- Mol Biosyst 7 (1): 48-51 Jan 2011. PMID: 20607165
A combinatorial approach to characterize the
substrate specificity of protein arginine methyltransferase 1
Bicker, KL; Obianyo, O*; Rust, HL*; Thompson, PR*
- *Department of Chemistry
The dysregulation of protein arginine methyltransferases (PRMTs) is implicated in a wide variety of disease states.
- J Biol Chem 285(52):40762-70 Dec 24, 2010. Epub 2010 Oct 13. PMID: 20943659
The 1.5 angstrom Crystal Structure of Human
Receptor for Advanced Glycation Endproducts (RAGE) Ectodomains Reveals Unique
Features Determining Ligand Binding
Park, H*; Boyington, JC
- *Department of Cancer Biology
Interaction of the pattern recognition receptor, RAGE with key ligands
such as advanced glycation end products (AGE), S100 proteins, amyloid β and HMGB1 has been linked to diabetic complications, inflammatory and neurodegenerative disorders, and cancer.
- Physiology 25 (6): 338-346 Dec 2010. PMID: 21186278
Olfactory Learning in Drosophila
Busto, GU; Cervantes-Sandoval, I; Davis, RL
- Department of Neuroscience
Studies of olfactory learning in Drosophila have provided key insights into the brain mechanisms underlying learning and memory.
- Chem Commun (Camb). 2010 Oct 14;46(38):7175-7. Epub
2010 Aug 25. PMID: 20740228
A fluopol-ABPP HTS assay to identify PAD inhibitors
Knuckley B, Jones JE, Bachovchin DA, Slack J,
Causey CP, Brown SJ, Rosen H, Cravatt BF, Thompson PR
- Department of Chemistry
Protein Arginine Deiminase (PAD) activity is dysregulated in numerous diseases, e.g., Rheumatoid Arthritis.
- Proc Ntl Acad Sci U.S.A. 107 (52): 22653-22658 Ded 28 2010. PMID: 21156827
Transfer of a prion strain to different hosts leads to emergence of strain variants
Mahal, SP; Browning, S; Li, JL; Suponitsky-Kroyter,
I;
Weissmann, C
- Department of Infectology
Prions consist mainly of PrP(Sc), a pathogenic conformer of host-encoded PrP(C).
- J Biol Chem. 2010 Nov 12;285(46):35386-92. Epub 2010 Sep 3. PMID: 20817722
Characterization of the core mammalian clock component, NPAS2, as a REV-ERBalpha/RORalpha target gene
Crumbley C, Wang Y, Kojetin DJ, Burris TP
- Department of Molecular Therapeutics
The mammalian clock is regulated at the cellular level by a
transcriptional/translational feedback loop.
- Neuropharmacology 60 (1): 58-65 Jan 2011. PMID: 20713067
The role of beta-arrestin2 in the severity of
antinociceptive tolerance and physical dependence induced by different opioid
pain therapeutics
Raehal, KM; Bohn, LM
- Department of Molecular Therapeutics and Neuroscience
Ligands acting at the same receptor can differentially activate distinct signal transduction pathways, which in turn, can have diverse
functional consequences.
- J Am Chem Soc. 2011 Feb 10. PMID: 21309555
Stepwise Synthesis of Giant Unilamellar Vesicles on a Microfluidic Assembly Line
Matosevic S, Paegel BM
- Department of Chemistry
Among the molecular milieu of the cell, the membrane bilayer stands out as a complex and elusive synthetic target.
- J Org Chem. 2010 Dec 3;75(23):8048-59. Epub 2010
Nov 11 PMID: 21069994
Preparation of stereodefined homoallylic amines
from the reductive cross-coupling of allylic alcohols with imines
Chen MZ*, McLaughlin M, Takahashi M*, Tarselli MA,
Yang D*, Umemura S, Micalizio GC*
- *Department of Chemistry
Regio-, diastereo-, and enantioselective coupling reactions between imines and allylic alcohols have been developed.
- Bioorg Med Chem Lett. 2011 Jan 22. PMID: 21316221
Synthesis and SAR of novel quinazolines as
potent and brain-penetrant c-jun N-terminal kinase (JNK) Inhibitors
He Y, Kamenecka TM, Shin Y, Song X, Jiang R,
Noel R, Duckett D*, Chen W, Ling YY, Cameron MD*, Lin L, Khan S, Koenig M,
Lo Grasso PV**
- * Department of Drug Metabolism and Pharmacokinetics; **Department of Molecular Therapeutics
A single amino acid change, F580Y (Legs at odd angles (Loa),
Dync1h1(Loa)), in the highly conserved and overlapping homodimerization,
intermediate chain, and light intermediate chain binding domain of the
cytoplasmic dynein heavy chain can cause severe motor and sensory neuron
loss in mice.
- Neurobiol Learn Mem. 2011 Feb 11. PMID: 21320618
The Path to Epigenetic Treatment of Memory
Disorders
Mikaelsson MA, Miller CA
- *Department of Metabolism & Aging
A new line of neuroscience research suggests that epigenetics may be the
site of nature and nurture integration by providing the environment with
a mechanism to directly influence the read-out of our genome.
- J Neurosci 2010 Dec 8;30(49):16699-708. PMID: 21148009
A Late-Phase, Long-Term Memory Trace Forms in the gamma Neurons of Drosophila Mushroom Bodies after Olfactory Classical
Conditioning
Akalal, DBG; Yu, DH; Davis, RL*
- *Department of Neuroscience
sing functional optical imaging in vivo, we demonstrate that the γ
mushroom body (MB) neurons of Drosophila melanogaster respond with
axonal calcium influx when odors or electric shock stimuli are presented
to the fly.
- Journal of Virology 85 (1): 596-605 Jan 2011. PMID: 20962076
Neutralizing Antibody-Resistant Hepatitis C Virus Cell-to-Cell Transmission
Brimacombe, CL; Grove, J; Meredith, LW; Hu, K; Syder, AJ; Flores, MV; Timpe, JM; Krieger, SE; Baumert, TF; Tellinghuisen, TL*;
Wong-Staal, F; Balfe, P; McKeating, JA
- *Department of Infectology
Hepatitis C virus (HCV) can initiate infection by cell-free particle and cell-cell contact-dependent transmission.
- Acta crystallographica. Section F, Structural biology and crystallization communications, 2010 Dec 1;66(Pt 12):1617-20. Epub 2010 Nov 25. PMID:21139209
Improving the diffraction of full-length human
selenomethionyl metavinculin crystals by streak-seeding
Rangarajan, Erumbi S.; Izard, Tina.
- Department of Cancer Biology
Metavinculin is an alternatively spliced isoform of vinculin that has a
68-residue insert in its tail domain (1134 total residues) and is
exclusively expressed in cardiac and smooth muscle tissue, where it
plays important roles in myocyte adhesion complexes.
- J Am Chem Soc. 2009 Aug 26;131(33):11686-8. PMID: 19653684
Transition-state charge transfer reveals
electrophilic, ambiphilic, and nucleophilic carbon-hydrogen bond activation
Periana RA*; Ess DH, Nielsen RJ, Goddard WA 3rd.
- *Department of Chemistry
Absolutely localized molecular orbital energy decomposition analysis of
C-H activation transition states (TSs), including Pt, Au, Ir, Ru, W, Sc,
and Re metal centers, shows an electrophilic, ambiphilic, and
nucleophilic charge transfer (CT) continuum irrespective of the bonding
paradigm (oxidative addition, sigma-bond metathesis, oxidative hydrogen
migration, 1,2-substitution).
- J Neurosci. 2011 Jan 26;31(4):1448-1460. PMID: 21273429
Regulation of Synapse Structure and Function by
Distinct Myosin II Motors
Rumbaugh G.*; Rubio MD, Johnson R, Miller CA, Huganir RL.
- *Department of Neuroscience
Ongoing synaptic function and rapid, bidirectional plasticity are both
controlled by regulatory mechanisms within dendritic spines.
- PLoS One. 2011 Jan 20;6(1):e16194. PMID: 21283762
Protein-Protein Interactions within Late Pre-40S Ribosomes
Campbell MG, Karbstein K.
- Department of Cancer Biology
Ribosome assembly in eukaryotic organisms requires more than 200
assembly factors to facilitate and coordinate rRNA transcription,
processing, and folding with the binding of the ribosomal proteins.
- Nature. 2011 Jan 30. [Epub ahead of print] PMID: 21278726
Habenular α5 nicotinic receptor subunit signalling controls nicotine intake.
Fowler CD, Lu Q, Johnson PM, Marks MJ, Kenny PJ.
- Laboratory for Behavioral and Molecular Neuroscience, Department of Molecular Therapeutics
Genetic variation in CHRNA5, the gene encoding the α5 nicotinic acetylcholine receptor subunit, increases vulnerability to tobacco addiction and lung cancer, but the underlying mechanisms are unknown.
- Stem Cells. 2011 Jan;29(1):3-4. doi: 10.1002/stem.553. PMID: 2128015
Twist, Epithelial-to-Mesenchymal Transition, and Stem Cells.
Phinney DG.
- *Department of Molecular Therapeutics
- BIOLOGY OF REPRODUCTION : 94-94 196 Suppl. S 2010
The CREB Coactivator CRTC1 Is Required for Energy Balance and Fertility
Altarejos, JY; Goebel, N; *Conkright, MD; Inoue, H; Xie, JX; Arias, CM; Sawchenko, PE; Montminy, M
- *Department of Cancer Biology
- Cell. 2011 Jan 7;144(1):132-42. PMID: 21215375
Identification of Candidate IgG Biomarkers for Alzheimer's Disease via Combinatorial Library Screening.
Reddy MM, Wilson R, Wilson J, Connell S, Gocke A, Hynan L, German D, Kodadek T.
- Opko Health Laboratories
The adaptive immune system is thought to be a rich source of protein biomarkers, but diagnostically useful antibodies remain unknown for a large number of diseases.
- Bioinformatics. 2011 Jan 6. [Epub ahead of print] PMID: 21216779
A Java API for working with PubChem data-sets.
Southern M, Griffin P.
- Translational Research Institute and Molecular Therapeutics,
PubChem is a public repository of chemical structures and associated biological activities.