunological and Clinical Principles. Hackett, C., and Harn, D.A., eds. Humana Press, Totowa, NJ, pg. 1-24, (2005).
2004 (16 articles)
X. Du, K. Tabeta, K. Hoebe, H. Liu, N. Mann, S. Mudd, K. Crozat, S. Sovath, X. Gong, and B. Beutler. Velvet, a dominant Egfr mutation that causes wavy hair and defective eyelid development in mice. Genetics 166:331-340, (2004).
K. Tabeta, P. Georgel, E.M. Janssen, X. Du, K. Hoebe, K. Crozat, S. Mudd, L. Shamel, S. Sovath, J. Goode, L. Alexopoulou, R. Flavell, and B. Beutler. TLR9 and TLR3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. U.S.A. 101:3516-3521, (2004).
N. Anfossi, S.H. Robbins, S. Ugolini, P. Georgel, K. Hoebe, C. Bouneaud, C. Ronet, A. Kaser, C.B. DiCioccio, E. Tomasello, B. Beutler, S.L. Reiner, L. Alexopoulou, O. Lantz , D.H. Raulet, L. Brossay, E. Vivier. Expansion and Function of CD8+ T Cells Expressing Ly49 Inhibitory Receptors Specific for MHC Class I Molecules. J. Immunol. 173:3773-3782, (2004).
K. Crozat and B. Beutler. TLR7: A new sensor of viral infection. Proc. Natl. Acad. Sci. U.S.A. 101:6835-6836, (2004).
B. Beutler. Preview: SHIP, TGF-β, and Endotoxin Tolerance. Immunity 21:134‑135, (2004).
K. Hoebe, E.M. Janssen, and B. Beutler. The Interface between Innate and Adaptive Immunity. Nat. Immunol. 5:971-974, (2004).
B. Beutler. The Toll-like receptors and their place in immunology – Where does the immune response to infection begin? Nat. Rev. Immunol. 4:498 (2004).
B. Beutler. Inferences, questions and possibilities in Toll-like receptor signaling. Nature 430:257-263, (2004).
K. Hoebe and B. Beutler. LPS, dsRNA and the interferon bridge to adaptive immune responses: Trif, Tram, and other TIR adaptor proteins. J.Endotoxin Res. 10:130-136, (2004).
I. Smythe, X. Du, M.S. Taylor, M. Justice, B. Beutler, and I.J. Jackson. The extracellular matrix gene Frem1 is essential for the normal adhesion of the embryonic epidermis. Proc. Natl. Acad. Sci. U.S.A. 101:13560-13565, (2004).
H. Weighardt, G. Jusek, J. Mages, R. Lang, K. Hoebe, B. Beutler, B. Holzmann. Identification of a TLR4- and TRIF-dependent activation program of dendritic cells. Eur.J.Immunol . 34:558-564, (2004).
B. Beutler. Innate Immunity: an overview. Mol. Immunol. 40:845-859, (2004).
B. Beutler, K. Hoebe, and L. Shamel. Forward genetic dissection of afferent immunity: the role of TIR adapter proteins in innate and adaptive immune responses. C. R. Biol. 327:571-80, (2004).
B. Beutler and J. Hoffmann. Innate immunity – Editorial overview. Curr. Opin. Immunol. 16:1-3, (2004).
B. Beutler, K. Hoebe, P. Georgel, K. Tabeta, and X. Du. Genetic analysis of innate immunity: TLR adapter proteins in innate and adaptive immune responses. Microbes Infection 6:1374-1381, (2004).
E.T. Rietschel, M. Rietschel, and B. Beutler. How the mighty have fallen: fatal infectious diseases of divine composers. Editor: B.A. Cunha and R.C. Moellering. In: Infectious Diseases Clinics of North America. W.B. Saunders Company, Philadelphia, PA, 18:311-339, (2004).
2003 (17 articles)
B. Beutler. Toll-like Receptors: The Origins of Inflammation. In: The Cytokine Handbook 4th Edition . T.A. Thomson and M.T. Lotze eds., Academic Press, 809-822, (2003).
B. Beutler and S. Beutler. The pathogenesis of fever. In: Cecil Textbook of Medicine 22nd Edition. D. Ausiello eds., W.B. Saunders, Philadelphia, PA, (2003).
K. Hoebe, X. Du, J. Goode, N. Mann, and B. Beutler. Lps2: a new locus required for responses to lipopolysaccharide, revealed by germline mutagenesis and phenotypic screening. J.Endotox.Res. 9:250-255, (2003).
I. Smirnova, N. Mann, A. Dols, H.H. Derkx, M. Hibberd, M. Levin, and B. Beutler. Assay of locus-specific genetic load implicates rare TLR4 mutations in meningococcal susceptibility. Proc. Natl. Acad. Sci. U.S.A. 100:6075-6080, (2003).
K. Hoebe, X. Du, P. Georgel, E.M. Janssen, K. Tabeta, S.O. Kim, J. Goode, P. Lin, N. Mann, S. Mudd, K. Crozat, S. Sovath, J. Han and B. Beutler. Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature 424:743-748, (2003).
K. Hoebe, E.M. Janssen, S.O. Kim, L. Alexopoulou, R.A. Flavell, J. Han and B. Beutler. Upregulation of costimulatory molecules induced by lipopolysaccharide and double-stranded RNA occurs by Trif-dependent and Trif-independent pathways. Nat. Immunol. 4:1223-1229, (2003).
T.R. Hawn, A. Verbon, K.D. Lettinga, L.P. Zhao, S.S. Li, R.J. Laws, S.J. Skerrett, B. Beutler, L. Schroeder, A. Nachman, A. Ozinsky, K.D. Smith, and A. Aderem. A common dominant TLR5 stop codon polymorphism abolishes flagellin signaling and is associated with susceptibility to legionnaires' disease. J. Exp. Med. 198:1563-1572, (2003).
B. Beutler. Innate immune responses to microbial poisons: Discovery and function of the Toll-like receptors. Annu. Rev. Pharmacol. Toxicol. 43:609-628, (2003).
B. Beutler. Key inflammatory and stress pathways in critical illness the central role of the Toll-like receptors. Crit. Care 7:39-46, (2003).
B. Beutler and E.T. Rietschel. Innate immune sensing and its roots: the story of endotoxin. Nat. Rev. Immunol. 3:169-176, (2003).
B.J. Stevenson, C. Iseli, B. Beutler, and C.V. Jongeneel. Using transcriptome data to unravel the fine structure of genes involved in sepsis. J. Infect. Dis. 187:S308-S314, (2003).
B. Beutler. TNF In: Encyclopedia of Hormones & Related Cell Regulators. H.L. Henry and A.W. Norman eds., Academic Press, San Diego, CA. 536-539, (2003).
B. Beutler, X. Du, and K. Hoebe. From phenomenon to phenotype, and from phenotype to gene: forward genetics and the problems of sepsis. J.Infect.Dis. 187:S321-326, (2003).
B. Beutler, K. Hoebe, X. Du, and R.J. Ulevitch. How we detect microbes and respond to them: the Toll-like receptors and their transducers. J.Leukoc. Biol. 74:479-485, (2003).
B. Beutler, K. Hoebe, X. Du, E.M. Janssen, P. Georgel, and K. Tabeta. Lps2 and signal transduction in sepsis: at the intersection of host responses to bacteria and viruses. Scan.J. Infect.Dis. 35:563-567, (2003).
B. Beutler. Not "molecular patterns" but molecules. Immunity 19:155-156 (2003).
S.O. Kim, Q. Jing, K. Hoebe, B. Beutler, N.S. Duesbery, and J. Han. Sensitizing anthrax lethal toxin-resistant macrophages to lethal toxin-induced killing by tumor necrosis factor-α. J.Biol.Chem. 278:7413-7421, (2003).
2002 (7 articles)
B. Beutler. Toll-like receptors: how they work and what they do. Curr. Opin. Hematol. 9:2-10, (2002).
B. Beutler. Innate immune sensing of microbial infection: the mechanism and the therapeutic challenge. Wien. Med. Wochenschr. 152:547-551, (2002).
B. Beutler. Endotoxin antagonism: conceptual basis and therapeutic potential. Expert Opin. Ther. Targets 6:147-158, (2002).
B. Beutler. TLR4 as the mammalian endotoxin sensor. In: Curr. Top. Microbiol. Immunol. B. Beutler and H. Wagner eds., Springer-Verlag, 109-120, (2002).
B. Beutler and M. Rehli. Evolution of the TIR, Tolls and TLRs: functional inferences from computational Biology. Curr. Top. Microbiol. Immunol. B. Beutler and H. Wagner eds., Springer-Verlag, 1-21, (2002).
B. Beutler. LPS in microbial pathogenesis: promise and fulfillment. J. Endotox. Res. 8:329-335, (2002).
B.Beutler and E. Beutler. Toll-like recetpor 4 polymorphisms and atherogenesis. New Engl. J. Med. 347:1978-1979, (2002).
2001 (13 articles)
I. Smirnova, M. Hamblin, C. McBride, B. Beutler and A. di Rienzo. Excess of rare amino acid polymorphisms in the Toll-like receptor 4 in humans. Genetics 158:1657-1664, (2001).
B. Beutler. Innate Immune Sensing and the Toll-like Receptors. In: The Liver: Biology and Pathobiology. I.M. Arias, J.L. Boyer, F.V. Chisari, et al., eds., 4th Edition, Lippincott, Williams & Wilkins, Philadelphia, PA, 581-589, (2001).
B. Beutler and A. Poltorak. Toll we meet again. Nat. Immunol. 2:9-10, (2001).
B. Beutler and A. Poltorak. The sole gateway to endotoxin response: how Lps was identified as Tlr4, and its role in innate immunity. Drug Metab.Dispos. 29:474-78, (2001).
B. Beutler and A. Poltorak. The Search for Lps: 1993-1998. J. Endotox. Res. 6:269-293, (2001).
B. Beutler. The Toll-like receptors as the primary sensors of the innate immune system. The Immunologist 8:123-130, (2001).
D. Kimbrell and B. Beutler. Evolution and genetics of innate immunity. Nat. Rev. 2:256-267, (2001).
B. Beutler, X. Du and A. Poltorak. Identification of Toll-like receptor 4 (TLR4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies. J. Endotox. Res. 7:277-280, (2001).
B. Beutler and A. Poltorak. Sepsis and the evolution of the innate immune response. Crit. Care Med. 29:S2-7, (2001).
B. Beutler. Autoimmunity and apoptosis: The Crohn's connection. Immunity 15:5-14 , (2001).
H.R. Redl, A. Aderem, B. Beutler, T. Calandra, J.P. Mira, R. Ulevitch. Clinical expert round table discussion (session 1) at the Margaux Conference on Critical Illness: innate immunity: host recognition of and sensitivity to bacterial components. Crit. Care Med. 29:S19-20, (2001).
R. Ulevitch and B. Beutler. Genetic analysis of host responses in sepsis. Curr. Infect. Dis. Rep. 3:419-426, (2001).
B. Beutler. Sepsis begins at the interface of pathogen and host. Biochem. Soc. Trans. 29:853-859, (2001).
2000 (9 articles)
A. Poltorak, P. Ricciardi-Castagnoli, S. Citterio, and B. Beutler. Physical contact between LPS and TLR4 revealed by genetic complementation. Proc. Natl. Acad. Sci. U.S.A. 97:2163-2167, (2000).
I. Smirnova, A. Poltorak, E.K.L. Chen, C. McBride, and B. Beutler. Phylogenetic variation and polymorphism at the toll-like receptor 4 locus (TLR4). Genome Biol. 1:1-10, (2000).
J. Nattermann, X. Du, Y. Wei, D. Shevchenko, and B. Beutler. Endotoxin-mimetic effect of antibodies against Toll-like receptor 4. J.Endotox.Res. 6:257-264, (2000).
A. Poltorak, I. Smirnova, R. Clisch, and B. Beutler . Limits of a deletion spanning Tlr4 in C57BL/10ScCr mice. J.Endotox.Res. 6:51-56, (2000).
X. Du, A. Poltorak, Y. Wei, and B. Beutler. Three novel mammalian toll-like receptors: gene structure, expression, and evolution. Eur. Cytokine Netw. 11:362-371, (2000).
M. Rehli, A. Poltorak, L. Schwarzfischer, S.W. Krause, R. Andreesen and B. Beutler . PU.1 and interferon consensus sequence-blinding protein regulate the myeloid expression of the human Toll-like receptor 4 gene. J. Biol. Chem. 275:9773-9781, (2000).
B. Beutler. Endotoxin, Toll-like receptor 4, and the afferent limb of innate immunity. Curr. Opin. Microbiol. 3:23-28, (2000).
B. Beutler. TLR4: Central component of the sole mammalian LPS sensor. Curr. Opin. Immunol. 12:20-26, (2000).
B. Beutler and A. Poltorak. Positional cloning of Lps and the general role of toll-like receptors in the innate immune response. Eur. Cytokine Netw. 11:143-152, (2000).
1999 (4 articles)
J.A. Koziol and B. Beutler. Estimation of physical distance in the genome through probabilistic analysis of marker density and yeast artificial chromosome (YAC) size. Biom. J. 41: 251-257, (1999).
G.R. Brown, M.D. Silva, P.A. Thompson, and B. Beutler. Lymphoid hyperplasia, CD45RB high/low T cell imbalance, and suppression of type I diabetes mellitus result from TNF blockade in NOD 6 NOD-scid adoptive T cell transfer. Diabetologia 41:1502-1510, (1999).
G.R. Brown, G. Lindberg, J. Meedings, M. Silva, B. Beutler, and D.Thiele. Tumor necrosis factor inhibitor ameliorates murine intestinal graft-versus-host disease. Gastroenterology 116:593-601, (1999).
X. Du, A. Poltorak, M. Silva, and B. Beutler. Analysis of Tlr4-mediated LPS signal transduction in macrophages by mutational modification of the receptor. Blood Cells Mol. Dis. 25:328-338, (1999).
1998 (3 articles)
A. Poltorak, I. Smirmova, X. He, M.-Y. Liu, C. Van Huffel, O. McNally, D. Birwell, E. Alejos, M. Silva, X. Du, P. Thompson, E.K.L. Chan, J. Ledesma, B. Roe, S. Clifton, S. Vogel, and B. Beutler. Genetic and physical mapping of the Lps locus: Identification of the Toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol. Dis. 24:340-355, (1998).
A. Poltorak, X. He, I. Smirnova, M.-Y. Liu, C. Van Huffel, X. Du, D. Birdwell, E. Alejos, M. Silva, C. Galanos, M. Freudenberg, P. Ricciardi-Castagnoli, B. Layton, and B. Beutler. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: Mutations in the TLR4 gene. Science 282:2085-2088, (1998).
B. Beutler and F. Bazzoni. TNF, apoptosis and autoimmunity: a common thread? Blood Cells Mol. Dis. 24:216-230, (1998).