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Scripps Research Joint Appointments

Faculty, Kellogg School of Science and Technology

Research Focus

The research in Luo's lab focuses on mechanistic and translational research in molecular signaling that connects epigenetic factors with genetic events during tumor genesis, progression and metastasis. Specifically, Luo's lab is working on how epigenetic signaling regulates cancer initial cells self-renewal and trans-differentiation.

Education

M.D., Clinical Medical Science, Hunan Medical University, 1989
Ph.D., Oncology and Cancer Biology, Hunan Medical University, 1997

Selected References

Wang, G. G., Song, J., Wang, Z., Dormann, H. L., Casadio, F., Li, H., Luo, J-L., Patel, D. J., and Allis, C. D. 2009. Haematopoietic malignancies initiated by dysregulation of a chromatin-binding PHD finger. Nature, May 19.

Kim, S., Takahashi, H., Lin, W-W., Descargues, P., Grivennikov, S., Kim Y., Luo, J-L., Karin M. 2009. Carcinoma Produced Factors Activate Myeloid Cells via TLR2 to Stimulate Metastasis.Nature, 457:102-6.

Matsuzawa, A., Tseng, P-H., Vallabhapurapu, S., Luo, J-L., Zhang, W., Wang, H., Vignali, D. A. A., Gallagher, E., Karin, M. (2008) Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex.Science, 321:663-8.

Luo, J-L., Tan, W., Ricono, J. M., Korchynskyi, O., Zhang, M., Gonias, S. L., Cheresh D. A., and Karin, M. (2007) Nuclear cytokine-activated IKKalpha controls prostate cancer metastasis by repressing Maspin. Nature, 446: 690-4.