Welcome to the laboratory of Prof. Velia M. Fowler: the Laboratory for Cellular Architecture!
We’re located in the Department of Cell and Molecular Biology at The Scripps Research Institute, situated on the beautiful Torrey Pines mesa in La Jolla, CA (see map). The Fowler laboratory studies cellular architecture: how cells spatially organize themselves and their interior compartments to achieve intricate geometries, mechanical strength, and physiological function. The principal driver of cellular architecture is the cytoskeleton, a collection of specialized and dynamic “building blocks” and “struts” that act as a cell’s structural scaffolding. Our investigations into the cytoskeleton focus on structural elements known as actin filaments, with a particular emphasis on the functions of the tropomodulin and tropomyosin families of proteins that interact with and regulate actin filaments. Feel free to use this website as a resource to learn about the exciting science in our laboratory.