Publications
Refereed Publications
1. Parmely, MJ, Gale, AJ, Clabaugh, M, Horvat, R, Zhou, WW. Proteolytic Inactivations of Cytokines by Pseudomonas aeruginosa. Infection and Immunity, 58, 3009-3014, 1990.
2. Parmely, MJ, Sterner, KE, Gale, AJ, Zhou, WW. U937 Cells Can Utilize Plasminogen Activator to Regulate Human Interferon-y. Journal of Interferon Research, 13, 397-406, 1993.
3. Kim, S, Landro, JA, Gale, AJ, Schimmel, P. C Terminal Peptide Appendix in a Class I tRNA Synthetase Needed for Acceptor Helix Contacts and Microhelix Aminoacylation. Biochemistry 32, 13026-13031, 1993.
4. Gale, AJ, Schimmel, P. Isolated RNA Binding Domain of a Class I tRNA Synthetase. Biochemistry, 34, 8896-8903, 1995.
5. Gale, AJ, Shi, JP, Schimmel, P. Evidence that Specificity of Microhelix Charging by a Class I tRNA Synthetase Occurs in Transition State of Catalysis. Biochemistry, 35, 608-615, 1996.
6. Gale, AJ, Sun, X, Heeb, MJ, Griffin, JH. Nonenzymatic Anticoagulant Activity of the Mutant Serine Protease Ser360Ala Activated Protein C Mediated by Factor Va. Protein Science, 6, 132-140, 1997.
7. Kojima, Y, Heeb, MJ, Gale, AJ, Hackeng, TM, Griffin, JH. Binding Site for Blood Coagulation Factor Xa Involving Residues 311-325 in Factor Va. Journal of Biological Chemistry 273:14900-14905, 1998. PDF
8. Pellequer, J-L, Gale, AJ, Griffin, JH, Getzoff, ED. Homology Models of the C domains of Blood Coagulation Factors V and VIII: A Proposed Membrane Binding Mode for FV and FVIII C2 Domains. Blood Cells, Molecules, and Diseases, 24, 448-461, 1998. PDF
9. Gale, AJ, Pellequer, J-L, Getzoff, ED, Griffin, JH. Structural Basis for Hemophilia A Caused by Mutations in the C Domains of Blood Coagulation Factor VIII. Thrombosis and Haemostasis, 83, 78-85, 2000.
10. Gale, AJ, Heeb, MJ, Griffin, JH. The Autolysis Loop of Activated Protein C Interacts with Factor Va and Differentiates Between the Arg506 and Arg306 Cleavage Sites. Blood, 96, 585-593, 2000.
11. Pellequer, J-L, Gale, AJ, Getzoff, ED, Griffin, JH. Three-Dimensional Model Of The Coagulation Factor Va Bound to Activated Protein C. Thrombosis and Haemostasis, 84, 849-857, 2000.
12. Gale, AJ, Tsavaler, A, Griffin, JH. Molecular Characterization of an Extended Binding Site for Coagulation Factor Va in the Positive Exosite of Activated Protein C. Journal of Biological Chemistry, 277, 28836-28840, 2002. PDF
13. Gale, AJ, Xu, X, Pellequer, J-L, Getzoff, ED, Griffin, JH., Interdomain Engineered Disulfide Bond Permitting Elucidation of Mechanisms of Inactivation of Coagulation Factor Vaby Activated Protein C. Protein Science, 11, 2091-2101, 2002.
14. Gale, AJ, Pellequer J-L. An engineered interdomain disulfide bond stabilizes human blood coagulation factor VIIIa. J Thromb Haemost, 1(9):1966-1971, 2003.
15. Gale, AJ, Griffin, JH. Characterization of a Thrombomodulin Binding Site on Protein C and its comparison to an Activated Protein C Binding Site for Factor Va. Proteins: Structure, Function and Bioinformatics, 54:433-41, 2004.
16. Mosnier, LO, Gale, AJ, Yegneswaran, S, Griffin, JH., Activated Protein C Variants with Normal Cytoprotective but Reduced Anticoagulant Activity. Blood, 104:1740-1744, 2004.
17. Gale, AJ, Radtke, K-P, Cunningham, MA, Chamberlain, D, Pellequer, J-L and Griffin, JH. Intrinsic stability and functional properties of disulfide bond-stabilized factor VIIIa variants. J Thromb Haemost, 4:1315-1322, 2006.
18. Radtke, K-P, Griffin, JH, Riceberg, J, Gale, AJ. Disulfide bond-stabilized factor VIII has prolonged factor VIIIa activity and improved potency in whole blood clotting assays. J Thromb Haemost, 5:102-108, 2007.
19. Gale, AJ, Yegneswaran, S, Xu, X, Pellequer, J-L and Griffin, JH. Characterization of a factor Xa binding site on factor Va near the Arg506 APC cleavage site. J Biol Chem, 282:21848-55, 2007.
20. Yegneswaran S, Kojima, Y, Nguyen, PM, Gale, AJ, Heeb, MJ and Griffin, JH. Factor Va residues 311-325 represent an activated protein C binding region. J Biol Chem, 282:28353-61, 2007.
21. Gale, AJ, Rozenshteyn, D. The leukocyte protease, cathepsin G, may modulate the activity of coagulation factor VIII. Thrombosis and Haemostasis, 99:44-51, 2008.
22. Gale, AJ, Cramer, TJ, Rozenshteyn, D, Cruz, JR. Detailed mechanisms of the inactivation of factor VIIIa by activated protein C and its cofactors, protein S and factor V. J Biol Chem, 283:16355-62, 2008. PMCID: PMC2423237.
23. Yegneswaran, S, Nguyen, PM, Gale, AJ, Griffin, JH, Prothrombin amino terminal region helps protect coagulation factor Va from proteolytic inactivation by activated protein C. Thrombosis and Haemostasis, 101:55-61, 2009. PMCID: PMC19132189.
24. Udit, AK, Everett, C, Gale AJ, Reiber Kyle, J, Ozkan, M, Finn MG. Heparin antagonism by polyvalent display of cationic motifs on virus-like particles. ChemBioChem, 10:503-510, 2009. PMCID: PMC19156786.
Invited Reviews and Conference Proceedings
1. Gale, AJ and Schimmel, P. Affinity Coelectrophoresis for Dissecting Protein‑RNA Domain‑Domain Interactions in a tRNA Synthetase System. Proceedings of the Young Scientists View of Molecular Biotechnology Conference, in Pharmaceutica Acta Helvetiae, 71, 45-50, 1996.
2. Pellequer, J-L, Gale, AJ, Getzoff, ED. Blood Coagulation: The Outstanding Hydrophobic Residues. Current Biology, 10, R237-R240, 2000.
3. Gale, AJ, Gordon, SG. An Update on Tumor Cell Procoagulant Factors. Acta Haematologica, 106:25-32, 2001.
4. Griffin, JH, Fernandez, JA, Gale, AJ, Mosnier, LO. Activated Protein C. ISTH 2007 State of the Art. J Thromb Haemost, 5 (suppl. 1), 73-80, 2007.
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