Macromolecular X-Ray Crystallography Core Facility

Long Term Collaborative Projects

-Inhibitor Design and Optimization of Protein Kinases

-RNA Repeat Expansion Disease

Crystals obtained from RNA constructs containing sequences of RNA repeat expansion disease.

-Receptor forAdvance Glycation Endproduct

Surface features of RAGE structure; Mixed hydrophobic and positively charged regions make up multiple ligand binding sites.

-Natural Product Inspired Synthesis

Crystal structure of Hsp90 in complex with a geldanamycin-like compound. The 2Fo-Fc electron density map of the bound compound is shown in three contour levels.