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Infectology

Publications

Weissmann Lab

Birth of a prion: Spontaneous generation revisited. C. Weissmann. Cell, 122, 165-168 (2005)

Prion strain discrimination in cell culture: The cell panel assay. S.P. Mahal, C.A. Baker, C.A. Demczyk, E.W. Smith, C. Julius and C. Weissmann. PNAS, 104, 20908-913 (2007)

Assaying Prions in Cell Culture: The Standard Scrapie Cell Assay (SSCA) and the Scrapie Cell Assay in End Point Format (SCEPA). Sukhvir P. Mahal, Cheryl A. Demczyk, Emery W. Smith, Jr., Peter-Christian Klohn and Charles Weissmann. In Methods in Molecular Biology: Prions, Ed. A.F. Hill, Humana Press. 459:49-68 (2008)

Transcriptional stability of cultured cells upon prion infection. C. Julius, G. Hutter, U. Wagner, H. Seeger, V. Kana, Jan Kranich, P. Klöhn, C. Weissmann, G. Miele and A. Aguzzi. J. Mol. Biol. 375,1222-1233 (2008)

A highly sensitive, quantitative cell-based assay for prions adsorbed to solid surfaces. J.A. Edgeworth, G. S. Jackson, A.R. Clarke, C. Weissmann and J. Collinge. PNAS, 106, 3479-83  (2009)

Prion strain discrimination based on rapid in vivo amplification and analysis by the cell panel assay. Y.E. Karapetyan, P. Saa, S. P.Mahal, G.F. Sferazza, A. Sherman, N. Sales, C. Weissmann and C.I. Lasmezas. PLoS One. 4, e5730 (2009)

Thoughts on mammalian prion strains. C. Weissmann. Folia Neuropathol., 47, 104-113 (2009)

Darwinian evolution of prions in cell culture. J. Li, S. Browning, S. P. Mahal, A.M. Oelschlegel and C. Weissmann. Science 12, 869-72 (2010). Epub 2009 Dec 31

Spontaneous generation of mammalian prions. J. Edgeworth, N. Gross, J. Alden, S. Joiner, J.D.F., Wadsworth, J. Linehan, S. Brandner, G.S. Jackson, C. Weissmann and J. Collinge. PNAS 1007, 14402-6 (2010). Epub 2010 Jul 26

Tellinghuisen Lab

Tellinghuisen, T.L., Paulson, M.S. and Rice, C.M. The NS5A Protein of Bovine Viral Diarrhea Virus Contains an Essential Zinc-Binding Site Similar to the Hepatitis C NS5A Protein. J. Virology. 80(15):7450-58, 2006.

Randall, G., Panis, M., Cooper, J.D., Tellinghuisen, T.L., Soukhodolets, K.E., Pfeffer, S., Landthaler, M., Landgraf, P., Kan, S., Lindenbach, B.D., Chien, M., Weir, D.B., Russo, J.J., Ju, J., Brownstein, M.J., Sheridan, R., Sander, C., Zavolan, M., Tuschl, T., and Rice, C.M. Cellular cofactors affecting hepatitis C virus infection and replication. Proc Natl Acad Sci U S A. 104(31):12884-9, 2007.

Tellinghuisen, T.L.*, Evans, M.J., Von Hahn, T., You, S., and Rice, C.M., Studying Hepatitis C…Making the Best Out of a Bad Virus. J Virol. 81, 117:8853-57, 2007.

*Corresponding Author

Tellinghuisen, T.L., Treadaway. J., Foss, K. and Rice, C.M., Identification of Residues Required for RNA Replication in Domains II and III of the Hepatitis C Virus NS5A Protein. J. Virology. 82(3):1073-83, 2008.

Tellinghuisen, T.L.*, Foss, K.L., and Treadaway, J. C., Regulation of hepatitis C virion production via phosphorylation of the NS5A protein. PLOS Pathogens. Mar 21;4(3), 2008. *Corresponding Author

Tellinghuisen, T.L., and Marcotrigiano, J., Purification and Crystallization of NS5A Domain I of Hepatitis C Virus. Book Chapter in Hepatitis C, 2nd edition. Methods Mol. Biol., 510:85-94, 2009.

Tellinghuisen, T.L., and Lindenbach, B.D., Reverse Transcription PCR-Based

Sequence Analysis of Hepatitis C Virus Replicon RNA. Book Chapter in Hepatitis C, 2nd edition. Methods Mol. Biol., 510:165-175, 2009.

Tellinghuisen, T.L., Foreword to Hepatitis C, 2nd edition, Methods Mol. Biol., 510, 2009.

Lindenbach, B.D., and Tellinghuisen, T.L., Hepatitis C Virus RNA Replication. Book Chapter in Viral Genome Replication. Cameron, C.E. and Gotte, M., editiors. Springer press, 2009.

Shapshak, P., Somboonwit, C., Drumright, L.N., Frost, S.D., Commins, D.,

Tellinghuisen, T.L., Scott, W.K., Duncan, R., McCoy, C., Page, J.B., Giunta, B.,

Fernandez, F., Singer, E., Levine, A., Minagar, A., Oluwadara, O., Kotila, T., Chiappelli, F., and Sinnott, J.T. Molecular and contextual markers of hepatitis C virus and drug abuse. Mol Diagn Ther. 13(3):153-79. 2009.

Lemon, S.M., McKeating, J.A., Pietschmann, T., Frick, D.N., Glenn, J.S., Tellinghuisen, T.L., Symons, J., and Furman, P.A. Development of Novel Therapies for Hepatitis C. Antiviral Res. 6(1):79-92. 2010.

Brimacombe, C.L., Grove, J., Meredith, L.W., Hu, K., Syder, A.J., Flores, M.V., Timpe, J.M., Krieger, S.E., Baumert, T.F., Tellinghuisen, T.L., Wong-Staal, F., Balfe, P., McKeating, J.A., Neutralizing antibody resistant hepatitis C virus cell-to-cell transmission. J Virol. 2010 Oct 20. [Epub ahead of print]

Tellinghuisen, T.L., Current view of the HCV viral lifecycle. Book Chapter in Hepatitis C: Antiviral Drug Discovery and Development. Horizon Press. In press.

Tellinghuisen, T.L., BMS-790052, a HCV NS5A inhibitor for the treatment of HCV infection. Current Opinion in Drug Discovery & Development. In press.

Tellinghuisen, T.L., The Hepatitis C NS5A Protein; from Pariah to Potent Drug Target. Viruses. In press.

Foss-LeMay, K.L., Paulson, M.S., Treadaway, J., Cannizzaro, C., Angulo-Herrera, I., and Tellinghuisen, T.L., Mutational Analysis of the Hepatitis C Virus NS5A Protein Dimer Interface. In revision.

Lasmezas Lab

Gauczynski, S., Nikles, D., El-Gogo, S., Papy-Garcia, D., Rey, C.,Barritault, D., Lasmézas, C.I. and Weiss, S. The 37 kDa/67 kDa laminin receptor acts as a receptor for infectious prions and is inhibited by polysulfated glycanes. J Inf Dis; 2006 : 194(5):702-9.

Vidal C, Meric P., Provost F., Herzog, C., Lasmézas C., Gillet B., Beloeil J.C., Dormont D. Preclinical metabolic changes in mouse prion diseases detected by 1H-nuclear magnetic resonance spectroscopy. Neuroreport 2006; 17(1):89-93.

Lasmézas C.I. Of mice and men… and vCJD. The Lancet Neurology 2006; 5:374-5.

Simoneau S., Rezaei H., Salès N., Kaiser-Schulz G., Lefebvre-Roque M., Vida C., Fournier J.-G., Comte J., Wopfner F., Grosclaude J., Schätzl H., Lasmézas C.I. In vitro and in vivo neurotoxicity of prion protein oligomers.  PLoS Pathogens; 2007:3(8):1175-86.

Lefebvre-Roque M., Kremmer E., Gilch S., Zou Wen-Quan, Féraudet C., Mourton Gilles C., Salès N., Grassi J., Gambetti P., Baron T., SChätzl H., Lasmézas C.I. Toxic effects of intracerebral PrP antibody administration during the course of BSE infection in mice. Prion; 2007:1(3):198-206.

Comoy E.E., Casalone C., Lescoutra-Etchegaray N., Zanusso G., Freire S., Marcé D., Auvré F., Ruchoux M., Ferrari S., Monaco S., Salès N., Caramelli M., Leboulch P., Brown P., Lasmézas C.I., Deslys J.P. Atypical BSE (BASE) transmitted from asymptomatic aging cattle to a primate. PLoS ONE; 2008:3:e3017. PMC# MCC2515088.

Vidal C., Herzog ., Haeberle A.M., Bombarde C., Miquel M.C., Carimalo J., Launay J.M., Mouillet-Richard S., Lasmézas C.I., Dormont D., Kellermann O., Bailly Y. Early dysfunction of central 5-HT system in a murine model of bovine spongiform encephalopathy. Neuroscience; 2009:160: 731-743.

Karapetyan Y., Saa P., Mahal S., Sferrazza G., Sherman A., Salès N., Weissmann C. and. Lasmézas C.I. Prion strain discrimination based on rapid in vivo amplification and analysis by the cell panel assay. PLoS ONE; 2009:4:e5730. PMC# 2684634.

Strosberg Lab

Kota, S., Scampavia, L., Spicer, T., Beeler, A.B., Takahashi, V., Snyder, J.K., Porco, J.A. Jr., Hodder, P., Strosberg, A.D. A Time-Resolved Fluorescence-Resonance Energy Transfer Assay for Identifying Inhibitors of Hepatitis C Virus Core Dimerization. ASSAY and Drug Development Technologies 8(1): 96-105 (2010).

Wei, W., Cai, C., Kota, S., Takahashi, V., Strosberg, A.D, Snyder, J.K. New Small Molecule Inhibitors of Hepatitis C Virus. Bioorganic & Medicinal Chemistry Letters, 19(24): 6926-6930 (2009).

Kota, S., Coito, C., Mousseau, G., Lavergne, J-P., and Strosberg, A.D., "Peptide inhibitors of Hepatitis C Virus Core Oligomerization and Virus Production", J Gen Virol. 90(Pt 6): 1319-1328 (2009).

Strosberg, A.D., Kota, S., Takahashi, V., Snyder, J.K., Mousseau, G. Core as a Novel Viral Target for Hepatitis C Drugs. Viruses, 2(8): 1734-51 (2010).

Mousseau, G., Kota, S., Takahashi, V., Frick, D.N., Strosberg, A.D. “Dimerization-driven interaction of Hepatitis C Virus core protein with NS3 helicase”, Journal of General Virology, 92(1): 101-111 (2011).

Patent Application:

Snyder, J.K., Strosberg, A.D., Wei, W-G., Ni, F., Kota, S., Takahashi, V. Small Molecule Inhibitors of Hepatitis C Virus. Patent Application Number: 61/279,856 Filed October 27, 2009.