Phil LoGrasso Publications
Lab Members Publications

  • Jiang, R., Duckett, D., Chen, W., Habel, J., Ling, Y-Y., LoGrasso, Philip, and Kamenecka, T.M.  2007. 3,5- Disubstituted Quinolines as Novel c-Jun N-Terminal Kinase Inhibitors. Bioorg. Med. Chem. Lett. 17:6378-6382.

  • eng,Yangbo, Cameron, Michael, D., Frackowiak, Bozena, Griffin, Evelyn, Lin, Li, Ruiz, Claudia, Schroter, Thomas, and LoGrasso, Philip. 2007. Structure Activity Relationships and Drug Metabolism and Pharmacokinetic Properties for Indazole Piperazine and Indazole Piperidine Inhibitors of ROCK-II  Bioorganic Med. Chem. Lett., 17:2355-2360.
  • Rech, Jason C., Yato, Michihisa, Duckett, Derek, Ember, Brian, LoGrasso, Philip V., Bergman, Robert G., and Ellman, Jonathan, A. 2007. Synthesis of Potent Bicyclic Bis-Arylimidazole c-Jun N-Terminal Kinase Inhibitors by Catalytic C-H Bond Activation J. Am Chem Soc., 129:490-491.
  • Zhang ,Wen Xiao, Wang, Ruixiu, Wisniewski, Douglas, Marcy, Alice, Cameron, Patricia, LoGrasso, Philip , Lisnock, Jean Marie, Cummings, Richard, and Thompson, James. 2005 Fluorescence Resonance Energy Transfer Assays for the Binding of Nucleotide and Protein Substrates to p38 a Protein Kinase Analytical Biochemistry , 343: 76-83.

  • Fricker, Michael, LoGrasso, Philip , Ellis, Semantha, Wilkie, Neil, Hunt, Peter, and Pollack, Scott. 2005. Substituting c-Jun N-terminal kinase-3 (JNK3) ATP-binding site amino acid residues with their p38 counterparts affects binding of JNK- and p38-selective inhibitors Archives Biochemistry and Biophysics , 438: 195-205.

  • LoGrasso, Philip and McKelvy, Jeffrey. 2003. Advances in Pain Therapeutics Current Opinion in Chemical Biology 7: 452-456.

  • Scapin, Giovanna, Patel, Sangita, Lisnock, JeanMarie, Becker, Joseph, and LoGrasso, Philip . 2003. The Structure of JNK3 in Complex with Small Molecule Inhibitors: Structural Basis for Potency and Selectivity Chemistry and Biology 10: 1-20.

  • Trauger, John, Jiang, Alice, Stearns, Brian, and LoGrasso, Philip . 2002. Kinetics of Allopregnanolone Formation Catalyzed by Human 3 a -Hydroxysteroid Dehydrogenase Type III (AKR1C2) † Biochemistry 41: 13451-13459.

  • Trauger, John, Lin, Fen-Fen, Turner, Mary, Stephens, Jeffery, and LoGrasso, Philip . 2002. Kinetic Mechanism for Human Rho-Kinase II (ROCK II). † Biochemistry 41: 8948-8953.

  • Turner, Mary, Lin, Fen-Fen, Trauger, John, Stephens, Jeffery, and LoGrasso, Philip . 2002. Characterization and Purification of Truncated Human Rho-Kinase II Expressed in Sf -21 cells. Archives of Biochemistry and Biophysics 405:13-20.

  • LoGrasso, Philip , Bilsland, James, Harper, Sarah, Lisnock, JeanMarie, Tam, John, Xanthoudakis, Steven, and Young, Lisa. Use of (Di-Substituted-Phenyl)-Pyrimidinyl-Imidazole Derivatives as JNK-Inhibitors. Patent WO200191749: Issued March, 2002.

  • LoGrasso, Philip , Hawkins, Julio, and Lisnock, JeanMarie. Isolated Nucleic Acid Molecules Encoding a Novel Human Signal Transducing Kinase-MAPKAP2; Encoded Proteins, Cells Transformed Therewith and Uses Thereof. † Case: PCT 20813. Filed March 2002.

  • Harper, Sarah, and LoGrasso, Philip . 2001. Inhibitors of the JNK Signaling Pathway. † Drugs of the Future 26: † 957-973.

  • Harper, Sarah, and LoGrasso, Philip . 2001. Signaling for Survival and Death in Neurons: The Role of Stress-Activated Kinases, JNK and p38. † Cellular Signaling 13:299-310.

  • Hawkins, Julio, Zheng, Song, Frantz, Betsy, and LoGrasso, Philip . 2000 p38 MAP Kinase Substrate Specificity Differs Greatly for Protein and Peptide Substrates. Archives of Biochemistry and Biophysics 382:310-313.

  • Lisnock, JeanMarie, Griffin, Patrick, Calaycay, Jimmy, Frantz, Betsy, Parsons, Janey, O'Keefe, Stephen, and LoGrasso, Philip . 2000. Activation of JNK3 a 1 requires both MKK4 and MKK7: Kinetic Characterization of in vitro phosphorylated JNK3a1. † Biochemistry 39: 3141-3148.

  • Wisniewski, Doug, LoGrasso, Philip , Calaycay, Jimmy, and Marcy, Alice. 1999. Assay for I kB Kinases using an in vi vo Biotinylated I kB Protein Substrate. † Analytical Biochemistry 274:220-228.

  • Xue, Song, Green, Michael A., LoGrasso, Philip V. , Boettcher, Brian R., Madison, Edwin L., Curtiss, Linda K., and Miles, Lindsey A. 1999. Comparison of the Effects of Apo(a) Kringle IV-10 and Plasminogen Kringles on the Interactions of Lipoprotein(a) with Regulatory Molecules . Thromb. Haemost. 81: 428-435.

  • Lisnock, JeanMarie, Tebben, Andy, Frantz, Betsy, O'Neill, Edward, A., Croft, Gist, O'Keefe, Stephen, J., Li, Bing, Hacker, Candace, de Laszlo, Stephen, Smith, Anthony, Libby, Brian, Liverton, Nigel, Hermes, Jeffrey, and LoGrasso, Philip . 1998.
    Molecular Basis for p38 Protein Kinase Inhibitor Specificity. Biochemistry 37:† 16573-16581
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  • LoGrasso, Philip V. , Frantz, Betsy, Rolando, Anna M., O'Keefe, Stephen J., Hermes, Jeffery D. and O'Neill, Edward A. † 1997. Kinetic Mechanism For p38 MAP Kinase. † Biochemistry † 36:10422-10427.

  • LoGrasso, Philip V. , Hawkins, Julio, Frank, Lori J., Wisniewski, Douglas and Marcy, Alice. † 1996. Mechanism of Activation For Zap 70 Catalytic Activity. † Proc. Natl. Acad. Sci. 93:12165-12170.