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X-Ray Crystallography Core Facility

Selected Recent Publications

  1. Disney JC, Yildirim I, Park H, Lohman J, Guan L, Tran T, Sarkar P, Schatz GC, Disney MD. Structure of the Myotonic Dystrophy Type 2 RNA and Designed Small Molecules That Reduce Toxicity. JACS, 2014.
  2. Childs-Disney JL, Stepniak-Konieczna E, Tran T, Yildirim I, Park H, Chen CZ, Hoskins J, Southall N, Marugan JJ, Patnaik S, Zheng W, Austin C, George C. Schatz G, Sobczak K, Thornton CA, Disney MD. Induction and Reversal of Myotonic Dystrophy Type 1 Pre-mRNA Splicing Defects by Small Molecules. Nature Communications, 2013, Jun 28;4:2044.
  3. Feng Y, Chambers JW, Iqbal S, Koenig M, Park H, Cherry L, Hernandez P, Figuera-Losada M, LoGrasso PV. A Small Molecule Bidentate-Binding Dual Inhibitor Probe of the LRRK2 and JNK Kinases. ACS Chem Biol., 2013, Jun 10;8(8):1747-54.
  4. Yin Y, Lin L, Ruiz C, Khan S, Cameron MD, Grant W, Pocas J, Eid N, Park H, Schroeter T, LoGrasso PV, Feng Y. Synthesis and Biological Evaluation of Urea Derivatives as Highly Potent and Selective Rho Kinase (ROCK) Inhibitors. J Med Chem., 2013, Apr 9;56(9):3568-81.
  5. Jeso, V, Iqbal S, Hernandez P, Cameron MD, Park H, LoGrasso PV, Micalizio GC. Synthesis of benzoquinone ansamycin-inspired macrocyclic lactams from shikimic acid. Angewandte Chemie International Edition, 2013, Apr 26;52(18):4800-4.
  6. Yildirim I, Park H, Disney MD, Schatz GE. A Dynamic Structural Model of Expanded RNA CAG Repeats: A Refined X-ray Structure and Computational Investigations Using Molecular Dynamics and Umbrella Sampling Simulations. JACS, 2013, Mar 6, 135(9):3528-38.
  7. Zhang T, Inesta-Vaquera F, Niepel M, Zhang J, Ficarro SB, Machleidt T, Xie T, Marto JA, Kim N, Sim T, Laughlin JD, Park H, LoGrasso PV, Patricelli M, Nomanbhoy TK, Sorger PK, Alessi Dr, Gray NS. Discovery of Potent and Selective Covalent Inhibitors of JNK. Chem & Biol, 2012, Jan 27;19(1):140-54.
  8. Kumar A, Park H, Fang P, Parkesh R, Guo M, Nettles KW, Disney MD. Myotonic Dystrophy Type 1 RNA Crystal Structures Reveal Heterogeneous 1 x 1 Nucleotide UU Internal Loop Conformations. Biochemistry, 2011, Oct 11;50(45):9928-35.
  9. Park H, Lee JH, Gouin E, Cossart P, Izard T. The Rickettsia surface cell antigen 4 applies mimicry to bind to and activate vinculin. J Biol Chem., 2011, Jul 1;286(40):35096-103.
  10. Kumar A, Fang P, Park H, Guo M, Nettles KW, Disney MD. A Crystal Structure of a Model of the Repeating r(CGG) Transcript Found in Fragile X Syndrome. ChemBiochem, 2011, 12:2140-42.
  11. Lee JH, AN JY, Park H, Kim HJ, Eom SH. Crystallization and preliminary X-ray crystallographic analysis of the human kindling-2 PH domain. Acta Cryst F, 2011, 67(Pt 6):696-9
  12. Park H, Valencia-Gallardo C, Nhieu G, Izard T. Novel vinculin binding site of the IpaA invasin of Shigella. J Biol Chem., 2011, Jul 1;286(26):23214-21.
  13. Lee JH*, Park H*, Park SJ, Kim HJ, Eom SH. Structural flexibility of Shank PDZ domain is important for its binding to different ligands. BBRC, 2011, Apr 1;407(1)207-212 (*shared first authorship).