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Translational Research Institute

Chairman's Overview

Patrick Griffin, Ph.D.Patrick Griffin, Ph.D., Chairman

The Scripps Research Institute's translational research program combines the drug discovery efforts at the Scripps Florida campus with technology platforms such as high throughput genomic screening and proteomics. The goal of the drug discovery operation is to discover and develop novel therapeutic agents for unmet medical needs in areas such as inflammation, neurodegeneration, stroke, cancer, and metabolic disorders. These efforts are coordinated through the Translational Research Institute (TRI), which oversees and coordinates the different functional areas of the program such as medicinal chemistry, discovery biology, drug metabolism and pharmacokinetics, lead identification and high throughput small molecule screening, informatics, and pharmacology. In addition to the drug discovery components of the TRI, the high throughput genomic screening core provides support and assay development for large scale cDNA and siRNA functional studies. The Proteomics Core focuses on the application of liquid chromatography and mass spectrometry to identify, quantify, and characterize the proteome.