2007 Recent Publications

Tetrahedron. 2007 Jun 25;63(26):5768-5796.
Total Synthesis of Amphidinolide E and Amphidinolide E Stereoisomers.
Va P, Roush WR.
- Departments of Chemistry and Biochemistry
Four amphidinolide E stereoisomers, amphidinolide E (1), 2-epi-amphidinolide E (2), 19-epi-amphidinolide E (3), and 2-epi-19-epi-amphidinolide E (4), have been synthesized...

Bioorg Med Chem Lett. 2007 Nov 15;17(22):6378-82.
3,5-Disubstituted quinolines as novel c-Jun N-terminal kinase inhibitors.
Jiang R, Duckett D, Chen W, Habel J, Ling YY, LoGrasso P, Kamenecka TM
-Department of Medicinal Chemistry
The structure-based design and synthesis of a novel series of c-Jun N-terminal kinase (JNK) inhibitors ...

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20314-9.
A coactivator trap identifies NONO (p54nrb) as a component of the cAMP-signaling pathway.
Amelio AL, Miraglia LJ, Conkright JJ, Mercer BA, Batalov S, Cavett V, Orth AP, Busby J, Hogenesch JB, Conkright MD.
-Departments of Cancer Biology, Molecular Therapeutics, and Translational Research Institute
Signal transduction pathways often use a transcriptional component to mediate adaptive cellular responses...