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• Mol Biosyst 7 (1): 48-51 Jan 2011. PMID: 20607165
  A combinatorial approach to characterize the substrate specificity of protein arginine methyltransferase 1
  Bicker, KL; Obianyo, O*; Rust, HL*; Thompson, PR*
  - *Department of Chemistry
  The dysregulation of protein arginine methyltransferases (PRMTs) is implicated in a wide variety of disease states.
  
  
• J Biol Chem 285(52):40762-70 Dec 24, 2010. Epub 2010 Oct 13. PMID: 20943659
  The 1.5 angstrom Crystal Structure of Human Receptor for Advanced Glycation Endproducts (RAGE) Ectodomains Reveals Unique Features Determining Ligand Binding
  Park, H*; Boyington, JC
  - *Department of Cancer Biology
  Interaction of the pattern recognition receptor, RAGE with key ligands such as advanced glycation end products (AGE), S100 proteins, amyloid β and HMGB1 has been linked to diabetic complications, inflammatory and neurodegenerative disorders, and cancer.
  
  
• Physiology 25 (6): 338-346 Dec 2010. PMID: 21186278
  Olfactory Learning in Drosophila
  Busto, GU; Cervantes-Sandoval, I; Davis, RL
  - Department of Neuroscience
  Studies of olfactory learning in Drosophila have provided key insights into the brain mechanisms underlying learning and memory.
  
  
• Chem Commun (Camb). 2010 Oct 14;46(38):7175-7. Epub 2010 Aug 25. PMID: 20740228
  A fluopol-ABPP HTS assay to identify PAD inhibitors
  Knuckley B, Jones JE, Bachovchin DA, Slack J, Causey CP, Brown SJ, Rosen H, Cravatt BF, Thompson PR
  - Department of Chemistry
  Protein Arginine Deiminase (PAD) activity is dysregulated in numerous diseases, e.g., Rheumatoid Arthritis.
  
  
• Proc Ntl Acad Sci U.S.A. 107 (52): 22653-22658 Ded 28 2010. PMID: 21156827
  Transfer of a prion strain to different hosts leads to emergence of strain variants
  Mahal, SP; Browning, S; Li, JL; Suponitsky-Kroyter, I;
  Weissmann, C
  - Department of Infectology
  Prions consist mainly of PrP(Sc), a pathogenic conformer of host-encoded PrP(C).
  
  
• J Biol Chem. 2010 Nov 12;285(46):35386-92. Epub 2010 Sep 3. PMID: 20817722
  Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene
  Crumbley C, Wang Y, Kojetin DJ, Burris TP
  - Department of Molecular Therapeutics
  The mammalian clock is regulated at the cellular level by a transcriptional/translational feedback loop.
  
  
• Neuropharmacology 60 (1): 58-65 Jan 2011. PMID: 20713067
  The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics
  Raehal, KM; Bohn, LM
  - Department of Molecular Therapeutics and Neuroscience
  Ligands acting at the same receptor can differentially activate distinct signal transduction pathways, which in turn, can have diverse functional consequences.
  
  
• J Am Chem Soc. 2011 Feb 10. PMID: 21309555
  Stepwise Synthesis of Giant Unilamellar Vesicles on a Microfluidic Assembly Line
  Matosevic S, Paegel BM
  - Department of Chemistry
  Among the molecular milieu of the cell, the membrane bilayer stands out as a complex and elusive synthetic target.
  
  
• J Org Chem. 2010 Dec 3;75(23):8048-59. Epub 2010 Nov 11 PMID: 21069994
  Preparation of stereodefined homoallylic amines from the reductive cross-coupling of allylic alcohols with imines
  Chen MZ*, McLaughlin M, Takahashi M*, Tarselli MA, Yang D*, Umemura S, Micalizio GC*
  - *Department of Chemistry
  Regio-, diastereo-, and enantioselective coupling reactions between imines and allylic alcohols have been developed.
  
  
• Bioorg Med Chem Lett. 2011 Jan 22. PMID: 21316221
  Synthesis and SAR of novel quinazolines as potent and brain-penetrant c-jun N-terminal kinase (JNK) Inhibitors
  He Y, Kamenecka TM, Shin Y, Song X, Jiang R, Noel R, Duckett D*, Chen W, Ling YY, Cameron MD*, Lin L, Khan S, Koenig M, Lo Grasso PV**
  - * Department of Drug Metabolism and Pharmacokinetics; **Department of Molecular Therapeutics
  A single amino acid change, F580Y (Legs at odd angles (Loa), Dync1h1(Loa)), in the highly conserved and overlapping homodimerization, intermediate chain, and light intermediate chain binding domain of the cytoplasmic dynein heavy chain can cause severe motor and sensory neuron loss in mice.
  
  
• Neurobiol Learn Mem. 2011 Feb 11. PMID: 21320618
  The Path to Epigenetic Treatment of Memory Disorders
  Mikaelsson MA, Miller CA
  - *Department of Metabolism & Aging
  A new line of neuroscience research suggests that epigenetics may be the site of nature and nurture integration by providing the environment with a mechanism to directly influence the read-out of our genome.
  
  
• J Neurosci 2010 Dec 8;30(49):16699-708. PMID: 21148009
  A Late-Phase, Long-Term Memory Trace Forms in the gamma Neurons of Drosophila Mushroom Bodies after Olfactory Classical Conditioning
  Akalal, DBG; Yu, DH; Davis, RL*
  - *Department of Neuroscience
  sing functional optical imaging in vivo, we demonstrate that the γ mushroom body (MB) neurons of Drosophila melanogaster respond with axonal calcium influx when odors or electric shock stimuli are presented to the fly.
  
  
• Journal of Virology 85 (1): 596-605 Jan 2011. PMID: 20962076
  Neutralizing Antibody-Resistant Hepatitis C Virus Cell-to-Cell Transmission
  Brimacombe, CL; Grove, J; Meredith, LW; Hu, K; Syder, AJ; Flores, MV; Timpe, JM; Krieger, SE; Baumert, TF; Tellinghuisen, TL*; Wong-Staal, F; Balfe, P; McKeating, JA
  - *Department of Infectology
  Hepatitis C virus (HCV) can initiate infection by cell-free particle and cell-cell contact-dependent transmission.
  
  
• Acta crystallographica. Section F, Structural biology and crystallization communications, 2010 Dec 1;66(Pt 12):1617-20. Epub 2010 Nov 25. PMID:21139209
  Improving the diffraction of full-length human selenomethionyl metavinculin crystals by streak-seeding
  Rangarajan, Erumbi S.; Izard, Tina.
  - Department of Cancer Biology
  Metavinculin is an alternatively spliced isoform of vinculin that has a 68-residue insert in its tail domain (1134 total residues) and is exclusively expressed in cardiac and smooth muscle tissue, where it plays important roles in myocyte adhesion complexes.
  
  
• J Am Chem Soc. 2009 Aug 26;131(33):11686-8. PMID: 19653684
  Transition-state charge transfer reveals electrophilic, ambiphilic, and nucleophilic carbon-hydrogen bond activation
  Periana RA*; Ess DH, Nielsen RJ, Goddard WA 3rd.
  - *Department of Chemistry
  Absolutely localized molecular orbital energy decomposition analysis of C-H activation transition states (TSs), including Pt, Au, Ir, Ru, W, Sc, and Re metal centers, shows an electrophilic, ambiphilic, and nucleophilic charge transfer (CT) continuum irrespective of the bonding paradigm (oxidative addition, sigma-bond metathesis, oxidative hydrogen migration, 1,2-substitution).
  
  
• J Neurosci. 2011 Jan 26;31(4):1448-1460. PMID: 21273429
  Regulation of Synapse Structure and Function by Distinct Myosin II Motors
  Rumbaugh G.*; Rubio MD, Johnson R, Miller CA, Huganir RL.
  - *Department of Neuroscience
  Ongoing synaptic function and rapid, bidirectional plasticity are both controlled by regulatory mechanisms within dendritic spines.
  
  
• PLoS One. 2011 Jan 20;6(1):e16194. PMID: 21283762
  Protein-Protein Interactions within Late Pre-40S Ribosomes
  Campbell MG, Karbstein K.
  - Department of Cancer Biology
  Ribosome assembly in eukaryotic organisms requires more than 200 assembly factors to facilitate and coordinate rRNA transcription, processing, and folding with the binding of the ribosomal proteins.
  
  
• Nature. 2011 Jan 30. [Epub ahead of print] PMID: 21278726
  Habenular α5 nicotinic receptor subunit signalling controls nicotine intake.
  Fowler CD, Lu Q, Johnson PM, Marks MJ, Kenny PJ.
  - Laboratory for Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics
  Genetic variation in CHRNA5, the gene encoding the α5 nicotinic acetylcholine receptor subunit, increases vulnerability to tobacco addiction and lung cancer, but the underlying mechanisms are unknown.
  
  
• Stem Cells. 2011 Jan;29(1):3-4. doi: 10.1002/stem.553. PMID: 2128015
  Twist, Epithelial-to-Mesenchymal Transition, and Stem Cells.
  Phinney DG.
  - *Department of Molecular Therapeutics
  
  
• BIOLOGY OF REPRODUCTION : 94-94 196 Suppl. S 2010
  The CREB Coactivator CRTC1 Is Required for Energy Balance and Fertility
  Altarejos, JY; Goebel, N; *Conkright, MD; Inoue, H; Xie, JX; Arias, CM; Sawchenko, PE; Montminy, M
  - *Department of Cancer Biology
  
  
• Cell. 2011 Jan 7;144(1):132-42. PMID: 21215375
  Identification of Candidate IgG Biomarkers for Alzheimer's Disease via Combinatorial Library Screening.
  Reddy MM, Wilson R, Wilson J, Connell S, Gocke A, Hynan L, German D, Kodadek T.
  - Opko Health Laboratories
  The adaptive immune system is thought to be a rich source of protein biomarkers, but diagnostically useful antibodies remain unknown for a large number of diseases.
  
  
• Bioinformatics. 2011 Jan 6. [Epub ahead of print] PMID: 21216779
  A Java API for working with PubChem data-sets.
  Southern M, Griffin P.
  - Translational Research Institute and Molecular Therapeutics,
  PubChem is a public repository of chemical structures and associated biological activities.
  
  

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