Directory | Contact | Careers | Intranet | Home

Scripps Research Joint Appointments

Associate Professor, Department of Molecular Therapeutics

Research Focus

The Hodder laboratory, in collaboration with other scientists at Scripps and around the world, identifies “lead” compounds that can help better understand and ultimately cure diseases such as cancer, diabetes, Alzheimer's and hepatitis. By combining robotics, biology, chemistry and informatics, we are able to perform High-Throughput Screening, a robotic process employing sophisticated automation, detection and assay technologies that tests hundreds of thousands of drug-like compounds for biological activity both rapidly and economically. In addition we have the personnel and facilities to engage both pre- and post-HTS activities, including HTS assay development, cheminformatics, compound synthesis/procurement, compound QC (via LC-MS) and mechanism of action/profiling studies. We work with mammalian, yeast and bacterial targets. Our expertise can be accessed through collaborative mechanisms, such as the NIH’s Molecular Libraries initiative (http://mlpcn.florida.scripps.edu/). In other efforts, we research and develop novel automation, instrumentation and assay technologies that benefit the HTS disciplines. We are also engaged in developing novel probes and therapeutics relevant to infectious disease research.

 

Education

B.S., Chemistry, University of California, San Diego, 1994
Ph.D., Chemistry, University of Washington, 1999

Professional Experience

Research Fellow, Department of Automated Biotechnology, Merck Research Laboratories, 2003-2005.
Senior Research Biochemist, Department of Automated Biotechnology, Merck Research Laboratories, 1999-2003.

Awards & Professional Activities

Professional Memberships:
Society for Laboratory Automation and Screening, 1999-
American Society for Microbiology, 2008-
American Society for Pharmacology & Experimental Therapeutics, 2009-
American Chemical Society, 2011-
Service:
Steering Committee, Merck Technology Symposium, 2003-2005.
MRL Analytical Instrumentation & Nanotechnology Research and Licensing Committee, 2004-2005.
Consultant, Palm Beach Community College Biotechnology Program Business Partnership Council, May 2007.
Society for Biomolecular Sciences 2009-2011, Program Committee.
Society for Biomolecular Sciences 2011, Conference Co-Chair.
Society for Laboratory Automation and Screening 2013, Program Committee & Track Chair.
Society for Laboratory Automation and Screening 2014, Program Committee & Track Chair.
Study Section Memberships:
Scientific Reviewer, National Institutes of Health, Molecular and Integrative Signal Transduction, ZRG1 MIST-G (01), 2007.
Scientific Reviewer, National Institutes of Health, Assay Development for High Throughput Molecular Screening, ZMH1- ERB-Y (06), 2007.
Study Section Panelist, Ontario Institute for Cancer Research, The Cancer Research Fund (CRF), Assay Development and High Throughput Screens, 2007.
Scientific Reviewer, National Institutes of Health, Special Emphasis Panel Cell Biology, ZRG1 CB-B (10), 2008-2009.
Scientific Reviewer, National Institutes of Health, Cell Biology and Molecular Imaging, ZRG1 IMST-J 16/17, 2009-2010.
Scientific Reviewer, The Division of Research at Florida Atlantic University, 2010.
Scientific Reviewer, National Institutes of Health, Biological Chemistry and Macromolecular Biophysics, ZRG1 BCMB-A (51), 2010.
Scientific Reviewer, National Institutes of Health, Library of Integrated Network Based Cellular Signatures (LINCS) Panel/Scientific Review Group Study Section, RFA–RM-10-004, "Advanced Technologies for Detection of Perturbation-Induced Cellular Signature (U01)", 2011.
Scientific Reviewer, National Heart, Lung, and Blood Institute (NHLBI), Science Moving towArds Research Translation and Therapy (SMARTT) program, 2011.

Selected References

Nagano J.M., Hsu K.L., Whitby L.R., Niphakis M.J., Speers A.E., Brown S.J., Spicer T., Fernandez-Vega V., Ferguson J., Hodder P., Srinivasan P., Gonzalez T.D., Rosen H., Bahnson B.J., Cravatt B.F.
Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2).
Bioorg Med Chem Lett. 2013 Feb 1;23(3):839-43. PMID: 23260346

Jacobs J., Grum-Tokars V., Zhou Y., Turlington M., Saldanha S.A., Chase P., Eggler A., Dawson E.S., Baez-Santos Y.M., Tomar S., Mielech A.M., Baker S.C., Lindsley C.W., Hodder P., Mesecar A., Stauffer S.R.
Discovery, synthesis, and structure-based optimization of a series of N-(tert-Butyl)-2-(N-arylamido)-2-(pyridin-3-yl) acetamides (ML188) as potent noncovalent small molecule inhibitors of the severe acute respiratory syndrome coronavirus (SARS-CoV) 3CL protease. J Med Chem. 2013 Jan 24;56(2):534-46. PMID: 23231439

Qin Q, Knapinska A, Dobri N,
Madoux F, Chase P, Hodder P, Petrukhin K
In Pursuit of Synthetic Modulators for the Orphan Retina-Specific Nuclear
Receptor NR2E3.
J Ocul Pharmacol Ther. 2012 Oct 25. [Epub ahead of print]. PMID: 23098562

Urbano M, Guerrero M, Zhao J,
Velaparthi S, Adrian Saldanha S, Chase P, Wang Z, Civelli O, Hodder P,
Schaeffer MT, Brown S, Rosen H, Roberts E
Design, synthesis and SAR analysis of novel potent and selective small
molecule antagonists of NPBWR1 (GPR7).
Bioorg Med Chem Lett. 2012 Dec 1;22(23):7135-41 PMID: 23079522

Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder PS, Rosen H, Cravatt BF
Confirming Target Engagement for Reversible Inhibitors in Vivo by Kinetically Tuned Activity-Based Probes.
J Am Chem Soc. 2012 Jun 27;134(25):10345-8. PMID: 22690931

Amundsen SK, Spicer T, Karabulut AC, Londoño LM, Eberhart C, Fernandez VV, Bannister TD, Hodder P, Smith GR
Small-Molecule Inhibitors of Bacterial AddAB and RecBCD Helicase-Nuclease DNA Repair Enzymes.
ACS Chem Biol. 2012 May 18;7(5):879-91.  PMID: 22443934

Guerrero M, Urbano M, Zhao J, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E
Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P(4)-R) agonists.
Bioorg Med Chem Lett. 2012 Jan 1;22(1):537-42.  PMID: 22119461

Calamini B, Silva MC, Madoux F, Hutt DM, Khanna S, Chalfant MA, Saldanha SA, Hodder P, Tait BD, Garza D, Balch WE, and Morimoto RI
Small Molecule Proteostasis Regulators for Protein Conformational Diseases.
Nature Chemical Biology, 2011 Dec 25;8(2):185-96.  PMID: 22198733

Roth J, Minond D, Darout E, Liu Q, Lauer J, Hodder P, Fields GB, Roush WR
Identification of novel, exosite-binding matrix metalloproteinase-13 inhibitor scaffolds.
Bioorg Med Chem Lett., 2011 Dec 1;21(23):7180-4. PMID: 22018790

Urbano M, Guerrero M, Velaparthi S, Crisp M, Chase P, Hodder P, Schaeffer MT, Brown S, Rosen H, Roberts E Discovery, synthesis and SAR analysis of novel selective small molecule S1P(4)-R agonists based on a (2Z,5Z)-5-((pyrrol-3-yl)methylene)-3-alkyl-2-(alkylimino)thiazolidin-4-one chemotype
Bioorg Med Chem Lett., 2011 Nov 15;21(22):6739-45. PMID: 21982495

Peatey CL, Spicer T, Hodder P, Trenholme KR, Gardiner DL
A high-throughput assay for the identification of drugs against late-stage Plasmodium falciparum gametocytes Molecular & Biochemical Parasitology, 2011 Dec;180(2):127-31.  PMID: 21939693

Tsuboi K, Bachovchin DA, Speers AE, Spicer TP, Fernandez-Vega V, Hodder P, Rosen H, Cravatt BF
Potent and Selective Inhibitors of Glutathione S-transferase Omega 1 that Impair Cancer Drug Resistance.
J Am Chem Soc. 2011 Oct 19;133(41):16605-16.  PMID: 21899313

Bialkowska A, Crisp M, Bannister T, He Y, Chowdhury S, Schurer S, Chase P, Spicer T, Madoux F, Tian C, Hodder P, Zaharevitz D, Yang VW
Identification of small-molecule inhibitors of the colorectal cancer oncogene Krüppel-like factor 5 expression by ultrahigh-throughput screening
Mol Cancer Ther.  2011 Nov;10(11):2043-51. PMID: 21885866

Lone AM, Bachovchin D, Westwood D, Speers AE, Spicer TP, Fernandez-Vega V, Chase P, Hodder P, Rosen H, Cravatt BF, Saghatelian A
A substrate-free activity-based protein profiling screen for the discovery of selective PREPL inhibitors
J Am Chem Soc.  2011 Aug 3;133(30):11665-74.  PMID: 21692504

Baillargeon P, Scampavia L, Einsteder R, Hodder P
Monitoring of HTS compound library quality via a high-resolution image acquisition and processing instrument
J Lab Autom. 2011 Jun;16(3):197-203. PMID: 21609702

Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors
Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6811-6.   PMID: 21398589

Chou TF, Brown SJ, Minond D, Nordin BE, Li K, Jones AC, Chase P, Porubsky PR, Stoltz BM, Schoenen FJ, Patricelli MP, Hodder P, Rosen H, Deshaies RJ
Reversible inhibitor of p97 DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways
Proc Natl Acad Sci U S A.  2011 Mar 22;108(12):4834-9.  PMID: 21383145

Istrate MA, Spicer TP, Wang Y, Bernard JA, Helvering LM, Bocchinfuso WP, Richardson TI, Zink R, Kumar N, Montrose-Rafizadeh C, Dodge J, Hodder P, Griffin PR
Development of an HTS-compatible assay for discovery of RORα modulators using AlphaScreen® technology
J Biomol Screen.  2011 Feb;16(2):183-91.  PMID: 21297105

Doghman M, Madoux F, Hodder P, Lalli E
Identification and characterization of steroidogenic factor-1 inverse agonists
Methods Enzymol. 2010;485:3-23. PMID: 21050908

Madoux F, Simanski S, Chase P, Mishra JK, Roush WR, Ayad NG, Hodder PS
An ultra-high throughput cell-based screen for Wee1 degradation inhibitors
J Biomol Screen. 2010 Sep;15(8):907-17.  PMID: 20660794

Weide T, Saldanha SA, Minond D, Fotsing JR, Spaargaren M, Frère JM, Bebrone C, Sharpless KB, Hodder P, Fokin VV NH-1,2,3-triazole-based inhibitors of the VIM-2 metallo-beta-lactamase: synthesis and structure-activity studies.
ACS Med Chem Lett. 2010 Jul 8;1(4):150-154. PMID: 20625539

Brunell D, Weissbach H, Hodder P, Brot N
A high-throughput screening compatible assay for activators and inhibitors of methionine sulfoxide reductase A
Assay Drug Dev Technol. 2010 Oct;8(5):615-20.  PMID: 20515413

Bachovchin DA, Wolfe MR, Masuda K, Brown SJ, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF
Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9)
Bioorg Med Chem Lett. 2010 Apr 1;20(7):2254-8. PMID: 20207142

Grimm C, Jörs S, Saldanha SA, Obukhov AG, Pan B, Oshima K, Cuajungco MP, Chase P, Hodder P, Heller S
Small molecule activators of TRPML3
Chem Biol. 2010 Feb 26;17(2):135-48.  PMID: 20189104

Tanaka K, Koresawa M, Iida M, Fukasawa K, Stec EM, Cassaday J, Chase P, Rickert K, Hodder P, Takagi T, Komatani H
Multiplexed random peptide library and phospho-specific antibodies facilitate human polo-like kinase 1 inihibor screen
Assay Drug Dev Technol. 2010 Feb;8(1):47-62.  PMID: 20085455

Kota S, Scampavia L, Spicer T, Beeler AB, Takahashi V, Snyder JK, Porco JA, Hodder P, Strosberg AD
A time-resolved fluorescence-resonance energy transfer assay for identifying inhibitors of hepatitis C virus core dimerization
Assay Drug Dev Technol. 2010 Feb;8(1):96-105.  PMID: 20035614

Brothers SP, Saldanha SA, Spicer TP, Cameron M, Mercer BA, Chase P, McDonald P, Wahlestedt C, Hodder PS
Selective and brain penetrant neuropeptide Y Y2 receptor antagonists discovered by whole-cell high-throughput screening
Mol Pharmacol. 2010 Jan;77(1):46-57. PMID: 19837904

Minond D, Saldanha SA, Subramaniam P, Spaargaren M, Spicer T, Fotsing JR, Weide T, Fokin VV, Sharpless KB, Galleni M, Bebrone C, Lassaux P, Hodder P
Inhibitors of VIM-2 by screening pharmacologically active and click-chemistry compound libraries
Bioorg Med Chem. 2009 Jul 15;17(14):5027-37. PMID: 19553129

Doghman M, Cazareth J, Douguet D, Madoux F, Hodder P, Lalli E
Inhibition of adrenocortical carcinoma cell proliferation by steroidogenic factor-1 inverse agonists
J Clin Endocrinol Metab. 2009 Jun;94(6):2178-83.  PMID: 19318454

Lauer-Fields JL, Minond D, Chase PS, Baillargeon PE, Saldanha SA, Stawikowska R, Hodder P, Fields GB
High throughput screening of potentially selective MMP-13 exosite inhibitors utilizing a triple-helical FRET substrate
Bioorg Med Chem. 2009 Feb 1;17(3):990-1005.  PMID: 18358729

Schürer SC, Brown SJ, Gonzalez-Cabrera PJ, Schaeffer MT, Chapman J, Jo E, Chase P, Spicer T, Hodder P, Rosen H
Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening
ACS Chem Biol. 2008 Aug 15;3(8):486-98.  PMID: 18590333

Chung CC, Ohwaki K, Schneeweis JE, Stec E, Varnerin JP, Goudreau PN, Chang A, Cassaday J, Yang L, Yamakawa T, Kornienko O, Hodder P, Inglese J, Ferrer M, Strulovici B, Kusunoki J, Tota MR, Takagi T
A fluorescence-based thiol quantification assay for ultra-high-throughput screening for inhibitors of coenzyme A production
Assay Drug Dev Technol. 2008 Jun;6(3):361-74.  PMID: 18452391

Madoux F, Li X, Chase P, Zastrow G, Cameron MD, Conkright JJ, Griffin PR, Thacher S, Hodder P Potent, selective and cell penetrant inhibitors of SF-1 by functional ultra-high-throughput screening.
Mol Pharmacol. 2008 Jun;73(6):1776-84. PMID: 18334597

Roth J, Madoux F, Hodder P, Roush WR
Synthesis of small molecule inhibitors of the orphan nuclear receptor steroidogenic factor-1 (NR5A1) based on isoquinolinone scaffolds
Bioorg Med Chem Lett. 2008 Apr 15;18(8):2628-32.  PMID: 18374567

Schröter T, Minond D, Weiser A, Dao C, Habel J, Spicer T, Chase P, Baillargeon P, Scampavia L, Schürer S, Chung C, Mader C, Southern M, Tsinoremas N, LoGrasso P, Hodder P
Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of rho-kinase II (ROCK-II)
J Biomol Screen. 2008 Jan;13(1):17-28.  PMID: 18227223

Lauer-Fields JL, Spicer TP, Chase PS, Cudic M, Burstein GD, Nagase H, Hodder P, Fields GB
Screening of potential a disintegrin and metalloproteinase with thrombospondin motifs-4 inhibitors using a collagen model fluorescence resonance energy transfer substrate
Anal Biochem. 2008 Feb 1;373(1):43-51.  PMID: 17949675

Hodder PS
Building a uHTS laboratory
Drug Discovery World. 2005 Winter;6:31-42

Hodder PS
Integration of miniaturisation technologies into the high throughput screening laboratory
European Pharmaceutical Review. 2005;2:47-55

Zuck P, O'Donnell GT, Cassaday J, Chase P, Hodder P, Strulovici B, Ferrer M
Miniaturization of absorbance assays using the fluorescent properties of white microplates
Anal Biochem. 2005 Jul 15;342(2):254-9.  PMID: 15949786

Hale JJ, Lynch CL, Neway W, Mills SG, Hajdu R, Keohane CA, Rosenbach MJ, Milligan JA, Shei GJ, Parent SA, Chrebet G, Bergstrom J, Card D, Ferrer M, Hodder P, Strulovici B, Rosen H, Mandala S
A rational utilization of high-throughput screening affords selective, orally bioavailable 1-benzyl-3-carboxyazetidine sphingosine-1-phosphate-1 receptor agonists
J Med Chem. 2004 Dec 30;47(27):6662-5.  PMID: 15615513

Hodder P, Mull R, Cassaday J, Berry K, Strulovici B
Miniaturization of intracellular calcium functional assays to 1536-well plate format using a fluorometric imaging plate reader
J Biomol Screen. 2004 Aug;9(5):417-26.  PMID: 15296641

Kunapuli P, Ransom R, Murphy KL, Pettibone D, Kerby J, Grimwood S, Zuck P, Hodder P, Lacson R, Hoffman I, Inglese J, Strulovici B
Development of an intact cell reporter gene beta-lactamase assay for G protein-coupled receptors for high-throughput screening
Anal Biochem. 2003 Mar 1;314(1):16-29.  PMID: 12633598

Hodder P, Cassaday J, Peltier R, Berry K, Inglese J, Feuston B, Culberson C, Bleicher L, Cosford ND, Bayly C, Suto C, Varney M, Strulovici B
Identification of metabotropic glutamate receptor antagonists using an automated high throughput screening system
Anal Biochem. 2003 Feb 15;313(2):246-54.  PMID: 12605861

Hodder PS, Beeson C, Ruzicka J
Equilibrium and kinetic measurement of muscarinic receptor antagonism on living cells using bead injection spectroscopy
Anal Chem. 2000 Jul 15;72(14):3109-15.  PMID: 10939374

Scampavia LD, Hodder PS, Lähdesmäki I, Ruzicka J
Automation of functional assays by flow injection fluorescence microscopy
Trends Biotechnol. 1999 Nov;17(11):443-7.   PMID: 10511702

Hodder PS, Ruzicka J
A flow injection renewable surface technique for cell-based drug discovery functional assays
Anal Chem. 1999 Mar 15;71(6):1160-6. PMID: 10093496

Hodder PS, Blankenstein G, Ruzicka J
Microfabricated flow chamber for fluorescence-based chemistries and stopped-flow injection cytometry
Analyst. 1997 Sep;122(9):883-7.  PMID: 9374023

BELOW IS A LISTING OF PROBE REPORTS THAT WERE CREATED AS PART OF THE MOLECULAR LIBRARIES PROBE PRODUCTION CENTER NETWORK (MLPCN), MORE INFORMATION CAN BE FOUND here.

Guerrero M, Urbano M, Wang Z, Zhao J, Velaparthi S, Schaeffer MT, Brown SJ, Saldanha SA, Chase P, Ferguson J, Civelli O, Roberts E, Hodder P, Rosen H
[ML181] Optimization and Characterization of an Antagonist for G-Protein Coupled Receptor 7 (GPR7)
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010 Oct 13 [updated 2011 Nov 21].  PMID 22834040.

Busby S, Nuhant P, Cameron M, Mercer BA, Hodder P, Roush WR, Griffin PR
[ML179/ML180] Discovery of Inverse Agonists for the Liver Receptor Homologue-1 (LRH1; NR5A2)
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US);2010 Oct 12 [updated 2011 Dec 12]. PMID: 23166964

Guerrero M, Urbano M, Velaparthi S, Zhao J, Schaeffer MT, Brown SJ, Crisp M, Ferguson J, Roberts E, Oldstone M, Hodder P, Rosen H
[ML178] Probe Development Efforts to Identify Novel Agonists of the Sphingosine 1-phosphate Receptor 4 (S1P4)
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010 Oct 12 [updated 2011 Dec 12].  PMID 22834032.

Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H
[ML175] Optimization and Characterization of an Inhibitor for Glutathione S-Tranferase Omega 1 (GSTO1)
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010 Aug 31 [updated 2011 Dec 12].  PMID 22834034.

Bachovchin DA, Speers AE, Brown SJ, Spicer TP, Fernandez-Vega, Ferguson J, Mohr JT, Murphy J, Fu GC, Cravatt BF, Hodder PS, Rosen H
[ML174] Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1)
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010 Aug 31 [updated 2011 Dec 12].  PMID 22834039

Gianni D, Nicolas N, Zhang H, Der Mardirossian C, Kister J, Martinez L, Ferguson J, Roush WR, Brown SJ, Bokoch GM, Hodder P, Rosen H
[ML171] Optimization and Characterization of an Inhibitor for NADPH Oxidase 1 (NOX-1)
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010 Oct 13 [updated 2011 Dec 12].  PMID 22834042

Bachovchin DA, Speers AE, Zuhl AM, Brown SJ, Cravatt BF, Fernandez-Vega , Spicer T, Mercer BA, Ferguson J, Hodder P, Rosen HR
[ML136] Probe Report for PME-1 Inhibitors.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010 Feb 26 [updated 2010 Oct 20]. PMID: 21433379

Oldstone M, Hodder P, Crisp M, Roberts E, Guerrero M, Urbano M, Velaparthi S, Zhao J, Rosen H, Schaeffer MT, Brown S, Ferguson J
[ML131] Probe Development Efforts to Identify Novel Antagonists of the Sphingosine 1-phosphate Receptor 4 (S1P4).
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010 Feb 24 [updated 2010 Dec 16].  PMID: 21433398 

Kumar N, Solt LA, Conkright J, Wang Y, Istrate MA, Busby SA, Garcia-Ordonez RD, Nuhant P, Burris T, Mercer BA, Hodder P, Roush WR, Rosen H, Griffin PR
[ML124/ML125]Campaign to identify novel modulators of the Retinoic acid receptor-related Orphan Receptors (ROR).
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2009 Jan 3 [updated 2011 Mar 11].  PMID: 21735608 

Saldanha SA, Grimm C, Mercer BA, Choi JY, Allais C, Roush WR, Heller S, Hodder P.
[ML122/ML123] Campaign to Identify Agonists of Transient Receptor Potential Channels 3 and 2 (TRPML3 & TRPML2).
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US);2009 Nov 13 [updated 2011 May 5]. PMID: 22049579

Minond D, Saldanha SA, Spicer T, Qin L, Mercer BA, Roush WR, Hodder P.
[ML121] HTS Assay for Discovery of Novel Metallo-Beta-lactamase (MBL) Inhibitors.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2009 Nov 13 [updated 2011 May 5]. PMID: 21961119

Madoux F, Mishra J, Mercer BA, Ayad N, Roush W, Hodder P, Rosen HR
[ML118] Small Molecule Inhibitors of Wee1 Degradation and Mitotic Entry.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2009 Aug 14 [updated 2011 Mar 25].   PMID: 21735595 

Madoux F, Koenig M, Sessions H, Nelson E, Mercer BA, Cameron M, Roush W, Frank D, Hodder P
[ML116] Modulators of STAT Transcription Factors for the Targeted Therapy of Cancer (STAT3 Inhibitors). Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2009 Aug 28 [updated 2011 Mar 25]. PMID: 21735601

Madoux F, Koenig M, Nelson E, Chowdhury S, Cameron M, Mercer B, Roush W, Frank D, Hodder P
[ML115] Modulators of STAT Transcription Factors for the Targeted Therapy of Cancer (STAT3 Activators).
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2009 Aug 27 [updated 2010 Dec 16].  PMID: 21433395

Bachovchin DA, Speers AE, Brown SJ, Cravatt BF, V , Spicer T, Mercer BA, Ferguson J, Hodder P, Rosen HR
[ML114] Probe Report for RBBP9 Inhibitors.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2009 Aug 20 [updated 2010 Oct 20]. PMID: 21433382

Brown SJ, Gianni D, Bokoch G, Mercer BA, Hodder P, Rosen HR
[ML090] Probe Report for NOX1 Inhibitors
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2009 Apr 23 [updated 2010 Sep 2].   PMID: 21433358

Brown SJ, Bachovchin DA, Cravatt BF, Fernandez-Vega V, Spicer T, Mercer BA, Hodder P, Rosen HR
[ML081] Probe Report for RBBP9 Inhibitors
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2009 Mar 13 [updated 2010 Sep 2].   PMID: 21433353 

Brown SJ, Chou TF, Deshaies R, Roberts E, Guerrero M, Minond D, Mercer BA, Hodder P, Rosen HR
[ML080] Probe Report for P97/cdc48 Inhibitors.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2009 Mar 6 [updated 2010 Aug 6].   PMID: 21433362

Saldanha SA, Brothers SP, Spicer T, Cameron M, Mercer BA, Chase P, McDonald P, Wahlestedt C, Hodder PS
[ML072/ML073/ML074/ML075] Probe Report for NPY-Y2 Receptor Antagonists.
Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2009 Jan 13 [updated 2010 Aug 6].  PMID: 21433370 

SRIMSC
[ML287/ML288] Probe Report for Activators of Small Heterodimer Partner (SHP)
Probe Reports from the NIH Molecular Libraries Program [Internet]; 2008 Mar 27. SRIMSC website

SRIMSC
[ML056] Probe Report for S1P1 Antagonist
Probe Reports from the NIH Molecular Libraries Program [Internet]; 2008 Mar 30. MLI website

SRIMSC
[ML034] TSRI MLSCN Probe Report for Inhibitors of MMP-8
Probe Reports from the NIH Molecular Libraries Program [Internet]; 2007 Dec 20. MLI website

SRIMSC
[ML032/ML033] TSRI MLSCN Probe Report for Inhibitors of MMP-13
Probe Reports from the NIH Molecular Libraries Program [Internet]; 2007 Dec 19. MLI website

SRIMSC
[ML031] Probe Report for S1P Receptor Agonists and Antagonists, S1P2 Agonist
Probe Reports from the NIH Molecular Libraries Program [Internet]; 2007 Dec 14. MLI website

SRIMSC
[ML027] TSRI MLSCN Probe Report for Inhibitors of ADAMTS-4: Piceatannol
Probe Reports from the NIH Molecular Libraries Program [Internet]; 2007 Dec 7. MLI website

SRIMSC
[ML021] Probe Report for Toll-Like Receptors
Probe Reports from the NIH Molecular Libraries Program [Internet]; 2007 Oct 29. MLI website

SRIMSC
[ML019] Probe Report for Select Orphan Nuclear Receptors
Probe Reports from the NIH Molecular Libraries Program [Internet]; 2007 Oct 22. MLI website

SRIMSC
[ML018] Probe Report for Inverse Agonists of Retinoic Acid Receptors (RAR)
Probe Reports from the NIH Molecular Libraries Program [Internet]; 2007 Oct 22. MLI website

SRIMSC
[ML017] Probe Report for Inhibitors of SF-1/NR5A1
Probe Reports from the NIH Molecular Libraries Program [Internet]; 2007 Oct 22. MLI website

SRIMSC
[ML014] MLSCN Probe Summary: Rho Kinase II
Probe Reports from the NIH Molecular Libraries Program [Internet]; 2007 Aug 23. MLI website

SRIMSC
[ML007] MLSCN Probe Summary: S1P1 Agonist
Probe Reports from the NIH Molecular Libraries Program [Internet]; 2007 Feb 1. MLI website

SRIMSC
[ML003/ML004/ML005/ML006] MLSCN Probe Summary: S1P3 Agonist
Probe Reports from the NIH Molecular Libraries Program [Internet]; 2007 Feb 1. MLI website

Links

Scripps Molecular Screening Center

Lead Identification

Complete List of Publications